Suppression of Th2-driven, allergen-induced airway inflammation by sauchinone

Biochemical and Biophysical Research Communications

Volumn 385, Issue 2, 2009, Pages 204-209

  Min, Hyun Jung ^a   Won, Hee Yeon ^a   Kim, Young Choong ^b   Sung, Sang Hyun ^b   Byun, Mi Ran ^c   Hwang, Jun Ha ^c   Hong, Jeong Ho ^c   Hwang, Eun Sook ^a  

^a Ewha Womans University   (South Korea)

^b Seoul National University   (South Korea)

^c Korea University   (South Korea)

Author keywords

Airway inflammatory diseases; Allergen induced airway inflammation; GATA 3; Sauchinone; Th2 cell development

Indexed keywords

ALLERGEN; ANTIASTHMATIC AGENT; COLLAGEN; EOTAXIN; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; PLANT EXTRACT; SAUCHINONE; TRANSCRIPTION FACTOR GATA 3; UNCLASSIFIED DRUG;

ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL HYPERPLASIA; CELL MATURATION; CELLULAR IMMUNITY; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; DRUG ISOLATION; DRUG POTENCY; ENZYME INHIBITION; EOSINOPHIL; GENE EXPRESSION; GENE REPRESSION; GOBLET CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG; LUNG LAVAGE; LYMPHATIC DRAINAGE; LYMPHOCYTE; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MEDICINAL PLANT; MOUSE; MUCOUS CELL; NEUTROPHIL; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; RESPIRATORY TRACT INFLAMMATION; SAURURUS CHINENSIS; TH1 CELL; TH17 CELL; TH2 CELL;

ALLERGENS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BENZOPYRANS; CHEMOKINE CCL11; DIOXOLES; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION; GOBLET CELLS; IMMUNOSUPPRESSION; INTERLEUKIN-13; INTERLEUKIN-15; INTERLEUKIN-4; INTERLEUKIN-5; LYMPH NODES; MICE; MICE, INBRED BALB C; PROMOTER REGIONS, GENETIC; RHINITIS, ALLERGIC, PERENNIAL; TH2 CELLS;

MURINAE; MUS; SAURURUS CHINENSIS;

EID: 67349252050     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.05.039     Document Type: Article

References (33)

1. Sung S.H., and Kim Y.C. Hepatoprotective diastereomeric lignans from Saururus chinensis herbs. J. Nat. Prod. 63 (2000) 1019-1021
2. Sung S.H., Lee E.J., Cho J.H., Kim H.S., and Kim Y.C. Sauchinone, a lignan from Saururus chinensis, attenuates CCl4-induced toxicity in primary cultures of rat hepatocytes. Biol. Pharm. Bull. 23 (2000) 666-668
3. Song H., Kim Y.C., and Moon A. Sauchinone, a lignan from Saururus chinensis, inhibits staurosporine-induced apoptosis in C6 rat glioma cells. Biol. Pharm. Bull. 26 (2003) 1428-1430
4. Han K.Y., Yang D., Chang E.J., Lee Y., Huang H., Sung S.H., Lee Z.H., Kim Y.C., and Kim H.H. Inhibition of osteoclast differentiation and bone resorption by sauchinone. Biochem. Pharmacol. 74 (2007) 911-923
5. Seo C.S., Lee Y.K., Kim Y.J., Jung J.S., Jahng Y., Chang H.W., Song D.K., and Son J.K. Protective effect of lignans against sepsis from the roots of Saururus chinensis. Biol. Pharm. Bull. 31 (2008) 523-526
6. Hwang B.Y., Lee J.H., Jung H.S., Kim K.S., Nam J.B., Hong Y.S., Paik S.G., and Lee J.J. Sauchinone, a lignan from Saururus chinensis, suppresses iNOS expression through the inhibition of transactivation activity of RelA of NF-kappaB. Planta Med. 69 (2003) 1096-1101
7. Lee A.K., Sung S.H., Kim Y.C., and Kim S.G. Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. Br. J. Pharmacol. 139 (2003) 11-20
8. Inman M.D., Ellis R., Wattie J., Denburg J.A., and O'Byrne P.M. Allergen-induced increase in airway responsiveness, airway eosinophilia, and bone-marrow eosinophil progenitors in mice. Am. J. Respir. Cell. Mol. Biol. 21 (1999) 473-479
9. Ohkawara Y., Lei X.F., Stampfli M.R., Marshall J.S., Xing Z., and Jordana M. Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation. Am. J. Respir. Cell. Mol. Biol. 16 (1997) 510-520
10. Tagaya E., and Tamaoki J. Mechanisms of airway remodeling in asthma. Allergol. Int. 56 (2007) 331-340
11. Davies D.E., Wicks J., Powell R.M., Puddicombe S.M., and Holgate S.T. Airway remodeling in asthma: new insights. J. Allergy Clin. Immunol. 111 (2003) 215-225 quiz 226
12. Carter P.M., Heinly T.L., Yates S.W., and Lieberman P.L. Asthma: the irreversible airways disease. J. Investig. Allergol. Clin. Immunol. 7 (1997) 566-571
13. Foster P.S., Hogan S.P., Ramsay A.J., Matthaei K.I., and Young I.G. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. J. Exp. Med. 183 (1996) 195-201
14. Corry D.B., Folkesson H.G., Warnock M.L., Erle D.J., Matthay M.A., Wiener-Kronish J.P., and Locksley R.M. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183 (1996) 109-117
15. Wills-Karp M., Luyimbazi J., Xu X., Schofield B., Neben T.Y., Karp C.L., and Donaldson D.D. Interleukin-13: central mediator of allergic asthma. Science 282 (1998) 2258-2261
16. Grunig G., Warnock M., Wakil A.E., Venkayya R., Brombacher F., Rennick D.M., Sheppard D., Mohrs M., Donaldson D.D., Locksley R.M., and Corry D.B. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282 (1998) 2261-2263
17. Murphy K.M., and Reiner S.L. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2 (2002) 933-944
18. Pai S.Y., Truitt M.L., and Ho I.C. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc. Natl. Acad. Sci. USA 101 (2004) 1993-1998
19. Ranganath S., and Murphy K.M. Structure and specificity of GATA proteins in Th2 development. Mol. Cell. Biol. 21 (2001) 2716-2725
20. Zheng W., and Flavell R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89 (1997) 587-596
21. Park J.W., Min H.J., Sohn J.H., Kim J.Y., Hong J.H., Sigrist K.S., Glimcher L.H., and Hwang E.S. Restoration of T-box-containing protein expressed in T cells protects against allergen-induced asthma. J. Allergy Clin. Immunol. 123 (2009) 479-485
22. Iwamoto I., Tomoe S., Tomioka H., Takatsu K., and Yoshida S. Role of CD4+ T lymphocytes and interleukin-5 in antigen-induced eosinophil recruitment into the site of cutaneous late-phase reaction in mice. J. Leukoc. Biol. 52 (1992) 572-578
23. Wills-Karp M. Immunologic basis of antigen-induced airway hyperresponsiveness. Annu. Rev. Immunol. 17 (1999) 255-281
24. Hamid Q.A., and Cameron L.A. Recruitment of T cells to the lung in response to antigen challenge. J. Allergy Clin. Immunol. 106 (2000) S227-S234
25. Crosby J.R., Shen H.H., Borchers M.T., Justice J.P., Ansay T., Lee J.J., and Lee N.A. Ectopic expression of IL-5 identifies an additional CD4(+) T cell mechanism of airway eosinophil recruitment. Am. J. Physiol. Lung Cell Mol. Physiol. 282 (2002) L99-L108
26. Castilow E.M., Meyerholz D.K., and Varga S.M. IL-13 is required for eosinophil entry into the lung during respiratory syncytial virus vaccine-enhanced disease. J. Immunol. 180 (2008) 2376-2384
27. Lamkhioued B., Renzi P.M., Abi-Younes S., Garcia-Zepada E.A., Allakhverdi Z., Ghaffar O., Rothenberg M.D., Luster A.D., and Hamid Q. Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation. J. Immunol. 159 (1997) 4593-4601
28. Pope S.M., Brandt E.B., Mishra A., Hogan S.P., Zimmermann N., Matthaei K.I., Foster P.S., and Rothenberg M.E. IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism. J. Allergy Clin. Immunol. 108 (2001) 594-601
29. Bamias G., and Cominelli F. Immunopathogenesis of inflammatory bowel disease: current concepts. Curr. Opin. Gastroenterol. 23 (2007) 365-369
30. Rohn T.A., Jennings G.T., Hernandez M., Grest P., Beck M., Zou Y., Kopf M., and Bachmann M.F. Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis. Eur. J. Immunol. 36 (2006) 2857-2867
31. Veldhoen M., and Stockinger B. TGFbeta1, a "Jack of all trades": the link with pro-inflammatory IL-17-producing T cells. Trends Immunol. 27 (2006) 358-361
32. Ray A., and Cohn L. Th2 cells and GATA-3 in asthma: new insights into the regulation of airway inflammation. J. Clin. Invest. 104 (1999) 985-993
33. McGeachy M.J., Bak-Jensen K.S., Chen Y., Tato C.M., Blumenschein W., McClanahan T., and Cua D.J. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol. 8 (2007) 1390-1397