Transforming growth factor betas and their receptors in human liver cirrhosis

European Journal of Gastroenterology and Hepatology

Volumn 10, Issue 12, 1998, Pages 1031-1039

  Baer, Hans U ^a   Friess, Helmut ^a   Abou Shady, Mohamed ^a   Berberat, Pascal ^a   Zimmermann, Arthur ^a   Gold, Leslie I ^b   Korc, Murray ^b   Büchler, Markus W ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Inselspital ^*

Author keywords

Fibrogenesis; Immunohistochemistry; Liver cirrhosis; Northern blot analysis; Transforming growth factor beta; Transforming growth factor beta receptors

Indexed keywords

RNA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFLAMMATORY CELL; LIVER CIRRHOSIS; MALE; NORTHERN BLOTTING; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RNA ANALYSIS;

EID: 0032436178     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-199812000-00009     Document Type: Article

References (52)

1. Roberts AB, Sporn MB. (1990) Transforming growth factor-betas. In: Handbook of Experimental Pharmacology vol 95, pp. 419-472.
2. Jakowlew SB, Mead JE, Danielpour D, Wu J, Roberts AB, Fausto N. Transforming growth factor-β isoforms in rat liver regeneration: messenger RNA expression and activation of latent TGF-beta. Cell Regul 1991; 2:535-548.
3. Russel WE, Coffey RJ, Ouellette AJ, Moses HL. Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat. Proc Natl Acad Sci USA 1988; 85:5126-5130.
4. Massague J. The transforming growth factor-β family. Annu Rev Cell Biol 1990; 6:597-641.
5. Sporn MB, Roberts AB. Transforming growth factor-beta: recent progress and new challenges. J Cell Biol 1992; 119:1017-1021.
6. Massague J. Receptors for the TGF-beta family. Cell 1992; 69:1067-1070.
7. Bachem M, Meyer D, Melchior R, Sell KM, Gressner AM. Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblast-like cells. J Clin Invest 1992; 89:19-27.
8. Friedman SL, Arthur MJ. Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium: direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. J Clin Invest 1989; 84:1780-1785.
9. Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, et al. Transforming growth factor type-β: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 1986; 83:4167-4171.
10. Czaja MJ, Weiner FR, Flanders KC, Giambrone MA, Wind R, Biempica L, Zern MA. In vitro and in vivo association of transforming growth factor beta with hepatic fibrosis. J Cell Biol 1989; 108:2477-2482.
11. Raghow R, Postlethwaite AE, Keski-Oja J, Moses HL, Kang AH. Transforming growth factor-β increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts. J Clin Invest 1987; 79:1285-1288.
12. Edwards DR, Murphy G, Reynolds JJ, Whitham SE, Docherty AJ, Angel P, Heath JR. Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J 1987; 6:1899-1904.
13. Nagy P, Schaff Z, Lapis K. Immunohistochemical detection of transforming growth factor beta-1 in fibrotic liver diseases. Hepatology 1991; 14:269-273.
14. Massague J. Receptors for the TGF-beta family. Cell 1992; 69:1067-1070.
15. Lin HY, Wang XF, Ng-Eaton E, Weinberg RA, Lodisch HF. Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. Cell 1992; 68:775-785.
16. Wrana JL, Attisano I, Carcamo J, Zentella A, Doody J, Laiho M, et al. TGF-β signals through a heteromeric protein kinase receptor complex. Cell 1992; 71:1003-1014.
17. Lopez-Casillas F, Cheifetz S, Doody J, Andres JL, Lane WS, Massague J. Structure and expression of the membrane proteoglycan, a component of the TGF-β receptor system. Cell 1991; 67:785-795.
18. Wang XF, Lin HY, Ng-Eaton E, Downward J, Lodisch HF, Weinberg RA. Expression cloning and characterization of the TGF-β type III receptor. Cell 1991; 67:797-805.
19. ten Dijke P, Yamashita H, Ichijo H, Franzen P, Laiho M, Miyazono K, Heldin CH. Characterization of type I receptors for transforming growth factor-beta and activin. Science 1994; 264:101-104.
20. Matsuzaki K, Xu J, Wang F, McKeehan WL, Krummen L, Kan M. A widely expressed transmembrane serine/threonine kinase that does not bind activin, inhibin, transforming growth factor beta, or bone morphogenic factor. J Biol Chem 1993; 268:12719-12723.
21. Yamanaka Y, Friess H, Büchler M, Beger HG, Gold LI, Korc M. Synthesis and expression of transforming growth factor-beta 1, -beta 2, and -beta 3 in the endocrine and exocrine pancreas. Diabetes 1993; 42:746-756.
22. Friess H, Zhao L, Riesle E, Uhl W, Bründler MA, Horvath L, et al. Enhanced expression of TGF-βs and their receptors in human acute pancreatitis. Ann Surg 1998; 227:95-104.
23. McMullen H, Longaker MT, Cabera RC, Sung JJ, Canete J, Siebert JW, et al. Analysis of TGF-β1, TGF-β2, and TGF-β3 immunoreactivity during bovine wound repair. Wound Repair Regen 1995; 3:141-156.
24. Deflorin J, Friess H, Schobinger St, Bründler MA, Schilling M, Naef M, et al. Overexpression of the epidermal growth factor receptor family in gastric cancer suggests a role in tumor pathogenesis. Dig Surg 1997; 14:252-259.
25. Korc M, Chandrasekar B, Yamanaka Y, Friess H, Büchler M, Beger HG. Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increase in the levels of epidermal growth factor and transforming growth factor alpha. J Clin Invest 1992; 90:1352-1360.
26. Friess H, Yamanaka Y, Büchler M, Ebert M, Beger HG, Gold LI, Korc M. Enhanced expression of transforming growth factor-beta isoforms in pancreatic cancer correlates with decreased survival. Gastroenterology 1993; 105:1846-1856.
27. Friess H, Yamanaka Y, Büchler M, Beger HG, Kobrin MS, Baldwin RI, Korc M. Enhanced expression of type II transforming growth factor-beta receptor in human pancreatic cancer cells without alteration of type III receptor expression. Cancer Res 1993; 53:2704-2707.
28. Lu Z, Friess H, Graber HU, Guo XZ, Schilling M, Zimmermann A, et al. The presence of two signalling TGF-β receptors in human pancreatic cancer correlates with advanced tumor stage. Dig Dis Sci 1997; 42:2054-2063.
29. Baldwin RL, Friess H, Yokoyama M, Lopez ME, Kobrin MS, Buchler MW, Korc M. Attenuated ALK5 receptor expression in human pancreatic cancer: correlation with resistance to growth inhibition. Int J Cancer 1996; 67:283-288.
30. Kashiwagi M, Friess H, UhI W, Graber H, Duarte R, Zimmermann A, Büchler MW. Phospholipase A2 isoforms are altered in chronic pancreatitis. Ann Surg 1998; 227:220-228.
31. Guo XZ, Friess H, Graber HU, Kashiwagi M, Zimmermann A, Korc M, Büchler MW. KAI1 expression is up-regulated in early pancreatic cancer and decreased in the presence of metastasis. Cancer Res 1996; 56:4876-4880.
32. Siegel S. Nonparametric Statistics for Behavioral Sciences. New York: McGraw-Hill Book Co., 1956.
33. Nguyen MT, Herrine SK, Zern MA. Cytokine involvement in the liver. Curr Opin Gastroenterol 1994; 10:277-284.
34. Arenson DM, Friedman SL, Bissell DM. Formation of extracellular matrix in normal rat liver: lipocytes as a major source of proteoglycan. Gastroenterology 1988; 95:441-447.
35. Geerts A, Vrijsen R, Rauteeberg J, Burt A, Schelink P, Wisse E. In vitro differentiation of fat-storing cells parallels marked increase of collagen synthesis and secretion. J Hepatol 1989; 9:59-68.
36. Friedman S. The cellular basis of hepatic fibrosis: mechanisms and treatment strategies. N Engl J Med 1993; 328:1828-1835.
37. Fynan TM, Reiss M. Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis. Crit Rev Oncog 1993; 4:493-540.
38. Takiya S, Tagaya T, Takahashi K, Kawashima H, Kamiya M, Fukuzawa Y, et al. Role of transforming growth factor-betal in hepatic regeneration and apoptosis in liver diseases. J Clin Pathol 1995; 48:1093-1097.
39. Factor VM, Kao CY, Santoni-Rugiu E, Woitach JT, Jensen MR, Thorgeirsson SS. Constitutive expression of mature transforming growth factor-beta1 in the liver accelerates hepatocarcinogenesis in transgenic mice. Cancer Res 1997; 57:2089-2095.
40. Fausto N, Mead JE, Gruppuso PA, Braun L. TGF-beta in liver development, regeneration and carcinogenesis. Ann NY Acad Sci 1990; 593:231-242.
41. Bedossa P, Peltier E, Terris B, Franco D, Poynard T. Transforming growth factor-beta 1 (TGF-β1) and TGF-β1 receptors in normal, cirrhotic, and neoplastic human livers. Hepatology 1995; 21:760-766.
42. Bachem MG, Sell KM, Meyer D, Melchior RJ, Gressner AM. Paracrine activation of fat-storing cells and autocrine stimulation of myofibroblast-like cells via polypeptide growth regulators. In: Molecular and Cell Biology of Liver Fibrogenesis. Gressner AM, Ramadori G (editors). Dordrecht, The Netherlands: Kluwer Academic Publishers, 1992. pp. 400-415.
43. Milani S, Herbst H, Schuppan D, Stein H, Surrenti C. Transforming growth factors β1 and β2 are differentially expressed in fibrotic liver disease. Am J Pathol 1991; 139:1221-1229.
44. Malizia G, Brunt EM, Peters MG, Rizzo A, Broekelmann TJ, McDonald JA. Growth factor and procollagen type I gene expression in human liver disease. Gastroenterology 1995; 108:145-156.
45. Bissell DM, Wang S, Jarnagin WR, Roll FJ. Cell-specific expression of transforming growth factor-β in rat liver: evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest 1995; 96:447-455.
46. Lautt WW, Greenway CV. Conceptual review of the hepatic vascular bed. Hepatology 1987; 7:952-963.
47. Hardonk MJ, Armosoerodjo-Briggs J. Evidence for the anatomical connection between the space of Disse and the portal tract in human and rat liver. In: Cells of the Hepatic Sinusoids, Volume 4. Knook DL, Wisse E (editors). Leiden, The Netherlands: Kupffer Cell Foundation, 1993. pp. 182-184.
48. Vollmar B, Wolf B, Siegmund S, Katsen AD, Menger MD. Lymph vessel expansion and function in the development of hepatic fibrosis and cirrhosis. Am J Pathol 1997; 151:169-175.
49. Callea F, Desmet VG. Transformation of fat storing cells (Ito cells) to myofibroblasts [Abstract]. J Hepatol 1985; 2(suppl):206.
50. Callea F, Mebis J, Desmet VJ. Myofibroblasts in focal nodular hyperplasia of the liver. Virchows Arch [A] 1982; 396:155-166.
51. Zhao D, Reichen J, Zimmermann A. Myofibroblasts (MFBs) show a bimodal distribution of volume fraction and form an extralittoral compartment in the cirrhotic rat liver. In: Falk Symposium No. 71; Fat Storing Cells and Liver Fibrosis. Florence, 1993.
52. Demirci G, Nashan B, Pichlmayr R. Fibrosis in chronic rejection of human liver allografts: expression patterns of transforming growth factor-beta1 and beta3. Transplantation 1996; 62:1776-1783.