Enhancement of γ-aminobutyric acid(A) receptor activity by α- chloralose

Journal of Pharmacology and Experimental Therapeutics

Volumn 285, Issue 2, 1998, Pages 680-686

  Garrett, Kennon M ^a   Gan, Jiangping ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ANESTHETIC AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; CHLORAL HYDRATE; CHLORALOSE; NEUROSTEROID; SEROTONIN; SEROTONIN 3 RECEPTOR; TRICHLOROETHANOL; URETHAN;

ANIMAL CELL; ARTICLE; CHLORIDE CONDUCTANCE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; FEMALE; GENERAL ANESTHESIA; MEMBRANE CURRENT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; XENOPUS;

EID: 0031808130     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Balls GU and Monroe RR (1964) The pharmacology of chloralose. Psychopharmacology 6:1-30.
2. Breimer DD (1977) Clinical pharmacokinetics of hypnotics. Clin Pharmacokinet 2:93-109.
3. Butler TC (1948) The metabolic fate of chloral hydrate. J Pharmacol Exp Ther 92:49-58.
4. Franks NP and Lieb WR (1994) Molecular and cellular mechanisms of general anesthesia. Nature 367:607-614.
5. Garrett KM, Duman RS, Saito N, Blume AJ, Vitek MP and Tallman JF (1988) Isolation of a cDNA clone for the alpha subunit of the human GABA-A receptor. Biochem Biophys Res Commun 156:1039-1045.
6. Garrett KM, Saito N, Duman RS, Abel MS, Ashton RA, Fujimori S, Beer B, Tallman JF, Vitek MP and Blume AJ (1989) Differential expression of GABA-A receptor subunits. Mol Pharmacol 37:652-657.
7. Harris RA, Mihic SJ, Dildy-Mayfield JE and Machu TK (1995) Actions of anesthetics on ligand-gates ion channels: Role of receptor subunit composition. FASEB J 9:1454-1462.
8. Harrison NL, Kugler JL, Jones MV, Greenblatt EP and Pritchett DB (1993) Positive modulation of human γ-aminobutyric acid type A and glycine receptors by the inhalation anesthetic isoflurane. Mol Pharmacol 44:628-632.
9. Hobbs WR, Rall TW and Verdoorn TA (1995) Hypnotics and sedatives: Ethanol. In The Pharmacological Basis of Therapeutics, ed. by Hardman JG, Limbird LE, Molinoff PB, Ruddon RW and Gillman AG, pp. 361-396, McGraw-Hill, New York, NY.
10. Ishizuka S, Sikdar SK, Yasui S, Oyarna Y and Akaike N (1989) α-Chloralose opens the chloride channel of frog isolated sensory neurons. Brain Res 498:181-184.
11. A-receptor current in rat septal cholinergic neurons in culture. J Neurophys 75:2294-2299.
12. Kusano K, Miledi R and Stinnakre J (1982) Cholinergic and catecholaminergic receptors in the Xenopus oocyte membrane. J Physiol 328:143-170.
13. A-benzodiazepine receptor. Eur J Pharmacol 188:403-406.
14. A receptor structure. J Neurochem 60:1548-1553.
15. Lin L-H, Chen LL and Harris RA (1993b) Enflurane inhibits NMDA, AMPA and kainate-induced currents in Xenopus oocytes expressing mouse and human mRNA. FASEB J 7:479-485.
16. A receptors expresses by Xenopus oocytes: Lack of involvement of intracellular calcium. J Pharmacol Exp Ther 263:569-578.
17. - channels in cultured embryonic rat thalamic neurons. J Membr Biol 143:279-284.
18. A receptors in hippocampal neurons. J Pharmacol Exp Ther 264:1097-1103.
19. A receptor channel of mouse spinal neurones in culture. J Physiol 417:483-500.
20. Machu TK and Harris RA (1994) Alcohols and anesthetics enhance the function of 5-hydroxytryptamine3 receptors expressed in Xenopus laevis oocytes. J Pharmacol Exp Ther 271:898-905.
21. Maggi CA and Meli A (1986) Suitability of urethane anesthesia for physiopharmacological investigations in various systems. Part 1:General considerations. Experientia 42:109-114.
22. A receptor. J Neurosci 10:2330-2337.
23. Mihic SJ, McQuilkin SJ, Eger EI, Ionescu P and Harris RA (1994) Potentiation of γ-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia. Mol Pharmacol 46:851-857.
24. A and glycine receptors. Nature 389:385-389.
25. Moody EJ, Suzdak PD, Paul SM and Skolnick P (1988) Modulation of the benzodiazepine/γ-aminobutyric acid receptor chloride channel complex by inhalation anesthetics. J Neurochem 51:1386-1393.
26. Nattel S, Wag Z and Matthews C (1990) Direct electrophysiological actions of pentobarbital at concentrations achieved during general anesthesia. Am J Physiol 259:H1743-H1751.
27. Nicoll RA and Wojtowicz JM (1980) The effects of pentobarbital and related compounds on frog motoneurons. Brain Res 191:225-237.
28. Parker I, Gundersen CB and Miledi R (1986) Actions of pentobarbital on rat brain receptors expressed in Xenopus oocytes. J Neurosci 6:2290-2297.
29. Peoples RW and Weight FF (1994) Trichloroethanol potentiation of γ-aminobutyric acid-activated chloride current in mouse hippocampal neurons. Br J Pharmacol 113:555-563.
30. A receptor. Neuropharmacology 32:59-63.
31. A receptor on the response to a neurosteroid. Eur J Pharmacol 206:77-80.
32. A receptor channel expressed in Xenopus oocytes. J Neurosci 8:289-295.
33. Silverman J and Muir WW (1993) A review of laboratory animal anesthesia with chloral hydrate and chloralose. Lab Animal Sci 43:210-216.
34. Study RE and Barker JL (1981) Diazepam and (-)-pentobarbital: Fluctuational analysis reveals different mechanisms for potentiation of γ-aminobutyric acid responses in cultured central neurons. Proc Natl Acad Sci USA 78:7180-7184.
35. A receptor complex by steroids in slices of rat cuneate nucleus. Br J Pharmacol 96:409-417.
36. - channels are randomly activated by continuous GABA secretion in cultured embryonic rat hippocampal neurons. Neurosci Lett 155:199-203.