Fluvastatin attenuates IGF-1-induced ERK1/2 activation and cell proliferation by mevalonic acid depletion in human mesangial cells

Life Sciences

Volumn 84, Issue 21-22, 2009, Pages 725-731

  Shibata, Tatsuya ^a,b   Tamura, Masahito ^b   Kabashima, Narutoshi ^b   Serino, Ryota ^a   Tokunaga, Masaki ^b   Matsumoto, Mika ^a   Miyamoto, Tetsu ^a   Miyazaki, Mieko ^a   Furuno, Yumi ^a   Takeuchi, Masaaki ^a   Abe, Haruhiko ^a   Okazaki, Masahiro ^a   Otsuji, Yutaka ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b School of Medicine   (Japan)

Author keywords

Cell proliferation; Glomerular disease; HMG CoA reductase inhibitor (statin); Insulin like growth factor 1; MAP kinase; Mesangial cells

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CYCLIN D1; FLUINDOSTATIN; MEVALONIC ACID; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; SOMATOMEDIN C;

ARTICLE; ATTENUATION; CELL CULTURE; CELL PROLIFERATION; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; MESANGIUM CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RENAL PROTECTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL PROLIFERATION; FATTY ACIDS, MONOUNSATURATED; FLAVONOIDS; GLOMERULAR MESANGIUM; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INDOLES; INSULIN-LIKE GROWTH FACTOR I; MEVALONIC ACID; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 67349100516     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2009.02.022     Document Type: Article

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