Dermal-resident CD14+ cells differentiate into Langerhans cells

Nature Immunology

Volumn 2, Issue 12, 2001, Pages 1151-1158

  Larregina, Adriana T ^a   Morelli, Adrian E ^b   Spencer, Lori A ^a   Logar, Alison J ^b   Watkins, Simon C ^b   Thomson, Angus W ^b   Falo Jr , Louis D ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CHEMOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 4; LANGERIN; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOLOGY; EPIDERMIS; GENETIC ENGINEERING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOPATHOLOGY; IMMUNOREGULATION; IMMUNOSTIMULATION; LANGERHANS CELL; PRIORITY JOURNAL; SKIN DISEASE; STEM CELL;

ANTIGENS; ANTIGENS, CD14; CELL DIFFERENTIATION; CELL DIVISION; CELLS, CULTURED; CHEMOKINES, CC; CHEMOTAXIS; CYTOKINES; DERMIS; ENDOCYTOSIS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LANGERHANS CELLS; LYMPHOCYTE ACTIVATION; MACROPHAGE INFLAMMATORY PROTEINS; RECEPTORS, CHEMOKINE; SKIN; STEM CELLS;

EID: 0035202722     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni731     Document Type: Article

References (41)

1. Dendritic cells and the control of the immunity
2. Langerhans cells require signals from both tumor necrosis factor α and IL-1β for migration
3. Localization of antigen in lymph node dendritic cells after exposure to the contact sensitizer fluorescein isothiocyanate
4. Migration and maturation of Langerhans cells in skin transplants and explants
5. Generating and regulating immune responses through cutaneous gene delivery
6. +) progenitor-derived dendritic cell vaccine
7. Langerin, a novel c-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules
8. Expression of monoclonal antibody HECA-452 defined E-selectin ligands on Langerhans cells in normal and diseased skin
9. An electronmicroscopy study of basal melanocytes and high level clear cells (Langerhans cells) in vitilligo
10. Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin
11. GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells
12. + hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF and TNF-α
13. + circulating hematopietic progenitors cells
14. + subset of human blood dendritic cells is a direct precursor of Langerhans cells
15. + hematopoietic progenitor cells
16. Flt3 ligand in cooperation with transforming growth factor-β1 potentiates in vitro development of Langerhans-type dendritic cells and allows single cell dendritic cell cluster formation under serum free conditions
17. Epidermal Langerhans cells development and differentiation
18. Transforming growth factor-β1, in the presence of Granulocyte/Macrophage Colony Stimulating Factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells
19. A role of endogenous transforming growth factor β1 in Langerhans cell biology: The skin of Transforming growth factor β1 null mice is devoid of epidermal Langerhans cells
20. A role of endogenous TGFβ1 in Langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFβ1 null mice
21. Macrophage inflammatory protein 3α is involved in the constitutive trafficking of epidermal Langerhans cells
22. Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functional distinctive subsets
23. Human and murine dermis contain dendritic cells. Isolation by means of a novel method and phenotypical and functional characterization
24. Both dendritic cells and memory T lymphocytes emigrate from organ cultures of human skin and form distinctive dendritic-T cell conjugates
25. Expression and modulation of C5a receptor (CD88) on skin dendritic cells. Chemotactic effect of C5a on skin migratory dendritic cells
26. s and CD36, and cross-present antigens to cytotoxic T lymphocytes
27. Immunochemical and immunocytochemical localization of S-100 antigen in normal human skin
28. Characterization of factor XIIIa positive dermal dendritic cells in normal and inflammed skin
29. A physiologic function for p-glycoprotein (MDR-I) during the migration of dendritic cells from skin via afferent lymphatic vessels
30. Phagocytosis of antigens by Langerhans cells in vitro
31. Quantitative evaluation of two distinct cell populations expressing HLA-DR antigens in normal human epidermis
32. A fresh morphological and functional look at dermal dendritic cells
33. Phenotypic transformation of macrophages to Langerhans cells in the skin
34. + Langerhans-like dendritic antigen-presenting cells are concomitantly depleted
35. + macrophages that infiltrate human epidermis after in vivo ultraviolet exposure potently produce IL-10 and represent the major secretory source of epidermal IL-10 protein
36. Dendritic cells in cutaneous lupus erythematosus: A clue to the pathogenesis of lesions
37. Expression of macrophage-associated antigens in tissues involved by Langerhans' cell histiocytosis (histiocytosis X)
38. TGF-β I promotes in vitro generation of dendritic cells by protecting progenitor cells from apoptosis
39. Pattern of cytokine receptors expressed by human dendritic cells migrated from dermal explants