Identification of therapeutic drug targets through genetically manipulated mice: Are we getting it right?

Pharmacology and Therapeutics

Volumn 123, Issue 1, 2009, Pages 32-36

  Matthaei, Klaus I ^a,b  

^a Australian National University   (Australia)

^b KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Genetic manipulation; Mouse; Phenotype; Strain variation; Transgenesis

Indexed keywords

GLUTATHIONE TRANSFERASE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INTERLEUKIN 13; INTERLEUKIN 5; OREXIN; TRANSCRIPTION FACTOR SOX18;

DNA MODIFICATION; DNA POLYMORPHISM; DRUG RESEARCH; DRUG TARGETING; GENETIC MANIPULATION; HUMAN; MOLECULAR THERAPY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVIEW; STRAIN DIFFERENCE; TRANSGENIC MOUSE;

ANIMALS; DRUG DESIGN; GENETIC ENGINEERING; HUMANS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; POLYMORPHISM, GENETIC; SPECIES SPECIFICITY;

EID: 67349244931     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2009.03.016     Document Type: Review

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