Gram-positive bacteria enhance HIV-1 susceptibility in Langerhans cells, but not in dendritic cells, via Toll-like receptor activation

Blood

Volumn 113, Issue 21, 2009, Pages 5157-5166

  Ogawa, Youichi ^a   Kawamura, Tatsuyoshi ^a   Kimura, Tetsuya ^b   Ito, Masahiko ^a   Blauvelt, Andrew ^c   Shimada, Shinji ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

^c PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; APOBEC3G PROTEIN, HUMAN; CYTIDINE DEAMINASE;

ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DENDRITIC CELL; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RISK; INFECTION SENSITIVITY; LANGERHANS CELL; PRIORITY JOURNAL; SEXUAL TRANSMISSION; SEXUALLY TRANSMITTED DISEASE; SKIN; CYTOLOGY; DISEASE PREDISPOSITION; DOWN REGULATION; DRUG POTENTIATION; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; VIROLOGY;

CYTIDINE DEAMINASE; DENDRITIC CELLS; DISEASE SUSCEPTIBILITY; DOWN-REGULATION; GRAM-POSITIVE BACTERIA; HIV INFECTIONS; HUMANS; IMMUNITY, INNATE; LANGERHANS CELLS; NOD SIGNALING ADAPTOR PROTEINS; SEXUALLY TRANSMITTED DISEASES; SKIN; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTORS;

EID: 67149083318     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-10-185728     Document Type: Article

References (50)

1. Galvin SR, Cohen MS. The role of sexually transmitted diseases in HIV transmission. Nat Rev Microbiol. 2004;2:33-42. (Pubitemid 39490046)
2. Fleming DT, Wasserheit JN. From epidemiological synergy to public health policy and practice: the contribution of other sexually transmitted diseases to sexual transmission of HIV infection. Sex Transm Infect. 1999;75:3-17.
3. Sewankambo N, Gray RH, Wawer MJ, et al. HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis. Lancet. 1997;350:546-550. (Pubitemid 27348430)
4. Taha TE, Hoover DR, Dallabetta GA, et al. Bacterial vaginosis and disturbances of vaginal flora: association with increased acquisition of HIV. AIDS. 1998;12:1699-1706.
5. McNabb SJ, Jajosky RA, Hall-Baker PA, et al. Summary of notifiable diseases - United States, 2006. Morbid Mortal Wkly Rep. 2008;55:1-92.
6. Martin HL, Jr., Nyange PM, Richardson BA, et al. Hormonal contraception, sexually transmitted diseases, and risk of heterosexual transmission of human immunodeficiency virus type 1. J Infect Dis. 1998;178:1053-1059. (Pubitemid 28452198)
7. Miller CJ, Shattock RJ. Target cells in vaginal HIV transmission. Microb Infect. 2003;5:59-67.
8. Lederman MM, Offord RE, Hartley O. Microbicides and other topical strategies to prevent vaginal transmission of HIV. Nat Rev Immunol. 2006;6:371-382.
9. Shattock RJ, Moore JP. Inhibiting sexual transmission of HIV-1 infection. Nat Rev Microbiol. 2003;1:25-34.
10. Kawamura T, Kurtz SE, Blauvelt A, Shimada S. The role of Langerhans cells in the sexual transmission of HIV. J Dermatol Sci. 2005;40:147-155. (Pubitemid 41728962)
11. Kawamura T, Cohen SS, Borris DL, et al. Candidate microbicides block HIV-1 infection of human immature Langerhans cells within epithelial tissue explants. J Exp Med. 2000;192:1491-1500. (Pubitemid 30953886)
12. Reece JC, Handley AJ, Anstee EJ, Morrison WA, Crowe SM, Cameron PU. HIV-1 selection by epidermal dendritic cells during transmission across human skin. J Exp Med. 1998;187:1623-1631. (Pubitemid 28235103)
13. Zaitseva M, Blauvelt A, Lee S, et al. Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection. Nat Med. 1997;3:1369-1375. (Pubitemid 28011037)
14. Kawamura T, Koyanagi Y, Nakamura Y, et al. Significant virus replication in Langerhans cells following application of HIV to abraded skin: relevance to occupational transmission of HIV. J Immunol. 2008;180:3297-3304.
15. Zhu T, Mo H, Wang N, et al. Genotypic and phenotypic characterization of HIV-1 patients with primary infection. Science. 1993;261:1179-1181. (Pubitemid 23300886)
16. Liu R, Paxton WA, Choe S, et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 1996;86:367-377. (Pubitemid 26272077)
17. Hu J, Gardner MB, Miller CJ. Simian immunodeficiency virus rapidly penetrates the cervicovaginal mucosa after intravaginal inoculation and infects intraepithelial dendritic cells. J Virol. 2000;74:6087-6095. (Pubitemid 30412980)
18. Geijtenbeek TB, Kwon DS, Torensma R, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell. 2000;100:587-597.
19. Granelli-Piperno A, Pritsker A, Pack M, et al. Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction. J Immunol. 2005;175:4265-4273. (Pubitemid 41361960)
20. Burleigh L, Lozach PY, Schiffer C, et al. Infection of dendritic cells (DCs), not DC-SIGN-mediated internalization of human immunodeficiency virus, is required for long-term transfer of virus to T cells. J Virol. 2006;80:2949-2957. (Pubitemid 43346390)
21. Turville SG, Cameron PU, Handley A, et al. Diversity of receptors binding HIV on dendritic cell subsets. Nat Immunol. 2002;3:975-983. (Pubitemid 35154012)
22. De Witte L, Nabatov A, Pion M, et al. Langerin is a natural barrier to HIV-1 transmission by Langerhans cells. Nat Med. 2007;13:367-371. (Pubitemid 46376681)
23. Lederman MM, Veazey RS, Offord R, et al. Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. Science. 2004;306:485-487. (Pubitemid 39372448)
24. Veazey RS, Klasse PJ, Schader SM, et al. Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion. Nature. 2005;438:99-102. (Pubitemid 41599827)
25. Trinchieri G, Sher A. Cooperation of Toll-like receptor signals in innate immune defense. Nat Rev Immunol. 2007;7:179-190. (Pubitemid 46310482)
26. Inohara N, Nunez G. NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol. 2003;3:371-382. (Pubitemid 37323197)
27. Mares D, Simoes JA, Novak RM, Spear GT. TLR2-mediated cell stimulation in bacterial vaginosis. J Reprod Immunol. 2008;77:91-99.
28. Zhang J, Li G, Bafica A, et al. Neisseria gonorrhoeae enhances infection of dendritic cells by HIV type 1. J Immunol. 2005;174:7995-8002.
29. Equils O, Salehi KK, Cornataeanu R, et al. Repeated lipopolysaccharide (LPS) exposure inhibits HIV replication in primary human macrophages. Microb Infect. 2006;8:2469-2476. (Pubitemid 44515147)
30. Sundstrom JB, Little DM, Villinger F, Ellis JE, Ansari AA. Signaling through Toll-like receptors triggers HIV-1 replication in latently infected mast cells. J Immunol. 2004;172:4391-4401. (Pubitemid 38375254)
31. Bafica A, Scanga CA, Schito ML, Hieny S, Sher A. Cutting edge: in vivo induction of integrated HIV-1 expression by mycobacteria is critically dependent on Toll-like receptor 2. J Immunol. 2003;171:1123-1127. (Pubitemid 36900038)
32. Kawamura T, Qualbani M, Thomas EK, Orenstein JM, Blauvelt A. Low levels of productive HIV infection in Langerhans cell-like dendritic cells differentiated in the presence of TGF-β1 and increased viral replication with CD40 ligand-induced maturation. Eur J Immunol. 2001;31:360-368. (Pubitemid 32166589)
33. Pion M, Granelli-Piperno A, Mangeat B, et al. APOBEC3G/3F mediates intrinsic resistance of monocyte-derived dendritic cells to HIV-1 infection. J Exp Med. 2006;203:2887-2893. (Pubitemid 46026166)
34. Peiser M, Wanner R, Kolde G. Human epidermal Langerhans cells differ from monocyte-derived Langerhans cells in CD80 expression and in secretion of IL-12 after CD40 cross-linking. J Leukocyte Biol. 2004;76:616-622. (Pubitemid 39129094)
35. Flacher V, Bouschbacher M, Verronese E, et al. Human Langerhans cells express a specific TLR profile and differentially respond to viruses and Gram-positive bacteria. J Immunol. 2006;177:7959-7967. (Pubitemid 44846312)
36. Borkowski TA, Letterio JJ, Farr AG, Udey MC. A role for endogenous transforming growth factor β1 in Langerhans cell biology: the skin of transforming growth factor β1 null mice is devoid of epidermal Langerhans cells. J Exp Med. 1996;184:2417-2422.
37. + cells differentiate into Langerhans cells. Nat Immunol. 2001;2:1151-1158.
38. Geissmann F, Prost C, Monnet JP, Dy M, Brousse N, Hermine O. Transforming growth factor β1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells. J Exp Med. 1998;187:961-966. (Pubitemid 28141669)
39. Takeuchi J, Watari E, Shinya E, et al. Down-regulation of Toll-like receptor expression in monocyte-derived Langerhans cell-like cells: implications of low-responsiveness to bacterial components in the epidermal Langerhans cells. Biochem Biophys Res Commun. 2003;306:674-679. (Pubitemid 37323815)
40. +T cell stimulatory capacity. J Leukocyte Biol. 2008;83:1118-1127.
41. Kawamura T, Gulden FO, Sugaya M, et al. R5 HIV productively infects Langerhans cells, and infection levels are regulated by compound CCR5 polymorphisms. Proc Natl Acad Sci U S A. 2003;100:8401-8406. (Pubitemid 36842557)
42. Van der Aar AM, Sylva-Steenland RM, Bos JD, Kapsenberg ML, de Jong EC, Teunissen MB. Loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition. J Immunol. 2007;178:1986-1990.
43. Sallusto F, Schaerli P, Loetscher P, et al. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur J Immunol. 1998;28:2760-2769. (Pubitemid 28425234)
44. Bieniasz PD. Intrinsic immunity: a front-line defense against viral attack. Nat Immunol. 2004;5:1109-1115.
45. Wahl SM, Greenwell-Wild T, Vazquez N. HIV accomplices and adversaries in macrophage infection. J Leukocyte Biol. 2006;80:973-983. (Pubitemid 44646303)
46. Renn CN, Sanchez DJ, Ochoa MT, et al. TLR activation of Langerhans cell-like dendritic cells triggers an antiviral immune response. J Immunol. 2006;177:298-305.
47. De Jong MA, de Witte L, Oudhoff MJ, Gringhuis SI, Gallay P, Geijtenbeek TB. TNF-α and TLR agonists increase susceptibility to HIV-1 transmission by human Langerhans cells ex vivo. J Clin Invest. 2008;118:3440-3452.
48. Darville T, O'Neill JM, Andrews CW Jr, Nagarajan UM, Stahl L, Ojcius DM. Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection. J Immunol. 2003;171:6187-6197. (Pubitemid 37467242)
49. Deva R, Shankaranarayanan P, Ciccoli R, Nigam S. Candida albicans induces selectively transcriptional activation of cyclooxygenase-2 in HeLa cells: pivotal roles of Toll-like receptors, p38 mitogen-activated protein kinase, and NF-κB. J Immunol. 2003;171:3047-3055.
50. Heimesaat MM, Fischer A, Siegmunel B, et al. Shift toward pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One. 2007;2:e662. (Pubitemid 351308764)