The essential roles of TGFB1 in reproduction

Cytokine and Growth Factor Reviews

Volumn 20, Issue 3, 2009, Pages 233-239

  Ingman, Wendy V ^a   Robertson, Sarah A ^a  

^a UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Mouse model; Reproductive biology; TGFB1

Indexed keywords

LUTEINIZING HORMONE; TESTOSTERONE; TRANSFORMING GROWTH FACTOR BETA1;

DRUG MECHANISM; EJACULATION; ESTRUS CYCLE; FEMALE INFERTILITY; FERTILITY; HORMONE DEFICIENCY; HORMONE SYNTHESIS; HUMAN; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; IMMUNOCOMPETENT CELL; MALE INFERTILITY; MAMMARY GLAND; MATING; MORPHOGENESIS; MUTANT; NONHUMAN; OOCYTE DEVELOPMENT; OVARY FUNCTION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN FUNCTION; REPRODUCTION; REVIEW; SEXUAL DYSFUNCTION; SEXUAL FUNCTION;

ANIMALS; FEMALE; HUMANS; INFERTILITY; MALE; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; REPRODUCTION; TRANSFORMING GROWTH FACTOR BETA1;

MUS;

EID: 67349178111     PISSN: 13596101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2009.05.003     Document Type: Review

References (76)

1. Anzano M.A., Roberts A.B., Meyers C.A., et al. Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells. Cancer Res 42 (1982) 4776-4778
2. Moses H.L., Branum E.L., Proper J.A., and Robinson R.A. Transforming growth factor production by chemically transformed cells. Cancer Res 41 (1981) 2842-2848
3. Roberts A.B., Anzano M.A., Lamb L.C., Smith J.M., and Sporn M.B. New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues. Proc Natl Acad Sci USA 78 (1981) 5339-5343
4. Beanes S.R., Dang C., Soo C., and Ting K. Skin repair and scar formation: the central role of TGF-beta. Expert Rev Mol Med 5 (2003) 1-22
5. Zavadil J., and Bottinger E.P. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 24 (2005) 5764-5774
6. Li M.O., and Flavell R.A. TGF-beta: a master of all T cell trades. Cell 134 (2008) 392-404
7. Verrecchia F., and Mauviel A. Transforming growth factor-beta signaling through the Smad pathway: role in extracellular matrix gene expression and regulation. J Invest Dermatol 118 (2002) 211-215
8. Rahimi R.A., and Leof E.B. TGF-beta signaling: a tale of two responses. J Cell Biochem 102 (2007) 593-608
9. Bachman K.E., and Park B.H. Duel nature of TGF-beta signaling: tumor suppressor vs. tumor promoter. Curr Opin Oncol 17 (2005) 49-54
10. Jakowlew S.B. Transforming growth factor-beta in cancer and metastasis. Cancer Metastasis Rev 25 (2006) 435-457
11. Dunker N., and Krieglstein K. Targeted mutations of transforming growth factor-beta genes reveal important roles in mouse development and adult homeostasis. Eur J Biochem 267 (2000) 6982-6988
12. Ingman W.V., and Robertson S.A. Defining the actions of transforming growth factor beta in reproduction. Bioessays 24 (2002) 904-914
13. Shull M.M., Ormsby I., Kier A.B., et al. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature 359 (1992) 693-699
14. Kulkarni A.B., Huh C.G., Becker D., et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 90 (1993) 770-774
15. Letterio J.J., Geiser A.G., Kulkarni A.B., Roche N.S., Sporn M.B., and Roberts A.B. Maternal rescue of transforming growth factor-beta 1 null mice. Science 264 (1994) 1936-1938
16. Diebold R.J., Eis M.J., Yin M., et al. Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated. Proc Natl Acad Sci USA 92 (1995) 12215-12219
17. Kobayashi S., Yoshida K., Ward J.M., et al. Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse. J Immunol 163 (1999) 4013-4019
18. Letterio J.J., Geiser A.G., Kulkarni A.B., et al. Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression. J Clin Invest 98 (1996) 2109-2119
19. Bosma M.J., and Carroll A.M. The SCID mouse mutant: definition, characterization, and potential uses. Annu Rev Immunol 9 (1991) 323-350
20. Kallapur S., Ormsby I., and Doetschman T. Strain dependency of TGFbeta1 function during embryogenesis. Mol Reprod Dev 52 (1999) 341-349
21. Dickson M.C., Martin J.S., Cousins F.M., Kulkarni A.B., Karlsson S., and Akhurst R.J. Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice. Development 121 (1995) 1845-1854
22. Shull M.M., and Doetschman T. Transforming growth factor-beta 1 in reproduction and development. Mol Reprod Dev 39 (1994) 239-246
23. Ingman W.V., and Robertson S.A. Transforming growth factor-beta1 null mutation causes infertility in male mice associated with testosterone deficiency and sexual dysfunction. Endocrinology 148 (2007) 4032-4043
24. Ingman W.V., Robker R.L., Woittiez K., and Robertson S.A. Null mutation in transforming growth factor beta1 disrupts ovarian function and causes oocyte incompetence and early embryo arrest. Endocrinology 147 (2006) 835-845
25. Bottner M., Unsicker K., and Suter-Crazzolara C. Expression of TGF-beta type II receptor mRNA in the CNS. Neuroreport 7 (1996) 2903-2907
26. Qian X., Jin L., Grande J.P., and Lloyd R.V. Transforming growth factor-beta and p27 expression in pituitary cells. Endocrinology 137 (1996) 3051-3060
27. Prevot V., Bouret S., Croix D., et al. Evidence that members of the TGFbeta superfamily play a role in regulation of the GnRH neuroendocrine axis: expression of a type I serine-threonine kinase receptor for TGRbeta and activin in GnRH neurones and hypothalamic areas of the female rat. J Neuroendocrinol 12 (2000) 665-670
28. Denef C. Paracrine control of lactotrope proliferation and differentiation. Trends Endocrinol Metab 14 (2003) 188-195
29. Sarkar D.K., Kim K.H., and Minami S. Transforming growth factor-beta 1 messenger RNA and protein expression in the pituitary gland: its action on prolactin secretion and lactotropic growth. Mol Endocrinol 6 (1992) 1825-1833
30. Gore A.J., Philips D.P., Miller W.L., and Bernard D.J. Differential regulation of follicle stimulating hormone by activin A and TGFB1 in murine gonadotropes. Reprod Biol Endocrinol 3 (2005) 73
31. Buchanan C.D., Mahesh V.B., and Brann D.W. Estrogen-astrocyte-luteinizing hormone-releasing hormone signaling: a role for transforming growth factor-beta(1). Biol Reprod 62 (2000) 1710-1721
32. Bottner M., Krieglstein K., and Unsicker K. The transforming growth factor-betas: structure, signaling, and roles in nervous system development and functions. J Neurochem 75 (2000) 2227-2240
33. Matsubara H., Ikuta K., Ozaki Y., et al. Gonadotropins and cytokines affect luteal function through control of apoptosis in human luteinized granulosa cells. J Clin Endocrinol Metab 85 (2000) 1620-1626
34. Matsuyama S., Shiota K., and Takahashi M. Possible role of transforming growth factor-beta as a mediator of luteotropic action of prolactin in rat luteal cell cultures. Endocrinology 127 (1990) 1561-1567
35. Bogdan C., and Nathan C. Modulation of macrophage function by transforming growth factor beta, interleukin-4, and interleukin-10. Ann NY Acad Sci 685 (1993) 713-739
36. Fukumatsu Y., Katabuchi H., Naito M., Takeya M., Takahashi K., and Okamura H. Effect of macrophages on proliferation of granulosa cells in the ovary in rats. J Reprod Fertil 96 (1992) 241-249
37. Matsuyama S., and Takahashi M. Immunoreactive (ir)-transforming growth factor (TGF)-beta in rat corpus luteum: ir-TGF beta is expressed by luteal macrophages. Endocr J 42 (1995) 203-217
38. Van der Hoek K.H., Maddocks S., Woodhouse C.M., van Rooijen N., Robertson S.A., and Norman R.J. Intrabursal injection of clodronate liposomes causes macrophage depletion and inhibits ovulation in the mouse ovary. Biol Reprod 62 (2000) 1059-1066
39. Pate J.L., and Landis Keyes P. Immune cells in the corpus luteum: friends or foes?. Reproduction 122 (2001) 665-676
40. Duranthon V., and Renard J.P. The developmental competence of mammalian oocytes: a convenient but biologically fuzzy concept. Theriogenology 55 (2001) 1277-1289
41. Rodriguez K.F., and Farin C.E. Gene transcription and regulation of oocyte maturation. Reprod Fertil Dev 16 (2004) 55-67
42. Gilchrist R.B., Morrissey M.P., Ritter L.J., and Armstrong D.T. Comparison of oocyte factors and transforming growth factor-beta in the regulation of DNA synthesis in bovine granulosa cells. Mol Cell Endocrinol 201 (2003) 87-95
43. Robinson S.D., Silberstein G.B., Roberts A.B., Flanders K.C., and Daniel C.W. Regulated expression and growth inhibitory effects of transforming growth factor-beta isoforms in mouse mammary gland development. Development 113 (1991) 867-878
44. Forrester E., Chytil A., Bierie B., et al. Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis. Cancer Res 65 (2005) 2296-2302
45. Gorska A.E., Jensen R.A., Shyr Y., Aakre M.E., Bhowmick N.A., and Moses H.L. Transgenic mice expressing a dominant-negative mutant type II transforming growth factor-beta receptor exhibit impaired mammary development and enhanced mammary tumor formation. Am J Pathol 163 (2003) 1539-1549
46. Gorska A.E., Joseph H., Derynck R., Moses H.L., and Serra R. Dominant-negative interference of the transforming growth factor beta type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice. Cell Growth Differ 9 (1998) 229-238
47. Joseph H., Gorska A.E., Sohn P., Moses H.L., and Serra R. Overexpression of a kinase-deficient transforming growth factor-beta type II receptor in mouse mammary stroma results in increased epithelial branching. Mol Biol Cell 10 (1999) 1221-1234
48. Ewan K.B., Shyamala G., Ravani S.A., et al. Latent transforming growth factor-beta activation in mammary gland: regulation by ovarian hormones affects ductal and alveolar proliferation. Am J Pathol 160 (2002) 2081-2093
49. Ingman W.V., and Robertson S.A. Mammary gland development in transforming growth factor beta1 null mutant mice: systemic and epithelial effects. Biol Reprod 79 (2008) 711-717
50. Ingman W.V., McGrath L.M., Breed W.G., Musgrave I.F., Robker R.L., and Robertson S.A. The mechanistic basis for sexual dysfunction in male transforming growth factor beta1 null mutant mice. J Androl (2009)
51. Smith A.J., and Humphries S.E. Cytokine and cytokine receptor gene polymorphisms and their functionality. Cytokine Growth Factor Rev 20 (2009) 43-59
52. Tang Y., McKinnon M.L., Leong L.M., Rusholme S.A., Wang S., and Akhurst R.J. Genetic modifiers interact with maternal determinants in vascular development of Tgfb1(-/-) mice. Hum Mol Genet 12 (2003) 1579-1589
53. Fried G., and Wramsby H. Increase in transforming growth factor beta1 in ovarian follicular fluid following ovarian stimulation and in-vitro fertilization correlates to pregnancy. Hum Reprod 13 (1998) 656-659
54. Robertson S.A., Ingman W.V., O'Leary S., Sharkey D.J., and Tremellen K.P. Transforming growth factor beta-a mediator of immune deviation in seminal plasma. J Reprod Immunol 57 (2002) 109-128
55. Ryu J.K., Song S.U., Choi H.K., et al. Plasma transforming growth factor-beta1 levels in patients with erectile dysfunction. Asian J Androl 6 (2004) 349-353
56. Djurovic S., Schjetlein R., Wisloff F., Haugen G., Husby H., and Berg K. Plasma concentrations of Lp(a) lipoprotein and TGF-beta1 are altered in preeclampsia. Clin Genet 52 (1997) 371-376
57. Fornari M.C., Sarto A., Berardi V.E., et al. Effect of ovaric hyper-stimulation on blood lymphocyte subpopulations, cytokines, leptin and nitrite among patients with unexplained infertility. Am J Reprod Immunol 48 (2002) 394-403
58. Pomeroy C., Eckert E., Hu S., et al. Role of interleukin-6 and transforming growth factor-beta in anorexia nervosa. Biol Psychiatry 36 (1994) 836-839
59. Yener S., Demir T., Akinci B., et al. Transforming growth factor-beta 1 levels in women with prior history of gestational diabetes mellitus. Diabetes Res Clin Pract 76 (2007) 193-198
60. Okamoto Y., Gotoh Y., Uemura O., Tanaka S., Ando T., and Nishida M. Age-dependent decrease in serum transforming growth factor (TGF)-beta 1 in healthy Japanese individuals: population study of serum TGF-beta 1 level in Japanese. Dis Markers 21 (2005) 71-74
61. Alonso K., Pontiggia P., Medenica R., and Rizzo S. Cytokine patterns in adults with AIDS. Immunol Invest 26 (1997) 341-350
62. Nelson D.R., Gonzalez-Peralta R.P., Qian K., et al. Transforming growth factor-beta 1 in chronic hepatitis C. J Viral Hepat 4 (1997) 29-35
63. Bivalacqua T.J., Diner E.K., Novak T.E., et al. A rat model of Peyronie's disease associated with a decrease in erectile activity and an increase in inducible nitric oxide synthase protein expression. J Urol 163 (2000) 1992-1998
64. McGrath L.M., Ingman W.V., Robker R.L., and Robertson S.A. Efficacy of exogenous transforming growth factor beta1 replacement to restore fertility of male Tgfb1 null mutant mice. Reprod Fertil Dev 21 (2009) 561-570
65. Longenecker G., Thyagarajan T., Nagineni C.N., et al. Endocrine expression of the active form of TGF-beta1 in the TGF-beta1 null mice fails to ameliorate lethal phenotype. Cytokine 18 (2002) 43-50
66. Chagraoui H., Giraudier S., Vainchenker W., and Wendling F. Adenoviral supply of active transforming growth factor-beta1 (TGF-beta1) did not prevent lethality in transforming growth factor-beta1-knockout embryos. Eur Cytokine Netw 12 (2001) 561-567
67. Robertson S.A., Guerin L.R., Bromfield J.J., Branson K.M., Ahlstrom A.C., and Care A.S. Seminal fluid drives expansion of the CD4 + CD25 + T regulatory cell pool and induces tolerance to paternal alloantigens in mice. Biol Reprod 80 (2009) 1036-1045
68. Horwitz D.A., Zheng S.G., Wang J., and Gray J.D. Critical role of IL-2 and TGF-beta in generation, function and stabilization of Foxp3 + CD4 + Treg. Eur J Immunol 38 (2008) 912-915
69. Zenclussen A.C. Regulatory T cells in pregnancy. Springer Semin Immunopathol 28 (2006) 31-39
70. Cohen P.E., Nishimura K., Zhu L., and Pollard J.W. Macrophages: important accessory cells for reproductive function. J Leukoc Biol 66 (1999) 765-772
71. Letterio J.J., and Roberts A.B. Regulation of immune responses by TGF-beta. Annu Rev Immunol 16 (1998) 137-161
72. Cohen P.E., Chisholm O., Arceci R.J., Stanley E.R., and Pollard J.W. Absence of colony-stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice results in male fertility defects. Biol Reprod 55 (1996) 310-317
73. Gouon Evans V., Rothenberg M.E., and Pollard J.W. Postnatal mammary gland development requires macrophages and eosinophils. Development 127 (2000) 2269-2282
74. Cohen P.E., Zhu L., and Pollard J.W. Absence of colony stimulating factor-1 in osteopetrotic (csfmop/csfmop) mice disrupts estrous cycles and ovulation. Biol Reprod 56 (1997) 110-118
75. Pollard J.W., and Hennighausen L. Colony stimulating factor 1 is required for mammary gland development during pregnancy. Proc Natl Acad Sci USA 91 (1994) 9312-9316
76. Cohen P.E., Zhu L., Nishimura K., and Pollard J.W. Colony-stimulating factor 1 regulation of neuroendocrine pathways that control gonadal function in mice. Endocrinology 143 (2002) 1413-1422