High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithin-cholesteryl acyltransferase

Nature Medicine

Volumn 3, Issue 7, 1997, Pages 744-749

  Bérard, Annie M ^a   Föger, Bernhard ^a   Remaley, Alan ^a   Shamburek, Robert ^a   Vaisman, Boris L ^a   Talley, Glenda ^a   Paigen, Beverly ^b   Hoyt Jr , Robert F ^a   Marcovina, Santica ^c   Brewer Jr , H Bryan ^a   Santamarina Fojo, Silvia ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b JACKSON LABORATORY   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE;

ANIMAL MODEL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; FAT INTAKE; LIPOPROTEIN BLOOD LEVEL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; AORTA; ARTERIOSCLEROSIS; CHOLESTEROL; DIET, ATHEROGENIC; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; LIPIDS; LIPOPROTEINS, HDL; MALE; MICE; MICE, TRANSGENIC; PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE;

ANIMALIA; MUS MUSCULUS;

EID: 0344429365     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0797-744     Document Type: Article

References (46)

1. Gordon, D.J. & Rifkind, B.M. High-density lipoprotein: The clinical implications of recent studies. N. Engl. J. Med. 321, 1311-1316 (1989).
2. Miller, N.E. Associations of high-density lipoprotein subclasses and apolipoproteins with ischemic heart disease and coronary atherosclerosis. Am. Heart J. 113, 589-597 (1987).
3. Gordon, D.J. et al. High-density lipoprotein cholesterol and cardiovascular disease: Four prospective American studies. Circulation 79, 8-15 (1989).
4. 3 cholesterol, apo A-I and apo A-II, and increased risk of myocardial infarction. Circulation 85, 22-29 (1992).
5. Badimon, J.J., Badimon, L. & Fuster, V. Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit. J. Clin. Invest. 85, 1234-1241 (1990).
6. Rubin, E.M., Krauss, R.M., Spangler, E.A., Verstuyft, J.G. & Clift, S.M. Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI. Nature 353, 265-267 (1991).
7. Plump, A.S., Scott, C.J. & Breslow, J.L Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc. Natl. Acad. Sci. USA. 91, 9607-9611 (1994).
8. Glomset, J.A. The plasma lecithin:cholesterol acyltransferase reaction. J. Lipid Res. 9, 155-167 (1968).
9. McLean, J., Wion, K., Drayna, D., Fielding, C. & Lawn, R. Human lecithin-cholesterol acyltransferase gene: Complete gene sequence and sites of expression. Nucleic Acids Res. 14, 9397-9406 (1986).
10. Francone, O.L., Gurakar, A. & Fielding, C. Distribution and functions of lecithin:cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins. J. Biol. Chem. 264, 7066-7072 (1989).
11. Huang, Y., von Eckardstein, A., Wu, S. & Assmann, G. Cholesterol efflux, cholesterol esterification, and cholesteryl ester transfer by LpA-I and LpA-I/A-II in native plasma. Arterioscler. Thromb. Vasc. Biol. 15, 1412-1418 (1995).
12. Marzetta, C.A., Meyers, T.J. & Albers, J.J. Lipid transfer protein-mediated distribution of HDL-derived cholesteryl esters among plasma apo B-containing lipoprotein subpopulations. Arterioscler. Thromb. 13, 834-841 (1993).
13. Tall, A.R. Plasma cholesteryl ester transfer protein. J. Lipid Res. 34, 1255-1274 (1993).
14. Miller, N.E., La Ville, A. & Crook, D. Direct evidence that reverse cholesterol transport is mediated by high-density lipoprotein in rabbit. Nature 314, 109-111 (1985).
15. Klein, H.-G. et al. In vitro expression of structural defects in the lecithin-cholesterol acyltransferase gene. J. Biol. Chem. 270, 9443-9447 (1995).
16. Glomset, J.A., Assmann, G., Gjone, E. & Norum, K.R. Lecithin:cholesterol acyltransferase deficiency and fish eye disease. in The Metabolic and Molecular Bases of Inherited Disease. (eds. Scriver, C.R. et al.) 1933-1951 (McGraw-Hill, New York, 1995).
17. Vaisman, B.L. et al. Overexpression of human lecithin cholesterol acyltransferase leads to hyperalphalipoproteinemia in transgenic mice. J. Biol. Chem. 270, 12269-12275 (1995).
18. Paigen, B., Morrow, A., Holmes, P.A., Mitchell, D. & Williams, R.A. Quantitative assessment of atherosclerotic lesions in mice. Atherosclerosis 68, 231-240 (1987).
19. Nakashima, Y., Plump, A.S., Raines, E.W., Breslow, J.L. & Ross, R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler. Thromb. 14, 133-140 (1994).
20. Alaupovic, P. The physicochemical and immunological heterogeneity of human plasma high density lipoproteins. in Clinical and Metabolic Aspects of High Density Lipoproteins. (eds. Miller, N.E. et al.) 1-45 (Elsevier Science, Amsterdam, 1984).
21. Duverger, N., Rader, D.J., Duchateau, P., Fruchart, J.C., Castro, G. & Brewer, H.B., Jr. Biochemical characterization of the three major subclasses of lipoprotein A-I (LpA-I) preparatively isolated from human plasma. Biochemistry 32, 12373-12379 (1993).
22. Fruchart, J.C. & Ailhaud, G. Apolipoprotein A-containing lipoprotein particles: Physiological role, quantification, and clinical significance. Clin. Chem. 38, 793-797 (1992).
23. Forte, T.M. & McCall, M.R. The role of apolipoprotein A-I-containing lipoproteins in atherosclerosis. Curr. Opin. Lipidol. 5, 354-364 (1994).
24. Barbaras, R., Puchois, P., Fruchart, J.C. & Ailhaud, G. Cholesterol efflux from cultured adipose cells is mediated by LpAI particles but not by LpAI:AII particles. Biochem. Biophys. Res. Commun. 142, 63-69 (1987).
25. Rader, D.J. et al. Very low high-density lipoproteins without coronary atherosclerosis. Lancet. 342, 1455-1458 (1993).
26. Hirano, K.-I. et al. Atherosclerotic disease in marked hyperalphalipoproteinemia: Combined reduction of cholesteryl ester transfer protein and hepatic triglyceride lipase. Arterioscler. Thromb. Vasc. Biol. 15, 1849-1856 (1995).
27. Zhong, S. et al. Increased coronary heart disease in Japanese-American men with mutation in the cholesteryl ester transfer protein gene despite increased HDL levels. J. Clin. Invest. 97, 2917-2923 (1996).
28. Schultz, J.R., Verstuyft, J.G., Gong, E.L., Nichols, A.V. & Rubin, E.M. Protein composition determines the anti-atherogenic properties of HDL in transgenic mice. Nature 365, 762-764 (1993).
29. Warden, C.H., Hedrick, C.C., Qiao, J.-H., Castllani, L.W. & Lusis, A.J. Atherosclerosis in transgenic mice overexpressing apolipoprotein A-II. Science 261, 469-472 (1993).
30. Dugi, K.A. et al. Adenovirus-mediated transfer of hepatic lipase in LCAT transgenic mice provides new insights into the role of hepatic lipase in HDL metabolism. J. Lipid Res. (in the press).
31. Sakai, N. et al. Analysis of LCAT and CETP gene-gene interaction using adenovirus-mediated gene transfer of CETP in control and LCAT transgenic mice. Circulation 92 (Suppl.), Abstr. 1-495 (1995).
32. Parthasarathy, S., Barnett, J. & Fong, L.G. High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein. Biochim. Biophys. Acta 1044, 275-283 (1990).
33. Mackness, M.I., Arrol, S., Abbott, C. & Durrington, P.N. Protection of low-density lipoprotein against oxidative modification by high-density lipoprotein associated paraoxonase. Atherosclerosis 104, 129-135 (1993).
34. Saku, K., Ahmad, M., Glas-Greenwalt, P. & Kashyap, M.L. Activation of fibrinolysis by apolipoproteins of high density lipoproteins in man. Thromb. Res. 39, 1-8 (1985).
35. Hoeg, J.M. et al. Lecithin-cholesterol acyltransferase overexpression generates hyperalpha-lipoproteinemia and a nonatherogenic lipoprotein pattern in transgenic rabbits. J. Biol. Chem. 271, 4396-4402 (1996).
36. Hoeg, J.M. et al. Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis. Proc. Natl. Acad. Sci. USA 93, 11448-11453 (1996).
37. Nishina, P.M., Verstuyft, J. & Paigen, B. Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J. Lipid Res. 31, 859-869 (1990).
38. Burstein, M., Scholnick, H.R. & Morfin, R. Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J. Lipid Res. 11, 583-95 (1970).
39. Terpstra, A.H.M. & Pels, A.E., III. Isolation of plasma lipoproteins by a combination of differential and density gradient ultracentrifugation. Fresenius Z. Anal. Chem. 330, 149-151 (1988).
40. Kashyap, V.S. et al. Apolipoprotein E deficiency in mice: Gene replacement and prevention of atherosclerosis using adenovirus vectors. J. Clin. Invest. 69, 1612-1620 (1995).
41. Chen, C.H. & Albers, J.J. Characterization of proteoliposomes containing apoprotein A-I: A new substrate for the measurement of lecithin:cholesterol acyltransferase activity. J. Lipid Res. 23, 680-691 (1982).
42. Albers, J.J., Adolphson, J.L. & Chen, C.-H. Radioimmunoassay of human plasma lecithin-cholesterol acyltransferase. J. Clin. Invest. 67, 141-148 (1981).
43. De la Llera-Moya, M. et al. A cell culture system for screening human serum for ability to promote cellular cholesterol efflux: Relations between serum components and efflux, esterification, and transfer. Arterioscler. Thromb. 14, 1056-1065 (1994).
44. Morton, R.E. & Zilversmit, D.B. A plasma inhibitor of triglyceride and cholesteryl ester transfer activities, J. Biol. Chem. 256, 11992-11995 (1981).
45. Tollefson, J.H. & Albers, J.J. Isolation, characterization, and assay of plasma lipid transfer proteins. Methods Enzymol. 129, 797-816 (1986).
46. Paigen, B., Ishida, B.Y., Verstuyft, J., Winters, R.B. & Albee, D. Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice. Arteriosclerosis 10, 316-323 (1990).