Elucidation of the molecular basis of cholecystokinin peptide docking to its receptor using site-specific intrinsic photoaffinity labeling and molecular modeling

Biochemistry

Volumn 48, Issue 23, 2009, Pages 5303-5312

  Dong, Maoqing ^a   Lam, Polo C H ^b   Pinon, Delia I ^a   Abagyan, Ruben ^b   Miller, Laurence J ^b,c  

^a MAYO GRADUATE SCHOOL   (United States)

^b MOLSOFT LLC   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE PROBE; ADENOSINE RECEPTOR; ADRENERGIC RECEPTORS; COVALENT ATTACHMENT; DRUG DEVELOPMENT; EXPERIMENTAL DATA; EXTRACELLULAR LOOPS; FLUORESCENCE RESONANCE ENERGY TRANSFER; G PROTEIN COUPLED RECEPTORS; HOMOLOGY MODELS; LIGAND BINDING; MOLECULAR BASIS; NATURAL PEPTIDE; PEPTIDE HORMONES; PHOTOAFFINITY LABELING; PROTEOLYTIC PEPTIDES; RECEPTOR MODEL; REFINED MODEL; SITE-SPECIFIC; STRUCTURAL BASIS; STRUCTURAL DETERMINATION; WILD TYPES; WORK FOCUS;

AMINES; BINDING ENERGY; ENERGY TRANSFER; FLUORESCENCE; LIGANDS; MOLECULAR MODELING; PROBES;

LABELING;

ADENOSINE A2A RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CHOLECYSTOKININ LIKE PEPTIDE; CHOLECYSTOKININ OCTAPEPTIDE; CHOLECYSTOKININ RECEPTOR; CHOLECYSTOKININ TYPE 1 RECEPTOR; G PROTEIN COUPLED RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; FLUORESCENCE RESONANCE ENERGY TRANSFER; LIGAND BINDING; MOLECULAR MODEL; MOLECULAR PROBE; NONHUMAN; PEPTIDE MAPPING; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN STRUCTURE; PURIFICATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; CHO CELLS; CHOLECYSTOKININ; COS CELLS; CRICETINAE; CRICETULUS; FLUORESCENCE RESONANCE ENERGY TRANSFER; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PHOTOAFFINITY LABELS; PROTEIN CONFORMATION; RECEPTOR, ADENOSINE A2A; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, CHOLECYSTOKININ;

EID: 67049100554     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9004705     Document Type: Article

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