Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through Β-catenin

Modern Pathology

Volumn 22, Issue 6, 2009, Pages 839-847

  Liao, Xiaoyun ^a   Siu, Michelle K Y ^a   Au, Christy W H ^a   Chan, Queeny K Y ^a   Chan, Hoi Yan ^a   Wong, Esther S Y ^a   Ip, Philip P C ^a   Ngan, Hextan Y S ^a   Cheung, Annie N Y ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

B catenin; Endometrial cancers; Gli1

Indexed keywords

BETA CATENIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL DIFFERENTIATION; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ENDOMETRIUM CARCINOMA; ENDOMETRIUM HYPERPLASIA; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; BETA CATENIN; BLOTTING, WESTERN; CELL NUCLEUS; ENDOMETRIAL NEOPLASMS; FEMALE; HEDGEHOG PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; KAPLAN-MEIERS ESTIMATE; MIDDLE AGED; NEOPLASM STAGING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 67349260818     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2009.45     Document Type: Article

References (34)

1. Ries L, Melbert D, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2004. National Cancer Institute: Bethesda, MD, 2007.
2. Hospital Authority. Hong Kong Cancer Statistics, Hong Kong Cancer Registry 2006.
3. Bokhman JV. Two pathogenetic types of endometrial carcinoma. Gynecol oncol 1983;15:10-17.
4. Hecht JL, Mutter GL. Molecular and pathologic aspects of endometrial carcinogenesis. J Clin Oncol 2006;24: 4783-4791.
5. Watt FM. Unexpected Hedgehog-Wnt interactions in epithelial differentiation. Trends Mol Med 2004;10: 577-580.
6. Taipale J, Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature 2001;411:349-354.
7. Saegusa M, Hashimura M, Yoshida T, et al. beta-Catenin mutations and aberrant nuclear expression during endometrial tumorigenesis. Br J Cancer 2001; 84:209-217.
8. Palacios J, Catasus L, Moreno-Bueno G, et al. Beta- and gamma-catenin expression in endometrial carcinoma. Relationship with clinicopathological features and microsatellite instability. Virchows Arch 2001;438: 464-469.
9. Xie J, Murone M, Luoh SM, et al. Activating Smooth-ened mutations in sporadic basal-cell carcinoma. Nature 1998;391:90-92.
10. Sanchez P, Hernandez AM, Stecca B, et al. Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling. Proc Natl Acad Sci USA 2004;101:12561-12566.
11. Kayed H, Kleeff J, Keleg S, et al. Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer. Int J Cancer 2004;110:668-676.
12. Lees C, Howie S, Sartor RB, et al. The hedgehog signalling pathway in the gastrointestinal tract: implications for development, homeostasis, and disease. Gastroenterology 2005;129:1696-1710.
13. Stecca B, Mas C, Ruiz i Altaba A. Interference with HH-GLI signaling inhibits prostate cancer. Trends Mol Med 2005;11:199-203.
14. Evangelista M, Tian H, de Sauvage FJ. The hedgehog signaling pathway in cancer. Clin Cancer Res 2006;12: 5924-5928.
15. van den Brink GR, Bleuming SA, Hardwick JC, et al. Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet 2004;36:277-282.
16. Akiyoshi T, Nakamura M, Koga K, et al. Gli1, down-regulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation. Gut 2006;55:991-999.
17. Alonso L, Fuchs E. Stem cells in the skin: waste not, Wnt not. Genes Dev 2003;17:1189-1200.
18. Maeda O, Kondo M, Fujita T, et al. Enhancement of GLI1-transcriptional activity by beta-catenin in human cancer cells. Oncol Rep 2006;16:91-96.
19. Feng YZ, Shiozawa T, Miyamoto T, et al. Overexpres-sion of hedgehog signaling molecules and its involvement in the proliferation of endometrial carcinoma cells. Clin Cancer Res 2007;13:1389-1398.
20. Ronnett BM, Zaino RJ, Ellenson LH, et al. Endometrial carcinoma. In: Kurman RJ (ed). Blaustein's Pathology of the Female Genital Tract. Springer-Verlag: New York, 2002, pp 501-559. 84
21. Kamelle S, Sienko A, Benbrook DM. Retinoids and steroids regulate menstrual phase histological features in human endometrial organotypic cultures. Fertil Steril 2002;78:596-602.
22. Liao X, Siu MK, Chan KY, et al. Hypermethylation of RAS effector related genes and DNA methyltrans-ferase 1 expression in endometrial carcinogenesis. Int J Cancer 2008;123:296-302.
23. Sasaki H, Nishizaki Y, Hui C, et al. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 1999;126: 3915-3924.
24. Chan HY, Siu MK, Zhang HJ, et al. Activated Stat3 expression in gestational trophoblastic disease: correlation with clinicopathological parameters and apop-totic indices. Histopathology 2008;53:139-146.
25. Siu MK, Wong ES, Chan HY, et al. Overexpression of NANOG in gestational trophoblastic diseases: effect on apoptosis, cell invasion, and clinical outcome. Am J Pathol 2008;173:1165-1172.
26. Kubo M, Nakamura M, Tasaki A, et al. Hedgehog signaling pathway is a new therapeutic target for patients with breast cancer. Cancer Res 2004;64:6071-6074.
27. Moreno-Bueno G, Hardisson D, Sanchez C, et al. Abnormalities of the APC/beta-catenin pathway in endometrial cancer. Oncogene 2002;21:7981-7990.
28. Ikeda T, Yoshinaga K, Semba S, et al. Mutational analysis of the CTNNB1 (beta-catenin) gene in human endometrial cancer: frequent mutations at codon 34 that cause nuclear accumulation. Oncol Rep 2000;7:323-326.
29. Yanai K, Nakamura M, Akiyoshi T, et al. Crosstalk of hedgehog and Wnt pathways in gastric cancer. Cancer Lett 2008;263:145-156.
30. Meng X, Poon R, Zhang X, et al. Suppressor of fused negatively regulates beta-catenin signaling. J Biol Chem 2001;276:40113-40119.
31. Li X, Deng W, Lobo-Ruppert SM, et al. Gli1 acts through Snail and E-cadherin to promote nuclear signaling by beta-catenin. Oncogene 2007;26:4489-4498.
32. Hoseong Yang S, Andl T, Grachtchouk V, et al. Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta-catenin signaling. Nat Genet 2008;40:1130-1135.
33. Saldanha G, Ghura V, Potter L, et al. Nuclear beta-catenin in basal cell carcinoma correlates with increased proliferation. Br J Dermatol 2004;151:157-164.
34. Kalderon D. Similarities between the Hedgehog and Wnt signaling pathways. Trends Cell Biol 2002;12: 523-531.