Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations

Blood

Volumn 110, Issue 10, 2007, Pages 3780-3783

  De Domenico, Ivana ^a   Vaughn, Michael B ^a   Yoon, Donghoon ^a   Kushner, James P ^a   Ward, Diane M ^a   Kaplan, Jerry ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; COMPLEMENTARY DNA; HEPCIDIN; MUTANT PROTEIN; PROTEIN FERROPORTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CONTROLLED STUDY; DISEASE SEVERITY; EMBRYO DEVELOPMENT; ERYTHROPOIESIS; GENE MUTATION; HEMOCHROMATOSIS; IRON OVERLOAD; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; ZEBRA FISH;

EID: 36349020323     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-07-100248     Document Type: Article

References (18)

1. De Domenico I, Ward DM, Musci G, Kaplan J. Evidence for the multimeric structure of ferroportin. Blood. 2007;109:2205-2209.
2. Pietrangelo A. The ferroportin disease. Blood Cells Mol Dis. 2004;32:131-138.
3. De Domenico I, McVey Ward D, Nemeth E, et al. Molecular and clinical correlates in iron overload associated with mutations in ferroportin. Haematologica. 2006;91:1092-1095.
4. Drakesmith H, Schimanski LM, Ormerod E, et al. Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin. Blood. 2005;106:1092-1097.
5. Schimanski LM, Drakesmith H, Merryweather-Clarke AT, et al. In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations. Blood. 2005;105:4096-4102.
6. De Domenico I, Ward DM, Nemeth E, et al. The molecular basis of ferroportin-linked hemochromatosis. Proc Natl Acad Sci U S A. 2005;102:8955-8960.
7. Liu XB, Yang F, Haile DJ. Functional consequences of ferroportin 1 mutations. Blood Cells Mol Dis. 2005;35:33-46.
8. Zohn IE, De Domenico I, Pollock A, et al. The flat-iron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease. Blood. 2007;109:4174-4180.
9. Pietrangelo A, Montosi G, Totaro A, et al. Hereditary hemochromatosis in adults without pathogenic mutations in the hemochromatosis gene. N Engl J Med. 1999;341:725-732.
10. Westerfield M. The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Brachydanio rerio). Eugene, OR: University of Oregon Press; 1993.
11. Detrich HW 3rd, Kieran MW, Chan FY, et al. Intraembryonic hematopoietic cell migration during vertebrate development. Proc Natl Acad Sci U S A. 1995;92:10713-10717.
12. Brownlie A, Donovan A, Pratt SJ, et al. Positional cloning of the zebrafish sauternes gene: a model for congenital sideroblastic anaemia. Nat Genet. 1998;20:244-250.
13. Graham RC Jr, Karnovsky MJ. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. J Histochem Cytochem. 1966;14:291-302.
14. Donovan A, Brownlie A, Zhou Y, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000;403:776-781.
15. Donovan A, Brownlie A, Dorschner MO, et al. The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1). Blood. 2002;100:4655-4659.
16. Brown JE, Theil EC. Red cells, ferritin, and iron storage during amphibian development. J Biol Chem. 1978;253:2673-2678.
17. Fraenkel PG, Traver D, Donovan A, et al. Ferroportin I is required for normal iron cycling in zebrafish. J. Clin Inv. 2005;115:1532-1541.
18. Donovan A, Lima CA, Pinkus JL, et al. The iron exporter ferroportin/Slc40al is essential for iron homeostasis. Cell Metab. 2005;1:191-200.