The effect of assay formats on the estimation of melanocortin agonist affinity and efficacy using the operation model of agonism

European Journal of Pharmacology

Volumn 615, Issue 1-3, 2009, Pages 33-39

  Simon, Sylvie ^a   Young, Tim J ^a   Nickolls, Sarah A ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Affinity; Agonist; Efficacy; Melanocortin; Operational model

Indexed keywords

2 ETHOXY 1(2H) QUINOLINECARBOXYLIC ACID ETHYL ESTER; ALPHA INTERMEDIN; BETA LACTAMASE; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MB 243; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN RECEPTOR AGONIST; MELANOTAN II; N [2 [4 CYCLOHEXYL 4 [[(1,1 DIMETHYLETHYL)AMINO]CARBONYL] 1 PIPERIDINYL] 1 [(4 FLUOROPHENYL)METHYL] 2 OXOETHYL] 4 METHYL 2 PIPERAZINECARBOXAMIDE; TETRAHYDROISOQUINOLINE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY;

ANIMALS; BETA-LACTAMASES; BINDING SITES; BINDING, COMPETITIVE; BIOLOGICAL ASSAY; CELL LINE; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, REPORTER; KINETICS; MODELS, BIOLOGICAL; PROTEIN BINDING; QUINOLINES; RADIOLIGAND ASSAY; RECEPTOR, MELANOCORTIN, TYPE 3; RECEPTOR, MELANOCORTIN, TYPE 4;

EID: 67449146885     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.04.065     Document Type: Article

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