Endoplasmic reticulum proteins in cardiac development and dysfunction

Canadian Journal of Physiology and Pharmacology

Volumn 87, Issue 6, 2009, Pages 419-425

  Prins, Daniel ^a   Michalak, Marek ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Calcium; Calreticulin; Chaperones; Congenital heart problems; Endoplasmic reticulum; Endoplasmic reticulum stress; Sarcoplasmic reticulum

Indexed keywords

CALCIUM ION; CALRETICULIN; GLUCOSE REGULATED PROTEIN 78; GLUCOSE REGULATED PROTEIN 94; SECRETORY PROTEIN;

CALCIUM HOMEOSTASIS; CATALYSIS; CELL ORGANELLE; CELL STRESS; ENDOPLASMIC RETICULUM; GENETIC CODE; HEART DEVELOPMENT; HEART DISEASE; HUMAN; HYPOXIA; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FOLDING; QUALITY CONTROL; REVIEW; SARCOPLASMIC RETICULUM; TRANSCRIPTION REGULATION;

ANIMALS; CALCIUM; CARDIOVASCULAR DISEASES; ENDOPLASMIC RETICULUM; HEART; HUMANS; MEMBRANE PROTEINS; MOLECULAR CHAPERONES; MYOCARDIUM; PROTEIN FOLDING; SARCOPLASMIC RETICULUM; STRESS, PHYSIOLOGICAL;

EID: 67449136348     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-032     Document Type: Review

References (46)

1. Azfer, A., Niu, J., Rogers, L.M., Adamski, F.M., and Kolattukudy, P.E. 2006. Activation of endoplasmic reticulum stress response during the development of ischemic heart disease. Am. J. Physiol. Heart Circ. Physiol. 291(3): H1411-H1420. doi:10.1152/ajpheart.01378.2005. PMID:16617122.
2. Baumann, O., and Walz, B. 2001. Endoplasmic reticulum of animal cells and its organization into structural and functional domains. Int. Rev. Cytol. 205: 149-214. doi:10.1016/S0074-7696(01)05004-5. PMID:11336391.
3. Bedard, K., Szabo, E., Michalak, M., and Opas, M. 2005. Cellular functions of endoplasmic reticulum chaperones calreticulin, calnexin, and ERp57. Int. Rev. Cytol. 245: 91-121. doi:10.1016/S0074-7696(05)45004-4. PMID:16125546.
4. Crabtree, G.R. 2001. Calcium, calcineurin, and the control of transcription. J. Biol. Chem. 276(4): 2313-2316. doi:10.1074/jbc.R000024200. PMID:11096121.
5. Crabtree, G.R., and Olson, E.N. 2002. NFAT signaling: choreographing the social lives of cells. Cell, 109(Suppl): S67-S79. doi:10.1016/S0092-8674(02) 00699-2. PMID:11983154. (Pubitemid 34457853)
6. Frey, N., and Olson, E.N. 2003. Cardiac hypertrophy: the good, the bad, and the ugly. Annu. Rev. Physiol. 65: 45-79. doi:10.1146/annurev.physiol.65. 092101.142243. PMID:12524460.
7. Fu, H.Y., Minamino, T., Tsukamoto, O., Sawada, T., Asai, M., Kato, H., et al. 2008. Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition. Cardiovasc. Res. 79(4): 600-610. doi:10.1093/cvr/cvn128. PMID:18508854.
8. Guo, L., Lynch, J., Nakamura, K., Fliegel, L., Kasahara, H., Izumo, S., et al. 2001. COUP-TF1 antagonizes Nkx2.5-mediated activation of the calreticulin gene during cardiac development. J. Biol. Chem. 276: 2797-2801. doi:10.1074/jbc.C000822200. PMID:11106640.
9. Guo, L., Nakamura, K., Lynch, J., Opas, M., Olson, E.N., Agellon, L.B., et al. 2002. Cardiac-specific expression of calcineurin reverses embryonic lethality in calreticulin-deficient mouse. J. Biol. Chem. 277(52): 50776-50779. doi:10.1074/jbc.M209900200. PMID:12377773.
10. Hamada, H., Suzuki, M., Yuasa, S., Mimura, N., Shinozuka, N., Takada, Y., et al. 2004. Dilated cardiomyopathy caused by aberrant endoplasmic reticulum quality control in mutant KDEL receptor transgenic mice. Mol. Cell. Biol. 24(18): 8007-8017. doi:10.1128/MCB.24.18.8007-8017.2004. PMID:15340063.
11. Hattori, K., Nakamura, K., Hisatomi, Y., Matsumoto, S., Suzuki, M., Harvey, R.P., et al. 2007. Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart. Mol. Genet. Metab. 91(3): 285-293. doi:10.1016/j.ymgme.2007.02.003. PMID:17482496.
12. Hebert, D.N., and Molinari, M. 2007. In and out of the ER: protein folding, quality control, degradation, and related human diseases. Physiol. Rev. 87(4): 1377-1408. doi:10.1152/physrev.00050.2006. PMID:17928587.
13. Imanaka-Yoshida, K., Knudsen, K.A., and Linask, K.K. 1998. Ncadherin is required for the differentiation and initial myofibrillogenesis of chick cardiomyocytes. Cell Motil. Cytoskeleton, 39(1): 52-62. doi:10.1002/(SICI)1097- 0169(1998)39:1〈52::AIDCM5〉3.0.CO;2-I. PMID:9453713.
14. 2+ ATPase of cardiac sarcoplasmic reticulum: physiological role and relevance to diseases. Biochem. Biophys. Res. Commun. 369(1): 182-187. doi:10.1016/j.bbrc. 2007.11.161. PMID:18068669.
15. 2+ checkpoint in cardiac myofibrillogenesis. J. Cell Biol. 158(1):103-113. doi:10.1083/jcb. 200204092. PMID:12105184.
16. Lozyk, M.D., Papp, S., Zhang, X., Nakamura, K., Michalak, M., and Opas, M. 2006. Ultrastructural analysis of development of myocardium in calreticulin-deficient mice. BMC Dev. Biol. 6: 54. doi:10.1186/1471-213X-6-54. PMID:17112388.
17. Luo, S., Mao, C., Lee, B., and Lee, A.S. 2006. GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development. Mol. Cell. Biol. 26(15): 5688-5697. doi:10.1128/MCB.00779-06. PMID:16847323.
18. 2+-dependent signaling cascade. J. Cell Biol. 170(1): 37-47. doi:10.1083/jcb.200412156. PMID:15998798.
19. Lynch, J.M., Chilibeck, K., Qui, Y., and Michalak, M. 2006. Assembling pieces of the cardiac puzzle; calreticulin and calcium-dependent pathways in cardiac development, health, and disease. Trends Cardiovasc. Med. 16(3): 65-69. doi:10.1016/j.tcm.2006.01.004. PMID:16546685.
20. Mao, C., Tai, W.C., Bai, Y., Poizat, C., and Lee, A.S. 2006. In vivo regulation of Grp78/BiP transcription in the embryonic heart: role of the endoplasmic reticulum stress response element and GATA-4. J. Biol. Chem. 281(13): 8877-8887. doi:10.1074/jbc.M505784200. PMID:16452489.
21. Martindale, J.J., Fernandez, R., Thuerauf, D., Whittaker, R., Gude, N., Sussman, M.A., et al. 2006. Endoplasmic reticulum stress gene induction and protection from ischemia/reperfusion injury in the hearts of transgenic mice with a tamoxifen-regulated form of ATF6. Circ. Res. 98(9): 1186-1193. doi:10.1161/01.RES.0000220643.65941.8d. PMID:16601230.
22. Mery, A., Aimond, F., Menard, C., Mikoshiba, K., Michalak, M., and Puceat, M. 2005. Initiation of embryonic cardiac pacemaker activity by inositol 1,4,5-trisphosphate-dependent calcium signaling. Mol. Biol. Cell, 16(5): 2414-2423. doi:10.1091/mbc.E04-10-0883. PMID:15758029.
23. Mesaeli, N., Nakamura, K., Zvaritch, E., Dickie, P., Dziak, E., Krause, K.-H., et al. 1999. Calreticulin is essential for cardiac development. J. Cell Biol. 144: 857-868. doi:10.1083/jcb.144.5.857. PMID:10085286. (Pubitemid 29238963)
24. Michalak, M., Robert Parker, J.M., and Opas, M. 2002. Ca2+ signaling and calcium binding chaperones of the endoplasmic reticulum. Cell Calcium, 32(5-6): 269-278. doi:10.1016/S0143416002001884. PMID:12543089. (Pubitemid 36175750)
25. Molkentin, J.D.,andDorn,I.G., 2nd. 2001.Cytoplasmic signaling pathways that regulate cardiac hypertrophy. Annu. Rev. Physiol. 63: 391-426.doi:10.1146/ annurev.physiol.63.1.391.PMID:11181961.
26. Nakamura, K., Robertson, M., Liu, G., Dickie, P., Guo, J.Q., Duff, H.J., et al. 2001. Complete heart block and sudden death in mouse over-expressing calreticulin. J. Clin. Invest. 107(10): 1245-1253. doi:10.1172/JCI12412. PMID:11375414.
27. Ni, M., and Lee, A.S. 2007. ER chaperones in mammalian development and human diseases. FEBS Lett. 581(19): 3641-3651. doi:10.1016/j.febslet.2007.04. 045. PMID:17481612. (Pubitemid 47082516)
28. Nicchitta, C.V. 1998. Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96. Curr. Opin. Immunol. 10: 103-109. doi:10.1016/S0952-7915(98)80039-3. PMID:9523119.
29. Okada, K., Minamino, T., Tsukamoto, Y., Liao, Y., Tsukamoto, O., Takashima, S., et al. 2004. Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis. Circulation, 110(6): 705-712. doi:10.1161/01.CIR.0000137836.95625.D4. PMID:15289376. (Pubitemid 39056270)
30. Qiu, Y., and Michalak, M. 2009. Transcriptional control of the calreticulin gene in health and disease. Int. J. Biochem. Cell Biol. 41(3): 531-538. doi:10.1016/j.biocel.2008.06.020. PMID:18765291.
31. Qiu, Y., Lynch, J., Guo, L., Yatsula, B., Perkins, A.S., and Michalak, M. 2008. Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factors. Biochemistry, 47(12): 3697-3704. doi:10.1021/bi702524v. PMID:18303859.
32. Rauch, F., Prud'homme, J., Arabian, A., Dedhar, S., and St-Arnaud, R. 2000. Heart, brain, and body wall defects in mice lacking calreticulin. Exp. Cell Res. 256(1): 105-111. doi:10.1006/excr.2000.4818. PMID:10739657.
33. 2+: molecular determinants and functional consequences. Physiol. Rev. 86(1): 369-408. doi:10.1152/physrev.00004.2005. PMID:16371601.
34. Ron, D., and Walter, P. 2007. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 8(7): 519-529. doi:10.1038/nrm2199. PMID:17565364.
35. Rossi, A.E., and Dirksen, R.T. 2006. Sarcoplasmic reticulum: the dynamic calcium governor of muscle. Muscle Nerve, 33(6): 715-731. doi:10.1002/mus.20512. PMID:16477617. (Pubitemid 43856788)
36. Rossi, D., Barone, V., Giacomello, E., Cusimano, V., and Sorrentino, V. 2008. The sarcoplasmic reticulum: an organized patchwork of specialized domains. Traffic, 9(7): 1044-1049. doi:10.1111/j.1600-0854.2008.00717.x. PMID:18266914. (Pubitemid 351916881)
37. Schroder, M., and Kaufman, R.J. 2005. The mammalian unfolded protein response. Annu. Rev. Biochem. 74: 739-789. doi:10.1146/annurev.biochem.73. 011303.074134. PMID:15952902.
38. Szabo, E., Qiu, Y., Baksh, S., Michalak, M., and Opas, M. 2008. Calreticulin inhibits commitment to adipocyte differentiation. J. Cell Biol. 182(1): 103-116. doi:10.1083/jcb.200712078. PMID:18606846. (Pubitemid 352008625)
39. Szegezdi, E., Duffy, A., O'Mahoney, M.E., Logue, S.E., Mylotte, L.A., O'Brien, T., et al. 2006. ER stress contributes to ischemia-induced cardiomyocyte apoptosis. Biochem. Biophys. Res. Commun. 349(4): 1406-1411. doi:10.1016/j.bbrc.2006.09.009. PMID:16979584.
40. Thuerauf, D.J., Marcinko, M., Gude, N., Rubio, M., Sussman, M.A., and Glembotski, C.C. 2006. Activation of the unfolded protein response in infarcted mouse heart and hypoxic cultured cardiac myocytes. Circ. Res. 99(3): 275-282. doi:10.1161/01.RES.0000233317.70421.03. PMID:16794188.
41. Tsukamoto, O., Minamino, T., Okada, K., Shintani, Y., Takashima, S., Kato, H., et al. 2006. Depression of proteasome activities during the progression of cardiac dysfunction in pressure-overloaded heart of mice. Biochem. Biophys. Res. Commun. 340(4): 1125-1133. doi:10.1016/j.bbrc.2005.12. 120. PMID:16403436.
42. Venetucci, L.A., and Eisner, D.A. 2008. Calsequestrin mutations and sudden death: a case of too little sarcoplasmic reticulum calcium buffering? Circ. Res. 103(3): 223-225. doi:10.1161/CIRCRESAHA.108.181636. PMID:18669926.
43. Vitadello, M., Ausma, J., Borgers, M., Gambino, A., Casarotto, D.C., and Gorza, L. 2001. Increased myocardial GRP94 amounts during sustained atrial fibrillation: a protective response? Circulation, 103(17): 2201-2206. PMID:11331263.
44. Wanderling, S., Simen, B.B., Ostrovsky, O., Ahmed, N.T., Vogen, S.M., Gidalevitz, T., et al. 2007. GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol. Biol. Cell, 18(10): 3764-3775. doi:10.1091/mbc.E07-03-0275. PMID:17634284.
45. Wehrens, X.H., and Marks, A.R. 2004. Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nat. Rev. Drug Discov. 3(7): 565-573. doi:10.1038/nrd1440. PMID:15232578.
46. Yoshida, H. 2007. ER stress and diseases. FEBS J. 274: 630-658. doi:10.1111/j.1742-4658.2007.05639.x. PMID:17288551. (Pubitemid 46150855)