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Volumn 29, Issue 3, 2009, Pages 391-401

VEGF and Bcl-2 interact via MAPKs signaling pathway in the response to hypoxia in neuroblastoma

Author keywords

Bcl 2; Hypoxia; MAPKs; VEGF

Indexed keywords

CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; PROCASPASE 3; PROTEIN BAX; PROTEIN BCL 2; VASCULOTROPIN;

EID: 67349176383     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10571-008-9331-9     Document Type: Article
Times cited : (27)

References (48)
  • 1
    • 33847328289 scopus 로고    scopus 로고
    • The Bcl-2 apoptotic switch in cancer development and therapy
    • 10.1038/sj.onc.1210220
    • JM Adams S Cory 2007 The Bcl-2 apoptotic switch in cancer development and therapy Oncogene 26 1324 1337 10.1038/sj.onc.1210220
    • (2007) Oncogene , vol.26 , pp. 1324-1337
    • Adams, J.M.1    Cory, S.2
  • 2
    • 0036132872 scopus 로고    scopus 로고
    • C-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription
    • 10.1128/MCB.22.1.12-22.2002
    • A Alfranca MD Gutiérrez A Vara J Aragonés F Vidal MO Landázuri 2002 c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription Mol Cell Biol 22 12 22 10.1128/MCB.22.1.12-22.2002
    • (2002) Mol Cell Biol , vol.22 , pp. 12-22
    • Alfranca, A.1    Gutiérrez, M.D.2    Vara, A.3    Aragonés, J.4    Vidal, F.5    Landázuri, M.O.6
  • 3
    • 33846817095 scopus 로고    scopus 로고
    • Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC-3 prostate tumor xenografts
    • 10.1158/1535-7163.MCT-06-0367
    • S Anai S Goodison K Shiverick Y Hirao BD Brown CJ Rosser 2007 Knock-down of Bcl-2 by antisense oligodeoxynucleotides induces radiosensitization and inhibition of angiogenesis in human PC-3 prostate tumor xenografts Mol Cancer Ther 6 101 111 10.1158/1535-7163.MCT-06-0367
    • (2007) Mol Cancer Ther , vol.6 , pp. 101-111
    • Anai, S.1    Goodison, S.2    Shiverick, K.3    Hirao, Y.4    Brown, B.D.5    Rosser, C.J.6
  • 4
    • 0034881019 scopus 로고    scopus 로고
    • Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals
    • BA Ballif J Blenis 2001 Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals Cell Growth Differ 12 397 408
    • (2001) Cell Growth Differ , vol.12 , pp. 397-408
    • Ballif, B.A.1    Blenis, J.2
  • 6
    • 3042753807 scopus 로고    scopus 로고
    • MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription
    • 10.1182/blood-2003-08-2661
    • E Benasciutti G Pagès O Kenzior W Folk F Blasi MP Crippa 2004 MAPK and JNK transduction pathways can phosphorylate Sp1 to activate the uPA minimal promoter element and endogenous gene transcription Blood 104 256 262 10.1182/blood-2003-08-2661
    • (2004) Blood , vol.104 , pp. 256-262
    • Benasciutti, E.1    Pagès, G.2    Kenzior, O.3    Folk, W.4    Blasi, F.5    Crippa, M.P.6
  • 8
    • 0034657111 scopus 로고    scopus 로고
    • Hypoxia-induced silencing of NMDA receptors in turtle neurons
    • PE Bickler PH Donohoe LT Buck 2000 Hypoxia-induced silencing of NMDA receptors in turtle neurons J Neurosci 20 3522 3528
    • (2000) J Neurosci , vol.20 , pp. 3522-3528
    • Bickler, P.E.1    Donohoe, P.H.2    Buck, L.T.3
  • 9
    • 0036848491 scopus 로고    scopus 로고
    • The role of MAPK pathways in the action of chemotherapeutic drugs
    • 10.1093/carcin/23.11.1831
    • S Boldt UH Weidle W Kolch 2002 The role of MAPK pathways in the action of chemotherapeutic drugs Carcinogenesis 23 1831 1838 10.1093/carcin/23.11.1831
    • (2002) Carcinogenesis , vol.23 , pp. 1831-1838
    • Boldt, S.1    Weidle, U.H.2    Kolch, W.3
  • 10
    • 0033081066 scopus 로고    scopus 로고
    • Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
    • 10.1093/emboj/18.3.664
    • A Brunet D Roux P Lenormand S Dowd S Keyse J Pouysségur 1999 Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry EMBO J 18 664 674 10.1093/emboj/18.3.664
    • (1999) EMBO J , vol.18 , pp. 664-674
    • Brunet, A.1    Roux, D.2    Lenormand, P.3    Dowd, S.4    Keyse, S.5    Pouysségur, J.6
  • 12
    • 2442502511 scopus 로고    scopus 로고
    • Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons
    • 10.1074/jbc.M311164200
    • WS Choi DS Eom BS Han WK Kim BH Han EJ Choi TH Oh GJ Markelonis JW Cho YJ Oh 2004 Phosphorylation of p38 MAPK induced by oxidative stress is linked to activation of both caspase-8- and -9-mediated apoptotic pathways in dopaminergic neurons J Biol Chem 279 20451 20460 10.1074/jbc.M311164200
    • (2004) J Biol Chem , vol.279 , pp. 20451-20460
    • Choi, W.S.1    Eom, D.S.2    Han, B.S.3    Kim, W.K.4    Han, B.H.5    Choi, E.J.6    Oh, T.H.7    Markelonis, G.J.8    Cho, J.W.9    Oh, Y.J.10
  • 13
    • 0033551609 scopus 로고    scopus 로고
    • Selective activation of p38alpha and p38gamma by hypoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells
    • 10.1074/jbc.274.33.23570
    • PW Conrad RT Rust J Han DE Millhorn D Beitner-Johnson 1999 Selective activation of p38alpha and p38gamma by hypoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells J Biol Chem 274 23570 23576 10.1074/jbc.274.33.23570
    • (1999) J Biol Chem , vol.274 , pp. 23570-23576
    • Conrad, P.W.1    Rust, R.T.2    Han, J.3    Millhorn, D.E.4    Beitner-Johnson, D.5
  • 14
    • 34147131311 scopus 로고    scopus 로고
    • Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death
    • 10.1016/j.nbd.2006.12.023
    • M Dewil VF dela Cruz L Van Den Bosch W Robberecht 2007 Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death Neurobiol Dis 26 2 332 341 10.1016/j.nbd.2006.12.023
    • (2007) Neurobiol Dis , vol.26 , Issue.2 , pp. 332-341
    • Dewil, M.1    Dela Cruz, V.F.2    Van Den Bosch, L.3    Robberecht, W.4
  • 15
    • 0036530301 scopus 로고    scopus 로고
    • VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition
    • 10.1182/blood.V99.7.2532
    • S Dias SV Shmelkov G Lam S Rafii 2002 VEGF(165) promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition Blood 99 2532 2540 10.1182/blood.V99.7.2532
    • (2002) Blood , vol.99 , pp. 2532-2540
    • Dias, S.1    Shmelkov, S.V.2    Lam, G.3    Rafii, S.4
  • 16
    • 6044277953 scopus 로고    scopus 로고
    • Human Bcl-2 activates ERK signaling pathway to regulate activating protein-1, lens epithelium-derived growth factor and downstream genes
    • 10.1038/sj.onc.1208041
    • H Feng H Xiang YW Mao J Wang JP Liu XQ Huang Y Liu SJ Liu C Luo XJ Zhang Y Liu DW Li 2004 Human Bcl-2 activates ERK signaling pathway to regulate activating protein-1, lens epithelium-derived growth factor and downstream genes Oncogene 23 7310 7321 10.1038/sj.onc.1208041
    • (2004) Oncogene , vol.23 , pp. 7310-7321
    • Feng, H.1    Xiang, H.2    Mao, Y.W.3    Wang, J.4    Liu, J.P.5    Huang, X.Q.6    Liu, Y.7    Liu, S.J.8    Luo, C.9    Zhang, X.J.10    Liu, Y.11    Li, D.W.12
  • 18
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • 10.1038/nm0603-669
    • N Ferrara HP Gerber J LeCouter 2003 The biology of VEGF and its receptors Nat Med 9 669 676 10.1038/nm0603-669
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 19
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • 10.1093/jnci/82.1.4
    • J Folkman 1990 What is the evidence that tumors are angiogenesis dependent? J Natl Cancer Inst 82 4 6 10.1093/jnci/82.1.4
    • (1990) J Natl Cancer Inst , vol.82 , pp. 4-6
    • Folkman, J.1
  • 20
    • 0030614893 scopus 로고    scopus 로고
    • Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
    • 10.1038/nm0297-177
    • G Helmlinger F Yuan M Dellian RK Jain 1997 Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation Nat Med 3 177 182 10.1038/nm0297-177
    • (1997) Nat Med , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 21
    • 0037073753 scopus 로고    scopus 로고
    • Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis
    • 10.1074/jbc.M206336200
    • ST Hou X Xie A Baggley DS Park G Chen T Walker 2002 Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis J Biol Chem 277 48764 48770 10.1074/jbc.M206336200
    • (2002) J Biol Chem , vol.277 , pp. 48764-48770
    • Hou, S.T.1    Xie, X.2    Baggley, A.3    Park, D.S.4    Chen, G.5    Walker, T.6
  • 22
    • 0036270263 scopus 로고    scopus 로고
    • MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad
    • 10.1046/j.0022-3042.2001.00678.x
    • K Jin XO Mao Y Zhu DA Greenberg 2002 MEK and ERK protect hypoxic cortical neurons via phosphorylation of Bad J Neurochem 80 119 125 10.1046/j.0022-3042. 2001.00678.x
    • (2002) J Neurochem , vol.80 , pp. 119-125
    • Jin, K.1    Mao, X.O.2    Zhu, Y.3    Greenberg, D.A.4
  • 23
    • 0034927814 scopus 로고    scopus 로고
    • Apoptotic signaling in dopamine-induced cell death: The role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases
    • 10.1046/j.1471-4159.2001.00425.x
    • E Junn MM Mouradian 2001 Apoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases J Neurochem 78 374 383 10.1046/j.1471-4159.2001.00425. x
    • (2001) J Neurochem , vol.78 , pp. 374-383
    • Junn, E.1    Mouradian, M.M.2
  • 24
    • 33845666847 scopus 로고    scopus 로고
    • The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia
    • 10.1096/fj.05-4829fje
    • E Kilic U Kilic Y Wang CL Bassetti HH Marti DM Hermann 2006 The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia FASEB J 20 1185 1187 10.1096/fj.05-4829fje
    • (2006) FASEB J , vol.20 , pp. 1185-1187
    • Kilic, E.1    Kilic, U.2    Wang, Y.3    Bassetti, C.L.4    Marti, H.H.5    Hermann, D.M.6
  • 25
    • 17044434252 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis
    • DS Kim SY Kim JE Lee SB Kwon YH Joo SW Youn KC Park 2003 Sphingosine-1-phosphate-induced ERK activation protects human melanocytes from UVB-induced apoptosis Arch Pharm Res 26 739 746
    • (2003) Arch Pharm Res , vol.26 , pp. 739-746
    • Kim, D.S.1    Kim, S.Y.2    Lee, J.E.3    Kwon, S.B.4    Joo, Y.H.5    Youn, S.W.6    Park, K.C.7
  • 26
    • 0032991703 scopus 로고    scopus 로고
    • Rat embryo fibroblasts transformed by c-Jun display highly metastatic and angiogenic activities in vivo and deregulate gene expression of both angiogenic and antiangiogenic factors
    • M Kraemer R Tournaire V Dejong N Montreau D Briane C Derbin B Binétruy 1999 Rat embryo fibroblasts transformed by c-Jun display highly metastatic and angiogenic activities in vivo and deregulate gene expression of both angiogenic and antiangiogenic factors Cell Growth Differ 10 193 200
    • (1999) Cell Growth Differ , vol.10 , pp. 193-200
    • Kraemer, M.1    Tournaire, R.2    Dejong, V.3    Montreau, N.4    Briane, D.5    Derbin, C.6    Binétruy, B.7
  • 27
    • 0032937879 scopus 로고    scopus 로고
    • Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death
    • H Le-Niculescu E Bonfoco Y Kasuya F Claret DR Green M Karin 1999 Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death Mol Cell Biol 19 751 763
    • (1999) Mol Cell Biol , vol.19 , pp. 751-763
    • Le-Niculescu, H.1    Bonfoco, E.2    Kasuya, Y.3    Claret, F.4    Green, D.R.5    Karin, M.6
  • 28
    • 0033525760 scopus 로고    scopus 로고
    • An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia
    • 10.1074/jbc.274.10.6272
    • K Mackay D Mochly-Rosen 1999 An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia J Biol Chem 274 6272 6279 10.1074/jbc.274.10.6272
    • (1999) J Biol Chem , vol.274 , pp. 6272-6279
    • MacKay, K.1    Mochly-Rosen, D.2
  • 29
    • 0035034537 scopus 로고    scopus 로고
    • Modulating sensitivity to drug-induced apoptosis: The future for chemotherapy?
    • 10.1186/bcr289
    • G Makin C Dive 2001 Modulating sensitivity to drug-induced apoptosis: the future for chemotherapy? Breast Cancer Res 3 150 153 10.1186/bcr289
    • (2001) Breast Cancer Res , vol.3 , pp. 150-153
    • Makin, G.1    Dive, C.2
  • 30
    • 0035955751 scopus 로고    scopus 로고
    • Antiischemic effects of SB203580 are mediated through the inhibition of p38alpha mitogen-activated protein kinase: Evidence from ectopic expression of an inhibition-resistant kinase
    • 10.1161/hh2101.099504
    • JL Martin M Avkiran RA Quinlan P Cohen MS Marber 2001 Antiischemic effects of SB203580 are mediated through the inhibition of p38alpha mitogen-activated protein kinase: Evidence from ectopic expression of an inhibition-resistant kinase Circ Res 89 750 752 10.1161/hh2101.099504
    • (2001) Circ Res , vol.89 , pp. 750-752
    • Martin, J.L.1    Avkiran, M.2    Quinlan, R.A.3    Cohen, P.4    Marber, M.S.5
  • 31
    • 44649119818 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK) during hypoxia in cerebral cortical nuclei of guinea pig fetus at term: Role of nitric oxide
    • 10.1016/j.neulet.2008.02.037
    • D Maulik QM Ashraf OP Mishra M Delivoria-Papadopoulos 2008 Activation of p38 mitogen-activated protein kinase (p38 MAPK), extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK) during hypoxia in cerebral cortical nuclei of guinea pig fetus at term: Role of nitric oxide Neurosci Lett 439 94 99 10.1016/j.neulet.2008.02.037
    • (2008) Neurosci Lett , vol.439 , pp. 94-99
    • Maulik, D.1    Ashraf, Q.M.2    Mishra, O.P.3    Delivoria-Papadopoulos, M.4
  • 32
    • 0033105792 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor (VEGF) and its receptors in human neuroblastoma
    • 10.1016/S0959-8049(98)00387-6
    • B Meister F Grünebach F Bautz W Brugger FM Fink L Kanz R Möhle 1999 Expression of vascular endothelial growth factor (VEGF) and its receptors in human neuroblastoma Eur J Cancer 35 445 449 10.1016/S0959-8049(98)00387-6
    • (1999) Eur J Cancer , vol.35 , pp. 445-449
    • Meister, B.1    Grünebach, F.2    Bautz, F.3    Brugger, W.4    Fink, F.M.5    Kanz, L.6    Möhle, R.7
  • 33
    • 0032907687 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) and its receptors
    • G Neufeld T Cohen S Gengrinovitch Z Poltorak 1999 Vascular endothelial growth factor (VEGF) and its receptors FASEB J 13 9 22
    • (1999) FASEB J , vol.13 , pp. 9-22
    • Neufeld, G.1    Cohen, T.2    Gengrinovitch, S.3    Poltorak, Z.4
  • 34
  • 35
    • 2642517937 scopus 로고    scopus 로고
    • Normoxic induction of the hypoxic-inducible factor-1 alpha by interleukin-1 beta involves the extracellular signal-regulated kinase 1/2 pathway in normal human cytotrophoblast cells
    • 10.1095/biolreprod.103.025031
    • D Qian HY Lin HM Wang X Zhang DL Liu QL Li C Zhu 2004 Normoxic induction of the hypoxic-inducible factor-1 alpha by interleukin-1 beta involves the extracellular signal-regulated kinase 1/2 pathway in normal human cytotrophoblast cells Biol Reprod 70 1822 1827 10.1095/biolreprod.103.025031
    • (2004) Biol Reprod , vol.70 , pp. 1822-1827
    • Qian, D.1    Lin, H.Y.2    Wang, H.M.3    Zhang, X.4    Liu, D.L.5    Li, Q.L.6    Zhu, C.7
  • 36
    • 0344406956 scopus 로고    scopus 로고
    • Bcl-2 is significantly overexpressed in localized radio-recurrent prostate carcinoma, compared with localized radio-naive prostate carcinoma
    • 10.1016/S0360-3016(02)04468-1
    • CJ Rosser AO Reyes F Vakar-Lopez LB Levy DA Kuban DC Hoover AK Lee LL Pisters 2003 Bcl-2 is significantly overexpressed in localized radio-recurrent prostate carcinoma, compared with localized radio-naive prostate carcinoma Int J Radiat Oncol Biol Phys 56 1 6 10.1016/S0360-3016(02)04468-1
    • (2003) Int J Radiat Oncol Biol Phys , vol.56 , pp. 1-6
    • Rosser, C.J.1    Reyes, A.O.2    Vakar-Lopez, F.3    Levy, L.B.4    Kuban, D.A.5    Hoover, D.C.6    Lee, A.K.7    Pisters, L.L.8
  • 38
    • 0035313697 scopus 로고    scopus 로고
    • HIF-1 and mechanisms of hypoxia sensing
    • 10.1016/S0955-0674(00)00194-0
    • GL Semenza 2001 HIF-1 and mechanisms of hypoxia sensing Curr Opin Cell Biol 13 167 171 10.1016/S0955-0674(00)00194-0
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 167-171
    • Semenza, G.L.1
  • 40
    • 25144511910 scopus 로고    scopus 로고
    • The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions
    • 10.1042/CS20040370
    • H Takahashi M Shibuya 2005 The vascular endothelial growth factor (VEGF)/VEGF receptor system and its role under physiological and pathological conditions Clin Sci (Lond) 109 227 241 10.1042/CS20040370
    • (2005) Clin Sci (Lond) , vol.109 , pp. 227-241
    • Takahashi, H.1    Shibuya, M.2
  • 41
    • 0038664296 scopus 로고    scopus 로고
    • Involvement of SAPK/JNK in basic fibroblast growth factor-induced vascular endothelial growth factor release in osteoblasts
    • 10.1677/joe.0.1770101
    • H Tokuda K Hirade X Wang Y Oiso O Kozawa 2003 Involvement of SAPK/JNK in basic fibroblast growth factor-induced vascular endothelial growth factor release in osteoblasts J Endocrinol 177 101 107 10.1677/joe.0.1770101
    • (2003) J Endocrinol , vol.177 , pp. 101-107
    • Tokuda, H.1    Hirade, K.2    Wang, X.3    Oiso, Y.4    Kozawa, O.5
  • 42
    • 1342325424 scopus 로고    scopus 로고
    • Bcl-2 induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: Involvement of ERK1/ERK2 activity
    • 10.1074/jbc.M308938200
    • D Trisciuoglio A Iervolino A Candiloro G Fibbi M Fanciulli U Zangemeister-Wittke G Zupi D Del Bufalo 2004 bcl-2 induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: involvement of ERK1/ERK2 activity J Biol Chem 279 6737 6745 10.1074/jbc.M308938200
    • (2004) J Biol Chem , vol.279 , pp. 6737-6745
    • Trisciuoglio, D.1    Iervolino, A.2    Candiloro, A.3    Fibbi, G.4    Fanciulli, M.5    Zangemeister-Wittke, U.6    Zupi, G.7    Del Bufalo, D.8
  • 43
    • 24344458927 scopus 로고    scopus 로고
    • Involvement of PI3 K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells
    • 10.1091/mbc.E04-12-1087
    • D Trisciuoglio A Iervolino G Zupi D Del Bufalo 2005 Involvement of PI3 K and MAPK signaling in bcl-2-induced vascular endothelial growth factor expression in melanoma cells Mol Biol Cell 16 4153 4162 10.1091/mbc.E04-12-1087
    • (2005) Mol Biol Cell , vol.16 , pp. 4153-4162
    • Trisciuoglio, D.1    Iervolino, A.2    Zupi, G.3    Del Bufalo, D.4
  • 44
    • 1842583652 scopus 로고    scopus 로고
    • Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine
    • 10.1158/1078-0432.CCR-03-0488
    • K Yokoi IJ Fidler 2004 Hypoxia increases resistance of human pancreatic cancer cells to apoptosis induced by gemcitabine Clin Cancer Res 10 2299 2306 10.1158/1078-0432.CCR-03-0488
    • (2004) Clin Cancer Res , vol.10 , pp. 2299-2306
    • Yokoi, K.1    Fidler, I.J.2
  • 45
    • 0348049834 scopus 로고    scopus 로고
    • VEGF signalling: Integration and multi-tasking in endothelial cell biology
    • I Zachary 2003 VEGF signalling: integration and multi-tasking in endothelial cell biology Biochem Soc Trans 31 Pt 6 1171 1177
    • (2003) Biochem Soc Trans , vol.31 , Issue.PT 6 , pp. 1171-1177
    • Zachary, I.1
  • 47
    • 46249092224 scopus 로고    scopus 로고
    • Distinct signaling pathways confer different vascular responses to VEGF 121 and VEGF 165
    • 10.1080/08977190802105909
    • Y Zhang M Furumura E Morita 2008 Distinct signaling pathways confer different vascular responses to VEGF 121 and VEGF 165 Growth Factors 26 125 131 10.1080/08977190802105909
    • (2008) Growth Factors , vol.26 , pp. 125-131
    • Zhang, Y.1    Furumura, M.2    Morita, E.3
  • 48


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