K-value and low insulin secretion in a non-obese white population: Predicted glucose tolerance after 25 years

Diabetologia

Volumn 48, Issue 11, 2005, Pages 2262-2268

  Alvarsson, M ^a   Wajngot, A ^a   Cerasi, E ^b   Efendic, S ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

First phase insulin response; Insulin sensitivity; K value; Oral glucose tolerance test; Pathogenesis of type 2 diabetes

Indexed keywords

GLUCOSE; INSULIN;

ADOLESCENT; ADULT; ARTICLE; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FOLLOW UP; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INFUSION; GLUCOSE TOLERANCE; HIGH RISK POPULATION; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAVENOUS GLUCOSE TOLERANCE TEST; MAJOR CLINICAL STUDY; MALE; MEDICAL ASSESSMENT; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; PREDICTION; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR;

ADOLESCENT; ADULT; BLOOD GLUCOSE; CHILD; CROSS-SECTIONAL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; OBESITY; PREDICTIVE VALUE OF TESTS; REFERENCE VALUES; REGRESSION ANALYSIS; SWEDEN;

EID: 27744442528     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-1929-6     Document Type: Article

References (42)

1. Kahn CR (1994) Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 43:1066-1084
2. Efendic S, Luft R, Wajngot A (1984) Aspects of pathogenesis of type 2 diabetes. Endocr Rev 5:395-410
3. DeFronzo RA, Bonadonna RC, Ferrannini E (1992) Pathogenesis of NIDDM: a balanced overview. Diabetes Care 15:318-368
4. Jensen CC, Cnop M, Hull RL, Fujimoto WY, Kahn SE, American Diabetes Association GENNID Study Group (2002) β-Cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the US. Diabetes 51:2170-2178
5. Pimenta W, Korytkowski M, Mitrakou A et al (1995) Pancreatic beta-cell dysfunction as the primary genetic lesion in NIDDM. Evidence from studies in normal glucose-tolerant individuals with a first-degree NIDDM relative. J Am Med Assoc 273:1855-1861
6. Kadowaki T, Miyake Y, Hagura R et al (1984) Risk factor for worsening to diabetes in subjects with impaired glucose tolerance. Diabetologia 26:44-49
7. Warram J, Martin B, Krolewski A, Soeldner S, Kahn RC (1990) Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic patients. Ann Intern Med 113:909-915
8. Lillioja S, Mott DM, Spraul M et al (1993) Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N Engl J Med 329:1988-1992
9. Haffner SM, Miettinen H, Gaskill SP, Stern MP (1995) Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of NIDDM in Mexican-Americans. Diabetes 44:1386-1391
10. Eriksson J, Franssila-Kallunki A, Ekstrand A et al (1989) Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 321:337-343
11. Cerasi E, Luft R (1967) The plasma insulin response to glucose infusion in healthy subjects and in diabetes mellitus. Acta Endocrinol (Copenh) 55:287-304
12. Ikkos D, Luft R (1957) On the intravenous glucose tolerance test. Acta Endocrinol (Copenh) 25:312-334
13. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
14. Kahn SE, Prigeon RL, McCulloch DK et al (1993) Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function. Diabetes 42:1663-1673
15. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus (1997) Report of the Expert Committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 20:1183-1197
16. Cerasi E (1995) Insulin deficiency and insulin resistance in the pathogenesis of type 2 diabetes: is a divorce possible? Diabetologia 38:992-997
17. Cavaghan MK, Ehrman DA, Polonsky KS (2000) Interactions between insulin resistance and insulin secretion in the development of glucose intolerance. J Clin Invest 106:329-333
18. Kahn SE (2001) The importance of β-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 86:4047-4058
19. Catalano PM, Tyzbir ED, Wolfe RR et al (1993) Carbohydrate metabolism during pregnancy in control subjects and women with gestational diabetes. Am J Physiol 264:E60-E67
20. Efendic S, Hanson U, Persson B, Wajngot A, Luft R (1987) Glucose tolerance, insulin release, and insulin sensitivity in normal-weight women with previous gestational diabetes mellitus. Diabetes 36:413-419
21. Dunaif A, Finegood DT (1996) β-Cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome. J Clin Endocrinol Metab 81:942-947
22. Austin A, Kalhan SC, Orenstein D, Nixon P, Arslanian S (1994) Roles of insulin resistance and β-cell dysfunction in the pathogenesis of glucose intolerance in cystic fibrosis. J Clin Endocrinol Metab 79:80-85
23. Kahn SE, Larson VG, Schwartz RS et al (1992) Exercise training delineates the importance of beta-cell dysfunction to the glucose intolerance of human aging. J Clin Endocrinol Metab 74:1336-1342
24. Larsson H, Ahrén B (1996) Failure to adequately adapt reduced insulin sensitivity with increased insulin secretion in women with impaired glucose tolerance. Diabetologia 39:1099-1107
25. Cerasi E, Luft R (1963) Plasma-insulin response to sustained hyperglycaemia induced by glucose infusion in human subjects. Lancet ii: 1359-1361
26. Cerasi E, Luft R (1967) "What is inherited - what is added?" hypothesis for the pathogenesis of diabetes mellitus. Diabetes 16:615-627
27. Phillips DIW, Clark PM, Hales CN, Osmond C (1994) Understanding oral glucose tolerance: comparison of glucose or insulin measurements during the oral glucose tolerance test with specific measurements of insulin resistance and insulin secretion. Diabet Med 11:286-292
28. Pratley RE, Weyer C (2001) The role of impaired early insulin secretion in the pathogenesis of type II diabetes mellitus. Diabetologia 44:929-945
29. Cerasi E, Luft R (1967) Further studies on healthy subjects with low and high insulin response to glucose infusion. Acta Endocrinol (Copenh) 55:305-329
30. Grill V, Persson G, Carlsson S et al (1999) Family history of diabetes in middle-aged Swedish men is a gender unrelated factor which associates with insulinopenia in newly diagnosed diabetic subjects. Diabetologia 42:15-23
31. Unwin N, Shaw J, Zimmet P, Alberti KGMM (2002) Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention. Diabet Med 19:708-723
32. Moorhouse JA, Grahame GR, Rosen NJ (1964) Relationship between intravenous glucose tolerance and the fasting blood glucose levels in healthy and in diabetic subjects. J Clin Endocrinol Metab 24:145-159
33. Thorell JI (1973) Effect of transient elevation of plasma insulin within physiological levels (simulated early insulin response) on blood glucose. J Clin Endocrinol Metab 37:423-430
34. Efendic S, Cerasi E, Elander I et al (1979) Studies on low insulin responders. Glucose tolerance and insulin response to intravenous and oral glucose challenges in 226 normal subjects and 25 subjects with mild or chemical diabetes. Acta Endocrinol Suppl (Copenh) 224:5-32
35. Grill V, Adamson U, Cerasi E (1978) Immediate and time-dependent effects of glucose on insulin release from rat pancreatic tissue; evidence for different mechanisms of action. J Clin Invest 61:1034-1043
36. Nesher R, Cerasi E (2002) Modeling phasic insulin release: immediate and time-dependent effects of glucose. Diabetes 51:S53-S59
37. Cerasi E (1975) Potentiation of insulin release by glucose in man. III. Normal recognition of glucose as a potentiator in subjects with low insulin response and in mild diabetes. Acta Endocrinol (Copenh) 79:511-534
38. Weyer C, Tataranni PA, Bogardus C, Pratley RE (2000) Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care 24:89-94
39. Wallace TM, Levy JC, Matthews DR (2004) Use and abuse of HOMA modeling. Diabetes Care 27:1487-1495
40. Arner P, Pollare T, Lithell H (1991) Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects. Diabetologia 34:483-487
41. Zierath JR, Krook A, Wallberg-Henriksson H (1998) Insulin action in skeletal muscle from patients with NIDDM. Mol Cell Biochem 182:153-160
42. Sasson S, Edelson D, Cerasi E (1987) In vitro autoregulation of glucose utilization in the rat soleus muscle. Diabetes 36:1041-1046