Cooperation between molecular targets of costimulation in promoting T cell persistence and tumor regression

Journal of Immunology

Volumn 182, Issue 11, 2009, Pages 6744-6752

  Zhao, Baohua ^b   Song, Aihua ^c   Haque, Rizwanul ^a   Lei, Fengyang ^a   Weiler, Lauren ^a   Xiong, Xiaofang ^a   Wu, Yuzhang ^d   Croft, Michael ^c   Song, Jianxun ^a,d,e  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b HEBEI NORMAL UNIVERSITY   (China)

^c LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^d THIRD MILITARY MEDICAL UNIVERSITY   (China)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL XL; RETROVIRUS VECTOR; SURVIVIN; VIRUS PROTEIN; ANTIGEN; APOPTOSIS REGULATORY PROTEIN; CROSS LINKING REAGENT; MICROTUBULE ASSOCIATED PROTEIN; PROTEIN BCL X; SURVIVIN PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN RECOGNITION; ARTICLE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL SURVIVAL; CONTROLLED STUDY; EFFECTOR CELL; GENETIC TRANSDUCTION; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE TRANSFER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TUMOR IMMUNITY; TUMOR REGRESSION; ANIMAL; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; NEOPLASM; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS; APOPTOSIS REGULATORY PROTEINS; BCL-X PROTEIN; CD8-POSITIVE T-LYMPHOCYTES; CROSS-LINKING REAGENTS; LYMPHOCYTE ACTIVATION; MICE; MICE, TRANSGENIC; MICROTUBULE-ASSOCIATED PROTEINS; NEOPLASMS; TRANSDUCTION, GENETIC;

EID: 67449155869     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0804387     Document Type: Article

References (53)

1. Croft, M. 2003. Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nat. Rev. Immunol. 3: 609-620.
2. Watts, T. H. 2005. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 23: 23-68.
3. Yang, Y., X. K. Liu, T. Nguyen, C. Bishop, D. Graf, and C. Dong. 2007. Characterization of B7S3 as a novel negative regulator of T cells. J. Immunol. 178: 3661-3667. (Pubitemid 46417633)
4. Zang, X., and J. P. Allison. 2006. To be or not to be B7. J. Clin. Invest. 116: 2590-2593.
5. Khoury, S. J., and M. H. Sayegh. 2004. The roles of the new negative T cell costimulatory pathways in regulating autoimmunity. Immunity 20: 529-538.
6. Rietz, C., and L. Chen. 2004. New B7 family members with positive and negative costimulatory function. Am. J. Transplant. 4: 8-14.
7. Dong, H., S. E. Strome, D. R. Salomao, H. Tamura, F. Hirano, D. B. Flies, P. C. Roche, J. Lu, G. Zhu, K. Tamada, et al. 2002. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 8: 793-800.
8. Greenwald, R. J., G. J. Freeman, and A. H. Sharpe. 2005. The B7 family revisited. Annu. Rev. Immunol. 23: 515-548.
9. Goldberg, M. V., C. H. Maris, E. L. Hipkiss, A. S. Flies, L. Zhen, R. M. Tuder, J. F. Grosso, T. J. Harris, D. Getnet, K. A. Whartenby, et al. 2007. Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood 110: 186-192.
10. 5+ follicular B helper T cell maintenance in vivo. J. Immunol. 175: 2340-2348.
11. Glenney, G. W., and G. D. Wiens. 2007. Early diversification of the TNF super-family in teleosts: genomic characterization and expression analysis. J. Immunol. 178: 7955-7973.
12. Bossen, C., K. Ingold, A. Tardivel, J. L. Bodmer, O. Gaide, S. Hertig, C. Ambrose, J. Tschopp, and P. Schneider. 2006. Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J. Biol. Chem. 281: 13964-13971.
13. Serghides, L., J. Bukczynski, T. Wen, C. Wang, J. P. Routy, M. R. Boulassel, R. P. Sekaly, M. Ostrowski, N. F. Bernard, and T. H. Watts. 2005. Evaluation of OX40 ligand as a costimulator of human antiviral memory CD8 T cell responses: comparison with B7.1 and 4-1BBL. J. Immunol. 175: 6368-6377. (Pubitemid 41598877)
14. Dawicki, W., E. M. Bertram, A. H. Sharpe, and T. H. Watts. 2004. 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses. J. Immunol. 173: 5944-5951. (Pubitemid 39487748)
15. French, R. R., V. Y. Taraban, G. R. Crowther, T. F. Rowley, J. C. Gray, P. W. Johnson, A. L. Tutt, A. Al-Shamkhani, and M. J. Glennie. 2007. Eradication of lymphoma by CD8 T cells following anti-CD40 monoclonal antibody therapy is critically dependent on CD27 costimulation. Blood 109: 4810-4815.
16. Gavrieli, M., J. Sedy, C. A. Nelson, and K. M. Murphy. 2006. BTLA and HVEM cross talk regulates inhibition and costimulation. Adv. Immunol. 92: 157-185.
17. Silva-Santos, B., D. J. Pennington, and A. C. Hayday. 2005. Lymphotoxin-mediated regulation of γδ cell differentiation by αβ T cell progenitors. Science 307: 925-928.
18. Song, J., S. Salek-Ardakani, P. R. Rogers, M. Cheng, L. Van Parijs, and M. Croft. 2004. The costimulation-regulated duration of PKB activation controls T cell longevity. Nat. Immunol. 5: 150-158.
19. Rogers, P. R., J. Song, I. Gramaglia, N. Killeen, and M. Croft. 2001. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity 15: 445-455.
20. Song, J., T. So, M. Cheng, X. Tang, and M. Croft. 2005. Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity 22: 621-631.
21. Song, J., S. Salek-Ardakani, T. So, and M. Croft. 2007. The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nat. Immunol. 8: 64-73.
22. Song, J., T. So, and M. Croft. 2008. Activation of NF-κB1 by OX40 contributes to antigen-driven T cell expansion and survival. J. Immunol. 180: 7240-7248.
23. Osborn, M. J., A. Panoskaltsis-Mortari, R. T. McElmurry, S. K. Bell, D. A. Vignali, M. D. Ryan, A. C. Wilber, R. S. McIvor, J. Tolar, and B. R. Blazar. 2005. A picornaviral 2A-like sequence-based tricistronic vector allowing for high-level therapeutic gene expression coupled to a dual-reporter system. Mol. Ther. 12: 569-574.
24. Bosselut, R. 2006. Retroviral TCR gene transduction: 2A for two. Nat. Methods 3: 162-164.
25. Donnelly, M. L., L. E. Hughes, G. Luke, H. Mendoza, E. ten Dam, D. Gani, and M. D. Ryan. 2001. The 'cleavage' activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring '2A-like' sequences. J. Gen. Virol. 82: 1027-1041.
26. Luke, G. A., P. de Felipe, A. Lukashev, S. E. Kallioinen, E. A. Bruno, and M. D. Ryan. 2008. Occurrence, function and evolutionary origins of '2A-like' sequences in virus genomes. J. Gen. Virol. 89: 1036-1042.
27. Donnelly, M. L., G. Luke, A. Mehrotra, X. Li, L. E. Hughes, D. Gani, and M. D. Ryan. 2001. Analysis of the aphthovirus 2A/2B polyprotein 'cleavage' mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal 'skip'. J. Gen. Virol. 82: 1013-1025.
28. de Felipe, P., L. E. Hughes, M. D. Ryan, and J. D. Brown. 2003. Co-translational, intraribosomal cleavage of polypeptides by the foot-and-mouth disease virus 2A peptide. J. Biol. Chem. 278: 11441-11448.
29. Szymczak, A. L., C. J. Workman, Y. Wang, K. M. Vignali, S. Dilioglou, E. F. Vanin, and D. A. Vignali. 2004. Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector. Nat. Biotechnol. 22: 589-594.
30. Hart, D. P., S. A. Xue, S. Thomas, M. Cesco-Gaspere, A. Tranter, B. Willcox, S. P. Lee, N. Steven, E. C. Morris, and H. J. Stauss. 2008. Retroviral transfer of a dominant TCR prevents surface expression of a large proportion of the endogenous TCR repertoire in human T cells. Gene Ther. 15: 625-631.
31. Holst, J., A. L. Szymczak-Workman, K. M. Vignali, A. R. Burton, C. J. Workman, and D. A. Vignali. 2006. Generation of T-cell receptor retrogenic mice. Nat. Protoc. 1: 406-417.
32. Holst, J., K. M. Vignali, A. R. Burton, and D. A. Vignali. 2006. Rapid analysis of T-cell selection in vivo using T cell-receptor retrogenic mice. Nat. Methods. 3: 191-197.
33. Denk, A., M. Goebeler, S. Schmid, I. Berberich, O. Ritz, D. Lindemann, S. Ludwig, and T. Wirth. 2001. Activation of NF-κB via the Ikappa B kinase complex is both essential and sufficient for proinflammatory gene expression in primary endothelial cells. J. Biol. Chem. 276: 28451-28458.
34. Herrmann, O., B. Baumann, R. de Lorenzi, S. Muhammad, W. Zhang, J. Kleesiek, M. Malfertheiner, M. Kohrmann, I. Potrovita, I. Maegele, et al. 2005. IKK mediates ischemia-induced neuronal death. Nat. Med. 11: 1322-1329.
35. Ochi, S., M. Shinohara, K. Sato, H. J. Gober, T. Koga, T. Kodama, T. Takai, N. Miyasaka, and H. Takayanagi. 2007. Pathological role of osteoclast costimulation in arthritis-induced bone loss. Proc. Natl. Acad. Sci. USA 104: 11394-11399.
36. Thebeau, L. G., S. P. Vagvala, Y. M. Wong, and L. A. Morrison. 2007. B7 costimulation molecules expressed from the herpes simplex virus 2 genome rescue immune induction in B7-deficient mice. J. Virol. 81: 12200-12209.
37. Seshasayee, D., W. P. Lee, M. Zhou, J. Shu, E. Suto, J. Zhang, L. Diehl, C. D. Austin, Y. G. Meng, M. Tan, et al. 2007. In vivo blockade of OX40 ligand inhibits thymic stromal lymphopoietin driven atopic inflammation. J. Clin. Invest. 117: 3868-3878.
38. Piconese, S., B. Valzasina, and M. P. Colombo. 2008. OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection. J. Exp. Med. 205: 825-839.
39. + phagocytes. J. Exp. Med. 204: 2075-2087.
40. + T cells support the induction of therapeutic cancer immunity. Cancer Res. 67: 10012-10018.
41. Benson, M. J., S. R. Dillon, E. Castigli, R. S. Geha, S. Xu, K. P. Lam, and R. J. Noelle. 2008. Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL. J. Immunol. 180: 3655-3659.
42. Morgan, R. A., M. E. Dudley, J. R. Wunderlich, M. S. Hughes, J. C. Yang, R. M. Sherry, R. E. Royal, S. L. Topalian, U. S. Kammula, N. P. Restifo, et al. 2006. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 314: 126-129.
43. Jorritsma, A., R. Gomez-Eerland, M. Dokter, W. van de Kasteele, Y. M. Zoet, I. I. Doxiadis, N. Rufer, P. Romero, R. A. Morgan, T. N. Schumacher, and J. B. Haanen. 2007. Selecting highly affine and well-expressed TCRs for gene therapy of melanoma. Blood 110: 3564-3572.
44. Augustine, C. K., Y. Yoshimoto, M. Gupta, P. A. Zipfel, M. A. Selim, P. Febbo, A. M. Pendergast, W. P. Peters, and D. S. Tyler. 2008. Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment. Cancer Res. 68: 3777-3784.
45. June, C. H. 2007. Adoptive T cell therapy for cancer in the clinic. J. Clin. Invest. 117: 1466-1476.
46. Gattinoni, L., D. J. Powell, Jr., S. A. Rosenberg, and N. P. Restifo. 2006. Adoptive immunotherapy for cancer: building on success. Nat Rev Immunol. 6: 383-393.
47. + T cell survival controlled by clonal abundance. Science 312: 114-116.
48. Seki, Y., J. Yang, M. Okamoto, S. Tanaka, R. Goitsuka, M. A. Farrar, and M. Kubo. 2007. IL-7/STAT5 cytokine signaling pathway is essential but insufficient for maintenance of naive CD4 T cell survival in peripheral lymphoid organs. J. Immunol. 178: 262-270. (Pubitemid 46033609)
49. + T cell precursor can develop into diverse effector and memory subsets. Immunity 27: 985-997.
50. + regulatory T cells originate from both naive T cells and naturally occurring naive-like regulatory T cells. J. Immunol. 180: 146-155.
51. + T cells. J. Clin. Invest. 115: 1616-1626.
52. + T cells confer superior antitumor immunity compared with effector memory T cells. Proc. Natl. Acad. Sci. USA 102: 9571-9576.
53. Kaech, S. M., J. T. Tan, E. J. Wherry, B. T. Konieczny, C. D. Surh, and R. Ahmed. 2003. Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol. 4: 1191-1198.