-
1
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 1 (2000) 57-70
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
48849114364
-
Bortezomib in the front-line treatment of multiple myeloma
-
Richardson P.G., Mitsiades C., Schlossman R., Ghobrial I., Hideshima T., Munshi N., and Andersion J.C. Bortezomib in the front-line treatment of multiple myeloma. Expert Review Anti-Cancer Therapeutics 8 7 (2008) 1053-1072
-
(2008)
Expert Review Anti-Cancer Therapeutics
, vol.8
, Issue.7
, pp. 1053-1072
-
-
Richardson, P.G.1
Mitsiades, C.2
Schlossman, R.3
Ghobrial, I.4
Hideshima, T.5
Munshi, N.6
Andersion, J.C.7
-
3
-
-
52649150833
-
Targeting angiogenesis driven by vascular endothelial growth factors using antibody-based therapies
-
Grothey A., and Ellis L.M. Targeting angiogenesis driven by vascular endothelial growth factors using antibody-based therapies. Cancer Journal 14 3 (2008) 170-177
-
(2008)
Cancer Journal
, vol.14
, Issue.3
, pp. 170-177
-
-
Grothey, A.1
Ellis, L.M.2
-
4
-
-
4544335467
-
Translation of pharmacogenomics and pharmacogenetics: a regulatory perspective
-
Lesko L.J., and Woodcock J. Translation of pharmacogenomics and pharmacogenetics: a regulatory perspective. Nature Reviews Drug Discovery 3 9 (2003) 763-769
-
(2003)
Nature Reviews Drug Discovery
, vol.3
, Issue.9
, pp. 763-769
-
-
Lesko, L.J.1
Woodcock, J.2
-
5
-
-
67349087788
-
-
http://www.fda.gov.
-
-
-
-
6
-
-
28044471827
-
Acetylation and deacetylation of non-histone proteins
-
Glozak M.A., Sengupta N., Zhang X., and Seto E. Acetylation and deacetylation of non-histone proteins. Gene 363 (2005) 15-23
-
(2005)
Gene
, vol.363
, pp. 15-23
-
-
Glozak, M.A.1
Sengupta, N.2
Zhang, X.3
Seto, E.4
-
7
-
-
33644872992
-
Chromatin control and cancer-drug discovery: realizing the promise
-
Inche A.G., and La Thangue N.B. Chromatin control and cancer-drug discovery: realizing the promise. Drug Discovery Today 11 (2006) 97-109
-
(2006)
Drug Discovery Today
, vol.11
, pp. 97-109
-
-
Inche, A.G.1
La Thangue, N.B.2
-
8
-
-
0042905956
-
Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines
-
Glaser K.B., Staver M.J., Waring J.F., Stender J., Ulrich R.G., and Davidsen S.K. Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines. Molecular Cancer Therapeutics 2 (2003) 151-163
-
(2003)
Molecular Cancer Therapeutics
, vol.2
, pp. 151-163
-
-
Glaser, K.B.1
Staver, M.J.2
Waring, J.F.3
Stender, J.4
Ulrich, R.G.5
Davidsen, S.K.6
-
9
-
-
0041347519
-
Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?
-
Johnstone R.W., and Licht J.D. Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?. Cancer Cell 4 (2003) 13-18
-
(2003)
Cancer Cell
, vol.4
, pp. 13-18
-
-
Johnstone, R.W.1
Licht, J.D.2
-
10
-
-
9144220841
-
Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications
-
Mitsiades C.S., Mitsiades N.S., McMullan C.J., Poulaki V., Shringapure V., Hideshima T., Akiyama M., Chauhan D., Munshi N., Gu X., Bailey C., Joseph M., Libermann T.A., Richon V.M., Marks P.A., and Anderson K.C. Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications. Proceedings of the National Academy of Sciences 101 (2004) 540-545
-
(2004)
Proceedings of the National Academy of Sciences
, vol.101
, pp. 540-545
-
-
Mitsiades, C.S.1
Mitsiades, N.S.2
McMullan, C.J.3
Poulaki, V.4
Shringapure, V.5
Hideshima, T.6
Akiyama, M.7
Chauhan, D.8
Munshi, N.9
Gu, X.10
Bailey, C.11
Joseph, M.12
Libermann, T.A.13
Richon, V.M.14
Marks, P.A.15
Anderson, K.C.16
-
11
-
-
4143101371
-
Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumour proliferation
-
Park J.H., Yung Y., Kim T.Y., Kim S.G., Jong H.S., Lee J.W., Kim D.K., Lee J.S., Kim N.K., Kim T.Y., and Bang Y.J. Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumour proliferation. Clinical Cancer Research 10 (2004) 5271-5281
-
(2004)
Clinical Cancer Research
, vol.10
, pp. 5271-5281
-
-
Park, J.H.1
Yung, Y.2
Kim, T.Y.3
Kim, S.G.4
Jong, H.S.5
Lee, J.W.6
Kim, D.K.7
Lee, J.S.8
Kim, N.K.9
Kim, T.Y.10
Bang, Y.J.11
-
12
-
-
17144378591
-
Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression independent of histone deacetylase 1
-
Huang B.H., Laban M., Leung C.H., Lee L., Lee C.K., Salto-Tellez M., Raju G.C., and Hooi S.C. Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression independent of histone deacetylase 1. Cell Death and Differentiation 12 (2005) 395-404
-
(2005)
Cell Death and Differentiation
, vol.12
, pp. 395-404
-
-
Huang, B.H.1
Laban, M.2
Leung, C.H.3
Lee, L.4
Lee, C.K.5
Salto-Tellez, M.6
Raju, G.C.7
Hooi, S.C.8
-
13
-
-
0037416151
-
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo
-
Zhang Y., Li N., Caron C., Matthias G., Hess D., Khochbin S., and Matthias P. HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. The EMBO Journal 22 (2003) 1168-1179
-
(2003)
The EMBO Journal
, vol.22
, pp. 1168-1179
-
-
Zhang, Y.1
Li, N.2
Caron, C.3
Matthias, G.4
Hess, D.5
Khochbin, S.6
Matthias, P.7
-
14
-
-
33746541576
-
HDAC6-p97/VCP controlled polyubiquitin chain turnover
-
Boyault C., Gilquin B., Zhang Y., Rybin V., Garmen E., Meyer-Klaucke W., Matthias P., Muller C.W., and Khochbin S. HDAC6-p97/VCP controlled polyubiquitin chain turnover. The EMBO Journal 25 (2006) 3357-3366
-
(2006)
The EMBO Journal
, vol.25
, pp. 3357-3366
-
-
Boyault, C.1
Gilquin, B.2
Zhang, Y.3
Rybin, V.4
Garmen, E.5
Meyer-Klaucke, W.6
Matthias, P.7
Muller, C.W.8
Khochbin, S.9
-
15
-
-
0037162697
-
Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy
-
Zhang C.L., McKinsey T.A., Chang S., Antos C.L., Hill J.A., and Olsen E.N. Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell 110 (2002) 479-488
-
(2002)
Cell
, vol.110
, pp. 479-488
-
-
Zhang, C.L.1
McKinsey, T.A.2
Chang, S.3
Antos, C.L.4
Hill, J.A.5
Olsen, E.N.6
-
16
-
-
8344261349
-
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
-
Vega R.B., Matsuda K., Oh J., Barbosa A.C., Yang X., Meadows E., McAnally J., pomajzl C., Shelton J.M., Richardson J.A., Karsenty G., and Olsen E.N. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell 119 (2004) 555-566
-
(2004)
Cell
, vol.119
, pp. 555-566
-
-
Vega, R.B.1
Matsuda, K.2
Oh, J.3
Barbosa, A.C.4
Yang, X.5
Meadows, E.6
McAnally, J.7
pomajzl, C.8
Shelton, J.M.9
Richardson, J.A.10
Karsenty, G.11
Olsen, E.N.12
-
17
-
-
33847183440
-
MEF2C transcription factor controls chondrocyte hypertrophy and bone development
-
Arnold M.A., Kim Y., Czubryt M.P., Phan D., McAnally J., Qi X., Shelton J.M., Richardson J.A., Bassel-Duby R., and Olson E.N. MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Developmental Cell 12 (2007) 377-389
-
(2007)
Developmental Cell
, vol.12
, pp. 377-389
-
-
Arnold, M.A.1
Kim, Y.2
Czubryt, M.P.3
Phan, D.4
McAnally, J.5
Qi, X.6
Shelton, J.M.7
Richardson, J.A.8
Bassel-Duby, R.9
Olson, E.N.10
-
18
-
-
0037728615
-
HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis
-
Dequiedt E., Kasler H., Fischle W., Kiermer V., Weinstein M., Herndier B.G., and Verdin E. HDAC7, a thymus-specific class II histone deacetylase, regulates Nur77 transcription and TCR-mediated apoptosis. Immunity 18 (2003) 687-698
-
(2003)
Immunity
, vol.18
, pp. 687-698
-
-
Dequiedt, E.1
Kasler, H.2
Fischle, W.3
Kiermer, V.4
Weinstein, M.5
Herndier, B.G.6
Verdin, E.7
-
19
-
-
0033539092
-
Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors
-
Finnin M.S., Donigian J.R., Cohen A., Richon V.M., Rifkind R.A., Marks P.A., Breslow R., and Pavletich N.P. Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Nature 401 6749 (1999) 188-193
-
(1999)
Nature
, vol.401
, Issue.6749
, pp. 188-193
-
-
Finnin, M.S.1
Donigian, J.R.2
Cohen, A.3
Richon, V.M.4
Rifkind, R.A.5
Marks, P.A.6
Breslow, R.7
Pavletich, N.P.8
-
20
-
-
34547122494
-
HDAC inhibitors: clinical update and mechanism-based potential
-
Glaser K.B., et al. HDAC inhibitors: clinical update and mechanism-based potential. Biochemical Pharmacology 74 5 (2007) 659-671
-
(2007)
Biochemical Pharmacology
, vol.74
, Issue.5
, pp. 659-671
-
-
Glaser, K.B.1
-
22
-
-
0035525781
-
Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report
-
Piekarz R.L., Robey R., Sandor V., Bakke S., Wilson W.H., Dalmoush L., Kingma D.M., Turner M.L., Altemus R., and Bates S.E. Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report. Blood 98 (2001) 2865-2868
-
(2001)
Blood
, vol.98
, pp. 2865-2868
-
-
Piekarz, R.L.1
Robey, R.2
Sandor, V.3
Bakke, S.4
Wilson, W.H.5
Dalmoush, L.6
Kingma, D.M.7
Turner, M.L.8
Altemus, R.9
Bates, S.E.10
-
23
-
-
13844261436
-
Update on the phase II trial and correlative studies of depsipeptide in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma
-
ASCO Annual Meeting Proceedings
-
Piekarz R.L., et al. Update on the phase II trial and correlative studies of depsipeptide in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma. ASCO Annual Meeting Proceedings. Journal of Clinical Oncology (2004) 3028
-
(2004)
Journal of Clinical Oncology
, pp. 3028
-
-
Piekarz, R.L.1
-
24
-
-
67349267080
-
Histone deacetylase inhibitors in peripheral and cutaneous T-cell lymphoma
-
Piekarz R.L. Histone deacetylase inhibitors in peripheral and cutaneous T-cell lymphoma. Clinical Advances in Hematologic Malignancies 4 (2007) 1-3
-
(2007)
Clinical Advances in Hematologic Malignancies
, vol.4
, pp. 1-3
-
-
Piekarz, R.L.1
-
25
-
-
34548542892
-
A phase II study of a novel oral isotype-selective histone deacetylase (HDAC) inhibitor in patients with relapsed or refractory Hodgkin lymphoma
-
ASCO Annual Meeting Proceedings Part I
-
Younes A., et al. A phase II study of a novel oral isotype-selective histone deacetylase (HDAC) inhibitor in patients with relapsed or refractory Hodgkin lymphoma. ASCO Annual Meeting Proceedings Part I. Journal of Clinical Oncology 25 18S (2007) 8000
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.18 S
, pp. 8000
-
-
Younes, A.1
-
26
-
-
66349133867
-
Isotype-selective histone deacetylase (HDAC) inhibitor MGCD0103 demonstrates clinical activity and safety in patients with relapsed/refractory classical Hodgkin Lymphoma (HL)
-
ASCO Annual Meeting Proceedings
-
Bociek R.G., et al. Isotype-selective histone deacetylase (HDAC) inhibitor MGCD0103 demonstrates clinical activity and safety in patients with relapsed/refractory classical Hodgkin Lymphoma (HL). ASCO Annual Meeting Proceedings. Journal of Clinical Oncology 20 (2008) 8507
-
(2008)
Journal of Clinical Oncology
, vol.20
, pp. 8507
-
-
Bociek, R.G.1
-
27
-
-
33846327942
-
The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances gemcitabine-induced cell death in pancreatic cancer
-
Arnold N.B., Arkus N., Gunn J., and Korc M. The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances gemcitabine-induced cell death in pancreatic cancer. Clinical Cancer Research 13 (2007) 18-26
-
(2007)
Clinical Cancer Research
, vol.13
, pp. 18-26
-
-
Arnold, N.B.1
Arkus, N.2
Gunn, J.3
Korc, M.4
-
28
-
-
33845209109
-
Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells
-
Dowdy S.C., Jiang S., Zhou X.C., Hou X., Jin F., Podratz K.C., and W Jiang S. Histone deacetylase inhibitors and paclitaxel cause synergistic effects on apoptosis and microtubule stabilization in papillary serous endometrial cancer cells. Molecular Cancer Therapeutics 5 (2006) 767-2776
-
(2006)
Molecular Cancer Therapeutics
, vol.5
, pp. 767-2776
-
-
Dowdy, S.C.1
Jiang, S.2
Zhou, X.C.3
Hou, X.4
Jin, F.5
Podratz, K.C.6
W Jiang, S.7
-
29
-
-
34447315913
-
Chemosensitization of oral squamous cell carcinoma cells to cisplatin by histone deacetylase inhibitor, suberoylanilide hydroxamic acid
-
Rikiishi H., Shinohara F., Sato T., Sato Y., Suzuki M., and Echigo S. Chemosensitization of oral squamous cell carcinoma cells to cisplatin by histone deacetylase inhibitor, suberoylanilide hydroxamic acid. International Journal of Oncology 30 (2007) 1181-1188
-
(2007)
International Journal of Oncology
, vol.30
, pp. 1181-1188
-
-
Rikiishi, H.1
Shinohara, F.2
Sato, T.3
Sato, Y.4
Suzuki, M.5
Echigo, S.6
-
30
-
-
0242610850
-
Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA
-
Kim M.S., Blake M., Baek J.H., Kohlhagen G., Pommier Y., and Carrier F. Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA. Cancer Research 63 (2003) 7291-7300
-
(2003)
Cancer Research
, vol.63
, pp. 7291-7300
-
-
Kim, M.S.1
Blake, M.2
Baek, J.H.3
Kohlhagen, G.4
Pommier, Y.5
Carrier, F.6
-
31
-
-
0345734267
-
Coadministration of the heat shock protein 90 antagonist 17-allylamino-17-demothoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukaemic cells
-
Rahmani M., Yu C., Dai Y., Reese E., Ahmed W., Dent P., and Grant S. Coadministration of the heat shock protein 90 antagonist 17-allylamino-17-demothoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukaemic cells. Cancer Research 63 (2003) 8420-8427
-
(2003)
Cancer Research
, vol.63
, pp. 8420-8427
-
-
Rahmani, M.1
Yu, C.2
Dai, Y.3
Reese, E.4
Ahmed, W.5
Dent, P.6
Grant, S.7
-
32
-
-
33645737411
-
Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells
-
Nawrocki S.T., Carew J.S., Pino M.S., Highshaw R.A., Andtbacka R.H., Dunner Jr. K., Pal A., Bornmann W.G., Chiao P.J., Huang P., Xiong H., Abbruzzese J.L., and McConkey D.J. Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. Cancer Research 66 (2006) 3773-3781
-
(2006)
Cancer Research
, vol.66
, pp. 3773-3781
-
-
Nawrocki, S.T.1
Carew, J.S.2
Pino, M.S.3
Highshaw, R.A.4
Andtbacka, R.H.5
Dunner Jr., K.6
Pal, A.7
Bornmann, W.G.8
Chiao, P.J.9
Huang, P.10
Xiong, H.11
Abbruzzese, J.L.12
McConkey, D.J.13
-
33
-
-
0032948005
-
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silences in cancer
-
Cameron E.E., Bachman K.E., Myohanen S., Herman J.G., and Baylin S.B. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silences in cancer. Nature Genetics 21 (1999) 103-107
-
(1999)
Nature Genetics
, vol.21
, pp. 103-107
-
-
Cameron, E.E.1
Bachman, K.E.2
Myohanen, S.3
Herman, J.G.4
Baylin, S.B.5
-
34
-
-
41549159879
-
Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo
-
Weichert W., Roske A., Niesporek S., Noske A., Buckendahl A.C., Dietel M., Gekeler V., Boehm M., Beckers T., and Denkert C. Class I histone deacetylase expression has independent prognostic impact in human colorectal cancer: specific role of class I histone deacetylases in vitro and in vivo. Clinical Cancer Research 14 6 (2008) 1669-1677
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.6
, pp. 1669-1677
-
-
Weichert, W.1
Roske, A.2
Niesporek, S.3
Noske, A.4
Buckendahl, A.C.5
Dietel, M.6
Gekeler, V.7
Boehm, M.8
Beckers, T.9
Denkert, C.10
-
35
-
-
38949086502
-
Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy
-
Weichert W., Roske A., Gekeler V., Beckers T., Stephan C., Jung K., Fritzsche F.R., Niesporek S., Denkert C., Dietel M., and Kristiansen G. Histone deacetylases 1, 2 and 3 are highly expressed in prostate cancer and HDAC2 expression is associated with shorter PSA relapse time after radical prostatectomy. British Journal of Cancer 98 3 (2008) 604-610
-
(2008)
British Journal of Cancer
, vol.98
, Issue.3
, pp. 604-610
-
-
Weichert, W.1
Roske, A.2
Gekeler, V.3
Beckers, T.4
Stephan, C.5
Jung, K.6
Fritzsche, F.R.7
Niesporek, S.8
Denkert, C.9
Dietel, M.10
Kristiansen, G.11
-
36
-
-
57049120498
-
Drug insight: histone deacetylase-based therapies for cutaneous T-cell lymphomas
-
Khan O., and La Thangue N.B. Drug insight: histone deacetylase-based therapies for cutaneous T-cell lymphomas. Nature Clinical Practise Oncology 5 12 (2008) 714-726
-
(2008)
Nature Clinical Practise Oncology
, vol.5
, Issue.12
, pp. 714-726
-
-
Khan, O.1
La Thangue, N.B.2
-
37
-
-
50049108874
-
Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell lymphoma
-
Marquard L., Gjerdrum L.M., Christensen Ib.J., Jensen P.B., Sehested M., and Ralfkiaer E. Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell lymphoma. Histopathology 53 3 (2008) 267-277
-
(2008)
Histopathology
, vol.53
, Issue.3
, pp. 267-277
-
-
Marquard, L.1
Gjerdrum, L.M.2
Christensen, Ib.J.3
Jensen, P.B.4
Sehested, M.5
Ralfkiaer, E.6
-
38
-
-
51649126841
-
Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma
-
Ellis L., Pan Y., Smith G.K., George D.J., McCormack C., Williams-Truax R., Mita M., Beck J., Burris H., Ryan G., Atadja P., Butterfoss D., Dugan M., Culver K., Johnstone R.W., and Prince H.M. Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma. Clinical Cancer Research 14 14 (2008) 4500-4510
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.14
, pp. 4500-4510
-
-
Ellis, L.1
Pan, Y.2
Smith, G.K.3
George, D.J.4
McCormack, C.5
Williams-Truax, R.6
Mita, M.7
Beck, J.8
Burris, H.9
Ryan, G.10
Atadja, P.11
Butterfoss, D.12
Dugan, M.13
Culver, K.14
Johnstone, R.W.15
Prince, H.M.16
-
39
-
-
51049090194
-
Antitumour activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model
-
Miyanaga A., Gemma A., Noro R., Kataoka K., Matsuda K., Nara M., Okano T., Seike M., Yoshimura A., Kawakami A., Uesaka H., Nakae H., and Kudoh S. Antitumour activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model. Molecular Cancer Therapeutics 7 7 (2008) 1923-1930
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, Issue.7
, pp. 1923-1930
-
-
Miyanaga, A.1
Gemma, A.2
Noro, R.3
Kataoka, K.4
Matsuda, K.5
Nara, M.6
Okano, T.7
Seike, M.8
Yoshimura, A.9
Kawakami, A.10
Uesaka, H.11
Nakae, H.12
Kudoh, S.13
-
40
-
-
44049101802
-
Identification of predictive biomarkers for the histone deacetylase inhibitor belinostat in a panel of human cancer cell lines
-
Dejligbjerg M., Grausland M., Christensen I.J., Tjornelund J., Buhl Jensen P., and Sehested M. Identification of predictive biomarkers for the histone deacetylase inhibitor belinostat in a panel of human cancer cell lines. Cancer Biomarkers 4 2 (2008) 101-109
-
(2008)
Cancer Biomarkers
, vol.4
, Issue.2
, pp. 101-109
-
-
Dejligbjerg, M.1
Grausland, M.2
Christensen, I.J.3
Tjornelund, J.4
Buhl Jensen, P.5
Sehested, M.6
-
41
-
-
1642453460
-
Pharmacodynamic response and inhibition of growth of human tumour xenografts by the novel histone deacetylase inhibitor PXD101
-
Plumb J.A., Finn P.W., Williams R.J., Bandara M.J., Romero M.R., Watkins C.J., La Thangue N.B., and Brown R. Pharmacodynamic response and inhibition of growth of human tumour xenografts by the novel histone deacetylase inhibitor PXD101. Molecular Cancer Therapeutics 2 (2003) 721-728
-
(2003)
Molecular Cancer Therapeutics
, vol.2
, pp. 721-728
-
-
Plumb, J.A.1
Finn, P.W.2
Williams, R.J.3
Bandara, M.J.4
Romero, M.R.5
Watkins, C.J.6
La Thangue, N.B.7
Brown, R.8
-
42
-
-
38949096781
-
Phase I study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukaemias and myelodysplastic syndromes
-
Garcia-Manero G., Yang H., Bueso-Ramos C., Ferrajoli A., Cortes J., Wierda W.G., Faderl S., Koller C., Morris G., Rosner G., Loboda A., Fantin V.R., Randolph S.S., Hardwick J.S., Reilly J.F., Chen C., Ricker J.L., Secrist J.P., Richon V.M., Frankel S.R., and Kantarjian H.M. Phase I study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukaemias and myelodysplastic syndromes. Blood 111 3 (2008) 1060-1066
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1060-1066
-
-
Garcia-Manero, G.1
Yang, H.2
Bueso-Ramos, C.3
Ferrajoli, A.4
Cortes, J.5
Wierda, W.G.6
Faderl, S.7
Koller, C.8
Morris, G.9
Rosner, G.10
Loboda, A.11
Fantin, V.R.12
Randolph, S.S.13
Hardwick, J.S.14
Reilly, J.F.15
Chen, C.16
Ricker, J.L.17
Secrist, J.P.18
Richon, V.M.19
Frankel, S.R.20
Kantarjian, H.M.21
more..
-
43
-
-
38949146399
-
A phase I pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advance solid tumours
-
Steele N.L., Plumb J.A., Vidal L., Tjornelund J., Knoblauch P., Rasmussen A., Ooi C.E., Buhl-Jensen P., Brown R., Jeffry Evans T.R., and De Bono J.S. A phase I pharmacokinetic and pharmacodynamic study of the histone deacetylase inhibitor belinostat in patients with advance solid tumours. Clinical Cancer Research 14 3 (2008) 804-810
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.3
, pp. 804-810
-
-
Steele, N.L.1
Plumb, J.A.2
Vidal, L.3
Tjornelund, J.4
Knoblauch, P.5
Rasmussen, A.6
Ooi, C.E.7
Buhl-Jensen, P.8
Brown, R.9
Jeffry Evans, T.R.10
De Bono, J.S.11
-
44
-
-
36148966966
-
R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies
-
Arts J., Angibaud P., Marien A., Floren W., Janssens B., King P., van Dun J., Janssen L., Geerts T., Tuman R.W., Johnson D.L., Andries L., Jung M., Janicot M., and van Emelen K. R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies. British Journal of Cancer 97 (2007) 1344-1353
-
(2007)
British Journal of Cancer
, vol.97
, pp. 1344-1353
-
-
Arts, J.1
Angibaud, P.2
Marien, A.3
Floren, W.4
Janssens, B.5
King, P.6
van Dun, J.7
Janssen, L.8
Geerts, T.9
Tuman, R.W.10
Johnson, D.L.11
Andries, L.12
Jung, M.13
Janicot, M.14
van Emelen, K.15
-
45
-
-
58149183232
-
Phase I pharmacokinetic and pharmacodynamic study of LAQ824, a hydroxamate histone deacetylase inhibitor with a heat shock protein-90 inhibitory profile, in patients with advance solid tumours
-
de Bono J.S., Kristeleit R., Tolcher A., Fong P., Pacey S., Karavasilis V., Mita M., Shaw H., Workman P., Kaye S., Rowinsky E.K., Aherne W., Atadja P., Scott J.W., and Patnaik A. Phase I pharmacokinetic and pharmacodynamic study of LAQ824, a hydroxamate histone deacetylase inhibitor with a heat shock protein-90 inhibitory profile, in patients with advance solid tumours. Clinical Cancer Research 14 20 (2008) 6663-6673
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.20
, pp. 6663-6673
-
-
de Bono, J.S.1
Kristeleit, R.2
Tolcher, A.3
Fong, P.4
Pacey, S.5
Karavasilis, V.6
Mita, M.7
Shaw, H.8
Workman, P.9
Kaye, S.10
Rowinsky, E.K.11
Aherne, W.12
Atadja, P.13
Scott, J.W.14
Patnaik, A.15
-
46
-
-
58049208190
-
Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis
-
Fotheringham S., Epping M.T., Stimson L., Khan O., Wood V., Pezzella F., Bernards R., and La Thangue N.B. Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis. Cancer Cell 15 (2009) 57-66
-
(2009)
Cancer Cell
, vol.15
, pp. 57-66
-
-
Fotheringham, S.1
Epping, M.T.2
Stimson, L.3
Khan, O.4
Wood, V.5
Pezzella, F.6
Bernards, R.7
La Thangue, N.B.8
|