Controlled destabilization of a liposomal drug delivery system enhances mitoxantrone antitumor activity

Nature Biotechnology

Volumn 17, Issue 8, 1999, Pages 775-779

  Adlakha Hutcheon, Gitanjali ^a   Bally, Marcel B ^b   Shew, Clifford R ^a   Madden, Thomas D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

Author keywords

Antitumor efficacy; Cationic liposomes; Mitoxantrone; Polyethylene glycol; Programmable fusogenic vesicles

Indexed keywords

LIPOSOME; MACROGOL; MITOXANTRONE; PHOSPHATIDYLETHANOLAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GRAFT; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG ELIMINATION; DRUG POTENTIATION; DRUG RELEASE; DRUG STABILITY; DRUG STRUCTURE; ENCAPSULATION; HUMAN; HUMAN CELL; LIPID COMPOSITION; MEMBRANE VESICLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; DRUG CARRIERS; FEMALE; HUMANS; LIPOSOMES; MICE; MITOXANTRONE; NEOPLASMS; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

ANIMALIA; MURINAE;

EID: 0032839194     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/11710     Document Type: Article

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