A nucleocytoplasmic malate dehydrogenase regulates p53 transcriptional activity in response to metabolic stress

Cell Death and Differentiation

Volumn 16, Issue 5, 2009, Pages 738-748

  Lee, S M ^a   Kim, J H ^a   Cho, E J ^b   Youn, H D ^a  

^a Seoul National University College of Medicine   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

MALATE DEHYDROGENASE; PROTEIN P53;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVITY; GENE LOCATION; HUMAN; HUMAN CELL; METABOLIC STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION;

APOPTOSIS; CELL CYCLE; CELL LINE; ENERGY METABOLISM; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; HUMANS; MALATE DEHYDROGENASE; RNA INTERFERENCE; STRESS, PHYSIOLOGICAL; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION;

EID: 67349272249     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2009.5     Document Type: Article

References (41)

1. Shi Y, Shi Y. Metabolic enzymes and coenzymes in transcription-a direct link between metabolism and transcription? Trends Genet 2004; 20: 445-452.
2. Bhardwaj A, Wilkinson MF. A metabolic enzyme doing double duty as a transcription factor. Bioessays 2005; 27: 467-471.
3. Ladurner AG. Rheostat control of gene expression by metabolites. Mol Cell 2006; 24: 1-11.
4. Zheng L, Roeder RG, Luo YS. S phase activation of the histone H2B promoter by OCA-S, a coactivator complex that contains GAPDH as a key component. Cell 2003; 114: 255-266.
5. Sen N, Hara MR, Kornberg MD, Cascio MB, Bae BI, Shahani N et al. Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis. Nat Cell Biol 2008; 10: 866-873.
6. Hall DA, Zhu H, Zhu X, Royce T, Gerstein M, Snyder M. Regulation of gene expression by a metabolic enzyme. Science 2004; 306: 482-484.
7. Cho YH, Yoo SD, Sheen J. Regulatory functions of nuclear hexokinase1 complex in glucose signaling. Cell 2006; 127: 579-589.
8. Warburg O. On respiratory impairment in cancer cells. Science 1956; 124: 269-270.
9. Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004; 4: 891-899.
10. Shaw RJ. Glucose metabolism and cancer. Curr Opin Cell Biol 2006; 18: 598-608.
11. Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumor growth. Nature 2008; 452: 230-234.
12. Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004; 10: 789-799.
13. Levine AJ, Hu W, Feng Z. The P53 pathway: What questions remain to be explored? Cell Death Differ 2006; 13: 1027-1036.
14. Kondoh H, Lleonart ME, Gil J, Wang J, Degan P, Peters G et al. Glycolytic enzymes can modulate cellular life span. Cancer Res 2005; 65: 177-185.
15. Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R et al TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 2006; 126: 107-120.
16. Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O et al. p53 regulates mitochondrial respiration. Science 2006; 312: 1650-1653.
17. κB pathway and inhibits cell transformation. Nat Cell Biol 2008; 10: 611-618.
18. Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 2002; 415: 45-53.
19. Maier B, Gluba W, Bernier B, Turner T, Mohammad K, Guise T et al. Modulation of mammalian life span by the short isoform of p53. Genes Dev 2004; 18: 306-319.
20. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 2005; 120: 513-522.
21. Schwartzenberg-Bar-Yoseph F, Armoni M, Karnieli E. The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res 2004; 64: 2627-2633.
22. Katz EB, Stenbit AE, Hatton K, DePinho R, Charron MJ. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature 1995; 377: 151-155.
23. Wadgaonkar R, Collins T. Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression. J Biol Chem 1999; 274: 13760-13767.
24. Birktoft JJ, Banaszak LJ. The presence of a histidine-aspartic acid pair in the active site of 2-hydroxyacid dehydrogenases. X-ray refinement of cytoplasmic malate dehydrogenase. J Biol Chem 1983; 258: 472-482.
25. Assaily W, Benchimol S. Differential utilization of two ATP-generating pathways in regulated by p53. Cancer Cell 2006; 10: 4-6.
26. Bensaad K, Vousden KH. p53: New roles in metabolism. Trends Cell Biol 2006; 17: 286-291.
27. Green DR, Chipuk JE. p53 and metabolism: Inside the TIGAR. Cell 2006; 126: 30-32.
28. Birktoft JJ, Fernley RT, Bradshaw RA, Banaszak LJ. Amino acid sequence homology among the 2-hydroxy acid dehydrogenases: Mitochondrial and cytoplasmic malate dehydrogenases form a homologous system with lactate dehydrogenase. Proc Natl Acad Sci USA 1982; 79: 6166-6170.
29. Ronai Z. Glycolytic enzymes as DNA binding proteins. Int J Biochem 1993; 25: 1073-1076.
30. Shi Y, Sawada J, Sui G, Affar EB, Whetstine JR, Lan F et al. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature 2003; 422: 735-738.
31. Grooteclaes M, Deveraux Q, Hildebrand J, Zhang Q, Goodman RH, Frisch SM. C-terminal-binding protein corepresses epithelial and proapoptotic gene expression programs. Proc Natl Acad Sci USA 2003; 100: 4568-4573.
32. Kim JH, Cho EJ, Kim ST, Youn HD. CtBP represses p300-mediated transcriptional activation by direct association with its bromodomain. Nat Struct Mol Biol 2005; 12: 423-428.
33. Webb LE, Hill EJ, Banaszak LJ. Conformation of nicotinamide adenine dinucleotide bound to cytoplasmic malate dehydrogenase. Biochemistry 1973; 12: 5101-5109.
34. Grant PM, Roderick SL, Grant GA, Banaszak LJ, Strauss AW. Comparison of the precursor and mature forms of rat heart mitochondrial malate dehydrogenase. Biochemistry 1987; 26: 128-134.
35. Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y et al. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Mol Cell 2005; 18: 283-293.
36. Thoreen CC, Sabatini DM. AMPK and p53 help cells through lean times. Cell Metab 2005; 1: 287-288.
37. Levine AJ, Feng Z, Mak TW, You H, Jin S. Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev 2006; 20: 267-275.
38. Kanai M, Hanashiro K, Kim SH, Hanai S, Boulares AH, Miwa M et al. Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation. Nat Cell Biol 2007; 9: 1175-1183.
39. Roe JS, Kim H, Lee SM, Kim ST, Cho EJ, Youn HD. p53 stabilization and transactivation by a von Hippel-Lindau protein. Mol Cell 2006; 22: 395-405.
40. He TC, Zhou S, da Costa LT, Yu J, Kinzler KW, Vogelstein B. A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci USA 1998; 95: 2509-2514.
41. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001; 25: 402-408.