Protective effect against type 2 diabetes mellitus identified within the ACDC gene in a black South African diabetic cohort

Metabolism: Clinical and Experimental

Volumn 56, Issue 5, 2007, Pages 587-592

  Olckers, Antonel ^a,b   Towers, G Wayne ^a   van der Merwe, Annelize ^a,b   Schwarz, Peter E H ^c   Rheeder, Paul ^d   Schutte, Aletta E ^a  

^a NORTH WEST UNIVERSITY   (South Africa)

^b DNAbiotec (Pty) Ltd   (South Africa)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d UNIVERSITY OF PRETORIA   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN;

ADULT; AGED; ALLELE; ARTICLE; COHORT ANALYSIS; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FEMALE; GENE IDENTIFICATION; GENE LOCUS; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POPULATION RESEARCH; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTH AMERICA;

ADIPONECTIN; ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; BLOOD GLUCOSE; BODY MASS INDEX; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; DNA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); SOUTH AFRICA; WAIST-HIP RATIO;

EID: 34147170372     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2006.10.004     Document Type: Article

References (24)

1. Barnett A.H., Eff C., Leslie R.D.G., and Pyke D.A. Diabetes in identical twins: a study of 200 pairs. Diabetologia 20 (1981) 87-93
2. Bergman R.N., Phillips L.S., and Cobelli C. Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 68 (1981) 1456-1467
3. King H., Aubert R.E., and Herman W.H. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care 21 (1998) 1414-1431
4. World Health Organisation. Handbook of resolutions and decisions of the World Health Assembly and the Executive Board. Vol. III, 1985-1992 (1993), WHO, Geneva 131-132
5. Alberti K.G.M.M., and Zimmet P.Z. World Health Organisation definition, diagnosis and classification of diabetes mellitus and its complications. Report of a WHO consultation. Part 1: diagnosis and classification of diabetes mellitus (1999), WHO Department of Noncommunicable Disease Surveillance, Geneva
6. Kissebah A.H., Sonnenberg G.E., Myklebust J., et al. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome. Proc Natl Acad Sci U S A 97 (2000) 14478-14483
7. Saito K., Tobe T., Yoda M., et al. Regulation of gelatin-binding protein 28 (GBP28) gene expression by C/EBP. Biol Pharm Bull 22 (1999) 1158-1162
8. Weyer C., Funahashi T., Tanaka S., et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86 (2001) 1930-1935
9. Yamauchi T., Kamon J., Waki H., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7 (2001) 941-946
10. Stumvoll M., Tschritter O., Fritsche A., et al. Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity. Diabetes 51 (2002) 37-41
11. Vasseur F., Helbecque N., Dina C., et al. Single-nucleotide polymorphism haplotypes in both the proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet 11 (2002) 2607-2614
12. Kondo H., Shimomura I., Matsukawa Y., et al. Association of adiponectin mutation with type 2 diabetes. Diabetes 51 (2002) 2325-2328
13. Schwarz P.E.H., Govindarajalu S., Towers W., Schwanebeck U., Fischer S., Vasseur F., et al. Haplotypes in the promoter region of the ADIPOQ gene are associated with increased diabetes risk in a German Caucasian population. Hormone Metab Res 38 (2006) 447-454
14. Hara K., Boutin P., Mori Y., et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 51 (2002) 536-540
15. Erasmus R.T., Blanco Blanco E., Okesina A.B., et al. Importance of family history in type 2 black South African diabetic patients. Postgrad Med J 77 (2001) 323-325
16. Chen Y.-S., Torroni A., Excoffier L., et al. Analysis of mtDNA variation in African populations reveals the most ancient of all human continent-specific haplogroups. Am J Hum Genet 57 (1995) 133-149
17. Cann R.L., Stoneking M., and Wilson A.C. Mitochondrial DNA and human evolution. Nature 325 (1987) 31-36
18. StatSoft Inc. STATISTICA (data analysis software system), version 7 (2004). www.statsoft.com
19. Excoffier LGL, Schneider S. Arlequin ver. 3.0: an integrated software package for population genetics data analysis. Evolutionary Bioinformatics Online, submitted 2005.
20. Bland J.M., and Altman D.G. The odds ratio. Br Med J 320 (2000) 1468
21. Wright A., Charlesworth B., Rudan I., et al. A polygenic basis for late-onset disease. Trends Genet 19 (2003) 97-106
22. Horikawa Y., Oda N., Cox N.J., et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet 26 (2000) 163-175
23. Cassell P.G., Jackson A.E., North B.V., et al. Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type 2 diabetes in South Indians. Diabetes 51 (2002) 622-628
24. Malecki M.T., Moczulski D.K., Klupa T., et al. Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population. Eur J Endocrinol 146 (2002) 695-699