Disruption of iron homeostasis and lung disease

Biochimica et Biophysica Acta - General Subjects

Volumn 1790, Issue 7, 2009, Pages 731-739

  Ghio, Andrew J ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Divalent metal transporter 1; Ferritin; Oxidative stress; Transferrin; Transferrin receptor

Indexed keywords

BLEOMYCIN; CYTOCHROME B; FERRITIN; FERROPORTIN 1; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PARAQUAT;

ACUTE DISEASE; CHRONIC DISEASE; CIGARETTE SMOKING; CYSTIC FIBROSIS; DUST; GASTROINTESTINAL TRACT; HOMEOSTASIS; HUMAN; IRON TRANSPORT; ISCHEMIA; LUNG ALVEOLUS PROTEINOSIS; LUNG DISEASE; LUNG INFECTION; LUNG TRANSPLANTATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION INJURY; RESPIRATORY DISTRESS SYNDROME; RETICULOENDOTHELIAL SYSTEM; REVIEW; TRANSFUSION RELATED ACUTE LUNG INJURY;

ACUTE LUNG INJURY; ANIMALS; CATION TRANSPORT PROTEINS; ENTEROCYTES; EPITHELIAL CELLS; FERRITINS; HOMEOSTASIS; HUMANS; IRON; LUNG DISEASES; LUNG INJURY; OXIDATIVE STRESS;

EID: 67349136495     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2008.11.004     Document Type: Review

References (71)

1. Crichton R.R., and Ward R.J. An overview of iron metabolism: molecular and cellular criteria for the selection of iron chelators. Curr. Med. Chem. 10 (2003) 997-1004
2. McKie A.T., Barrow D., Latunde-Dada G.O., Rolfs A., Sager G., Mudaly E., Mudaly M., Richardson C., Barlow D., Bomford A., Peters T.J., Raja K.B., Shirali S., Hediger M.A., Farzaneh F., and Simpson R.J. An iron-regulated ferric reductase associated with the absorption of dietary iron. Science 291 (2001) 1755-1759
3. Latunde-Dada G.O., Van der Westhuizen J., Vulpe C.D., Anderson G.J., Simpson R.J., and McKie A.T. Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism. Blood Cells Mol. Dis. 29 (2002) 356-360
4. Wood R.J., and Han O. Recently identified molecular aspects of intestinal iron absorption. J. Nutr. 128 (1998) 1841-1844
5. Vidal S.M., Malo D., Vogan K., Skamene E., and Gros P. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 73 (1993) 469-485
6. Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., Nussberger S., Gollan J.L., and Hediger M.A. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 (1997) 482-488
7. Mackenzie B., Takanaga H., Hubert N., Rolfs A., and Hediger M.A. Functional properties of multiple isoforms of human divalent metal-ion transporter 1 (DMT1). Biochem. J. 403 (2007) 59-69
8. Leibold E.A., and Guo B. Iron-dependent regulation of ferritin and transferrin receptor expression by the iron-responsive element binding protein. Annu. Rev. Nutr. 12 (1992) 345-368
9. Gunshin H., Allerson C.R., Polycarpou-Schwarz M., Rofts A., Rogers J.T., Kishi F., Hentze M.W., Rouault T.A., Andrews N.C., and Hediger M.A. Iron-dependent regulation of the divalent metal ion transporter. FEBS Lett. 509 (2001) 309-316
10. De Domenico I., Vaughn M.B., Yoon D., Kushner J.P., Ward D.M., and Kaplan J. Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations. Blood 110 (2007) 3780-3783
11. Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., Ganz T., and Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306 (2004) 2090-2093
12. Pietrangelo A. The ferroportin disease. Blood Cells Mol. Dis. 32 (2004) 131-138
13. Huebers H.A., and Finch C.A. The physiology of transferrin and transferrin receptors. Physiol. Rev. 67 (1987) 520-582
14. Knutson M.D. Steap proteins: implications for iron and copper metabolism. Nutr. Rev. 65 (2007) 335-340
15. Frazer D.M., and Anderson G.J. The orchestration of body iron intake: how and where do enterocytes receive their cues?. Blood Cells Mol. Dis. 30 (2003) 288-297
16. Nicolas G., Bennoun M., Devaux I., Beaumont C., Grandchamp B., Kahn A., and Vaulont S. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 8780-8785
17. Pigeon C., Ilyin G., Courselaud B., Leroyer P., Turlin B., Brissot P., and Loreal O. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276 (2001) 7811-7819
18. Schroeder W.H., Dobson M., Kane D.M., and Johnson N.D. Toxic trace elements associated with airborne particulate matter: a review. Japca 37 (1987) 1267-1285
19. Cozzi A., Santambrogio P., Levi S., and Arosio P. Iron detoxifying activity of ferritin. Effects of H and L human apoferritins on lipid peroxidation in vitro. FEBS Lett. 277 (1990) 119-122
20. Ghio A.J., Carter J.D., Richards J.H., Brighton L.E., Lay J.C., and Devlin R.B. Disruption of normal iron homeostasis after bronchial instillation of an iron-containing particle. Am. J. Physiol. 274 (1998) L396-L403
21. Wang X., Ghio A.J., Yang F., Dolan K.G., Garrick M.D., and Piantadosi C.A. Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 282 (2002) L987-L995
22. Breuer W., Greenberg E., and Cabantchik Z.I. Newly delivered transferrin iron and oxidative cell injury. FEBS Lett. 403 (1997) 213-219
23. Trinder D., Oates P.S., Thomas C., Sadleir J., and Morgan E.H. Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload. Gut 46 (2000) 270-276
24. Turi J.L., Wang X., McKie A.T., Nozik-Grayck E., Mamo L.B., Crissman K., Piantadosi C.A., and Ghio A.J. Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells. Am. J. Physiol. Lung Cell Mol. Physiol. 291 (2006) L272-L280
25. Buckhout T.J., Bell P.F., Luster D.G., and Chaney R.L. Iron-stress induced redox activity in tomato (Lycopersicum esculentum Mill.) is localized on the plasma membrane. Plant Physiol. 90 (1989) 151-156
26. Bienfait H.F. Regulated redox processes at the plasmalemma of plant root cells and their function in iron uptake. J. Bioenerg. Biomembr. 17 (1985) 73-83
27. Cakmak I., van de Wetering D.A., Marschner H., and Bienfait H.F. Involvement of superoxide radical in extracellular ferric reduction by iron-deficient bean roots. Plant Physiol. 85 (1987) 310-314
28. Ghio A.J., Nozik-Grayck E., Turi J., Jaspers I., Mercatante D.R., Kole R., and Piantadosi C.A. Superoxide-dependent iron uptake: a new role for anion exchange protein 2. Am. J. Respir. Cell Mol. Biol. 29 (2003) 653-660
29. Yang F., Wang X., Haile D.J., Piantadosi C.A., and Ghio A.J. Iron increases expression of iron-export protein MTP1 in lung cells. Am. J. Physiol., Lung Cell. Mol. Physiol. 283 (2002) L932-L939
30. Yang F., Haile D.J., Wang X., Dailey L.A., Stonehuerner J.G., and Ghio A.J. Apical location of ferroportin 1 in airway epithelia and its role in iron detoxification in the lung. Am. J. Physiol., Lung Cell. Mol. Physiol. 289 (2005) L14-L23
31. Skamene E. The Bcg gene story. Immunobiology 191 (1994) 451-460
32. Cartwright G.E., and Lee G.R. The anaemia of chronic disorders. Br. J. Haematol. 21 (1971) 147-152
33. Oppenheimer S.J. Iron and its relation to immunity and infectious disease. J. Nutr. 131 (2001) 616S-633S discussion 633S-635S
34. Fischbach M.A., Lin H., Liu D.R., and Walsh C.T. How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nat. Chem. Biol. 2 (2006) 132-138
35. Grigoriu B., Jacobs F., Beuzen F., El Khoury R., Axler O., Brivet F.G., and Capron F. Bronchoalveolar lavage cytological alveolar damage in patients with severe pneumonia. Crit. Care 10 (2006) R2
36. McDermid J.M., and Prentice A.M. Iron and infection: effects of host iron status and the iron-regulatory genes haptoglobin and NRAMP1 (SLC11A1) on host-pathogen interactions in tuberculosis and HIV. Clin. Sci. (Lond) 110 (2006) 503-524
37. Canonne-Hergaux F., Gruenheid S., Govoni G., and Gros P. The Nramp1 protein and its role in resistance to infection and macrophage function. Proc. Assoc. Am. Physicians 111 (1999) 283-289
38. Sharkey R.A., Donnelly S.C., Connelly K.G., Robertson C.E., Haslett C., and Repine J.E. Initial serum ferritin levels in patients with multiple trauma and the subsequent development of acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 159 (1999) 1506-1509
39. Connelly K.G., Moss M., Parsons P.E., Moore E.E., Moore F.A., Giclas P.C., Seligman P.A., and Repine J.E. Serum ferritin as a predictor of the acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 155 (1997) 21-25
40. Gutteridge J.M., Mumby S., Quinlan G.J., Chung K.F., and Evans T.W. Pro-oxidant iron is present in human pulmonary epithelial lining fluid: implications for oxidative stress in the lung. Biochem. Biophys. Res. Commun. 220 (1996) 1024-1027
41. Ghio A.J., Carter J.D., Richards J.H., Richer L.D., Grissom C.K., and Elstad M.R. Iron and iron-related proteins in the lower respiratory tract of patients with acute respiratory distress syndrome. Crit. Care Med. 31 (2003) 395-400
42. Cherry T., Steciuk M., Reddy V.V., and Marques M.B. Transfusion-related acute lung injury: past, present, and future. Am. J. Clin. Pathol. 129 (2008) 287-297
43. Livrea M.A., Tesoriere L., Pintaudi A.M., Calabrese A., Maggio A., Freisleben H.J., D'Arpa D., D'Anna R., and Bongiorno A. Oxidative stress and antioxidant status in beta-thalassemia major: iron overload and depletion of lipid-soluble antioxidants. Blood 88 (1996) 3608-3614
44. Jenkins Z.A., Hagar W., Bowlus C.L., Johansson H.E., Harmatz P., Vichinsky E.P., and Theil E.C. Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression. Pediatr. Hematol. Oncol. 24 (2007) 237-243
45. Dani C., Martelli E., Bertini G., Pezzati M., Rossetti M., Buonocore G., Paffetti P., and Rubaltelli F.F. Effect of blood transfusions on oxidative stress in preterm infants. Arch. Dis. Child. Fetal Neonatal Ed. 89 (2004) F408-F411
46. Kirschner R.E., and Fantini G.A. Role of iron and oxygen-derived free radicals in ischemia-reperfusion injury. J. Am. Coll. Surg. 179 (1994) 103-117
47. Green C.J., Gower J.D., Healing G., Cotterill L.A., Fuller B.J., and Simpkin S. The importance of iron, calcium and free radicals in reperfusion injury: an overview of studies in ischaemic rabbit kidneys. Free Radic. Res. Commun. 7 (1989) 255-264
48. Ghio A.J., Churg A., and Roggli V.L. Ferruginous bodies: implications in the mechanism of fiber and particle toxicity. Toxicol. Pathol. 32 (2004) 643-649
49. Wang X., Wu Y., Stonehuerner J.G., Dailey L.A., Richards J.D., Jaspers I., Piantadosi C.A., and Ghio A.J. Oxidant generation promotes iron sequestration in BEAS-2B cells exposed to asbestos. Am. J. Respir. Cell Mol. Biol. 34 (2006) 286-292
50. Prockop D.J. Role of iron in the synthesis of collagen in connective tissue. Fed. Proc. 30 (1971) 984-990
51. Clejan L., and Cederbaum A.I. Synergistic interactions between NADPH-cytochrome P-450 reductase, paraquat, and iron in the generation of active oxygen radicals. Biochem. Pharmacol. 38 (1989) 1779-1786
52. Ayaki H., Lee M.J., Sumino K., and Nishio H. Different cytoprotective effect of antioxidants and change in the iron regulatory system in rodent cells exposed to paraquat or formaldehyde. Toxicology 208 (2005) 73-79
53. Fernandez Y., Anglade F., and Mitjavila S. Potentiation of iron-induced lipid peroxidation by a series of bipyridyls in relation to their ability to reduce iron. Toxicol. Lett. 93 (1997) 65-71
54. Suntres Z.E. Role of antioxidants in paraquat toxicity. Toxicology 180 (2002) 65-77
55. Durken M., Herrnring C., Finckh B., Nagel S., Nielsen P., Fischer R., Berger H.M., Moison R.M., Pichlmeier U., Kohlschutter B., Zander A.R., and Kohlschutter A. Impaired plasma antioxidative defense and increased nontransferrin-bound iron during high-dose chemotherapy and radiochemotherapy preceding bone marrow transplantation. Free Radic. Biol. Med. 28 (2000) 887-894
56. Gordon L.I., Brown S.G., Tallman M.S., Rademaker A.W., Weitzman S.A., Lazarus H.M., Kelley C.H., Mangan C., Rubin H., Fox R.M., et al. Sequential changes in serum iron and ferritin in patients undergoing high-dose chemotherapy and radiation with autologous bone marrow transplantation: possible implications for treatment related toxicity. Free Radic. Biol. Med. 18 (1995) 383-389
57. Seymour J.F., and Presneill J.J. Pulmonary alveolar proteinosis: progress in the first 44 years. Am. J. Respir. Crit. Care Med. 166 (2002) 215-235
58. Witty L.A., Tapson V.F., and Piantadosi C.A. Isolation of mycobacteria in patients with pulmonary alveolar proteinosis. Medicine (Baltimore) 73 (1994) 103-109
59. Matulionis D.H., Kimmel E., and Diamond L. Morphologic and physiologic response of lungs to steroid and cigarette smoke: an animal model. Environ. Res. 36 (1985) 298-313
60. Ghio A.J., Stonehuerner J.G., Richards J.H., Crissman K.M., Roggli V.L., Piantadosi C.A., and Carraway M.S. Iron homeostasis and oxidative stress in idiopathic pulmonary alveolar proteinosis: a case-control study. Respir. Res. 9 (2008) 10
61. Baz M.A., Ghio A.J., Roggli V.L., Tapson V.F., and Piantadosi C.A. Iron accumulation in lung allografts after transplantation. Chest 112 (1997) 435-439
62. Pugh C., Hathwar V., Richards J.H., Stonehuerner J., and Ghio A.J. Disruption of iron homeostasis in the lungs of transplant patients. J. Heart Lung Transplant. 24 (2005) 1821-1827
63. Thompson A.B., Bohling T., Heires A., Linder J., and Rennard S.I. Lower respiratory tract iron burden is increased in association with cigarette smoking. J. Lab. Clin. Med. 117 (1991) 493-499
64. Ghio A.J., Stonehuerner J., and Quigley D.R. Humic-like substances in cigarette smoke condensate and lung tissue of smokers. Am. J. Physiol. 266 (1994) L382-L388
65. Stites S.W., Plautz M.W., Bailey K., O'Brien-Ladner A.R., and Wesselius L.J. Increased concentrations of iron and isoferritins in the lower respiratory tract of patients with stable cystic fibrosis. Am. J. Respir. Crit. Care Med. 160 (1999) 796-801
66. Reid D.W., Lam Q.T., Schneider H., and Walters E.H. Airway iron and iron-regulatory cytokines in cystic fibrosis. Eur. Respir. J. 24 (2004) 286-291
67. Reid D.W., Carroll V., O'May C., Champion A., and Kirov S.M. Increased airway iron as a potential factor in the persistence of Pseudomonas aeruginosa infection in cystic fibrosis. Eur. Respir. J. 30 (2007) 286-292
68. Kadiiska M.B., Mason R.P., Dreher K.L., Costa D.L., and Ghio A.J. In vivo evidence of free radical formation in the rat lung after exposure to an emission source air pollution particle. Chem. Res. Toxicol. 10 (1997) 1104-1108
69. Ghio A.J., Turi J.L., Madden M.C., Dailey L.A., Richards J.D., Stonehuerner J.G., Morgan D.L., Singleton S., Garrick L.M., and Garrick M.D. Lung injury after ozone exposure is iron dependent. Am. J. Physiol. Lung Cell. Mol. Physiol. 292 (2007) L134-L143
70. Ghio A.J., Jaskot R.H., and Hatch G.E. Lung injury after silica instillation is associated with an accumulation of iron in rats. Am. J. Physiol. 267 (1994) L686-L692
71. Louie S., Arata M.A., Offerdahl S.D., and Halliwell B. Effect of tracheal insufflation of deferoxamine on acute ozone toxicity in rats. J. Lab. Clin. Med. 121 (1993) 502-509