A WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions

Nucleic Acids Research

Volumn 37, Issue 10, 2009, Pages 3301-3309

  Maitra, Radhashree ^a   Sadofsky, Moshe J ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID MODULATORY ELEMENT BINDING PROTEIN 1; KARYOPHERIN ALPHA; LUCIFERASE; RAG1 PROTEIN; SPLICING FACTOR 3A2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE MAPPING; PHYLOGENY; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DETERMINATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; TWO HYBRID SYSTEM;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; HOMEODOMAIN PROTEINS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; SEQUENCE ALIGNMENT; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 67249100650     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkp192     Document Type: Article

References (41)

1. Gellert,M. (1992) Molecular analysis of V(D)J recombination. Ann. Rev. Genet., 22, 425-446.
2. Lewis,S.M. (1994) The mechanism of V(D)J joining: Lessons from molecular, immunological, and comparative analyses. Adv Immunol., 56, 27-150.
3. Schatz,D.G., Oettinger,M.A. and Baltimore,D. (1989) The V(D)J recombination activating gene, RAG-1. Cell, 59, 1035-1048.
4. Oettinger,M.A., Schatz,D.G., Gorka,C. and Baltimore,D. (1990) RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science, 248, 1517-1523.
5. Fugmann,S.D., Lee,A.I., Shockett,P.E., Villey,I.J. and Schatz,D.G. (2000) The RAG proteins and V(D)J recombination: Complexes, ends, and transposition. Annu. Rev. Immunol., 18, 495-527.
6. Sadofsky,M.J. (2001) The RAG proteins in V(D)J recombination: More than just a nuclease. Nucleic Acids Res., 29, 1399-1409.
7. Sadofsky,M.J., Hesse,J.E., McBlane,J.F. and Gellert,M. (1993) Expression and V(D)J recombination activity of mutated RAG-1 proteins. Nucleic Acids Res., 21, 5644-5650.
8. Silver,D.P., Spanopoulou,E., Mulligan,R.C. and Baltimore,D. (1993) Dispensable sequence motifs in the RAG-1 and RAG-2 genes for plasmid V(D)J recombination. Proc. Natl Acad. Sci. USA, 90, 6100-6104.
9. Kirch,S.A., Sudarsanam,P. and Oettinger,M.A. (1996) Regions of RAG1 protein critical for V(D)J recombination. Eur. J. Immunol., 26 886-891.
10. Lorick,K.L., Jensen,J.P., Fang,S., Ong,A.M., Hatakeyama,S. and Weissman,A.M. (1999) RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc. Natl Acad. Sci. USA, 96 11364-11369.
11. Yurchenko,V., Xue,Z. and Sadofsky,M. (2003) The RAG1 N-terminal domain is an E3 ubiquitin ligase. Genes Dev., 17, 581-585.
12. Jones,J.M. and Gellert,M. (2003) Autoubiquitylation of the V(D)J recombinase protein RAG1. Proc. Natl Acad. Sci. USA, 100, 15446-15451.
13. Kapitonov,V.V. and Jurka,J. (2005) RAG1 core and V(D)J recombination signal sequences were derived from Transib transposons. PLoS Biol. 3, e181.
14. Dudley,D.D., Sekiguchi,J., Zhu,C., Sadofsky,M.J., Whitlow,S., DeVido,J., Monroe,R.J., Bassing,C.H. and Alt,F.W. (2003) Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice. J. Exp. Med., 198, 1439-1450.
15. -/-) B cells reveals a requirement for novel elements in the N-terminus of RAG-1. Immunity, 7, 13-24.
16. McMahan,C.J., Difilippantonio,M.J., Rao,N., Spanopoulou,E. and Schatz,D.G. (1997) A basic motif in the N-terminal region of RAG1 enhances V(D)J recombination activity. Mol. Cell Biol., 17, 4544-4552.
17. Cuomo,C.A., Kirch,S.A., Gyuris,J., Brent,R. and Oettinger,M.A. (1994) Rch1, a protein that specifically interacts with the RAG-1 recombination-activating protein. Proc. Natl Acad. Sci. USA, 91 6156-6160.
18. Cortes,P., Ye,Z.S. and Baltimore,D. (1994) RAG-1 interacts with the repeated amino acid motif of the human homologue of the yeast protein SRP1. Proc. Natl Acad. Sci. USA, 91, 7633-7637.
19. Spanopoulou,E., Cortes,P., Shih,C., Huang,C.M., Silver,D.P., Svec,P. and Baltimore,D. (1995) Localization, interaction, and RNA-binding properties of the V(D)J recombination-activating proteins Rag1 and Rag2. Immunity, 3, 715-726.
20. Fields,S. and Song,O.-K. (1989) A novel genetic system to detect protein-protein interactions. Nature, 340, 245-246.
21. Chen,J., He,Y. and Simons,S.S. Jr. (2004) Structure/activity relationships for GMEB-2: The second member of the glucocorticoid modulatory element-binding complex. Biochemistry, 43, 245-255.
22. Difilippantonio,M.J., McMahan,C.J., Eastman,Q.M., Spanopoulou,E. and Schatz,D.G. (1996) RAG1 mediates signal sequence recognition and recruitment of RAG2 in V(D)J recombination. Cell, 87, 253-262.
23. Yurchenko,V., Xue,Z. and Sadofsky,M.J. (2006) SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair. Mol. Cell Biol., 26, 1786-1794.
24. Altschul,S.F., Madden,T.L., Schaffer,A.A., Zhang,J., Zhang,Z., Miller,W. and Lipman,D.J. (1997) Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res., 25, 3389-3402.
25. Landree,M.A., Wibbenmeyer,J.A. and Roth,D.B. (1999) Mutational analysis of RAG1 and RAG2 identifies three catalytic amino acids in RAG1 critical for both cleavage steps of V(D)J recombination. Genes Dev., 13 3059-3069.
26. Kim,D.R., Dai,Y., Mundy,C.L., Yang,W. and Oettinger,M.A. (1999) Mutations of acidic residues in RAG1 define the active site of the V(D)J recombinase. Genes Dev., 13, 3070-3080.
27. Liu,Y., Subrahmanyam,R., Chakraborty,T., Sen,R. and Desiderio,S. (2007) A plant homeodomain in RAG-2 that binds hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement. Immunity, 27, 561-571.
28. Matthews,A.G., Kuo,A.J., Ramon-Maiques,S., Han,S., Champagne,K.S., Ivanov,D., Gallardo,M., Carney,D., Cheung,P., Ciccone,D.N. et al. (2007) RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature, 450, 1106-1110.
29. Ramon-Maiques,S., Kuo,A.J., Carney,D., Matthews,A.G., Oettinger,M.A., Gozani,O. and Yang,W. (2007) The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Proc. Natl Acad. Sci. USA, 104, 18993-18998.
30. Kaul,S., Blackford,J.A. Jr, Chen,J., Ogryzko,V.V. and Simons,S.S. Jr. (2000) Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: Potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins. Mol. Endocrinol., 14, 1010-1027.
31. Christensen,J., Cotmore,S.F. and Tattersall,P. (2001) Minute virus of mice initiator protein NS1 and a host KDWK family transcription factor must form a precise ternary complex with origin DNA for nicking to occur. J. Virol., 75, 7009-7017.
32. Glickman,M.H. and Raveh,D. (2005) Proteasome plasticity. FEBS Lett. 579, 3214-3223.
33. Kajava,A.V., Gorbea,C., Ortega,J., Rechsteiner,M. and Steven,A.C. (2004) New HEAT-like repeat motifs in proteins regulating proteasome structure and function. J. Struct. Biol., 146, 425-430.
34. Takenaka,K., Nakagawa,H., Miyamoto,S. and Miki,H. (2004) The pre-mRNA-splicing factor SF3a66 functions as a microtubulebinding and -bundling protein. Biochem. J., 382, 223-230.
35. Gringel,S., van Bergeijk,J., Haastert,K., Grothe,C. and Claus,P. (2004) Nuclear fibroblast growth factor-2 interacts specifically with splicing factor SF3a66. Biol. Chem., 385, 1203-1208.
36. Burnett,E., Christensen,J. and Tattersall,P. (2001) A consensus DNA recognition motif for two KDWK transcription factors identifies flexible-length, CpG-methylation sensitive cognate binding sites in the majority of human promoters. J. Mol. Biol., 314, 1029-1039.
37. McElhinny,A.S., Kakinuma,K., Sorimachi,H., Labeit,S. and Gregorio,C.C. (2002) Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. J. Cell Biol., 157, 125-136.
38. Kaul,S., Blackford,J.A. Jr, Cho,S. and Simons,S.S. Jr. (2002) Ubc9 is a novel modulator of the induction properties of glucocorticoid receptors. J. Biol. Chem., 277, 12541-12549.
39. Nakagawa,T., Tsuruma,K., Uehara,T. and Nomura,Y. (2008) GMEB1, a novel endogenous caspase inhibitor, prevents hypoxiaand oxidative stress-induced neuronal apoptosis. Neurosci Lett, 438, 34-37.
40. Marchler-Bauer,A., Anderson,J.B., Derbyshire,M.K., DeWeese-Scott,C., Gonzales,N.R., Gwadz,M., Hao,L., He,S., Hurwitz,D.I., Jackson,J.D. et al. (2007) CDD: A conserved domain database for interactive domain family analysis. Nucleic Acids Res., 35, D237-D240.
41. Sudol,M. (2005) In Cesareni,G., Gimona,M., Sudol,M. and Yaffe,M. (eds), Modular Protein Domains. Wiley-VCH Verlag GmbH, Weinheim, FRG, pp. 59-72.