Connecting lipid droplet biology and the metabolic syndrome

Progress in Lipid Research

Volumn 48, Issue 3-4, 2009, Pages 191-195

  Lay, Soazig Le ^a,b,c   Dugail, Isabelle ^a,b,c  

^a CENTRE DE RECHERCHE DES CORDELIERS   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Caveolin; fsp27; Lipid droplet; Lipotoxicity; Perilipin

Indexed keywords

CAVEOLIN; FAT DROPLET; FAT SPECIFIC PROTEIN 27; FATTY ACID; PERILIPIN; PROTEIN; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ATHEROSCLEROSIS; BIOLOGY; CELL ORGANELLE; EPIDEMIC; HUMAN; LIPID STORAGE; METABOLIC DISORDER; METABOLIC SYNDROME X; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOGENESIS; PATHOLOGY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

ADIPOCYTES; ANIMALS; ATHEROSCLEROSIS; DIABETES MELLITUS, TYPE 2; HUMANS; LIPID METABOLISM; LIPIDS; METABOLIC DISEASES; OBESITY;

EID: 67349247810     PISSN: 01637827     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.plipres.2009.03.001     Document Type: Review

References (48)

1. Ohsaki Y., Cheng J., Suzuki M., Shinohara Y., Fujita A., and Fujimoto T. Biogenesis of cytoplasmic lipid droplets: from the lipid ester globule in the membrane to the visible structure. Biochim Biophys Acta (2008) 10.1016/j.bbalip.2008.10.00
2. Thiele C., and Spandl J. Cell biology of lipid droplets. Curr Opin Cell Biol 20 (2008) 378-385
3. Murphy S., Martin S., and Parton R.G. Lipid droplet-organelle interactions; sharing the fats. Biochim Biophys Acta (2008) 10.1016/j.bbalip.2008.07.00
4. Walther T.C., and Farese Jr. R.V. The life of lipid droplets. Biochim Biophys Acta (2008) 10.1016/j.bbalip.2008.10.00
5. Goodman J.M. The gregarious lipid droplet. J Biol Chem 283 (2008) 28005-28009
6. van Herpen N.A., and Schrauwen-Hinderling V.B. Lipid accumulation in non-adipose tissue and lipotoxicity. Physiol Behav 94 (2008) 231-241
7. Brasaemle D.L. Thematic review series: adipocyte biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J Lipid Res 48 (2007) 2547-2559
8. Greenberg A.S., Egan J.J., Wek S.A., Garty N.B., Blanchette-Mackie E.J., and Londos C. Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. J Biol Chem 266 (1991) 11341-11346
9. Tauchi-Sato K., Ozeki S., Houjou T., Taguchi R., and Fujimoto T. The surface of lipid droplets is a phospholipid monolayer with a unique fatty acid composition. J Biol Chem 277 (2002) 44507-44512
10. Liu L., and Pilch P.F. A critical role of cavin (polymerase I and transcript release factor) in caveolae formation and organization. J Biol Chem 283 (2008) 4314-4322
11. Fujimoto Y., Itabe H., Sakai J., Makita M., Noda J., Mori M., et al. Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Biochim Biophys Acta 164 (2004) 447-459
12. Umlauf E., Csaszar E., Moertelmaier M., Schuetz G.J., Parton R.G., and Prohaska R. Association of stomatin with lipid bodies. J Biol Chem 279 (2004) 23699-23709
13. Beller M., Riedel D., Jansch L., Dieterich G., Wehland J., Jackle H., et al. Characterization of the Drosophila lipid droplet subproteome. Mol Cell Proteomics 5 (2006) 1082-1094
14. Wan H.C., Melo R.C., Jin Z., Dvorak A.M., and Weller P.F. Roles and origins of leukocyte lipid bodies: proteomic and ultrastructural studies. FASEB J 21 (2007) 167-178
15. Tansey J.T., Sztalryd C., Gruia-Gray J., Roush D.L., Zee J.V., Gavrilova O., et al. Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci USA 98 (2001) 6494-6499
16. Brasaemle D.L., Rubin B., Harten I.A., Gruia-Gray J., Kimmel A.R., and Londos C. Perilipin A increases triacylglycerol storage by decreasing the rate of triacylglycerol hydrolysis. J Biol Chem 275 (2000) 38486-38493
17. Brasaemle D.L., Barber T., Wolins N.E., Serrero G., Blanchette-Mackie E.J., and Londos C. Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein. J Lipid Res 38 (1997) 2249-2263
18. Dalen K.T., Schoonjans K., Ulven S.M., Weedon-Fekjaer M.S., Bentzen T.G., Koutnikova H., et al. Adipose tissue expression of the lipid droplet-associating proteins S3-12 and perilipin is controlled by peroxisome proliferator-activated receptor-gamma. Diabetes 53 (2004) 1243-1252
19. Straub B.K., Stoeffel P., Heid H., Zimbelmann R., and Schirmacher P. Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis. Hepatology 47 (2008) 1936-1946
20. Bell M., Wang H., Chen H., McLenithan J.C., Gong D.W., Yang R.Z., et al. Consequences of lipid droplet coat protein downregulation in liver cells: abnormal lipid droplet metabolism and induction of insulin resistance. Diabetes 57 (2008) 2037-2045
21. Tansey J.T., Sztalryd C., Hlavin E.M., Kimmel A.R., and Londos C. The central role of perilipin a in lipid metabolism and adipocyte lipolysis. IUBMB Life 56 (2004) 379-385
22. Deram S., Nicolau C.Y., Perez-Martinez P., Guazzelli I., Halpern A., Wajchenberg B.L., et al. Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents. J Clin Endocrinol Metab 93 (2008) 4933-4940
23. Danesch U., Hoeck W., and Ringold G.M. Cloning and transcriptional regulation of a novel adipocyte-specific gene, FSP27. CAAT-enhancer-binding protein (C/EBP) and C/EBP-like proteins interact with sequences required for differentiation-dependent expression. J Biol Chem 267 (1992) 7185-7193
24. Matsusue K., Kusakabe T., Noguchi T., Takiguchi S., Suzuki T., Yamano S., et al. Hepatic steatosis in leptin-deficient mice is promoted by the PPARgamma target gene Fsp 27. Cell Metab 7 (2008) 302-311
25. Liang L., Zhao M., Xu Z., Yokoyama K.K., and Li T. Molecular cloning and characterization of CIDE-3, a novel member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family. Biochem J 370 (2003) 195-203
26. Brasaemle D.L., Dolios G., Shapiro L., and Wang R. Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes. J Biol Chem 279 (2004) 46835-46842
27. Keller P., Petrie J.T., De Rose P., Gerin I., Wright W.S., Chiang S.H., et al. Fat-specific protein 27 regulates storage of triacylglycerol. J Biol Chem 283 (2008) 14355-14365
28. Nishino N., Tamori Y., Tateya S., Kawaguchi T., Shibakusa T., Mizunoya W., et al. FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets. J Clin Invest 118 (2008) 2808-2821
29. Puri V., Konda S., Ranjit S., Aouadi M., Chawla A., Chouinard M., et al. Fat-specific protein 27, a novel lipid droplet protein that enhances triglyceride storage. J Biol Chem 282 (2007) 34213-34218
30. Puri V., Ranjit S., Konda S., Nicoloro S.M., Straubhaar J., and Chawla A. Cidea is associated with lipid droplets and insulin sensitivity in humans. Proc Natl Acad Sci USA 105 (2008) 7833-7838
31. Toh S.Y., Gong J., Du G., Li J.Z., Yang S., Ye J., et al. Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice. PLoS ONE 38 (2008) e2890
32. Marcinkiewicz A., Gauthier D., Garcia A., and Brasaemle D.L. The phosphorylation of serine 492 of perilipin a directs lipid droplet fragmentation and dispersion. J Biol Chem 281 (2006) 11901-11909
33. Li J.Z., Ye J., Xue B., Qi J., Zhang J., Zhou Z., et al. Cideb regulates diet-induced obesity, liver steatosis, and insulin sensitivity by controlling lipogenesis and fatty acid oxidation. Diabetes 56 (2007) 2523-2532
34. Zhou Z., Yon Toh S., Chen Z., Guo K., Ng C.P., Ponniah S., et al. Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat Genet 35 (2003) 49-56
35. Novikoff A.B., Novikoff P.M., Rosen O.M., and Rubin C.S. Organelle relationships in cultured 3T3-L1 preadipocytes. J Cell Biol 87 (1980) 180-196
36. Rothberg K.G., Heuser J.E., Donzell W.C., Ying Y.S., Glenney J.R., and Anderson R.G. Caveolin, a protein component of caveolae membrane coats. Cell 68 (1992) 673-682
37. Fujimoto T., Kogo H., Ishiguro K., Tauchi K., and Nomura R. Caveolin-2 is targeted to lipid droplets, a new "membrane domain" in the cell. J Cell Biol 152 (2001) 1079-1085
38. Ostermeyer A.G., Paci J.M., Zeng Y., Lublin D.M., Munro S., and Brown D.A. Accumulation of caveolin in the endoplasmic reticulum redirects the protein to lipid storage droplets. J Cell Biol 152 (2001) 1071-1078
39. Pol A., Luetterforst R., Lindsay M., Heino S., Ikonen E., and Parton R.G. A caveolin dominant negative mutant associates with lipid bodies and induces intracellular cholesterol imbalance. J Cell Biol 152 (2001) 1057-1070
40. Robenek M.J., Severs N.J., Schlattmann K., Plenz G., Zimmer K.P., Troyer D., et al. Lipids partition caveolin-1 from ER membranes into lipid droplets: updating the model of lipid droplet biogenesis. FASEB J 18 (2004) 866-868
41. Pol A., Martin S., Fernandez M.A., Ferguson C., Carozzi A., Luetterforst R., et al. Dynamic and regulated association of caveolin with lipid bodies: modulation of lipid body motility and function by a dominant negative mutant. Mol Biol Cell 15 (2004) 99-110
42. Le Lay S., Hajduch E., Lindsay M.R., Le Liepvre X., Thiele C., Ferré P., et al. Cholesterol-induced caveolin targeting to lipid droplets in adipocytes; a role for caveolar endocytosis. Traffic 5 (2006) 549-561
43. Le Lay S., Blouin C.M., Hajduch E., and Dugail I. Filling up adipocytes with lipids. Lessons from caveolin-1 deficiency. Biochim Biophys Acta (2008) 10.1016/j.bbalip.2008.10.00
44. Razani B., Combs T.P., Wang X.B., Frank P.G., Park D.S., Russell R.G., et al. Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities. J Biol Chem 277 (2002) 8635-8647
45. Kim A.C., Delepine M., Boutet E., El Mourabit H., Le Lay S., Meier M., et al. Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy. J Clin Endocrinol Metab 93 (2008) 1129-1134
46. Pol A., Martin S., Fernandez M.A., Ingelmo-Torres M., Ferguson C., Enrich C., et al. Cholesterol and fatty acids regulate dynamic caveolin trafficking through the golgi complex and between the cell surface and lipid bodies. Mol Biol Cell 16 (2005) 2091-2105
47. Blouin C.M., Le Lay S., Lasnier F., Dugail I., and Hajduch E. Regulated association of caveolins to lipid droplets during differentiation of 3T3-L1 adipocytes. Biochem Biophys Res Commun 376 (2008) 331-335
48. Kuerschner L., Moessinger C., and Thiele C. Imaging of lipid biosynthesis: how a neutral lipid enters lipid droplets. Traffic 9 (2008) 338-352