Selective dopamine D3 receptor antagonist SB-277011-A potentiates phMRI response to acute amphetamine challenge in the rat brain

Synapse

Volumn 54, Issue 1, 2004, Pages 1-10

  Schwarz, Adam ^a   Gozzi, Alessandro ^a   Reese, Torsten ^a   Bertani, Simone ^a   Crestan, Valerio ^a   Hagan, Jim ^a   Heidbreder, Christian ^a   Bifone, Angelo ^a  

^a GSK   (Italy)

Author keywords

Drug dependence; In vivo; MRI; Pharmacological; Rodent; Schizophrenia

Indexed keywords

DEXAMPHETAMINE; DOPAMINE 3 RECEPTOR; DOPAMINE 3 RECEPTOR BLOCKING AGENT; SB 277011 A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN REGION; CINGULATE GYRUS; COGNITION; CONTROLLED STUDY; DOPAMINE RECEPTOR BLOCKING; DOPAMINERGIC ACTIVITY; DORSAL RAPHE NUCLEUS; DRUG DEPENDENCE; DRUG SELECTIVITY; DRUG TARGETING; EMOTION; IMAGE ANALYSIS; LIMBIC CORTEX; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEUS ACCUMBENS; OLFACTORY NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROVOCATION TEST; PUTAMEN; RAT; REGULATORY MECHANISM; SCHIZOPHRENIA; SUBICULUM; THALAMUS; VENTRAL TEGMENTUM;

AMPHETAMINES; ANIMALS; BRAIN; CEREBROVASCULAR CIRCULATION; DOPAMINE ANTAGONISTS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; NITRILES; RATS; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; SUBSTANCE-RELATED DISORDERS; TETRAHYDROISOQUINOLINES;

EID: 4344563359     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/syn.20055     Document Type: Article

References (55)

1. Adams JU, Careri JM, Efferen TR, Rotrosen J. 2001. Differential effects of dopamine antagonists on locomotor activity, conditioned activity and conditioned place preference induced by cocaine in rats. Behav Pharmacol 12:603-611.
2. Andreoli M, Tessari M, Pilla M, Valerio E, Hagan JJ, Heidbreder CA. 2003. Selective antagonism at dopamine D3 receptors prevents nicotine-triggered relapse to nicotine-seeking behavior. Neuropsychopharmacology 28:1272-1280.
3. Ashby CR, Paul M, Gardner EL, Heidbreder CA, Hagan JJ. 2003. Acute administration of the selective D3 receptor antagonist SB-277011A blocks the acquisition and expression of the conditioned place preference response to heroin in male rats. Synapse 48:154-156.
4. Austin NE, Baldwin SJ, Cutler L, Deeks N, Kelly PJ, Nash M, Shardlow CE, Stemp G, Thewlis K, Ayrton A, Jeffrey P. 2001. Pharmacokinetics of the novel, high-affinity and selective dopamine D3 receptor antagonist SB-277011 in rat, dog and monkey: in vitro/in vivo correlation and the role of aldehyde oxidase. Xenobiotica 31:677-686.
5. Baker DA, Fuchs RA, Specio SE, Khroyan TV, Neisewander JL. 1998. Effects of intraaccumbens administration of SCH-23390 on cocaine-induced locomotion and conditioned place preference. Synapse 30:181-193.
6. Bouthenet ML, Souil E, Martres MP, Sokoloff P, Giros B, Schwartz JC. 1991. Localization of dopamine D3 receptor mRNA in the rat brain using in situ hybridization histochemistry: comparison with dopamine D2 receptor mRNA. Brain Res 564:203-219.
7. Chen Y-CI, Galpern W, Brownell A-L, Matthews RT, Bogdanov M, Isacson O, Keltner JR, Beal MF, Rosen B, Jenkins BG. 1997. Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis and behavioral data. Magn Reson Med 38:389-398.
8. Chen Y-CI, Brownell A-L, Galpern W, Isacson O, Bogdanov M, Beal MF, Livni E, Rosen BR, Jenkins BG. 1999. Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioural assessment. NeuroReport 10:2881-2886.
9. Choi J, Chen Y-CI, Hamel E, Jenkins BG. 2003. Coupling of hemodynamic changes induced by dopamine drugs with dopamine receptor distribution on the cerebral microvasculature. In: Book of abstracts: 11th Annual Meeting of the International Society of Magnetic Resonance in Medicine, p 356.
10. Cox RW, Hyde JS. 1997. Software tools for analysis and visualization of FMRI Data. NMR Biomed 10:171-178.
11. Di Ciano P, Underwood RJ, Hagan JJ, Everitt BJ. 2003. Attenuation of cue-controlled cocaine-seeking by a selective D3 dopamine receptor antagonist SB-277011-A. Neuropsychopharmacology 28:329-338.
12. Diaz J, Pilon C, Le Foll B, Gros C, Triller A, Schwartz JC, Sokoloff P. 2000. Dopamine D3 receptors expressed by all mesencephalic dopamine neurons. J Neurosci 20:8677-8684.
13. Floresco SB, Todd CL, Grace AA. 2001. Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons. J Neurosci 21:4915-4922.
14. Gainetdinov RR, Sotnikova TD, Grekhova TV, Rayevsky KS. 1996. In vivo evidence for preferential role of dopamine D3 receptor in the presynaptic regulation of dopamine release but not synthesis. Eur J Pharmacol 308:261-269.
15. Genovese CR, Lazar NA, Nichols T. 2002. Thresholding of statistical maps in functional neuroimaging using the false discovery rate. NeuroImage 15:870-878.
16. Groenewegen HJ, Vermeulen-Van der Zee E, te KA, Witter MP. 1987. Organization of the projections from the subiculum to the ventral striatum in the rat. A study using anterograde transport of Phaseolus vulgaris leucoagglutinin. Neuroscience 23:103-120.
17. Gurevich EV, Joyce JN. 1999. Distribution of dopamine D3 receptor expressing neurons in the human forebrain: comparison with D2 receptor expressing neurons. Neuropsychopharmacology 20:60-80.
18. Houston GC, Papadakis NG, Carpenter TA, Hall LD, Mukherjee B, James MF, Huang CL-H. 2001. Mapping of brain activation in response to pharmacological agents using fMRI in the rat. Magn Reson Imag 19:905-919.
19. Jaworski JN, Gonzales RA, Randall PK. 2001. Effect of dopamine D2/D3 receptor antagonist sulpiride on amphetamine-induced changes in striatal extracellular dopamine. Eur J Pharmacol 418:201-206.
20. Joseph JD, Wang YM, Miles PR, Budygin EA, Picetti R, Gainetdinov RR, Caron MG, Wightman RM. 2002. Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D(3) receptors. Neuroscience 112:39-49.
21. Kalivas PW, McFarland K. 2003. Brain circuitry and the reinstatement of cocaine-seeking behavior. Psychopharmacology (Berl) 168:44-56.
22. Koob GF. 2003. Neuroadaptive mechanisms of addiction: studies on the extended amygdala. Eur Neuropsychopharmacol 13:442-452.
23. Lacroix LP, Hows ME, Shah AJ, Hagan JJ, Heidbreder CA. 2003. Selective antagonism at dopamine D3 receptors enhances monoaminergic and cholinergic neurotransmission in the rat anterior cingulate cortex. Neuropsychopharmacology 28:839-849.
24. Landwehrmeyer B, Mengod G, Palacios JM. 1993. Differential visualization of dopamine D2 and D3 receptor sites in rat brain. A comparative study using in situ hybridization histochemistry and ligand binding autoradiography. Eur J Neurosci 5:145-153.
25. Le AD, Tomkins D, Higgins G, Quan B, Sellers EM. 1997. Effects of 5-HT3, D1 and D2 receptor antagonists on ethanol- and cocaine-induced locomotion. Pharmacol Biochem Behav 57:325-332.
26. Lejeune F, Millan MJ. 1995. Activation of dopamine D3 autoreceptors inhibits firing of ventral tegmental dopaminergic neurones in vivo. Eur J Pharmacol 275:R7-R9.
27. Levesque D, Diaz J, Pilon C, Martres MP, Giros B, Souil E, Schott D, Morgat JL, Schwartz JC, Sokoloff P. 1992. Identification, characterization, and localization of the dopamine D3 receptor in rat brain using 7-[3H]hydroxy-N,N- di-n-propyl-2-aminotetralin. Proc Natl Acad Sci U S A 89:8155-8159.
28. Lowe AS, Williams SCR, Symms MR, Stolerman IP, Shoaib M. 2002. Functional magnetic resonance neuroimaging of drug dependence: anloxone-precipitated morphine withdrawal. NeuroImage 17:902-910.
29. Mandeville JB, Marota JJA, Kosofsky BE, Keltner JR, Weissleder R, Rosen B, Weisskoff R. 1998. Dynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation. Magn Reson Med 39:615-624.
30. Mandeville JB, Belen D, Marota JJA, Waeber C, Kosofsky BE. 2002. fMRI pharmacology of cocaine in rats: dopamine agonists and serotonin antagonists. In: Book of abstracts: 10th Annual Meeting of the International Society of Magnetic Resonance in Medicine, p 1361.
31. Marota JJA, Mandeville JB, Weisskoff R, Moskowitz MA, Rosen B, Kosofsky BE. 2000. Cocaine activation discriminates dopaminergic projections by temporal response: an fMRI study in rat. NeuroImage 11:13-23.
32. McFarland K, Kalivas PW. 2001. The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior. J Neurosci 21:8655-8663.
33. McFarland K, Davidge SB, Lapish CC, Kalivas PW. 2004. Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior. J Neurosci 24:1551-1560.
34. Millan MJ, Gobert A, Newman-Tancredi A, Lejeune F, Cussac D, Rivet JM, Audinot V, Dubuffet T, Lavielle G. 2000. S33084, a novel, potent, selective, and competitive antagonist at dopamine D(3)-receptors. I. Receptorial, electrophysiological and neurochemical profile compared with GR218,231 and L741,626. J Pharmacol Exp Ther 293:1048-1062.
35. Paxinos G, Watson C. 1998. The rat brain in stereotactic coordinates. San Diego: Academic Press.
36. Pierce RC, Kalivas PW. 1997. A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Res Brain Res Rev 25:192-216.
37. Rausch M, Baumann D, Weber J, Sauter A, Rudin M. 2002. Hemodynamic changes in rat brain following pharmacological stimulation by amphetamine: correlation of fMRI signals signals. In: Book of abstracts: 10th Annual Meeting of the International Society of Magnetic Resonance in Medicine.
38. Reavill C, Taylor SG, Wood MD, Ashmeade T, Austin NE, Avenell KY, Boyfield I, Branch CL, Cilia J, Coldwell MC, Hadley MS, Hunter AJ, Jeffrey P, Jewitt F, Johnson CN, Jones DN, Medhurst AD, Middlemiss DN, Nash DJ, Riley GJ, Routledge C, Stemp G, Thewlis KM, Trail B, Vong AK, Hagan JJ. 2000. Pharmacological actions of a novel, high-affinity, and selective human dopamine D(3) receptor antagonist, SB-277011-A. J Pharmacol Exp Ther 294:1154-1165.
39. Reese T, Bjelke B, Porszasz R, Baumann D, Bochelen D, Sauter A, Rudin M. 2000. Regional brain activation by bicuculline visualized by functional magnetic resonance imaging. Time-resolved assessment of bicuculline-induced changes in local cerebral blood volume using an intravascular contrast agent. NMR Biomed 13:43-49.
40. Schindler CW, Carmona GN. 2002. Effects of dopamine agonists and antagonists on locomotor activity in male and female rats. Pharmacol Biochem Behav 72:857-863.
41. Schwarz AJ, Reese T, Gozzi A, Bifone A. 2003. Functional MRI using intravascular contrast agents: detrending of the relative cerebrovascular (rCBV) time course. Magn Reson Imag 21:1191-1200.
42. Schwarz AJ, Zocchi A, Reese T, Gozzi A, Varnier G, Girlanda E, Biscaro B, Bertani S, Crestan V, Heidbreder CA, Bifone A. 2004. The relationship between local dopamine changes and phMRI response to acute cocaine challenge in the rat revealed by concurrent in situ microdialysis. In: Book of abstracts: 12th Annual Meeting of the International Society of Magnetic Resonance in Medicine, p 646.
43. Shafer RA, Levant B. 1998. The D3 dopamine receptor in cellular and organismal function. Psychopharmacology 135:1-16.
44. Stanwood GD, Artymyshyn RP, Kung MP, Kung HF, Lucki I, McGonigle P. 2000. Quantitative autoradiographic mapping of rat brain dopamine D3 binding with [(125)I] 7-OH-PIPAT: evidence for the presence of D3 receptors on dopaminergic and nondopaminergic cell bodies and terminals. J Pharmacol Exp Ther 295:1223-1231.
45. Stein EA, Pankiewicz J, Harsch HH, Cho J-K, Fuller SA, Hoffmann RG, Hawkins M, Rao SM, Bandettini PA, Bloom AS. 1998. Nicotine-induced limbic cortical activation in the human brain: a functional MRI study. Am J Psychiatry 155:1009-1015.
46. Steketee JD, Braswell BC. 1997. Injection of SCH 23390, but not 7-hydroxy-DPAT, into the ventral tegmental area blocks the acute motor-stimulant response to cocaine. Behav Pharmacol 8:58-64.
47. Stemp G, Ashmeade T, Branch CL, Hadley MS, Hunter AJ, Johnson CN, Nash DJ, Thewlis KM, Vong AK, Austin NE, Jeffrey P, Avenell KY, Boyfield I, Hagan JJ, Middlemiss DN, Reavill C, Riley GJ, Routledge C, Wood M. 2000. Design and synthesis of trans-N-[4-[2-(6-cyano-1,2,3, 4-tetrahydroisoquinolin-2-yl)ethyl] cyclohexyl]-4-quinolinecarboxamide (SB-277011): a potent and selective dopamine D(3) receptor antagonist with high oral bioavailability and CNS penetration in the rat. J Med Chem 43:1878-1885.
48. Taepavarapruk P, Phillips AG. 2003. Neurochemical correlates of relapse to d-amphetamine self-administration by rats induced by stimulation of the ventral subiculum. Psychopharmacology (Berl) 168:99-108.
49. Tuor UI, McKenzie E, Tomanek B. 2002. Functional magnetic resonance imaging of tonic pain and vasopressor effects in rats. Magn Reson Imag 20:707-712.
50. Vorel SR, Liu X, Hayes RJ, Spector JA, Gardner EL. 2001. Relapse to cocaine-seeking after hippocampal theta burst stimulation. Science 292:1175-1178.
51. Vorel SR, Ashby CR, Paul M, Liu X, Hayes R, Hagan JJ, Middlemiss DN, Stemp G, Gardner EL. 2002. Dopamine D3 receptor antagonism inhibits cocaine-seeking and cocaine-enhanced brain reward in rats. J Neurosci 22:9595-9603.
52. Xi Z-X, Gilbert J, Campos A, Kline N, Ashby CR, Hagan JJ, Heidbreder CA, Gardner EL. 2004. Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats. Psychopharmacology (in press).
53. Xu H, Li S-J, Bodurka J, Zhao X, Xi Z-X, Stein EA. 2000. Heroin-induced neuronal activation in rat brain assessed by functional MRI. NeuroReport 11:1085-1092.
54. Zhang Z, Andersen A, Grondin R, Barber T, Avison R, Gerhardt G, Gash D. 2001. Pharmacological MRI mapping of age-associated changes in basal ganglia circuitry of awake rhesus monkeys. NeuroImage 14:1159-1167.
55. 3 receptor antagonist, potentiates cocaine-induced increase in dopamine levels in the shell of the nucleus accumbens. 6th Neurochemistry Winter Conference (Solden, Austria).