Metallic gold reduces TNFα expression, oxidative DNA damage and pro-apoptotic signals after experimental brain injury

Brain Research

Volumn 1271, Issue , 2009, Pages 103-113

  Pedersen, Mie Østergaard ^a   Larsen, Agnete ^b   Pedersen, Dan Sonne ^a,b   Stoltenberg, Meredin ^b   Penkowa, Milena ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Apoptosis; CNS injury; Inflammation; Metal ion; Oxidative stress

Indexed keywords

8 HYDROXYGUANINE; CASPASE 3; CYTOCHROME C; GOLD; PLACEBO; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN INJURY; CELL SURVIVAL; CONTROLLED STUDY; DISEASE MARKER; DNA DAMAGE; DRUG MECHANISM; FEMALE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; BRAIN INJURIES; CASPASE 3; CEREBRAL CORTEX; CYTOCHROMES C; DISEASE MODELS, ANIMAL; DNA DAMAGE; DOWN-REGULATION; FEMALE; GOLD; GUANINE; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 67349145269     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.03.022     Document Type: Article

References (69)

1. Ben-Hur T., Ben-Menachem O., Furer V., Einstein O., Mizrachi-Kol R., and Grigoriadis N. Effects of proinflammatory cytokines on the growth, fate, and motility of multipotential neural precursor cells. Mol. Cell Neurosci. 24 (2003) 623-631
2. Bot P.T., Hoefer I.E., Piek J.J., and Pasterkamp G. Hyaluronic acid: targeting immune modulatory components of the extracellular matrix in atherosclerosis. Curr. Med. Chem. 15 (2008) 786-791
3. Bragadin M., Scutari G., Folda A., Bindoli A., and Rigobello M.P. Effect of metal complexes on thioredoxin reductase and the regulation of mitochondrial permeability conditions. Ann. N.Y. Acad. Sci. 1030 (2004) 348-354
4. Bratt J., Belcher J., Vercellotti G.M., and Palmblad J. Effects of anti-rheumatic gold salts on NF-kappa B mobilization and tumour necrosis factor-alpha (TNF-alpha)-induced neutrophil-dependent cytotoxicity for human endothelial cells. Clin. Exp. Immunol. 120 (2000) 79-84
5. Burmester G.-R. Molecular mechanisms of action of gold treatment in rheumatoid arthritis - an update. Z. Rheumatol. 60 (2001) 167-173
6. Cacci E., Claasen J.H., and Kokaia Z. Microglia-derived tumor necrosis factor-alpha exaggerates death of newborn hippocampal progenitor cells in vitro. J. Neurosci. Res. 80 (2005) 789-797
7. Canumalla A.J., Al-Zamil N., Phillips M., Isab A.A., and Shaw III C.F. Redox and ligand exchange reactions of potential gold(I) and gold(III)-cyanide metabolites under biomimetic conditions. J. Inorg. Biochem. 85 (2001) 67-76
8. Caruso F., Villa R., Rossi M., Pettinari C., Paduano F., Pennati M., Daidone M.G., and Zaffaroni N. Mitochondria are primary targets in apoptosis induced by the mixed phosphine gold species chlorotriphenylphosphine-1,3-bis(diphenylphosphino)propanegold(I) in melanoma cell lines. Biochem. Pharmacol. 73 (2007) 773-781
9. Caso J.R., Lizasoain I., Lorenzo P., Moro M.A., and Leza J.C. The role of tumor necrosis factor-alpha in stress-induced worsening of cerebral ischemia in rats. Neuroscience 142 (2006) 59-69
10. Chiarini A., Dal Pra I., Whitfield J.F., and Armato U. The killing of neurons by beta-amyloid peptides, prions, and pro-inflammatory cytokines. Ital. J. Anat. Embryol. 111 (2006) 221-246
11. Chircorian A., and Barrios A.M. Inhibition of lysosomal cysteine proteases by chrysotherapeutic compounds: a possible mechanism for the antiarthritic activity of Au(I). Bioorg. Med. Chem. Lett. 14 (2004) 5113-5116
12. Danscher G. In vivo liberation of gold ions from gold implants. Autometallographic tracing of gold in cells adjacent to metallic gold. J. Histochem. Cytochem. 117 (2002) 447-452
13. Dheen S.T., Kaur C., and Ling E.A. Microglial activation and its implications in the brain diseases. Curr. Med. Chem. 14 (2007) 1189-1197
14. Dringen R. Oxidative and antioxidative potential of brain microglial cells. Antioxid. Redox Signal. 7 (2005) 1223-1233
15. Eisler R. Chrysotherapy: a synoptic review. Inflamm. Res. 52 (2003) 487-501
16. Ekdahl C.T., Claasen J.H., Bonde S., Kokaia Z., and Lindvall O. Inflammation is detrimental for neurogenesis in adult brain. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 13632-13637
17. Elder R.C., Zhao Z., Zhang Y., Dorsey J.G., Hess E.V., and Tepperman K. Dicyanogold (I) is a common human metabolite of different gold drugs. J. Rheumatol. 20 (1993) 268-272
18. Fernandes-Alnemri T., Litwack G., and Alnemri E.S. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J. Biol. Chem. 269 (1994) 30761-30764
19. Graham G.G., and Kettle A.J. The activation of gold complexes by cyanide produced by polymorphnuclear leukocytes III. The formation of aurocyanide by myeloperoxidase. Biochem. Pharmacol. 56 (1998) 307-312
20. Guggilam A., Haque M., Kerut E.K., McIlwain E., Lucchesi P., Seghal I., and Francis J. TNF-alpha blockade decreases oxidative stress in the paraventricular nucleus and attenuates sympathoexcitation in heart failure rats. Am. J. Physiol, Heart Circ. Physiol. 293 (2007) H599-609
21. Han S., Kim K., Kim H., Kwon J., Lee Y.H., Lee C.K., Song Y., Lee S.J., Ha N., and Kim K. Auranofin inhibits overproduction of pro-inflammatory cytokines, cyclooxygenase expression and PGE2 production in macrophages. Arch. Pharm. Res. 31 (2008) 67-74
22. Helbock H.J., Beckman K.B., and Ames B.N. 8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage. Methods Enzymol. 300 (1999) 156-166
23. Heyworth B.E., Lee J.H., Kim P.D., Lipton C.B., Strauch R.J., and Rosenwasser M.P. Hylan versus corticosteroid versus placebo for treatment of basal joint arthritis: a prospective, randomized, double-blinded clinical trial. J. Hand Surg. (Am). 33 (2008) 40-48
24. Huang Y., Erdmann N., Peng H., Zhao Y., and Zheng J. The role of TNF related apoptosis-inducing ligand in neurodegenerative diseases. Cell Mol. Immunol. 2 (2005) 113-122
25. Iosif R.E., Ekdahl C.T., Ahlenius H., Pronk C.J., Bonde S., Kokaia Z., Jacobsen S.E., and Lindvall O. Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis. J. Neurosci. 26 (2006) 9703-9712
26. Iranzo P., Alsina M.M., Martínez-De Pablo I., Segura S., Mascaró J.M., and Herrero C. Gold: an old drug still working in refractory pemphigus. J. Eur. Acad. Dermatol. Venereol. 21 (2007) 902-907
27. Kauppinen T.M., and Swanson R.A. Poly(ADP-ribose) polymerase-1 promotes microglial activation, proliferation, and matrix metalloproteinase-9-mediated neuron death. J. Immunol. 174 (2005) 2288-2296
28. Keane R.W., Davis A.R., and Dietrich W.D. Inflammatory and apoptotic signaling after spinal cord injury. J. Neurotrauma 23 (2006) 335-344
29. Kühn S.H., Gemperli M.B., and De Beer F.C. Effect of two gold compounds on human polymorphonuclear leukocyte lysosomal function and phagocytosis. Inflammation 9 (1985) 39-44
30. Larsen A., Kolind K., Pedersen D.S., Doering P., Pedersen M.O., Danscher G., Penkowa M., and Stoltenberg M. Treatment with metallic gold particles reduces neuroninflammation and apoptotic cell death after focal brain injury. Histochem. Cell Biol. 130 (2008) 681-692
31. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., and Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91 (1997) 479-489
32. Liu J.J., Galettis P., Farr A., Maharaj L., Samarasinha H., McGechan A.C., Baguley B.C., Bowen R.J., Berners-Price S.J., and McKeage M.J. In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake. J. Inorg. Biochem. 102 (2008) 303-310
33. Madrigal J.L., García-Bueno B., Caso J.R., Pérez-Nievas B.G., and Leza J.C. Stress-induced oxidative changes in brain. CNS Neurol. Disord. Drug Targets 5 (2006) 561-568
34. Marzano C., Gandin V., Folda A., Scutari G., Bindoli A., and Rigobello M.P. Inhibition of thioredoxin reductase by auranofin induces apoptosis in cisplatin-resistant human ovarian cancer cells. Free Radic. Biol. Med. 42 (2007) 872-881
35. Mattson M.P., and Camandola S. NF-kappaB in neuronal plasticity and neurodegenerative disorders. J. Clin. Invest. 107 (2001) 247-254
36. McKeage M.J. Gold opens mitochondrial pathways to apoptosis. Br. J. Pharmacol. 136 (2002) 1081-1082
37. Mémet S. NF-kappaB functions in the nervous system: from development to disease. Biochem. Pharmacol. 72 (2006) 1180-1195
38. Milacic V., Chen D., Ronconi L., Landis-Piwowar K.R., Fregona D., and Dou Q.P. A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts. Cancer Res. 66 (2006) 10478-10486
39. Milacic V., Fregona D., and Dou Q.P. Gold complexes as prospective metal-based anticancer drugs. Histol. Histopathol. 23 (2008) 101-108
40. Ming G.-L., and Song H. Adult neurogenesis in the mammalian central nervous system. Annu. Rev. Neurosci. 28 (2005) 223-250
41. Morganti-Kossmann M.C., Satgunaseelan, L., Bye N., and Kossmann T. Modulation of immune response by head injury. Injury 38 (2007) 1392-1400
42. Nam K.N., Koketsu M., and Lee E.H. 5-Chloroacetyl-2-amino-1,3-selenazoles attenuate microglial inflammatory responses through NF-kappaB inhibition. Eur. J. Pharmacol. 589 (2008) 53-57
43. Navarro M., Fraile G., Velásquez M., González E., Escalona J., Ilanjian R., Abad M.J., and Taylor P. Effect of a gold-chloroquine complex on inflammation-related leukocyte functions and cell viability. Comparison with auranofin. Arzneimittelforschung 56 (2006) 826-833
44. Parikh S., Koch M., and Narayan R.K. Traumatic brain injury. Int. Anesthesiol. Clin. 45 (2007) 119-135
45. Penkowa M., and Hidalgo J. Metallothionein treatment reduces proinflammatory cytokines IL-6 and TNF-alpha and apoptotic cell death during experimental autoimmune encephalomyelitis (EAE). Exp. Neurol. 170 (2001) 1-14
46. Penkowa M., and Moos T. Disruption of the blood-brain interface in neonatal rat neocortex induces a transient expression of metallothionein in reactive astrocytes. Glia 13 (1995) 217-227
47. Penkowa M., Moos T., Carrasco J., Hadberg H., Molinero A., Bluethmann H., and Hidalgo J. Strongly compromised inflammatory response to brain injury in Interleukin-6-deficient mice. Glia 25 (1999) 343-357
48. Penkowa M., Giralt M., Carrasco J., Hadberg H., and Hidalgo J. Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice. Glia 32 (2000) 271-285
49. Penkowa M., Camats J., Hadberg H., Quintana A., Rojas S., Giralt M., Molinero A., Campbell I.L., and Hidalgo J. Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide. J. Neurosci. Res. 73 (2003) 481-496
50. Pillarsetty N., Katti K.K., Hoffman T.J., Volkert W.A., Katti K.V., Kamei H., and Koide T. In vitro and in vivo antitumor properties of tetrakis((trishydroxy-methyl)phosphine)gold(I) chloride. J. Med. Chem. 46 (2003) 1130-1132
51. Quintana A., Giralt M., Rojas S., Penkowa M., Campbell I.L., Hidalgo J., and Molinero A. Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury. J. Neurosci. Res. 82 (2005) 701-716
52. Quintana A., Molinero A., Florit S., Manso Y., Comes G., Carrasco J., Giralt M., Borup R., Nielsen F.C., Campbell I.L., Penkowa M., and Hidalgo J. Diverging mechanisms for TNF-alpha receptors in normal mouse brains and in functional recovery after injury: from gene to behavior. J. Neurosci. Res. 85 (2007) 2668-2685
53. Rigobello M.P., Scutari G., Boscolo R., and Bindoli A. Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative. Br. J. Pharmacol. 136 (2002) 1162-1168
54. Rigobello M.P., Messori L., Marcon G., Agostina Cinellu M., Bragadin M., Folda A., Scutari G., and Bindoli A. Gold complexes inhibit mitochondrial thioredoxin reductase: consequences on mitochondrial functions. J. Inorg. Biochem. 98 (2004) 1634-1641
55. Rigobello M.P., Scutari G., Folda A., and Bindoli A. Mitochondrial thioredoxin reductase inhibition by gold(I) compounds and concurrent stimulation of permeability transition and release of cytochrome c. Biochem. Pharmacol. 67 (2004) 689-696
56. Rigobello M.P., Folda A., Baldoin M.C., Scutari G., and Bindoli A. Effect of auranofin on the mitochondrial generation of hydrogen peroxide. Role of thioredoxin reductase. Free Radic. Res. 39 (2005) 687-695
57. Rigobello M.P., Folda A., Dani B., Menabò R., Scutari G., and Bindoli A. Gold(I) complexes determine apoptosis with limited oxidative stress in Jurkat T cells. Eur. J. Pharmacol. 582 (2008) 26-34
58. Schiff M.H., and Whelton A. Renal toxicity associated with disease-modifying antirheumatic drugs used for the treatment of rheumatoid arthritis. Semin. Arthritis Rheum. 30 (2000) 196-208
59. Schouten J.W. Neuroprotection in traumatic brain injury: a complex struggle against the biology of nature. Curr. Opin. Crit. Care 13 (2007) 134-142
60. Simard A.R., and Rivest S. Role of inflammation in the neurobiology of stem cells. NeuroReport 15 (2004) 2305-2310
61. Thibeault S.L., and Duflo S. Inflammatory cytokine responses to synthetic extracellular matrix injection to the vocal fold lamina propria. Ann. Otol. Rhinol. Laryngol. 117 (2008) 221-226
62. Wang Y., He Q.Y., Sun R.W., Che C.M., and Chiu J.F. GoldIII porphyrin 1a induced apoptosis by mitochondrial death pathways related to reactive oxygen species. Cancer Res. 65 (2005) 11553-11564
63. Wataha J.C., Lewis J.B., Volkmann K.R., Lockwood P.E., Messer R.L., and Bouillaguet S. Sublethal concentrations of Au (III), Pd (II), and Ni(II) differentially alter inflammatory cytokine secretion from activated monocytes. J. Biomed. Mater. Res. B. Appl. Biomater. 69 (2004) 11-17
64. Werner C., and Engelhard K. Pathophysiology of traumatic brain injury. Br. J. Anaesth. 99 (2007) 4-9
65. Wilkie D.A., and Gemensky-Metzler A.J. Agents for intraocular surgery. Vet. Clin. North. Am. Small Anim. Pract. 34 (2004) 801-823
66. Yamashita M., Ashino S., Oshima Y., Kawamura S., Ohuchi K., and Takayanagi M. Inhibition of TPA-induced NF-kappaB nuclear translocation and production of NO and PGE2 by the anti-rheumatic gold compounds. J. Pharm. Pharmacol. 55 (2003) 245-251
67. Yang J.P., Merin J.P., Nakano T., Kato T., Kitade Y., and Okamoto T. Inhibition of the DNA-binding activity of NF-kappa B by gold compounds in vitro. FEBS Lett. 361 (1995) 89-96
68. Yoshida S.-i., Kato T., Sakurada S., Kurono C., Yang J.-P., Matsui N., Soji T., and Okamato T. Inhibition of IL-6 and IL-8 induction from cultured rheumatoid synovial fibroblasts by treatment with aurothioglucose. Int. Immunol. 11 (1999) 151-158
69. Zhang C.X., and Lippard S.J. New metal complexes as potential therapeutics. Curr. Opin. Chem. Biol. 7 (2003) 481-489