Hypercholesterolemia in the Rabbit Induced by Feeding Graded Amounts of Low-Level Cholesterol: Methodological Considerations Regarding Individual Variability in Response to Dietary Cholesterol and Development of Lesion Type

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 16, Issue 12, 1996, Pages 1454-1464

  Kolodgie, Frank D ^a   Katocs Jr , Andrew S ^b   Largis, Elwood E ^b   Wrenn, Simeon M ^b   Cornhill, J Fredrick ^c,d   Herderick, Edward E ^c   Lee, Sue J ^a   Virmani, Renu ^a  

^a ARMED FORCES INSTITUTE OF PATHOLOGY   (United States)

^b PFIZER INC   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Acyl coenzyme A:cholesterol acyltransferase; Atherosclerosis; Cholesterol; Rabbit; Sudanophilia

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATHEROGENIC DIET; CHOLESTEROL DIET; CORONARY ARTERY ATHEROSCLEROSIS; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; HYPERCHOLESTEROLEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; RISK ASSESSMENT;

ANIMALS; CHOLESTEROL; CHOLESTEROL, DIETARY; CORONARY ARTERIOSCLEROSIS; DIET, ATHEROGENIC; DISEASE MODELS, ANIMAL; HYPERCHOLESTEROLEMIA; MALE; ORGAN SPECIFICITY; RABBITS;

EID: 0030482548     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.16.12.1454     Document Type: Article

References (53)

1. Clarkson TB. Atherosclerosis: spontaneous and induced. Adv Lipid Res. 1963;1:211-252.
2. Stehbens WE. An appraisal of cholesterol feeding in experimental atherogenesis. Prog Cardiovasc Dis. 1986;29:107-128.
3. Vesselinovitch D. Animal models and the study of atherosclerosis. Arch Pathol Lab Med. 1988;112:1011-1017.
4. Jokinen MP, Clarkson TB, Prichard RW. Animal models in atherosclerosis research. Exp Mol Pathol. 1985;42:1-28.
5. Wissler RW, Vesselinovitch D. Experimental models of human atherosclerosis. Ann N Y Acad Sci. 1968;149:907-922.
6. Prior JT, Kurtz DM, Ziegler DD. The hypercholesterolemic rabbit: an aid to understanding arteriosclerosis in man? Arch Pathol. 1961; 71:672-684.
7. Adams CW, Miller NE, Morgan RS, Rao SN. Lipoprotein levels and tissue lipids in fatty-fibrous atherosclerosis induced in rabbits by two years' cholesterol feeding at a low level. Atherosclerosis. 1982;44:1-8.
8. Walker LN, Reidy MA, Bowyer DE. Morphology and cell kinetics of fatty streak lesion formation in the hypercholesterolemic rabbit. Am J Pathol. 1986;125:450-459.
9. Spagnoli LG, Orlandi A, Mauriello A, Santeusanio G, de Angelis C, Lucreziotti R, Ramacci MT. Aging and atherosclerosis in the rabbit, I: distribution, prevalence and morphology of atherosclerotic lesions. Atherosclerosis. 1991;89:11-24.
10. Bocan TM, Mueller SB, Uhlendorf PD, Ferguson E, Newton RS. Dietary and mechanically induced rabbit iliac-femoral atherosclerotic lesions: a chemical and morphologic evaluation. Exp Mol Pathol. 1991;54:201-217.
11. Lupu F, Danaricu I, Simionescu N. Development of intracellular lipid deposits in the lipid-laden cells of atherosclerotic lesions: a cytochemical and ultrastructural study. Atherosclerosis. 1987;67: 127-142.
12. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 1957;226:494-509.
13. Largis EE, Wang CH, DeVries VG, Schaffer SA. CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption. J Lipid Res. 1989;30:681-690.
14. Hashimoto S, Dayton S, Alfin-Slater RB, Bui PT, Baker N, Wilson L. Characteristics of the cholesterol-esterifying activity in normal and atherosclerotic rabbit aortas. Circ Res. 1974;34:176-183.
15. Cornhill JF, Herderick EE, Stary HC. Topography of human aortic sudanophilic lesions. Monogr Atheroscler. 1990;15:13-19.
16. Tsukada T, Rosenfeld M, Ross R, Gown AM. Immunocytochemical analysis of cellular components in atherosclerotic lesions: use of monoclonal antibodies with the Watanabe and fat-fed rabbit. Arteriosclerosis. 1986;6:601-613.
17. Shanks ME, Gambill R. Calculus of the Elementary Functions. New York, NY: Holt, Rinehart and Winston, Inc; 1969:313.
18. McLaughlin RM, Fish RE. Clinical biochemistry and hematology. In: Manning PJ, Ringler DH, Newcomer CE, eds. The Biology of the Laboratory Rabbit. 2nd ed. San Diego, Calif: Academic Press; 1994:111-127.
19. Thompson KH, Zilversmit DB. Plasma very low density lipoprotein (VLDL) in cholesterol-fed rabbits: chylomicron remnants or liver lipoproteins? J Nutr. 1983;113:2002-2010.
20. Mackinnon AM, Savage J, Gibson RA, Barter PJ. Secretion of cholesteryl ester-enriched very low density lipoproteins by the liver of cholesterol-fed rabbits. Atherosclerosis. 1985;54:145-155.
21. Kroon PA, Thompson GM, Chao Y. β-very low density lipoproteins in cholesterol-fed rabbits are of hepatic origin. Atherosclerosis. 1985;56:323-329.
22. Brattsand R. Distribution of cholesterol and triglycerides among lipoprotein fractions in fat-fed rabbits at different levels of serum cholesterol. Atherosclerosis. 1976;23:97-110.
23. Schwenke DC, Carew TE. Initiation of atherosclerotic lesions in cholesterol-fed rabbits, I: focal increases in arterial LDL concentration precede development of fatty streak lesions. Arteriosclerosis. 1989;9: 895-907.
24. Kovanen PT, Brown MS, Basu SK, Bilheimer DW, Goldstein JL. Saturation and suppression of hepatic lipoprotein receptors: a mechanism for the hypercholesterolemia of cholesterol-fed rabbits. Proc Natl Acad Sci U S A. 1981;78:1396-1400.
25. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Relationship of atherosclerosis in young men to serum lipoprotein cholesterol concentrations and smoking: a preliminary report from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) research group. JAMA. 1990;264:3018-3024.
26. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Natural history of aortic and coronary atherosclerotic lesions in youth: findings from the PDAY study. Arterioscler Thromb. 1993;13:1291-1298.
27. Solberg LA, Strong JP. Risk factors and atherosclerotic lesions: a review of autopsy studies. Arteriosclerosis. 1983;3:187-198.
28. Brattsand R. The effect of niceritrol (pentaerythritoltetranicotinate) on experimental atherosclerosis in cholesterol-fed rabbits at different levels of plasma cholesterol. Acta Pharmacol Toxicol. 1975;36:39-55.
29. Ross AC, Minick CR, Zilversmit DB. Equal atherosclerosis in rabbits fed cholesterol-free, low-fat diet or cholesterol-supplemented diet. Atherosclerosis. 1978;29:301-315.
30. de la Llera-Moya M, Rothblat GH, Click JM, England JM. Etoposide treatment suppresses atherosclerotic plaque development in cholesterol-fed rabbits. Arterioscler Thromb. 1992;12:1363-1370.
31. Bocan TM, Mueller SB, Mazur MJ, Uhlendorf PD, Brown EQ, Kieft KA. The relationship between the degree of dietary-induced hypercholesterolemia in the rabbit and atherosclerotic lesion formation. Atherosclerosis. 1993;102:9-22.
32. Adelman SSJ, Chandrasekaran A, Jayo J, St. Clair RW. Effect of 17α-dihydroequilin sulfate, a conjugated equine estrogen, and ethynylestradiol on atherosclerosis in cholesterol-fed rabbits. Arterioscler Thromb Vasc Biol. 1995;15:837-846.
33. McGill HC Jr. Atherosclerosis: problems in pathogenesis. Atheroscler Rev. 1977;2:27-59.
34. Orlandi A, Mauriello A, deAngelis C, Ramacci MT, Spagnoli LG. Age-related differences in the distribution and occurrence of atherosclerotic aortic lesions in the hyperlipemic rabbit. Arch Gerontol Geriatr. 1992;16:295-302.
35. Kritchevsky D, Tepper SA, Vesselinovitch D, Wissler RW. Cholesterol vehicle in experimental atherosclerosis, II: peanut oil. Atherosclerosis. 1971;14:53-64.
36. Constantinides P, Booth J, Carlson G. Production of advanced cholesterol atherosclerosis in the rabbit after cessation of cholesterol feeding. Arch Pathol. 1960;70:712-724.
37. Wilson RB, Miller RA, Middleton CC, Kinden D. Atherosclerosis in rabbits fed a low cholesterol diet for five years. Arteriosclerosis. 1982;2:228-241.
38. Daley SJ, Klemp KF, Guyton JR, Rogers KA. Cholesterol-fed and casein-fed rabbit models of atherosclerosis, II: differing morphological severity of atherogenesis despite matched plasma cholesterol levels. Arterioscler Thromb. 1994;14:105-114.
39. Daley SJ, Herderick EE, Cornhill JF, Rogers KA. Cholesterol-fed and casein-fed rabbit models of atherosclerosis, I: differing lesion area and volume despite equal plasma cholesterol levels. Arterioscler Thromb. 1994;14:95-104.
40. Mirhadi SA, Singh S, Gupta PP. Effect of garlic supplementation to cholesterol-rich diet on development of atherosclerosis in rabbits. Indian J Exp Biol. 1991;29:162-168.
41. Lacombe C, Corraze G, Nibbelink M. Increases in hyperlipoproteinemia, disturbances in cholesterol metabolism and atherosclerosis induced by dietary restriction in rabbits fed a cholesterol-rich diet. Lipids. 1983;18:306-312.
42. Restori G, Boiardi L, Barbagallo M, Novo S, Passeri M, Strano A. Progression of induced aortic atherosclerosis in rabbits fed a high cholesterol diet. Int Angiol. 1990;9:263-265.
43. Böttcher CJF. Chemical constituents of human atherosclerotic lesions. Proc R Soc Med. 1964;57:792-795.
44. Brecher PI, Chobanian AV. Cholesteryl ester synthesis in normal and atherosclerotic aortas of rabbits and rhesus monkeys. Circ Res. 1974; 35:692-701.
45. Kruth HS. Filipin-positive, oil red O-negative particles in atherosclerotic lesions induced by cholesterol feeding. Lab Invest. 1984; 50:87-93.
46. Simionescu N, Vasile E, Lupu F, Popescu G, Simionescu M. Prelesional events in atherogenesis: accumulation of extracellular cholesterol-rich liposomes in the arterial intima and cardiac valves of the hyperlipidemic rabbit. Am J Pathol. 1986;123:109-125.
47. Scott RF, Florentin RA, Daoud AS, Morrison ES, Jones RM, Hutt MS. Coronary arteries of children and young adults: a comparison of lipids and anatomic features in New Yorkers and East Africans. Exp Mol Pathol. 1966;5:12-42.
48. Smith EB, Evans PH, Downham MD. Lipids in the aortic intima: the correlation of morphologic and chemical characteristics. J Atheroscler Res. 1967;7:171-186.
49. Loree HM, Tobias BJ, Gibson LJ, Kamm RD, Small DM, Lee RT. Mechanical properties of model atherosclerotic lesion lipid pools. Arterioscler Thromb. 1994;14:230-234.
50. Suckling KE, Strange EF. Role of acyl-CoA:cholesterol acyltransferase in cellular cholesterol metabolism. J Lipid Res. 1985;26:647-671.
51. Proudlock JW, Day AJ. Cholesterol esterifying enzymes of atherosclerotic rabbit intima. Biochim Biophys Acta. 1972;260:716-723.
52. Morisaki N, Matsuoka N, Shiral K, Sato Y, Kumagai A. Studies on acyl-CoA synthetase in rat arterial wall. Atherosclerosis. 1980;37: 439-447.
53. Hunt CE, Duncan LA. Hyperlipoproteinaemia and atherosclerosis in rabbits fed low-level cholesterol and lecithin. Br J Exp Pathol. 1985;66:35-46.