Role of lysine187 within the second extracellular loop of the type A cholecystokinin receptor in agonist-induced activation. Use of complementary charge-reversal mutagenesis to define a functionally important interdomain interaction

Biochemistry

Volumn 46, Issue 15, 2007, Pages 4522-4531

  Dong, Maoqing ^a   Ding, Xi Qin ^a   Thomas, Scott E ^a   Gao, Fan ^a   Lam, Polo C H ^b   Abagyan, Ruben ^b   Miller, Laurence J ^a,c  

^a MAYO GRADUATE SCHOOL   (United States)

^b MOLSOFT LLC   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOACTIVITY; CONFORMATIONS; MOLECULAR STRUCTURE; MUTAGENESIS; PHYSIOLOGICAL MODELS;

CHOLECYSTOKININ RECEPTOR; CYTOSOLIC SURFACE; LYSINE;

PROTEINS;

CHOLECYSTOKININ; CHOLECYSTOKININ A RECEPTOR; G PROTEIN COUPLED RECEPTOR; LYSINE; CHOLECYSTOKININ RECEPTOR; PEPTIDE;

AMINO ACID COMPOSITION; ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; HORMONE RECEPTOR INTERACTION; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR OCCUPANCY; SITE DIRECTED MUTAGENESIS; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL; CRICETULUS; DRUG POTENTIATION; GENETICS; HAMSTER; METABOLISM; MUTAGENESIS; MUTATION; PROTEIN BINDING; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; LYSINE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTAGENESIS; MUTATION; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, CHOLECYSTOKININ; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 34247214479     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0622468     Document Type: Article

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