Transgenic overexpression of human lecithin: Cholesterol acyltransferase (LCAT) in mice does not increase aortic cholesterol deposition

Atherosclerosis

Volumn 165, Issue 1, 2002, Pages 89-100

  Furbee, James W ^a   Parks, John S ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

apoB lipoprotein; Atherosclerosis; Cholesterol ester; Cholesteryl ester; Cholic acid; Hepatic cholesterol; High density lipoprotein; Liver cholesterol; Low density lipoprotein; Mouse; Paigen diet; Polyunsaturated fatty acids

Indexed keywords

APOLIPOPROTEIN B; CHOLESTEROL; CHOLESTEROL ESTER; CHOLIC ACID; FATTY ACID; PALM OIL; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROGENIC DIET; ATHEROSCLEROSIS; CHOLESTEROL LIVER LEVEL; CONTROLLED STUDY; ESTERIFICATION; GENE OVEREXPRESSION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANALYSIS OF VARIANCE; ANIMALS; AORTA; APOLIPOPROTEINS B; ARTERIOSCLEROSIS; CHOLESTEROL ESTERS; CHOLESTEROL, HDL; DIET, ATHEROGENIC; DISEASE MODELS, ANIMAL; GENE EXPRESSION; HUMANS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY;

EID: 0036827813     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(02)00201-0     Document Type: Article

References (54)

1. Glomset J.A. The plasma lecithin:cholesterol acyltransferase reaction. J. Lipid Res. 9:1968;155-167.
2. Jonas A. Lecithin cholesterol acyltransferase. Biochim. Biophys. Acta. 1529:2000;245-256.
3. Glomset J.A., Janssen E.T., Kennedy R., Dobbins J. Role of plasma lecithin:cholesterol acyltransferase in the metabolism of high density lipoproteins. J. Lipid Res. 7:1966;638-648.
4. McLean J., Fielding C., Drayna D., Dieplinger H., Baer B., Kohr W., Henzel W., Lawn R. Cloning and expression of human lecithin-cholesterol acyltransferase cDNA. Proc. Natl. Acad. Sci. USA. 83:1986;2335-2339.
5. Cheung M.C., Wolf A.C., Lum K.D., Tollefson J.H., Albers J.J. Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins. J. Lipid Res. 27:1986;1135-1144.
6. Francone O.L., Gurakar A., Fielding C. Distribution and functions of lecithin: cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins. Evidence for a functional unit containing these activities together with apolipoproteins A-I and D that catalyzes the esterification and transfer of cell-derived cholesterol. J. Biol. Chem. 264:1989;7066-7072.
7. Fielding C.J., Shore V.G., Fielding P.E. A protein cofactor of lecithin:cholesterol acyltransferase. Biochem. Biophys. Res. Commun. 46:1972;1493-1498.
8. Jonas A. Synthetic substrates of lecithin: cholesterol acyltransferase. J. Lipid Res. 27:1986;689-698.
9. Fielding C.J., Fielding P.E. Molecular physiology of reverse cholesterol transport. J. Lipid Res. 36:1995;211-228.
10. Hill S.A., McQueen M.J. Reverse cholesterol transport - a review of the process and its clinical implications. Clin. Biochem. 30:1997;517-525.
11. Rothblat G.H., Llera-Moya M., Atger V., Kellner-Weibel G., Williams D.L., Phillips M.C. Cell cholesterol efflux: integration of old and new observations provides new insights. J. Lipid Res. 40:1999;781-796.
12. Mehlum A., Muri M., Hagve T.A., Solberg L.A., Prydz H. Mice overexpressing human lecithin: cholesterol acyltransferase are not protected against diet-induced atherosclerosis. APMIS. 105:1997;861-868.
13. Berard A.M., Foger B., Remaley A., Shamburek R., Vaisman B.L., Talley G., Paigen B., Hoyt R.F., Marcovina S., Brewer H.B., Santamarina-Fojo S. High plasma HDL concentrations associated with enhanced atherosclerosis in transgenic mice overexpressing lecithin-cholesteryl acyltransferase. Nat. Med. 3:1997;744-749.
14. Foger B., Chase M., Amar M.J., Vaisman B.L., Shamburek R.D., Paigen B., Fruchart-Najib J., Paiz J.A., Koch C.A., Hoyt R.F., Brewer H.B. Jr, Santamarina-Fojo S. Cholesteryl ester transfer protein corrects dysfunctional high density lipoproteins and reduces aortic atherosclerosis in lecithin cholesterol acyltransferase transgenic mice. J. Biol. Chem. 274:1999;36912-36920.
15. Hoeg J.M., Santamarina-Fojo S., Berard A.M., Cornhill J.F., Herderick E.E., Feldman S.H., Haudenschild C.C., Vaisman B.L., Hoyt R.F. Jr, Demosky S.J. Jr, Kauffman R.D., Hazel C.M., Marcovina S.M., Brewer H.B. Jr. Overexpression of lecithin:cholesterol acyltransferase in transgenic rabbits prevents diet-induced atherosclerosis. Proc. Natl. Acad. Sci. USA. 93:1996;11448-11453.
16. Portman O.W., Sugano M. Factors influencing the level and fatty acid specificity of the cholesterol esterification activity in human plasma. Arch. Biochem. Biophys. 105:1964;532-540.
17. Liu M., Bagdade J.D., Subbaiah P.V. Specificity of lecithin:cholesterol acyltransferase and atherogenic risk: comparative studies on the plasma composition and in vitro synthesis of cholesteryl esters in 14 vertebrate species. J. Lipid Res. 36:1995;1813-1824.
18. Pownall H.J., Pao Q., Massey J.B. Isolation and specificity of rat lecithin: cholesterol acyltransferase: comparison with the human enzyme using reassembled high-density lipoproteins containing ether analogs of phosphatidylcholine. Biochim. Biophys. Acta. 833:1985;456-462.
19. Mehlum A., Staels B., Duverger N., Tailleux A., Castro G., Fievet C., Luc G., Fruchart J.C., Olivecrona G., Skretting G., et al. Tissue-specific expression of the human gene for lecithin: cholesterol acyltransferase in transgenic mice alters blood lipids, lipoproteins and lipases towards a less atherogenic profile. Eur. J. Biochem. 230:1995;567-575.
20. Furbee J.W. Jr, Francone O., Parks J.S. Alteration of plasma HDL cholesteryl ester composition with transgenic expression of a point mutation (E149A) of human LCAT. J. Lipid Res. 42:2001;1626-1635.
21. Kingsbury K.J., Brett C., Stovold R., Chapman A., Anderson J., Morgan D.M. Abnormal fatty acid composition and human atherosclerosis. Postgrad. Med. J. 50:1974;425-440.
22. Kingsbury K.J., Stovold R., Morgan D.M., Brett C.G. The relationships between plasma cholesteryl polyunsaturated fatty acids, age and atherosclerosis. Postgrad. Med. J. 45:1969;591-601.
23. Parks J.S., Kaduck-Sawyer J., Bullock B.C., Rudel L.L. Effect of dietary fish oil on coronary artery and aortic atherosclerosis in African green monkeys. Arteriosclerosis. 10:1990;1102-1112.
24. Rudel L.L., Parks J.S., Johnson F.L., Babiak J. Low density lipoproteins in atherosclerosis. J. Lipid Res. 27:1986;465-474.
25. Rudel L.L., Parks J.S., Sawyer J.K. Compared with dietary monounsaturated and saturated fat, polyunsaturated fat protects African green monkeys from coronary artery atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 15:1995;2101-2110.
26. Rudel L.L., Kelley K., Sawyer J.K., Shah R., Wilson M.D. Dietary monounsaturated fatty acids promote aortic atherosclerosis in LDL receptor-null, human ApoB100-overexpressing transgenic mice. Arterioscler. Thromb. Vasc. Biol. 18:1998;1818-1827.
27. Francone O.L., Haghpassand M., Bennett J.A., Royer L., McNeish J. Expression of human lecithin:cholesterol acyltransferase in transgenic mice: effects on cholesterol efflux, esterification, and transport. J. Lipid Res. 38:1997;813-822.
28. Carr T.P., Andresen C.J., Rudel L.L. Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts. Clin. Biochem. 26:1993;39-42.
29. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
30. Parks J.S., Gebre A.K., Furbee J.W. Lecithin-cholesterol acyltransferase. Assay of cholesterol esterification and phospholipase A2 activities. Methods Mol. Biol. 109:1999;123-131.
31. Auerbach B.J., Parks J.S., Applebaum-Bowden D. A rapid and sensitive micro-assay for the enzymatic determination of plasma and lipoprotein cholesterol. J. Lipid Res. 31:1990;738-742.
32. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:1959;911-917.
33. Gillotte K.L., Lund-Katz S., De la Llera-Moya M., Parks J.S., Rudel L.L., Rothblat G.H., Phillips M.C. Dietary modification of high density lipoprotein phospholipid and influence on cellular cholesterol efflux. J. Lipid Res. 39:1998;2065-2075.
34. Vaisman B.L., Klein H.G., Rouis M., Berard A.M., Kindt M.R., Talley G.D., Meyn S.M., Hoyt R.F., Marcovina S.M., Albers J.J., et al. Overexpression of human lecithin cholesterol acyltransferase leads to hyperalphalipoproteinemia in transgenic mice. J. Biol. Chem. 270:1995;12269-12275.
35. Parks J.S., Bullock B.C. Effect of fish oil versus lard diets on the chemical and physical properties of low density lipoproteins of nonhuman primates. J. Lipid Res. 28:1987;173-182.
36. Rudel L.L., Haines J., Sawyer J.K., Shah R., Wilson M.S., Carr T.P. Hepatic origin of cholesteryl oleate in coronary artery atherosclerosis in African green monkeys - enrichment by dietary monounsaturated fat. J. Clin. Invest. 100:1997;74-83.
37. Mehlum A., Gjernes E., Solberg L.A., Hagve T.A., Prydz H. Overexpression of human lecithin:cholesterol acyltransferase in mice offers no protection against diet-induced atherosclerosis. APMIS. 108:2000;336-342.
38. Brousseau M.E., Kauffman R.D., Herderick E.E., Demosky S.J. Jr, Evans W., Marcovina S., Santamarina-Fojo S., Brewer H.B. Jr, Hoeg J.M. LCAT modulates atherogenic plasma lipoproteins and the extent of atherosclerosis only in the presence of normal LDL receptors in transgenic rabbits. Arterioscler. Thromb. Vasc. Biol. 20:2000;450-458.
39. Marotti K.R., Castle C.K., Boyle T.P., Lin A.H., Murray R.W., Melchior G.W. Severe atherosclerosis in transgenic mice expressing simian cholesteryl ester transfer protein. Nature. 364:1993;73-75.
40. Escola-Gil J.C., Marzal-Casacuberta A., Julve-Gil J., Ishida B.Y., Ordonez-Llanos J., Chan L., Gonzalez-Sastre F., Blanco-Vaca F. Human apolipoprotein A-II is a pro-atherogenic molecule when it is expressed in transgenic mice at a level similar to that in humans: evidence of a potentially relevant species-specific interaction with diet. J. Lipid Res. 39:1998;457-462.
41. Plump A.S., Scott C.J., Breslow J.L. Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse. Proc. Natl. Acad. Sci. USA. 91:1994;9607-9611.
42. Ueda Y., Gong E., Royer L., Cooper P.N., Francone O.L., Rubin E.M. Relationship between expression levels and atherogenesis in scavenger receptor class B, type I transgenics. J. Biol. Chem. 275:2000;20368-20373.
43. Schrade W.R.B.A.E.B. Fatty-acid distribution in the lipid fractions of healthy persons of different age, patients with atherosclerosis and patients with idiopathic hyperlipidaemia. J. Atheroscler. Res. 1:1961;47-61.
44. Lewis B. Composition of plasma cholesterol ester in relation to coronary-artery disease and dietary fat. Lancet. 1:1958;71-73.
45. Wolfe M.S., Sawyer J.K., Morgan T.M., Bullock B.C., Rudel L.L. Dietary polyunsaturated fat decreases coronary artery atherosclerosis in a pediatric-aged population of African green monkeys. Arterioscler. Thromb. 14:1994;587-597.
46. Nishina P.M., Lowe S., Verstuyft J., Naggert J.K., Kuypers F.A., Paigen B. Effects of dietary fats from animal and plant sources on diet-induced fatty streak lesions in C57BL/6J mice. J. Lipid Res. 34:1993;1413-1422.
47. Tall A.R., Small D.M., Atkinson D., Rudel L.L. Studies on the structure of low density lipoproteins isolated from Macaca fascicularis fed an atherogenic diet. J. Clin. Invest. 62:1978;1354-1363.
48. Morton R.E., Parks J.S. Plasma cholesteryl ester transfer activity is modulated by the phase transition of the lipoprotein core. J. Lipid Res. 37:1996;1915-1923.
49. Manning J.M., Gebre A.K., Edwards I.J., Wagner W.D., Rudel L.L., Parks J.S. Dietary polyunsaturated fat decreases interaction between low density lipoproteins and arterial proteoglycans. Lipids. 29:1994;635-641.
50. Glick J.M., Adelman S.J., Phillips M.C., Rothblat G.H. Cellular cholesteryl ester clearance. Relationship to the physical state of cholesteryl ester inclusions. J. Biol. Chem. 258:1983;13425-13430.
51. Adelman S.J., Glick J.M., Phillips M.C., Rothblat G.H. Lipid composition and physical state effects on cellular cholesteryl ester clearance. J. Biol. Chem. 259:1984;13844-13850.
52. Deckelbaum R.J., Tall A.R., Small D.M. Interaction of cholesterol ester and triglyceride in human plasma very low density lipoprotein. J. Lipid Res. 18:1977;164-168.
53. Thorngate F.E., Rudel L.L., Walzem R.L., Williams D.L. Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 20:2000;1939-1945.
54. Veniant M.M., Sullivan M.A., Kim S.K., Ambroziak P., Chu A., Wilson M.D., Hellerstein M.K., Rudel L.L., Walzem R.L., Young S.G. Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100. J. Clin. Invest. 106:2000;1501-1510.