Fluorescent indicators distributed throughout the pharmacophore of cholecystokinin provide insights into distinct modes of binding and activation of type A and B cholecystokinin receptors

Journal of Biological Chemistry

Volumn 281, Issue 37, 2006, Pages 27072-27080

  Harikumar, Kaleeckal G ^a   Pinon, Delia I ^a   Miller, Laurence J ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; FLUORESCENCE; IODINE COMPOUNDS; NITROGEN COMPOUNDS; PHOTOEMISSION; QUENCHING; SPECTRUM ANALYSIS;

CHOLECYSTOKININ; FLUORESCENCE ANISOTROPY; FLUORESCENCE EMISSION SPECTRA; IODIDE QUENCHING;

MOLECULAR STRUCTURE;

CARBON; CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ B RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; IODIDE; NITROGEN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANISOTROPY; ARTICLE; CELL LINE; CONFORMATION; FLUORESCENCE; MOLECULAR PROBE; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL MEMBRANE; CHO CELLS; CHOLECYSTOKININ; CRICETINAE; FLUORESCENT DYES; KINETICS; MODELS, CHEMICAL; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, CHOLECYSTOKININ A; RECEPTOR, CHOLECYSTOKININ B; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33748754344     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M605098200     Document Type: Article

References (34)

1. Kolakowski, L. F., Jr. (1994) Receptors & Channels 2, 1-7
2. van Kesteren, R. E., Tensen, C. P., Smit, A. B., van Minnen, J., Kolakowski, L. F., Meyerhof, W., Richter, D., van Heerikhuizen, H., Vreugdenhil, E., and Geraerts, W. P. (1996) J. Biol. Chem. 271, 3619-3626
3. Moyle, W. R., Campbell, R. K., Myers, R. V., Bernard, M. P., Han, Y., and Wang, X. (1994) Nature 368, 251-255
4. Schmitz, F., Pratt, D. S., Wu, M. J., Kolakowski, L. F., Jr., Beinborn, M., and Kopin, A. S. (1996) Mol. Pharmacol. 50, 436-441
5. Mutt, V. (1981) Peptides (N.Y.) 2, Suppl. 2, 209-214
6. Rehfeld, J. F. (2000) Regul. Pept. 93, 79-83
7. Miller, L. J., Rosenzweig, S. A., and Jamieson, J. D. (1981) J. Biol. Chem. 256, 12417-12423
8. Powers, S. P., Pinon, D. I., and Miller, L. J. (1988) Int. J. Pept. Protein Res. 31, 429-434
9. Cohen, B. E., McAnaney, T. B., Park, E. S., Jan, Y. N., Boxer, S. G., and Jan, L. Y. (2002) Science 296, 1700-1703
10. Hadac, E. M., Ghanekar, D. V., Holicky, E. L., Pinon, D. I., Dougherty, R. W., and Miller, L. J. (1996) Pancreas 13, 130-139
11. Cheng, Z. J., Harikumar, K. G., Holicky, E. L., and Miller, L. J. (2003) J. Biol. Chem. 278, 52972-52979
12. Harikumar, K. G., Pinon, D. I., Wessels, W. S., Prendergast, F. G., and Miller, L. J. (2002) J. Biol. Chem. 277, 18552-18560
13. Munson, P. J., and Rodbard, D. (1980) Anal. Biochem. 107, 220-239
14. Grynkiewicz, G., Poenie, M., and Tsien, R. Y. (1985) J. Biol. Chem. 260, 3440-3450
15. Harikumar, K. G., Clain, J., Pinon, D. I., Dong, M., and Miller, L. J. (2005) J. Biol. Chem. 280, 1044-1050
16. Chattopadhyay, A. (2003) Chem. Phys. Lipids 122, 3-17
17. Chattopadhyay, A., Rawat, S. S., Kelkar, D. A., Ray, S., and Chakrabarti, A. (2003) Protein Sci. 12, 2389-2403
18. Kelkar, D. A., Chattopadhyay, A., Chakrabarti, A., and Bhattacharyya, M. (2005) Biopolymers 77, 325-334
19. Weber, G., and Farris, F. J. (1979) Biochemistry 18, 3075-3078
20. Noble, F., Fournie-Zaluski, M. C., and Roques, B. P. (1999) Therapie 54, 121-133
21. Noble, F., Wank, S. A., Crawley, J. N., Bradwejn, J., Seroogy, K. B., Hamon, M., and Roques, B. P. (1999) Pharmacol. Rev. 51, 745-781
22. Arlander, S. J., Dong, M., Ding, X. Q., Pinon, D. I., and Miller, L. J. (2004) Mol. Pharmacol. 66, 545-552
23. Kopin, A. S., McBride, E. W., Quinn, S. M., Kolakowski, L. F., Jr., and Beinborn, M. (1995) J. Biol. Chem. 270, 5019-5023
24. Silvente-Poirot, S., and Wank, S. A. (1996) J. Biol. Chem. 271, 14698-14706
25. Dong, M., Liu, G., Pinon, D. I., and Miller, L. J. (2005) Biochemistry 44, 6693-6700
26. Anders, J., Bluggel, M., Meyer, H. E., Kuhne, R., ter Laak, A. M., Kojro, E., and Fahrenholz, F. (1999) Biochemistry 38, 6043-6055
27. Ji, Z., Hadac, E. M., Henne, R. M., Patel, S. A., Lybrand, T. P., and Miller, L. J. (1997) J. Biol. Chem. 272, 24393-24401
28. Sundd, M., and Robertson, A. D. (2002) Nat. Struct. Biol. 9, 500-501
29. Ding, X. Q., Dolu, V., Hadac, E. M., Holicky, E. L., Pinon, D. I., Lybrand, T. P., and Miller, L. J. (2001) J. Biol. Chem. 276, 4236-4244
30. Kennedy, K., Gigoux, V., Escrieut, C., Maigret, B., Martinez, J., Moroder, L., Frehel, D., Gully, D., Vaysse, N., and Fourmy, D. (1997) J. Biol. Chem. 272, 2920-2926
31. Ding, X. Q., Pinon, D. I., Furse, K. E., Lybrand, T. P., and Miller, L. J. (2002) Mol. Pharmacol. 61, 1041-1052
32. Dong, M., Ding, X. Q., Pinon, D. I., Hadac, E. M., Oda, R. P., Landers, J. P., and Miller, L. J. (1999) J. Biol. Chem. 274, 4778-4785
33. Dong, M., Hadac, E. M., Pinon, D. I., and Miller, L. J. (2005) Mol. Pharmacol. 67, 1892-1900
34. Hadac, E. M., Pinon, D. I., Ji, Z., Holicky, E. L., Henne, R. M., Lybrand, T. P., and Miller, L. J. (1998) J. Biol. Chem. 273, 12988-12993