메뉴 건너뛰기




Volumn 6, Issue 6, 2000, Pages 637-641

The 3' untranslated region of messenger RNA: A molecular 'hotspot' for pathology?

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

EID: 0034101197     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/76211     Document Type: Review
Times cited : (473)

References (38)
  • 2
    • 0031912139 scopus 로고    scopus 로고
    • Messenger RNAs in dendrites: Localization, stability, and implications for neuronal function
    • Gao, F.B. Messenger RNAs in dendrites: localization, stability, and implications for neuronal function. Bioessays 20, 70-8 (1998).
    • (1998) Bioessays , vol.20 , pp. 70-78
    • Gao, F.B.1
  • 3
    • 0033052063 scopus 로고    scopus 로고
    • Cytoplasmic polyadenylation in development and beyond
    • Richter, J.D. Cytoplasmic polyadenylation in development and beyond. Microbiol. Mol. Biol. Rev. 63, 446-56 (1999).
    • (1999) Microbiol. Mol. Biol. Rev. , vol.63 , pp. 446-456
    • Richter, J.D.1
  • 4
    • 0030939071 scopus 로고    scopus 로고
    • In vivo antisense oligodeoxynucleotide mapping reveals masked regulatory elements in an mRNA dormant in mouse oocytes
    • Stutz, A. et al. In vivo antisense oligodeoxynucleotide mapping reveals masked regulatory elements in an mRNA dormant in mouse oocytes. Mol. Cell. Biol. 17, 1759-1767 (1997).
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1759-1767
    • Stutz, A.1
  • 5
    • 0032529190 scopus 로고    scopus 로고
    • Masking, unmasking, and regulated polyadenylation cooperate in the translational control of a dormant mRNA in mouse oocytes
    • Stutz, A. et al. Masking, unmasking, and regulated polyadenylation cooperate in the translational control of a dormant mRNA in mouse oocytes. Genes Dev. 12, 2535-2548 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 2535-2548
    • Stutz, A.1
  • 6
    • 0032520688 scopus 로고    scopus 로고
    • Myotonic dystrophy: Molecular windows on a complex etiology
    • Korade-Mirnics, Z., Babitzke, P. & Hoffman, E. Myotonic dystrophy: molecular windows on a complex etiology. Nucleic Acids Res. 26, 1363-1368 (1998).
    • (1998) Nucleic Acids Res. , vol.26 , pp. 1363-1368
    • Korade-Mirnics, Z.1    Babitzke, P.2    Hoffman, E.3
  • 7
    • 0033073594 scopus 로고    scopus 로고
    • Myotonic dystrophy: The role of RNA CUG triplet repeats
    • Timchenko, L.T. Myotonic dystrophy: the role of RNA CUG triplet repeats. Am. J. Hum. Genet. 64, 360-364 (1999).
    • (1999) Am. J. Hum. Genet. , vol.64 , pp. 360-364
    • Timchenko, L.T.1
  • 8
    • 0034162839 scopus 로고    scopus 로고
    • Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties
    • Groenen, P.J. et al. Constitutive and regulated modes of splicing produce six major myotonic dystrophy protein kinase (DMPK) isoforms with distinct properties. Hum. Mol. Genet. 9, 605-616 (2000).
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 605-616
    • Groenen, P.J.1
  • 9
    • 0032502659 scopus 로고    scopus 로고
    • Definition of regulatory sequence elements in the promoter region and the first intron of the myotonic dystrophy protein kinase gene
    • Storbeck, C.J., Sabourin, L.A., Waring, J.D. & Korneluk, R.G. Definition of regulatory sequence elements in the promoter region and the first intron of the myotonic dystrophy protein kinase gene. J. Biol. Chem. 273, 9139-9147 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 9139-9147
    • Storbeck, C.J.1    Sabourin, L.A.2    Waring, J.D.3    Korneluk, R.G.4
  • 10
    • 0030904873 scopus 로고    scopus 로고
    • Myotonic dystrophy: Molecular and cellular consequences of expanded DNA repeats are elusive
    • Strong, P.N. & Brewster, B.S. Myotonic dystrophy: molecular and cellular consequences of expanded DNA repeats are elusive. J. Inherit. Metab. Dis. 20, 159-170 (1997).
    • (1997) J. Inherit. Metab. Dis. , vol.20 , pp. 159-170
    • Strong, P.N.1    Brewster, B.S.2
  • 11
    • 8944259903 scopus 로고    scopus 로고
    • Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy
    • Reddy, S. et al. Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy. Nature Genet. 13, 325-335 (1996).
    • (1996) Nature Genet. , vol.13 , pp. 325-335
    • Reddy, S.1
  • 12
    • 0030841672 scopus 로고    scopus 로고
    • Expansion of a CUG trinucleotide repeat in the 3′ untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts
    • Davis, B.M., McCurrach, M.E., Taneja, K.L., Singer, R.H. & Housman, D.E. Expansion of a CUG trinucleotide repeat in the 3′ untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts. Proc. Natl. Acad. Sci. USA 94, 7388-7393 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 7388-7393
    • Davis, B.M.1    McCurrach, M.E.2    Taneja, K.L.3    Singer, R.H.4    Housman, D.E.5
  • 13
    • 0032906538 scopus 로고    scopus 로고
    • Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy
    • Lu, X., Timchenko, N.A. & Timchenko, L.T. Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy. Hum. Mol. Genet. 8, 53-60 (1999).
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 53-60
    • Lu, X.1    Timchenko, N.A.2    Timchenko, L.T.3
  • 14
    • 0030662379 scopus 로고    scopus 로고
    • Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice
    • Roberts, R. et al. Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice. Proc. Natl. Acad. Sci. USA 94, 13221-13226 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 13221-13226
    • Roberts, R.1
  • 15
    • 0028947317 scopus 로고
    • Foci of trinucleotide repeat transcripts in nuclei of myotonic dystrophy cells and tissues
    • Taneja, K.L., McCurrach, M., Schalling, M., Housman, D. & Singer, R.H. Foci of trinucleotide repeat transcripts in nuclei of myotonic dystrophy cells and tissues. J. Cell Biol. 128, 995-1002 (1995).
    • (1995) J. Cell Biol. , vol.128 , pp. 995-1002
    • Taneja, K.L.1    McCurrach, M.2    Schalling, M.3    Housman, D.4    Singer, R.H.5
  • 16
    • 0032076126 scopus 로고    scopus 로고
    • Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy
    • Philips, A.V., Timchenko, L.T. & Cooper, T.A. Disruption of splicing regulated by a CUG-binding protein in myotonic dystrophy. Science 280, 737-741 (1998).
    • (1998) Science , vol.280 , pp. 737-741
    • Philips, A.V.1    Timchenko, L.T.2    Cooper, T.A.3
  • 17
    • 0033570899 scopus 로고    scopus 로고
    • CUG repeat binding protein (CUGBP1) interacts with the 5′ region of C/EBPβ mRNA and regulates translation of C/EBPβ isoforms
    • Timchenko, N.A., Welm, A.L., Lu, X. & Timchenko, L.T. CUG repeat binding protein (CUGBP1) interacts with the 5′ region of C/EBPβ mRNA and regulates translation of C/EBPβ isoforms. Nucleic Acids Res. 27, 4517-4525 (1999).
    • (1999) Nucleic Acids Res. , vol.27 , pp. 4517-4525
    • Timchenko, N.A.1    Welm, A.L.2    Lu, X.3    Timchenko, L.T.4
  • 18
    • 0033554611 scopus 로고    scopus 로고
    • An expanded CTG trinucleotide repeat causes trans RNA interference: A new hypothesis for the pathogenesis of myotonic dystrophy
    • Sasagawa, N., Takahashi, N., Suzuki, K. & Ishiura, S. An expanded CTG trinucleotide repeat causes trans RNA interference: a new hypothesis for the pathogenesis of myotonic dystrophy. Biochem. Biophys. Res. Commun. 264, 76-80 (1999).
    • (1999) Biochem. Biophys. Res. Commun. , vol.264 , pp. 76-80
    • Sasagawa, N.1    Takahashi, N.2    Suzuki, K.3    Ishiura, S.4
  • 19
    • 0028818586 scopus 로고
    • A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat
    • Boucher, C.A. et al. A novel homeodomain-encoding gene is associated with a large CpG island interrupted by the myotonic dystrophy unstable (CTG)n repeat. Hum. Mol. Genet. 4, 1919-1925 (1995).
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 1919-1925
    • Boucher, C.A.1
  • 20
    • 0030861573 scopus 로고    scopus 로고
    • 3rd. Expansion of the myotonic dystrophy CTG repeat reduces expression of the flanking DMAHP gene
    • Thornton, C.A., Wymer, J.P., Simmons, Z., McClain, C. & Moxley, R.T.3rd. Expansion of the myotonic dystrophy CTG repeat reduces expression of the flanking DMAHP gene. Nature Genet. 16, 407-409 (1997).
    • (1997) Nature Genet. , vol.16 , pp. 407-409
    • Thornton, C.A.1    Wymer, J.P.2    Simmons, Z.3    McClain, C.4    Moxley, R.T.5
  • 21
    • 0030845879 scopus 로고    scopus 로고
    • Trinucleotide repeat expansion at the myotonic dystrophy locus reduces expression of DMAHP
    • Klesert, T.R., Otten, A.D., Bird, T.D. & Tapscott, S.J. Trinucleotide repeat expansion at the myotonic dystrophy locus reduces expression of DMAHP. Nature Genet. 16, 402-406 (1997).
    • (1997) Nature Genet. , vol.16 , pp. 402-406
    • Klesert, T.R.1    Otten, A.D.2    Bird, T.D.3    Tapscott, S.J.4
  • 22
    • 0032971242 scopus 로고    scopus 로고
    • Simultaneous analysis of expression of the three myotonic dystrophy locus genes in adult skeletal muscle samples: The CTG expansion correlates inversely with DMPK and 59 expression levels, but notDMAHP levels
    • Eriksson, M., Ansved, T., Edstrom, L., Anvret, M. & Carey, N. Simultaneous analysis of expression of the three myotonic dystrophy locus genes in adult skeletal muscle samples: the CTG expansion correlates inversely with DMPK and 59 expression levels, but notDMAHP levels. Hum. Mol. Genet. 8, 1053-1060 (1999).
    • (1999) Hum. Mol. Genet. , vol.8 , pp. 1053-1060
    • Eriksson, M.1    Ansved, T.2    Edstrom, L.3    Anvret, M.4    Carey, N.5
  • 23
    • 0028788194 scopus 로고
    • AU-rich elements: Characterization and importance in mRNA degradation
    • Chen, C.Y. & Shyu, A.B. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 20, 465-470 (1995).
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 465-470
    • Chen, C.Y.1    Shyu, A.B.2
  • 24
    • 0032526417 scopus 로고    scopus 로고
    • RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein
    • Peng, S.S., Chen, C.Y., Xu, N. & Shyu, A.B. RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO J. 17, 3461-3470 (1998).
    • (1998) EMBO J. , vol.17 , pp. 3461-3470
    • Peng, S.S.1    Chen, C.Y.2    Xu, N.3    Shyu, A.B.4
  • 25
    • 0028319242 scopus 로고
    • Rearrangement of CCND1 (BCL1/PRAD1) 3′ untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias
    • Rimokh, R. et al. Rearrangement of CCND1 (BCL1/PRAD1) 3′ untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias. Blood 83, 3689-3696 (1994).
    • (1994) Blood , vol.83 , pp. 3689-3696
    • Rimokh, R.1
  • 26
    • 0030463479 scopus 로고    scopus 로고
    • Differential activity of ELAV-like RNA-binding proteins in human neuroblastoma
    • Chagnovich, D., Fayos, B.E. & Cohn, S.L. Differential activity of ELAV-like RNA-binding proteins in human neuroblastoma. J. Biol. Chem. 271, 33587-33591 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 33587-33591
    • Chagnovich, D.1    Fayos, B.E.2    Cohn, S.L.3
  • 27
    • 0030465062 scopus 로고    scopus 로고
    • Binding of a 40-kDa protein to the N-myc 3′-untranslated region correlates with enhanced N-myc expression in human neuroblastoma
    • Chagnovich, D. & Cohn, S.L. Binding of a 40-kDa protein to the N-myc 3′-untranslated region correlates with enhanced N-myc expression in human neuroblastoma. J. Biol. Chem. 271, 33580-33586 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 33580-33586
    • Chagnovich, D.1    Cohn, S.L.2
  • 28
    • 0031409334 scopus 로고    scopus 로고
    • Activity of a 40 kDa RNA-binding protein correlates with MYCN and c-fos mRNA stability in human neuroblastoma
    • Chagnovich, D. & Cohn, S.L. Activity of a 40 kDa RNA-binding protein correlates with MYCN and c-fos mRNA stability in human neuroblastoma. Eur. J. Cancer 33, 2064-2067 (1997).
    • (1997) Eur. J. Cancer , vol.33 , pp. 2064-2067
    • Chagnovich, D.1    Cohn, S.L.2
  • 29
    • 0033049125 scopus 로고    scopus 로고
    • Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA
    • Lai, W.S. et al. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol. Cell Biol. 19, 4311-4323 (1999).
    • (1999) Mol. Cell Biol. , vol.19 , pp. 4311-4323
    • Lai, W.S.1
  • 30
    • 0032516626 scopus 로고    scopus 로고
    • Feedback inhibition of macrophage tumor necrosis factor-α production by tristetraprolin
    • Carballo, E., Lai, W.S. & Blackshear, P.J. Feedback inhibition of macrophage tumor necrosis factor-α production by tristetraprolin. Science 281, 1001-1005 (1998).
    • (1998) Science , vol.281 , pp. 1001-1005
    • Carballo, E.1    Lai, W.S.2    Blackshear, P.J.3
  • 31
    • 0034653560 scopus 로고    scopus 로고
    • Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability
    • Carballo, E., Lai, W.S. & Blackshear, P.J. Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability. Blood 95, 1891-1899 (2000).
    • (2000) Blood , vol.95 , pp. 1891-1899
    • Carballo, E.1    Lai, W.S.2    Blackshear, P.J.3
  • 32
    • 0033103805 scopus 로고    scopus 로고
    • Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
    • Kontoyiannis, D., Pasparakis, M., Pizarro, T.T., Cominelli, F. & Kollias, G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10, 387-398 (1999).
    • (1999) Immunity , vol.10 , pp. 387-398
    • Kontoyiannis, D.1    Pasparakis, M.2    Pizarro, T.T.3    Cominelli, F.4    Kollias, G.5
  • 33
    • 0028919677 scopus 로고
    • Erythroid cell-specific mRNA stability elements in the α2-globin 3′ nontranslated region
    • Weiss, I.M. & Liebhaber, S.A. Erythroid cell-specific mRNA stability elements in the α2-globin 3′ nontranslated region. Mol. Cell Biol. 15, 2457-2465 (1995).
    • (1995) Mol. Cell Biol. , vol.15 , pp. 2457-2465
    • Weiss, I.M.1    Liebhaber, S.A.2
  • 34
    • 0028839055 scopus 로고
    • Detection and characterization of a 3′ untranslated region ribonucleoprotein complex associated with human alpha-globin mRNA stability
    • erratum: 15, 2331 (1995)
    • Wang, X., Kiledjian, M., Weiss, I.M. & Liebhaber, S.A. Detection and characterization of a 3′ untranslated region ribonucleoprotein complex associated with human alpha-globin mRNA stability. Mol Cell Biol 15, 1769-1777 (1995); erratum: 15, 2331 (1995).
    • (1995) Mol Cell Biol , vol.15 , pp. 1769-1777
    • Wang, X.1    Kiledjian, M.2    Weiss, I.M.3    Liebhaber, S.A.4
  • 35
    • 0030891730 scopus 로고    scopus 로고
    • Destabilization of human alpha-globin mRNA by translation anti-termination is controlled during erythroid differentiation and is paralleled by phased shortening of the poly(A) tail
    • Morales, J., Russell, J.E. & Liebhaber, S.A. Destabilization of human alpha-globin mRNA by translation anti-termination is controlled during erythroid differentiation and is paralleled by phased shortening of the poly(A) tail. J. Biol. Chem. 272, 6607-6613 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 6607-6613
    • Morales, J.1    Russell, J.E.2    Liebhaber, S.A.3
  • 36
    • 0030006957 scopus 로고    scopus 로고
    • The stability of human beta-globin mRNA is dependent on structural determinants positioned within its 3′ untranslated region
    • Russell, J.E. & Liebhaber, S.A. The stability of human beta-globin mRNA is dependent on structural determinants positioned within its 3′ untranslated region. Blood 87, 5314-5323 (1996).
    • (1996) Blood , vol.87 , pp. 5314-5323
    • Russell, J.E.1    Liebhaber, S.A.2
  • 37
    • 0032560851 scopus 로고    scopus 로고
    • An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy
    • Kobayashi, K. et al. An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy. Nature 394, 388-392 (1998).
    • (1998) Nature , vol.394 , pp. 388-392
    • Kobayashi, K.1
  • 38
    • 0029766553 scopus 로고    scopus 로고
    • Translational regulation of human p53 gene expression
    • Fu, L., Minden, M.D. & Benchimol, S. Translational regulation of human p53 gene expression. EMBO J. 15, 4392-4401 (1996).
    • (1996) EMBO J. , vol.15 , pp. 4392-4401
    • Fu, L.1    Minden, M.D.2    Benchimol, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.