Asthma: The irreversible airways disease

Journal of Investigational Allergology and Clinical Immunology

Volumn 7, Issue 6, 1997, Pages 566-571

  Carter, Paul M ^a,c   Heinly, Tammy L ^a   Yates, Scott W ^b   Lieberman, Phil L ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b NAVAL HOSPITAL JACKSONVILLE   (United States)

^c Minot Air Force Base   (United States)

Author keywords

Airway elastance; Antiinflammatory medication; Asthma; Bronchodilators; Collagen deposition; FEV1; Inflammation; Inhaled corticosteroids; Remodeling

Indexed keywords

ANTIINFLAMMATORY AGENT; BRONCHODILATING AGENT; COLLAGEN; CORTICOSTEROID;

AIRWAY; AIRWAY RESISTANCE; ASTHMA; BASEMENT MEMBRANE; BRONCHOSPASM; CELL HYPERPLASIA; CHRONIC INFLAMMATION; DESQUAMATION; FORCED EXPIRATORY VOLUME; GOBLET CELL; HUMAN; INHALATIONAL DRUG ADMINISTRATION; REVIEW;

ASTHMA; HUMANS; LUNG DISEASES, OBSTRUCTIVE;

EID: 0031454078     PISSN: 10189068     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (68)

1. Bousquet, J., Vignola, A.M., Chanez, P., Campbell, A.M., Bonsignore, G., Michel, F.B. Airways remodelling in asthma: No doubt no more? Int Arch Allergy Immunol 1995, 107: 211-4.
2. Kuwano, K., Bosken, C.H., Pare, P.D., Bai, T.R., Wiggs, B.R., Hogg, J.C. Small airways dimensions in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1993, 148: 1220-5.
3. James, A.L., Pare, P.D., Hogg, J.C. The mechanics of airway narrowing in asthma. Am Rev Respir Dis 1989, 1399: 242-6
4. Bramley, A.M., Thomson, R.J., Roberts, C.R., Schellenberg, R.R. Hypothesis: Excessive bronchoconstriction in asthma is due to decreased airway elastance. Eur Respir J 1994, 7: 337-41.
5. Roche, W.R., Beasley, R., Williams, J.H., Holgate, S.T. Subepithelial fibrosis in the bronchi of asthmatics. Lancet 1989, i: 520-4
6. Brewster, C.E.P., Howarth, P.H., Djukanovic, R., Wilson, J., Holgate, S.T., Roche, W.R. Myofibroblasts and subepithelial fibrosis in bronchial asthma Am J Respir Mol Biol 1990, 3: 507-11.
7. 2 receptors in nearby tissue cells. Virchows Arch [B] 1980, 34: 13-20.
8. Piaut, M., Pierce, J.H., Watson, C.J., Hanley-Hyde, J., Nordan, R.P., Paul, W.E. Mast cell produce lymphokines in response to crosslinkage of FceR1 or to calcium ionophores. Nature 1989, 339: 64-7.
9. Woodnar-Filipowicz, A., Hausser, C.H., Moroni, C. Production of the hematopoetic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation. Nature 1989, 339: 150-2.
10. Roche, W.R. Mast cells and tumors. The specific enhancement of tumor proliferation in vitro. Am J Pathol 1985, 119: 57-64.
11. Pincus, S.H., Ramesh, K.S., Wyler, D.J. Eosinophils stimulate fibroblast DNA synthesis. Blood 1987, 70: 572-4.
12. Springall, D.R., Howarth, P.H., Counihan, H., Djukanovic, R., Holgate, S.T., Polack, J.M. Endothelin immunoreactivity of airway epithelium in asthmatic patients. Lancet 1991, 337: 697-701.
13. McGowan, S.E. Extracellular matrix and the regulation of lung development and repair. FASEB J 1992, 6: 2895-904.
14. Laitinen, A., Altraja, A., Linden, M., Stallenheim, G., Venge, P., Hakansson, L., Virtanen, I., Laitinen, L.A. Treatment with inhaled budesonide and tenascin expression in bronchial mucosa of allergic asthmatics. Am J Respir Crit Care Med 1994, 149: A942.
15. Laitinen, L.A., Laitinen, A. Inhaled corticosteroid treatment and extracellular matrix in the airways in asthma. Int Arch Allergy Immunol 1995, 107: 215-6.
16. Bousquet, J., Chanez, P., Lacoste, J.Y., Barneon, G., Ghavanian, N., Enander, I., Venge, P., Ahlstedt, S., Simony-Lafontaine, J., Godard, P., Michel, F.B. Eosinophilic inflammation in asthma. N Engl J Med 1990, 323: 1033-9.
17. Laitinen, L.A., Heino, M., Laitinen, A., Kava, T., Haahtela, T. Damage of the airway epithelium and bronchial reactivity in patients with asthma. Am Rev Respir Dis 1985, 131: 599-606.
18. Laitinen, L.A., Laitinen, A., Haahtela, T. Airway mucosal inflammation even in patients with newly diagnosed asthma. Am Rev Respir Dis 1993, 147: 697-704
19. Johnson, N.F., Hubbs, A.F. Epithelial progenitor cells in rat trachea. Am J Respir Cell Mol Biol 1991, 4: 195-203.
20. Dunnill, M., Masserella, G., Anderson, J. Comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus. in chronic bronchitis, and in emphysema. Thorax 1969, 24: 176-9.
21. Carroll, N., Elliot, J., Morton, A., James, A. The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis 1993, 147: 405-10.
22. Conrad, D.H., Squire, C.M., Bartlett, W.C., Dierks, S.E. Fcε receptors. Curr Opin Immunol 1991, 3: 859.
23. Rouzer, C.A., Scott, W.A., Hamill, A.L., Cohn, Z.A. Secretion of leukotriene C and other arachadonic acid metabolites by macrophages challenged with immunoglobulin E immune complexes. J Exp Med 1982, 326: 298.
24. Serafin, W.E., Austen, K.F. Current concepts: Mediators of immediate hypersensitiwty reactions. N Eng J Med 1987, 317: 30.
25. Galli, S.J., Gordon, J.R., Wershil, B.K. Cytokine production by mast cells and basophils Current Opin Immunol 1991, 3: 865.
26. Poston, R.N., Chanez, P., Lacoste, J.Y., Litchfield, T., Lee, T.H., Bousquet, J. Immunohistochemical characterization of the cellular infiltration in the asthmatics and normal subjects. Am Rev Respir Dis 1992, 145: 918-21
27. Godard, P., Chaintreuil, J., Damon, M., Coupe, M., Flandre, O., Crastes-de-Paulet, A., Michel, F.B. Functional assessment of alveolar macrophages: Comparison of cells from asthmatics and normal subjects. J Aller N Clin Immunol 1982, 70: 88-93.
28. Gosset, P., Tsicopoulos, A., Wallaert, B., Vannimenus, C., Joseph, M., Tonnel, A.B., Capron, A Increased secretion of tumor necrosis factor alpha and interleukin-6 by alveolar macrophages consecutive to the development of the late asthmatic reaction. J Allergy Clin Immunol 1991, 88: 561-71.
29. Murphy, G., Bretz, U., Bagglioni, M., Reynolds, J.J. The latent collagenase and gelatinase of human polymorphonucleocytes. Biochem J 1980, 192: 517-25.
30. Hirose, H., Patterson, C., Pourmotabbed, T., Mainard, C.L., Hasty, K.A. Structure-function relationship of human neutrophil coilagenase: Identification of regions responsible for substrate specificity and general proteinase activity. Proc Natl Acad Sci USA 1993, 90: 2569-73.
31. Welgus, H.G., Campbell, E.J., Bar-shavit, Z., Senior, R.M., Teitelbaum, S.K. Human alveolar macrophages produce a fibroblast-like collagenase and collagenase inhibitor. J Clin Invest 1985, 76: 219-24.
32. Hossain, S. Quantitative measurement of bronchial muscle in men with asthma. Am Rev Respir Dis 1973, 107: 99-109.
33. Heard, B.E., Hossain, S. Hyperplasia of bronchial smooth muscle in asthma J Pathol 1973, 110: 319-31.
34. Panattieri, R.A., Rubinstein, N.A., Feuerstein, B., Kotlikoff, M.I. Beta-adrenergic inhibition of ASM proliferation. Am Rev Respir Dis 1993, 147: A1013.
35. Panettieri, R.A., Yadvish, P.A., Kelly, A.M., Rubinstein, N.A., Kotlikoff, M.I. Histamine stimulates proliferation of ASM and induces c-fos expression. Am J Physiol 1990, 259 (Lung Cell Mol Physiol 3): L365-71.
36. Yang, C.M., Chou, S.P., Sung, T.C., Chien, H.J. Regulation of functional muscarinic receptor expression in tracheal smooth muscle cells. Am J Physiol 1991, 261: C1123-9.
37. Tyler, C.L., Rouss, S.J., Hartman, T., Jones, C.A., Caughey, G.H., Brown, J.K. Potent mitogenicity of tryptase for ASM cells. Am Rev Respir Dis 1993, 147: A254.
38. Panettieri, R.A., Eszterhas, A., Murray, R.K. Agonist-induced proliferation of ASM is mediated by alterations in cytosolic calcium. Am Rev Respir Dis 1992, 145: A15.
39. Knox, A.J. Airway remodelling in asthma: Role of the airway smooth muscle. Clinical Science 1994; 86: 647-652.
40. Bramley, A.M., Roberts, C.R., Schellenberg, R.R. Increased contractility of human bronchial smooth muscle after collagenase treatment. Am Rev Respir Dis 1993, A844.
41. Bousquet, J., Lacoste, J., Chanez, P., Vie, P., Godard, P., Michel, F.B. Bronchial elastic fibers in normal and asthmatic patients. Am J Respir Crit Care Med 1996, 153: 1648-54.
42. Peat, J.K., Woolcock, A.J., Cullen, K. Rate of decline of lung function in subjects with asthma. Eur J Respir Dis 1987, 70: 171-9.
43. Schachter, E.N., Doyle, C.A., Beck, G.J. A prospective study of asthma in a rural community. Chest 1984, 85: 623-7.
44. 1 in adults in two community-based studies. Chest 1995, 108 (3): 656-60.
45. 1 in male smokers and ex-smokers. Thorax 1985, 40: 9-16.
46. Tabona, M., Chan-yeung, M., Enarson, D., McLean, L., Dorken, E., Schulzer, M. Host factors affecting longitudinal decline in lung spirometry among grain elevator workers. Chest 1984, 85: 782-6.
47. Parker, D.R., O'Conner, G.T., Sparrow, D., Segal, M.R., Weiss, S.T. The relationship of nonspecific airway responsiveness and atopy to the rate of decline of lung function. Am Rev Respir Dis 1990, 141: 589-94.
48. Postma, D.S., Lebowitz, M.D. Persistence and new onset of asthma and chronic bronchitis evaluated longitudinally in a community population sample of adults. Arch Intern Med 1995, 155: 1393-99
49. Kanner, R.E. The relationship between airways responsiveness and chronic airflow limitation Chest 1984, 86 (1): 54-57.
50. O'Conner, G.T., Sparrow, D., Weiss, S.T. A prospective study of methacholine airway responsiveness as a predictor of pulmonary-function decline. Am J Respir Crit Care Med 1995, 152: 87-92.
51. 1 in two cohort studies. Chest 1986, 90 (3): 416-23.
52. van Schayck, C.P., Dompeling, E., van Herwaarden, C.L.A., Folgering, H., Verbeek, A.L.M., van der Hoogen, H.J.M., van Weei, C. Bronchodilator treatment in moderate asthma or chrome bronchitis. Continuous or on demand? A randomized controlled study. BMJ 1991, 303: 1426-31.
53. Spitzer, W.O., Suissa, S., Ernst, P., Horwitz, R.I., Habbick, B., Cockcroft, D., Boivin, J.F., McNutt, M., Buist, A.S., Rebuck, A.S. The use of β-agonists and the risk of death and near death from asthma N Engl J Med 1992, 326: 501-6
54. Crane, J., Pearce, N., Flatt, A., Burgess, C., Jackson, R., Kwong, T., Ball, M., Beasley, R. Prescribed fenoterol and death from asthma in New Zealand, 1981-83: Case-control study. Lancet 1989, 1: 917-22.
55. van Schayck, C.P., Dompeling, E., van Herwaarden, C.L.A., Folgering, H., Akkermans, R.P., van den Broek, P.J.J.A., van Weel, C. Continuous and on demand use of bronchodilators in patients with nonsteroid dependent asthma and chronic bronchitis: Four year follow-up randomized controlled study Br J Gen Pract 1995, 45: 239-44.
56. Cockroft, D.W., McPartand, C.P., Britto, S.A., Swystun, V.A., Rutherford, B.C. Regular inhaled salbutamol and airway responsiveness to allergen. Lancet 1993, 342: 833-7
57. Dompeling, E., van Schayck, C.P., van Grunsven, P.M., van Herwaarden, C.L., Akkermans, R., Molema, J., Folgering, H., van Weel, C. Slowing the deterioration of asthma and chronic obstructive pulmonary disease observed during bronchodilator therapy by adding inhaled corticosteroids: A 4-year prospective study. Ann Intern Med 1993, 118: 770-8.
58. Trigg, C.J., Manolitsas, N.D., Wang, J., Calderon, M.A., McAulay, A., Jordan, S.E., Herdman, M.J., Jhaili, N., Duddle, J.M., Hamilton, S.A., Devalia, J.L., Davies, R.J. Placebo-controlled immunopathologic study of four months of inhaled corticosteroids in asthma. Am J Respir Crit Care Med 1994, 150: 17-22.
59. Jeffery, P.K., Godfrey, R.W., Adelroth, E., Nelson, F., Rogers, A., Johansson, S.A. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma. Am Retv Respir Dis 1992, 145: 890-5.
60. 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: A randomized, double-blind, parallel group controlled trial. J Allergy Clin Immunol 1992, 90: 32-42.
61. Djukanovic, R., Wilson, J.W., Britten, K.M., Wilson, S.J., Walls, A.F., Roche, W.R., Howarth, P.H., Holgate, S.T. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma Am Rev Respir Dis 1992, 145: 669-74.
62. Spinozzi, F., Agea, E., Bistoni, O., Forenza, N., Monaco, A., Bassoti, G., Nicoletti, I., Riccardi, C., Gngnani, F., Bertotto, A. Increase allergen-specific, steroid-sensitive γδ T-cells in bronchoalveolar lavage fluid from patients with asthma. Ann Intern Med 1996, 124: 223-7
63. Yates, S., Carter, P., Heinly, T., Lieberman, P. Accelerated irreversible decline in lung function in asthmatics. J Allergy Clin Immunol 1997, 99: S417.
64. Agertoft, L., Pederson, S. Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children. Respir Med 1994, 88: 373-81.
65. Haahtela, T., Jârvinen, M., Kava, T., Kiviranta, K., Koskinen, S., Lehtonen, K., Nikander, K., Persson, T., Selroos, O., Sovijarvi, A., Stenius-Aarniala, B., Svahn, T., Tamrnivaara, R., Laitnen, L.A. Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma. N Eng J Med 1994, 331: 700-5.
66. Selroos, O., Backman, R., Forsen, K.O., Löfroos, A.B., Niemisto, M., Nyberg, P., Nyholm, J.E., Pietinaiho, A., Riska, H. The effect of inhaled corticosteroids in asthma is related to the duration of pretreatment symptoms. Am J Hespir Crit Care Med 1994, 149: A211
67. Abramson, M.J., Puy, R.M., Weiner, J.M. Is allergen immunotherapy effective in asthma? Ametaanalysis of randomized controlled trials Am J Respir Crit Care Med 1995, 151: 969-74.
68. Rak, S., Bjâornson, A., Hâakanson, L., Sâorenson, S., Venge, P. The effect of immunotherapy on eosinophil accumulation and production of eosinophil chemotactic activity in the lung of subjects with asthma during natural pollen exposure. J Allergy Clin Immunol 1991, 88: 878-88.