APM1 gene variants -11377C/G and 4545G/C are associated respectively with obesity and with non-obesity in Chinese type 2 diabetes

Diabetes Research and Clinical Practice

Volumn 84, Issue 3, 2009, Pages 205-210

  Wang, Xizhen ^a   Zhang, Sizhong ^b,c   Chen, Yuanzhong ^a   Liu, Hekun ^a   Lan, Cailian ^a   Chen, Xuexiang ^a   Chi, Shuguang ^a   Chen, Suyun ^a   Zhang, Wei ^b,c  

^a FUJIAN MEDICAL UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Adiponectin; Diabesity; Obesity; Single nucleotide polymorphisms; Type 2 diabetes

Indexed keywords

ADIPONECTIN; CHOLESTEROL; GLUCOSE; HIGH DENSITY LIPOPROTEIN; INSULIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CELL FUNCTION; CHINESE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HAPLOTYPE; HUMAN; HUMAN TISSUE; INSULIN BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PANCREAS ISLET BETA CELL; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPONECTIN; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD GLUCOSE; CHINA; DIABETES MELLITUS, TYPE 2; DNA; EXONS; FEMALE; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; MIDDLE AGED; OBESITY; ODDS RATIO; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 67349265518     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2009.03.004     Document Type: Article

References (36)

1. Mokdad A.H., Ford E.S., Bowman B.A., Dietz W.H., Vinicor F., Bales V.S., et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289 (2003) 76-79
2. Ahima R.S., Saper G.B., Flier J.S., and Elmquist J.K. Leptin regulation of neuroendocrine systems. Front. Neuroendocrinol. 21 (2000) 263-307
3. Trayhurn P., and Beattie J.H. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc. Nutr. Soc. 60 (2001) 329-339
4. Holst D., and Grimaldi P.A. New factors in the regulation of adipose differentiation and metabolism. Curr. Opin. Lipidol. 13 (2002) 241-245
5. Berg A.H., Combs T.P., Du X., Brownlee M., and Scherer P.E. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med. 7 (2001) 947-953
6. Berg A.H., Combs T.P., and Scherer P.E. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol. Metab. 13 (2002) 84-89
7. Hotta K., Funahashi T., Arita Y., Takahashi M., Matsuda M., Okamoto Y., et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler. Thromb. Vasc. Biol. 20 (2000) 1595-1599
8. Arita Y., Kihar S., Ouchi N., Takahashi M., Maeda K., Miyagawa J., et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem. Biophys. Res. Commun. 257 (1999) 79-83
9. Spranger J., Kroke A., Möhlig M., Bergmann M.M., Ristow M., Boeing H., et al. Adiponectin and protection against type 2 diabetes mellitus. Lancet 361 (2003) 226-228
10. Tsao T.S., Lodish H.F., and Fruebis J. ACRP30, a new hormone controlling fat and glucose metabolism. Eur. J. Pharmacol. 440 (2002) 213-221
11. Comuzzie A.G., Funahashi T., Sonnenberg G., Martin L.J., Jacob H.J., Black A.E., et al. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. J. Clin. Endocrinol. Metab. 86 (2001) 4321-4325
12. Vionnet N., Han E.H., Dupont S., Gallina S., Francke S., Dotte S., et al. Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am. J. Hum. Genet. 67 (2000) 1470-1480
13. Kissebah A.H., Sonnenberg G.E., Myklebust J., Goldstein M., Broman K., James R.G., et al. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc. Natl. Acad. Sci. U.S.A. 97 (2000) 14478-14483
14. Mori Y., Otabe S., Dina C., Yasuda K., Populaire C., Lecoeur C., et al. Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. Diabetes 51 (2002) 1247-1255
15. Kishida K., Nagaretani H., Kondo H., Kobayashi H., Tanaka S., Maeda N., et al. Disturbed secretion of mutant adiponectin associated with the metabolic syndrome. Biochem. Biophys. Res. Commun. 306 (2003) 286-292
16. Vasseur F., Helbecque N., Dina C., Lobbens S., Delannoy V., Gaget S., et al. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum. Mol. Genet. 11 (2002) 2607-2614
17. Hara K., Boutin P., Mori Y., Tobe K., Dina C., Yasuda K., et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 51 (2002) 536-540
18. Vasseur F., Helbecque N., Lobbens S., Vasseur-Delannoy V., Dina C., Clément K., et al. Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. Diabetologia 48 (2005) 892-899
19. Cauchi S., Nead K.T., Choquet H., Horber F., Potoczna N., Balkau B., et al. The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies. BMC Med. Genet. 9 (2008)
20. Shi Y.Y., and He L. SHEsis: a powerful software platform for analyses of linkage disequilibrium, haplotype construction, and genetic association at polymorphism loci. Cell Res. 15 (2005) 97-98
21. Gu H.F., Abulaiti A., Ostenson C.G., Humphreys K., Wahlestedt C., Brookes A.J., et al. Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish Caucasians. Diabetes 53 (2004) S31-35
22. Dolley G., Bertrais S., Frochot V., Bebel J.F., Guerre-Millo M., Tores F., et al. Promoter adiponectin polymorphisms and waist/hip ratio variation in a prospective French adults study. Int. J. Obes. (Lond) 32 (2008) 669-675
23. Schwarz P.E., Towers G.W., Fischer S., Govindarajalu S., Schulze J., Bornstein S.R., et al. Hypoadiponectinemia is associated with progression toward type 2 diabetes and genetic variation in the ADIPOQ gene promoter. Diabetes Care 29 (2006) 1645-1650
24. Schwarz P.E., Towers G.W., van der Merwe A., Perez-Perez L., Rheeder P., Schulze J., et al. Global meta-analysis of the C-11377G alteration in the ADIPOQ gene indicates the presence of population-specific effects: challenge for global health initiatives. Pharmacogenomics J. 4 (2008)
25. Lillioja S., Mott D.M., Spraul M., Ferraro R., Foley J.E., Ravussin E., et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus, prospective studies of Pima Indians. N. Engl. J. Med. 329 (1993) 1988-1992
26. Alvarsson M., Wajngot A., Cerasi E., and Efendic S. K-value and low insulin secretion in a non-obese white population: predicted glucose tolerance after 25 years. Diabetologia 48 (2005) 2262-2268
27. Olckers A., Towers G.W., van der Merwe A., Schwarz P.E., Rheeder P., and Schutte A.E. Protective effect against type 2 diabetes mellitus identified within the ACDC gene in a black South African diabetic cohort. Metabolism 56 (2007) 587-592
28. Jang Y., Lee J.H., Chae J.S., Kim O.Y., Koh S.J., Kim J.Y., et al. Association of the 276G->T polymorphism of the adiponectin gene with cardiovascular disease risk factors in nondiabetic Koreans. Am. J. Clin. Nutr. 82 (2005) 760-767
29. Populaire C., Mori Y., Dina C., Vasseur F., Vaxillaire M., Kadowaki T., et al. Does the -11377 promoter variant of APM1 gene contribute to the genetic risk for type 2 diabetes mellitus in Japanese families?. Diabetologia 46 (2003) 443-445
30. Woo J.G., Dolan L.M., Deka R., Kaushal R.D., Shen Y., Pal P., et al. Interactions between noncontiguous haplotypes in the adiponectin gene ACDC are associated with plasma adiponectin. Diabetes 55 (2006) 523-529
31. Pollin T.I., Tanner K., O'connell J.R., Ott S.H., Damcott C.M., Shuldiner A.R., et al. Linkage of plasma adiponectin levels to 3q27 explained by association with variation in the APM1 gene. Diabetes 54 (2005) 268-274
32. Owecki M., Miczke A., Kaczmarek M., Hoppe-Gołebiewska J., Pupek-Musialik D., Słomski R., et al. The Y111 H (T415C) polymorphism in exon 3 of the gene encoding adiponectin is uncommon in Polish obese patients. Horm. Metab. Res. 39 (2007) 797-800
33. Saito K., Tobe T., Minoshima S., Asakawa S., Sumiya J., Yoda M., et al. Organization of the gene for gelatin-binding protein (GBP28). Gene 229 (1999) 67-73
34. Conn B., Stutz A., and Vassalli J.D. The 3′ untranslated region of messenger RNA: a molecular 'hotspot' for pathology?. Nat. Med. 6 (2000) 637-641
35. Frittitta L., Ercolino T., Bozzali M., Argiolas A., Graci S., Santagati M.G., et al. A cluster of three single nucleotide polymorphisms in the 3′-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content and insulin resistance-related abnormalities. Diabetes 50 (2001) 1952-1955
36. Di Paola R., Frittitta L., Miscio G., Bozzali M., Baratta R., Centra M., et al. A variation in 3′ UTR of hPTP1B increases specific gene expression and associates with insulin resistance. Am. J. Hum. Genet. 70 (2002) 806-812