Validation of cerebral blood perfusion imaging as a modality for quantitative pharmacological MRI in rats

Magnetic Resonance in Medicine

Volumn 61, Issue 6, 2009, Pages 1451-1458

  Bruns, Andreas ^a,b   Künnecke, Basil ^a   Risterucci, Céline ^a   Moreau, Jean Luc ^a   Von Kienlin, Markus ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Animal models; Arterial spin labeling; Cerebral perfusion; Pharmacological MRI; Psychostimulant

Indexed keywords

AMINES; ANESTHESIOLOGY; ANESTHETICS; ANIMALS; BLOOD; CHEMICAL ACTIVATION; DRUG DOSAGE; MAGNETIC RESONANCE IMAGING; NEUROPHYSIOLOGY;

ANIMAL MODEL; ARTERIAL SPIN LABELING; CENTRAL NERVOUS SYSTEMS; CEREBRAL PERFUSION; CONTINUOUS ARTERIAL SPIN LABELING; PSYCHOSTIMULANT; QUANTITATIVE IMAGING; QUANTITATIVE TECHNIQUES;

BRAIN;

AMPHETAMINE; ANESTHETIC AGENT; CHLORALOSE; ISOFLURANE; KETAMINE; PHENCYCLIDINE; PROPOFOL; PSYCHOSTIMULANT AGENT; XYLAZINE;

ANESTHESIA MECHANISM; ANIMAL EXPERIMENT; ARTERIAL SPIN LABELING; ARTICLE; BRAIN BLOOD FLOW; BRAIN PERFUSION; CENTRAL NERVOUS SYSTEM; CONTINUOUS ARTERIAL SPIN LABELING; DOPAMINERGIC SYSTEM; DRUG DOSE INCREASE; DRUG EFFECT; MALE; NEUROIMAGING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTITION COEFFICIENT; PHARMACOLOGICAL MAGNETIC RESONANCE IMAGING; QUANTITATIVE ANALYSIS; RAT; RELIABILITY; REPRODUCIBILITY; SIGNAL NOISE RATIO;

EID: 67049165145     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.21779     Document Type: Article

References (61)

1. Orban GA. Imaging image processing in the human brain. Curr Opin Neurol 2001;14:47-54. (Pubitemid 32116257)
2. Tootell RBH, Tsao D, Vanduffel W. Neuroimaging weighs in: humans meet macaques in "primate" visual cortex. J Neurosci 2003;23:3981-3989.
3. Orban GA, Van Essen D, Vanduffel W. Comparative mapping of higher visual areas in monkeys and humans. Trends Cogn Sci 2004;8:315-324. (Pubitemid 38887448)
4. Murphy FC, Nimmo-Smith I, Lawrence AD. Functional neuroanatomy of emotions: a meta-analysis. Cogn Affect Behav Neurosci 2003;3:207-233. (Pubitemid 38620283)
5. Baas D, Aleman A, Kahn RS. Lateralization of amygdala activation: a systematic review of functional neuroimaging studies. Brain Res Rev 2004;45:96-103. (Pubitemid 38625737)
6. Rajah MN, D'Esposito M. Region-specific changes in prefrontal function with age: a review of PET and fMRI studies on working and episodic memory. Brain 2005;128:1964-1983. (Pubitemid 41253265)
7. Leppänen JM. Emotional information processing in mood disorders: a review of behavioral and neuroimaging findings. Curr Opin Psychiatry 2006;19:34-39. (Pubitemid 44406142)
8. Jenkins BG, Choi JK, Mandeville JB, Chen YCI. Pharmacologic magnetic resonance imaging (phMRI). In: Beckmann N, ed. In vivo MR techniques in drug discovery and development. New York: Taylor & Francis; 2006. p 171-220.
9. Wise RG, Tracey I. The role of fMRI in drug discovery. J Magn Reson Imaging 2006;23:862-876. (Pubitemid 43825441)
10. Mueggler T, Sturchler-Pierrat C, Baumann D, Rausch M, Staufenbiel M, Rudin M. Compromised hemodynamic response in amyloid precursor protein transgenic mice. J Neurosci 2002;22:7218-7224. (Pubitemid 35379175)
11. 3 receptor antagonist SB-277011-A potentiates phMRI response to acute amphetamine challenge in the rat brain. Synapse 2004;54:1-10.
12. Risterucci C, Jeanneau K, Schöppenthau S, Bielser T, Künnecke B, von Kienlin M, Moreau JL. Functional magnetic resonance imaging reveals similar brain activity changes in two different animal models of schizophrenia. Psychopharmacology 2005;180:724-734. (Pubitemid 41317868)
13. Honey G, Bullmore E. Human pharmacological MRI. Trends Pharmacol Sci 2004;25:366-374. (Pubitemid 38829490)
14. Borsook D, Becerra L, Hargreaves R. A role for fMRI in optimizing CNS drug development. Nat Rev Drug Discov 2006;5:411-424. (Pubitemid 43904933)
15. Buxton RB, Uludag K, Dubowitz DJ, Liu TT. Modeling the hemodynamic response to brain activation. Neuroimage 2004;23:S220-S233. (Pubitemid 39421721)
16. Logothethis NK, Wandell BA. Interpreting the BOLD signal. Annu Rev Physiol 2004;66:735-769. (Pubitemid 40614461)
17. Smith AM, Lewis BK, Ruttimann UE, Ye FQ, Sinnwell TM, Yang Y, Duyn JH, Frank JA. Investigation of low frequency drift in fMRI signal. Neuroimage 1999;9:526-533. (Pubitemid 29372220)
18. Wang J, Aguirre GK, Kimberg DY, Roc AC, Li L, Detre JA. Arterial spin labeling perfusion fMRI with very low task frequency. Magn Reson Med 2003;49:796-802. (Pubitemid 36523464)
19. Aguirre GK, Detre JA, Zarahn E, Alsop DC. Experimental design and the relative sensitivity of BOLD and perfusion fMRI. Neuroimage 2002;15: 488-500. (Pubitemid 34852517)
20. Silva AC, Kim SG. Perfusion-based functional magnetic resonance imaging. Concepts Magn Reson A 2003;16A:16-27.
21. Parkes LM, Rashid W, Chard DT, Tofts PS. Normal cerebral perfusion measurements using arterial spin labeling: reproducibility, stability, and age and gender effects. Magn Reson Med 2004;51:736-743. (Pubitemid 38420450)
22. Hendrich KS, Kochanek PM, Melick JA, Schiding JK, Statler KD, Williams DS, Marison DW, Ho C. Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin-labeled MRI. Magn Reson Med 2001;46:202-206. (Pubitemid 32592156)
23. Lahti KM, Ferris CF, Li F, Sotak CH, King JA. Comparison of evoked cortical activity in conscious and propofol-anesthetized rats using functional MRI. Magn Reson Med 1999;41:412-416. (Pubitemid 29104530)
24. Peeters RR, Tindemans I, De Schutter E, Van der Linden A. Comparing BOLD fMRI signal changes in the awake and anesthetized rat during electrical forepaw stimulation. Magn Reson Imaging 2001;19:821-826. (Pubitemid 32845949)
25. Masamoto K, Kim T, Fukuda M, Wang P, Kim SG. Relationship between neural, vascular, and BOLD signals in isoflurane-anesthetized rat somatosensory cortex. Cereb Cortex 2007;17:942-950. (Pubitemid 46434635)
26. Austin VC, Blamire AM, Allers KA, Sharp T, Styles P, Matthews PM, Sibson NR. Confounding effects of anesthesia on functional activation in rodent brain: a study of halothane and α-chloralose anesthesia. Neuroimage 2005;24:92-100. (Pubitemid 39611029)
27. Sicard K, Shen Q, Brevard ME, Sullivan R, Ferris CF, King JA, Duong TQ. Regional cerebral blood flow and BOLD responses in conscious and anesthetized rats under basal and hypercapnic conditions: implications for functional MRI studies. J Cereb Blood Flow Metab 2003;23: 472-481. (Pubitemid 36403029)
28. Abo M, Suzuki M, Senoo A, Miyano S, Yamauchi H, Yonemoto K, Watanabe S, Edström L. Influence of isoflurane concentration and hypoxia on functional magnetic resonance imaging for the detection of bicuculline-induced neuronal activation. Neurosignals 2004;13:144-149. (Pubitemid 38456656)
29. Rausch M, Gentsch C, Enz A, Baumann D, Rudin M. A study paradigm allowing comparison of multiple high-resolution rCBV-maps for the examination of drug effects. NMR Biomed 2005;18:260-268. (Pubitemid 40936446)
30. Nieoullon A. Dopamine and the regulation of cognition and attention. Progress Neurobiol 2002;67:53-83. (Pubitemid 34786170)
31. Millan MJ. N-Methyl-D-aspartate receptors as a target for improved antipsychotic agents: novel insights and clinical perspectives. Psychopharmacology 2005;179:30-53. (Pubitemid 40576691)
32. Jentsch JD, Roth RH. The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 1999;20:201-225. (Pubitemid 29067401)
33. Hennig J, Nauerth A, Friedburg H. RARE imaging: a fast imaging method for clinical MR. Magn Reson Med 1986;3:823-833. (Pubitemid 17233280)
34. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. 4th ed. San Diego: Academic Press; 1998.
35. Haase A, Frahm J, Matthaei D, Hänicke W, Merboldt KD. FLASH imaging. Rapid NMR imaging using low flip-angle pulses. J Magn Reson 1986;67:258-266.
36. Williams DS, Detre JA, Leigh JS, Koretsky AP. Magnetic resonance imaging of perfusion using spin inversion of arterial water. Proc Natl Acad Sci USA 1992;89:212-216.
37. Alsop DC, Detre JA. Reduced transit-time sensitivity in noninvasive magnetic resonance imaging of human cerebral blood flow. J Cereb Blood Flow Metab 1996;16:1236-1249. (Pubitemid 26365376)
38. Deichmann R, Hahn D, Haase A. Fast T1 mapping on a whole-body scanner. Magn Reson Med 1999;42:206-209. (Pubitemid 29325632)
39. Shrout PE, Fleiss JL. Intraclass correlations: uses in assessing rater reliability. Psychol Bull 1979;86:420-428.
40. Villringer A, Dirnagl U. Coupling of brain activity and cerebral blood flow: basis of functional neuroimaging. Cerebrovasc Brain Metab Rev 1995;7:240-275.
41. Lahti KM, Ferris CF, Fuhai L, Sotak CH, King JA. Imaging brain activity in conscious animals using functional MRI. J Neurosci Methods 1998; 82:75-83. (Pubitemid 28335474)
42. Febo M, Segarra AC, Tenney JR, Brevard ME, Duong TQ, Ferris CF. Imaging cocaine-induced changes in the mesocorticolimbic dopaminergic system of conscious rats. J Neurosci Methods 2004;139:167-176. (Pubitemid 39370842)
43. King JA, Garelick TS, Brevard ME, Chen W, Messenger TL, Duong TQ, Ferris CF. Procedure for minimizing stress for fMRI studies in conscious rats. J Neurosci Methods 2005;148:154-160. (Pubitemid 41476226)
44. Hansen TD, Warner DS, Todd MM, Vusl LJ, Trawick DC. Distribution of cerebral blood flow during halothane versus isoflurane anesthesia in rats. Anesthesiology 1988;69:332-337. (Pubitemid 18226628)
45. Matta BF, Heath KJ, Tipping K, Summors AC. Direct cerebral vasodilatory effects of sevoflurane and isoflurane. Anesthesiology 1999;91: 677-680. (Pubitemid 29418648)
46. Werner C, Hoffman WE, Kochs E, Schulte am Esch J, Albrecht RF. The effect of propofol on cerebral and spinal cord blood flow in rats. Anesth Analg 1993;76:971-975.
47. Garrett KM, Gan J. Enhancement of γ-aminobutyric acid A receptor activity by α-chloralose. J Pharmacol Exp Ther 1998;285:680-686. (Pubitemid 28237448)
48. Trapani G, Altomare C, Liso G, Sanna E, Biggio G. Propofol in anesthesia. Mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem 2000;7:249-271.
49. Alkire MT, Haier RJ. Correlating in vivo anesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane. Br J Anesth 2001;86:618-626. (Pubitemid 32409401)
50. Balis GU, Monroe RR. The pharmacology of chloralose. A review. Psychopharmacologia 1964;6:1-30.
51. Ueki M, Mies G, Hossmann KA. Effect of alpha-chloralose, halothane, pentobarbital and nitrous oxide anesthesia on metabolic coupling in somatosensory cortex of rat. Acta Anaesthesiol Scand 1992;36:318-322.
52. Lindauer U, Villringer A, Dirnagl U. Characterization of CBF response to somatosensory stimulation: model and influence of anesthetics. Am J Physiol 1993;264:H1223-H1228. (Pubitemid 23115297)
53. Bonvento G, Charbonné R, Corrèze JL, Borredon J, Seylaz J, Lacombe P. Is α-chloralose plus halothane induction a suitable anesthetic regimen for cerebrovascular research? Brain Res 1994;665:213-221.
54. Silverman J, Muir 3rd WW. A review of laboratory animal anesthesia with chloral hydrate and chloralose. Lab Anim Sci 1993;43:210-216.
55. Lukasik VM, Gillies RJ. Animal anesthesia for in vivo magnetic resonance. NMR Biomed 2003;16:459-467. (Pubitemid 38072565)
56. Aguirre GK, Zarahn E, D'Esposito M. The inferential impact of global signal covariates in functional neuroimaging analyses. Neuroimage 1998;8:302-306. (Pubitemid 28476237)
57. Gavrilescu M, Shaw ME, Stuart GW, Eckersley P, Svalbe ID, Egan GF. Simulation of the effects of global normalization procedures in functional MRI. Neuroimage 2002;17:532-542. (Pubitemid 35316993)
58. Wang Z, Haracz JL, Rebec GV. BMY-14802, a sigma ligand and potential antipsychotic drug, reverses amphetamine-induced changes in neostriatal single-unit activity in freely moving rats. Synapse 1992;12: 312-321. (Pubitemid 23012548)
59. Kiyatkin EA, Rebec GV. Iontophoresis of amphetamine in the neostriatum and nucleus accumbens of awake, unrestrained rats. Brain Res 1997;771:14-24. (Pubitemid 27465685)
60. Marcus MM, Mathé JM, Nomikos GG, Svensson TH. Effects of competitive and non-competitive NMDA receptor antagonists on dopamine output in the shell and core subdivisions of the nucleus accumbens. Neuropharmacology 2001;40:482-490. (Pubitemid 32209033)
61. Hertel P, Mathé JM, Nomikos GG, Iurlo M, Mathé AA, Svensson TH. Effects of d-amphetamine and phencyclidine on behavior and extracellular concentrations of neurotensin and dopamine in the ventral striatum and the medial prefrontal cortex of the rat. Behav Brain Res 1996;72:103-114.