-
1
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Le Trong, I., Teller, D. C., Okada, T., Stenkamp, R. E., Yamamoto, M., and Miyano, M. (2000) Crystal structure of rhodopsin: A G protein-coupled receptor. Science 289, 739-745.
-
(2000)
Science
, vol.289
, pp. 739-745
-
-
Palczewski, K.1
Kumasaka, T.2
Hori, T.3
Behnke, C.A.4
Motoshima, H.5
Fox, B.A.6
Le Trong, I.7
Teller, D.C.8
Okada, T.9
Stenkamp, R.E.10
Yamamoto, M.11
Miyano, M.12
-
2
-
-
33750836895
-
Crystal structure of a photoactivated deprotonated intermediate of rhodopsin
-
Salom, D., Lodowski, D. T., Stenkamp, R. E., Le Trong, I., Golczak, M., Jastrzebska, B., Harris, T., Ballesteros, J. A., and Palczewski, K. (2006) Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc. Natl. Acad. Sci. U. S. A. 103, 16123-16128.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A
, vol.103
, pp. 16123-16128
-
-
Salom, D.1
Lodowski, D.T.2
Stenkamp, R.E.3
Le Trong, I.4
Golczak, M.5
Jastrzebska, B.6
Harris, T.7
Ballesteros, J.A.8
Palczewski, K.9
-
3
-
-
36448995359
-
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
-
Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G., Thian, F. S., Kobilka, T. S., Choi, H. J., Kuhn, P., Weis, W. I., Kobilka, B. K., and Stevens, R. C. (2007) High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 318, 1258-1265.
-
(2007)
Science
, vol.318
, pp. 1258-1265
-
-
Cherezov, V.1
Rosenbaum, D.M.2
Hanson, M.A.3
Rasmussen, S.G.4
Thian, F.S.5
Kobilka, T.S.6
Choi, H.J.7
Kuhn, P.8
Weis, W.I.9
Kobilka, B.K.10
Stevens, R.C.11
-
4
-
-
36448978229
-
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function
-
Rosenbaum, D. M., Cherezov, V., Hanson, M. A., Rasmussen, S. G., Thian, F. S., Kobilka, T. S., Choi, H. J., Yao, X. J., Weis, W. I., Stevens, R. C., and Kobilka, B. K. (2007) GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science 318, 1266-1273.
-
(2007)
Science
, vol.318
, pp. 1266-1273
-
-
Rosenbaum, D.M.1
Cherezov, V.2
Hanson, M.A.3
Rasmussen, S.G.4
Thian, F.S.5
Kobilka, T.S.6
Choi, H.J.7
Yao, X.J.8
Weis, W.I.9
Stevens, R.C.10
Kobilka, B.K.11
-
5
-
-
0032504237
-
G protein-coupled receptors. I. Diversity of receptor-ligand interactions
-
Ji, T. H., Grossmann, M., and Ji, I. (1998) G protein-coupled receptors. I. Diversity of receptor-ligand interactions. J. Biol. Chem. 273, 17299-17302.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 17299-17302
-
-
Ji, T.H.1
Grossmann, M.2
Ji, I.3
-
6
-
-
0027933763
-
Locating ligand-binding sites in 7TM receptors by protein engineering
-
Schwartz, T. W. (1994) Locating ligand-binding sites in 7TM receptors by protein engineering. Curr. Opin. Biotechnol. 5, 434-444.
-
(1994)
Curr. Opin. Biotechnol
, vol.5
, pp. 434-444
-
-
Schwartz, T.W.1
-
7
-
-
33644841711
-
Cholecystokinin and gastrin receptors
-
Dufresne, M., Seva, C., and Fourmy, D. (2006) Cholecystokinin and gastrin receptors. Physiol. Rev. 86, 805-847.
-
(2006)
Physiol. Rev
, vol.86
, pp. 805-847
-
-
Dufresne, M.1
Seva, C.2
Fourmy, D.3
-
8
-
-
0030969362
-
Cholecystokinin cells
-
Liddle, R. A. (1997) Cholecystokinin cells. Annu. Rev. Physiol. 59, 221-242.
-
(1997)
Annu. Rev. Physiol
, vol.59
, pp. 221-242
-
-
Liddle, R.A.1
-
9
-
-
46149118170
-
Structural basis of cholecystokinin receptor binding and regulation
-
Miller, L. J., and Gao, F. (2008) Structural basis of cholecystokinin receptor binding and regulation. Pharmacol. Ther. 119, 83-95.
-
(2008)
Pharmacol. Ther
, vol.119
, pp. 83-95
-
-
Miller, L.J.1
Gao, F.2
-
10
-
-
0036233457
-
Refinement of the conformation of a critical region of charge-charge interaction between cholecystokinin and its receptor
-
Ding, X. Q., Pinon, D. I., Furse, K. E., Lybrand, T. P., and Miller, L. J. (2002) Refinement of the conformation of a critical region of charge-charge interaction between cholecystokinin and its receptor. Mol. Pharmacol. 61, 1041-1052.
-
(2002)
Mol. Pharmacol
, vol.61
, pp. 1041-1052
-
-
Ding, X.Q.1
Pinon, D.I.2
Furse, K.E.3
Lybrand, T.P.4
Miller, L.J.5
-
11
-
-
33645783040
-
Probing a model of a GPCR/ligand complex in an explicit membrane environment: The human cholecystokinin-1 receptor
-
Henin, J., Maigret, B., Tarek, M., Escrieut, C., Fourmy, D., and Chipot, C. (2006) Probing a model of a GPCR/ligand complex in an explicit membrane environment: the human cholecystokinin-1 receptor. Biophys. J. 90, 1232-1240.
-
(2006)
Biophys. J
, vol.90
, pp. 1232-1240
-
-
Henin, J.1
Maigret, B.2
Tarek, M.3
Escrieut, C.4
Fourmy, D.5
Chipot, C.6
-
12
-
-
0032557448
-
Direct identification of a second distinct site of contact between cholecystokinin and its receptor
-
Hadac, E. M., Pinon, D. I., Ji, Z., Holicky, E. L., Henne, R. M., Lybrand, T. P., and Miller, L. J. (1998) Direct identification of a second distinct site of contact between cholecystokinin and its receptor. J. Biol. Chem. 273, 12988-12993.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 12988-12993
-
-
Hadac, E.M.1
Pinon, D.I.2
Ji, Z.3
Holicky, E.L.4
Henne, R.M.5
Lybrand, T.P.6
Miller, L.J.7
-
13
-
-
0030846864
-
Direct identification of a distinct site of interaction between the carboxyl-terminal residue of cholecystokinin and the type A cholecystokinin receptor using photoaffinity labeling
-
Ji, Z., Hadac, E. M., Henne, R. M., Patel, S. A., Lybrand, T. P., and Miller, L. J. (1997) Direct identification of a distinct site of interaction between the carboxyl-terminal residue of cholecystokinin and the type A cholecystokinin receptor using photoaffinity labeling. J. Biol. Chem. 272, 24393-24401.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 24393-24401
-
-
Ji, Z.1
Hadac, E.M.2
Henne, R.M.3
Patel, S.A.4
Lybrand, T.P.5
Miller, L.J.6
-
14
-
-
0035830920
-
Refinement of the structure of the ligand-occupied cholecystokinin receptor using a photolabile amino-terminal probe
-
Ding, X. Q., Dolu, V., Hadac, E. M., Holicky, E. L., Pinon, D. I., Lybrand, T. P., and Miller, L. J. (2001) Refinement of the structure of the ligand-occupied cholecystokinin receptor using a photolabile amino-terminal probe. J. Biol. Chem. 276, 4236-4244.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 4236-4244
-
-
Ding, X.Q.1
Dolu, V.2
Hadac, E.M.3
Holicky, E.L.4
Pinon, D.I.5
Lybrand, T.P.6
Miller, L.J.7
-
15
-
-
0032696904
-
Arginine 197 of the cholecystokinin-A receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin
-
Gigoux, V., Maigret, B., Escrieut, C., Silvente-Poirot, S., Bouisson, M., Fehrentz, J. A., Moroder, L., Gully, D., Martinez, J., Vaysse, N., and Fourmy, A. D. (1999) Arginine 197 of the cholecystokinin-A receptor binding site interacts with the sulfate of the peptide agonist cholecystokinin. Protein Sci. 8, 2347-2354.
-
(1999)
Protein Sci
, vol.8
, pp. 2347-2354
-
-
Gigoux, V.1
Maigret, B.2
Escrieut, C.3
Silvente-Poirot, S.4
Bouisson, M.5
Fehrentz, J.A.6
Moroder, L.7
Gully, D.8
Martinez, J.9
Vaysse, N.10
Fourmy, A.D.11
-
16
-
-
15644364730
-
Identification of two amino acids of the human cholecystokinin-A receptor that interact with the N-terminal moiety of cholecystokinin
-
Kennedy, K., Gigoux, V., Escrieut, C., Maigret, B., Martinez, J., Moroder, L., Frehel, D., Gully, D., Vaysse, N., and Fourmy, D. (1997) Identification of two amino acids of the human cholecystokinin-A receptor that interact with the N-terminal moiety of cholecystokinin. J. Biol. Chem. 272, 2920-2926.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 2920-2926
-
-
Kennedy, K.1
Gigoux, V.2
Escrieut, C.3
Maigret, B.4
Martinez, J.5
Moroder, L.6
Frehel, D.7
Gully, D.8
Vaysse, N.9
Fourmy, D.10
-
17
-
-
18544378433
-
The biologically crucial C terminus of cholecystokinin and the non-peptide agonist SR-146,131 share a common binding site in the human CCK1 receptor. Evidence for a crucial role of Met-121 in the activation process
-
Escrieut, C., Gigoux, V., Archer, E., Verrier, S., Maigret, B., Behrendt, R., Moroder, L., Bignon, E., Silvente-Poirot, S., Pradayrol, L., and Fourmy, D. (2002) The biologically crucial C terminus of cholecystokinin and the non-peptide agonist SR-146,131 share a common binding site in the human CCK1 receptor. Evidence for a crucial role of Met-121 in the activation process. J. Biol. Chem. 277, 7546-7555.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 7546-7555
-
-
Escrieut, C.1
Gigoux, V.2
Archer, E.3
Verrier, S.4
Maigret, B.5
Behrendt, R.6
Moroder, L.7
Bignon, E.8
Silvente-Poirot, S.9
Pradayrol, L.10
Fourmy, D.11
-
18
-
-
0033575274
-
Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin
-
Gigoux, V., Escrieut, C., Fehrentz, J. A., Poirot, S., Maigret, B., Moroder, L., Gully, D., Martinez, J., Vaysse, N., and Fourmy, D. (1999) Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin. J. Biol. Chem. 274, 20457-20464.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 20457-20464
-
-
Gigoux, V.1
Escrieut, C.2
Fehrentz, J.A.3
Poirot, S.4
Maigret, B.5
Moroder, L.6
Gully, D.7
Martinez, J.8
Vaysse, N.9
Fourmy, D.10
-
20
-
-
36349035022
-
Fluorescence resonance energy transfer analysis of secretin docking to its receptor: Mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues
-
Harikumar, K. G., Lam, P. C., Dong, M., Sexton, P. M., Abagyan, R., and Miller, L. J. (2007) Fluorescence resonance energy transfer analysis of secretin docking to its receptor: mapping distances between residues distributed throughout the ligand pharmacophore and distinct receptor residues. J. Biol. Chem. 282, 32834-32843.
-
(2007)
J. Biol. Chem
, vol.282
, pp. 32834-32843
-
-
Harikumar, K.G.1
Lam, P.C.2
Dong, M.3
Sexton, P.M.4
Abagyan, R.5
Miller, L.J.6
-
21
-
-
21444436216
-
Fluorescence resonance energy transfer analysis of the antagonist- and partial agonist-occupied states of the cholecystokinin receptor
-
Harikumar, K. G., and Miller, L. J. (2005) Fluorescence resonance energy transfer analysis of the antagonist- and partial agonist-occupied states of the cholecystokinin receptor. J. Biol. Chem. 280, 18631-18635.
-
(2005)
J. Biol. Chem
, vol.280
, pp. 18631-18635
-
-
Harikumar, K.G.1
Miller, L.J.2
-
22
-
-
1642454586
-
Measurement of intermolecular distances for the natural agonist Peptide docked at the cholecystokinin receptor expressed in situ using fluorescence resonance energy transfer
-
Harikumar, K. G., Pinon, D. I., Wessels, W. S., Dawson, E. S., Lybrand, T. P., Prendergast, F. G., and Miller, L. J. (2004) Measurement of intermolecular distances for the natural agonist Peptide docked at the cholecystokinin receptor expressed in situ using fluorescence resonance energy transfer. Mol. Pharmacol. 65, 28-35.
-
(2004)
Mol. Pharmacol
, vol.65
, pp. 28-35
-
-
Harikumar, K.G.1
Pinon, D.I.2
Wessels, W.S.3
Dawson, E.S.4
Lybrand, T.P.5
Prendergast, F.G.6
Miller, L.J.7
-
23
-
-
33748754344
-
Fluorescent indicators distributed throughout the pharmacophore of cholecystokinin provide insights into distinct modes of binding and activation of type A and B cholecystokinin receptors
-
Harikumar, K. G., Pinon, D. I., and Miller, L. J. (2006) Fluorescent indicators distributed throughout the pharmacophore of cholecystokinin provide insights into distinct modes of binding and activation of type A and B cholecystokinin receptors. J. Biol. Chem. 281, 27072-27080.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 27072-27080
-
-
Harikumar, K.G.1
Pinon, D.I.2
Miller, L.J.3
-
24
-
-
0038744320
-
Disulfide bond structure and accessibility of cysteines in the ectodomain of the cholecystokinin receptor: Specific monoreactive receptor constructs examine charge-sensitivity of loop regions
-
Ding, X. Q., Dolu, V., Hadac, E. M., Schuetz, M., and Miller, L. J. (2003) Disulfide bond structure and accessibility of cysteines in the ectodomain of the cholecystokinin receptor: specific monoreactive receptor constructs examine charge-sensitivity of loop regions. Recep. Channels 9, 83-91.
-
(2003)
Recep. Channels
, vol.9
, pp. 83-91
-
-
Ding, X.Q.1
Dolu, V.2
Hadac, E.M.3
Schuetz, M.4
Miller, L.J.5
-
25
-
-
0037166311
-
Environment and mobility of a series of fluorescent reporters at the amino terminus of structurally related peptide agonists and antagonists bound to the cholecystokinin receptor
-
Harikumar, K. G., Pinon, D. I., Wessels, W. S., Prendergast, F. G., and Miller, L. J. (2002) Environment and mobility of a series of fluorescent reporters at the amino terminus of structurally related peptide agonists and antagonists bound to the cholecystokinin receptor. J. Biol. Chem. 277, 18552-18560.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 18552-18560
-
-
Harikumar, K.G.1
Pinon, D.I.2
Wessels, W.S.3
Prendergast, F.G.4
Miller, L.J.5
-
26
-
-
0018267881
-
Effect of the orientation of donor and acceptor on the probability of energy transfer involving electronic transitions of mixed polarization
-
Haas, E., Katchalski-Katzir, E., and Steinberg, I. Z. (1978) Effect of the orientation of donor and acceptor on the probability of energy transfer involving electronic transitions of mixed polarization. Biochemistry 17, 5064-5070.
-
(1978)
Biochemistry
, vol.17
, pp. 5064-5070
-
-
Haas, E.1
Katchalski-Katzir, E.2
Steinberg, I.Z.3
-
27
-
-
0032823058
-
Alexa dyes, a series of new fluorescent dyes that yield exceptionally bright, photostable conjugates
-
Panchuk-Voloshina, N., Haugland, R. P., Bishop-Stewart, J., Bhalgat, M. K., Millard, P. J., Mao, F., Leung, W. Y., and Haugland, R. P. (1999) Alexa dyes, a series of new fluorescent dyes that yield exceptionally bright, photostable conjugates. J. Histochem. Cytochem. 47, 1179-1188.
-
(1999)
J. Histochem. Cytochem
, vol.47
, pp. 1179-1188
-
-
Panchuk-Voloshina, N.1
Haugland, R.P.2
Bishop-Stewart, J.3
Bhalgat, M.K.4
Millard, P.J.5
Mao, F.6
Leung, W.Y.7
Haugland, R.P.8
-
28
-
-
4944226721
-
Key differences in molecular complexes of the cholecystokinin receptor with structurally related peptide agonist, partial agonist, and antagonist
-
Arlander, S. J., Dong, M., Ding, X. Q., Pinon, D. I., and Miller, L. J. (2004) Key differences in molecular complexes of the cholecystokinin receptor with structurally related peptide agonist, partial agonist, and antagonist. Mol. Pharmacol. 66, 545-552.
-
(2004)
Mol. Pharmacol
, vol.66
, pp. 545-552
-
-
Arlander, S.J.1
Dong, M.2
Ding, X.Q.3
Pinon, D.I.4
Miller, L.J.5
-
29
-
-
0028913136
-
Fluorescence resonance energy transfer
-
Selvin, P. R. (1995) Fluorescence resonance energy transfer. Methods Enzymol. 246, 300-334.
-
(1995)
Methods Enzymol
, vol.246
, pp. 300-334
-
-
Selvin, P.R.1
-
30
-
-
0025249790
-
Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor
-
Dohlman, H. G., Caron, M. G., DeBlasi, A., Frielle, T., and Lefkowitz, R. J. (1990) Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor. Biochemistry 29, 2335-2342.
-
(1990)
Biochemistry
, vol.29
, pp. 2335-2342
-
-
Dohlman, H.G.1
Caron, M.G.2
DeBlasi, A.3
Frielle, T.4
Lefkowitz, R.J.5
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