메뉴 건너뛰기




Volumn 48, Issue 4, 2009, Pages 243-252

Clinical pharmacokinetic and pharmacodynamic profile of inhaled ciclesonide

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; CICLESONIDE; CORTICOSTEROID; CYTOCHROME P450 3A4; DESISOBUTYRYL CICLESONIDE; DRUG METABOLITE; ERYTHROMYCIN; FLUTICASONE; KETOCONAZOLE; NORFLURANE; PROPELLANT; UNCLASSIFIED DRUG;

EID: 66949133866     PISSN: 03125963     EISSN: 03125963     Source Type: Journal    
DOI: 10.2165/00003088-200948040-00002     Document Type: Review
Times cited : (27)

References (71)
  • 1
    • 33746323435 scopus 로고    scopus 로고
    • Treating asthma as an inflammatory disease
    • Canonica GW. Treating asthma as an inflammatory disease. Chest 2006; 130 Suppl. 1: 21S-28S
    • (2006) Chest , vol.130 , Issue.SUPPL. 1
    • Canonica, G.W.1
  • 2
    • 33747750597 scopus 로고    scopus 로고
    • The mechanisms, diagnosis, and management of severe asthma in adults
    • Holgate ST, Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet 2006; 368 (9537): 780-93
    • (2006) Lancet , vol.368 , Issue.9537 , pp. 780-793
    • Holgate, S.T.1    Polosa, R.2
  • 3
    • 0036855114 scopus 로고    scopus 로고
    • Expert panel report: Guidelines for the diagnosis and management of asthma update on selected topics - 2002
    • National Asthma Education and Prevention Program
    • National Asthma Education and Prevention Program. Expert panel report: guidelines for the diagnosis and management of asthma update on selected topics - 2002. J Allergy Clin Immunol 2002; 110 (5 Suppl.): S141-219
    • (2002) J Allergy Clin Immunol , vol.110 , Issue.5 SUPPL.
  • 4
    • 3242685853 scopus 로고    scopus 로고
    • online, Available from URL:, Accessed 2008 May 20
    • Masoli M, Fabian D, Holt S, et al. Global burden of asthma [online]. Available from URL: http://www.ginasthma.com/download.asp?intId=29 [Accessed 2008 May 20]
    • Global burden of asthma
    • Masoli, M.1    Fabian, D.2    Holt, S.3
  • 6
    • 33746294223 scopus 로고    scopus 로고
    • The global burden of asthma
    • Braman SS. The global burden of asthma. Chest 2006; 130 (1 Suppl.): 4S-12S
    • (2006) Chest , vol.130 , Issue.1 SUPPL.
    • Braman, S.S.1
  • 7
    • 0032905475 scopus 로고    scopus 로고
    • The 1997 asthma management guidelines and therapeutic issues relating to the treatment of asthma
    • Georgitis JW. The 1997 asthma management guidelines and therapeutic issues relating to the treatment of asthma. Chest 1999; 115: 210-7
    • (1999) Chest , vol.115 , pp. 210-217
    • Georgitis, J.W.1
  • 8
    • 33744477341 scopus 로고    scopus 로고
    • How corticosteroids control inflammation: Quintiles Prize Lecture 2005
    • Barnes PJ. How corticosteroids control inflammation: Quintiles Prize Lecture 2005. Br J Pharmacol 2006; 148 (3): 245-54
    • (2006) Br J Pharmacol , vol.148 , Issue.3 , pp. 245-254
    • Barnes, P.J.1
  • 9
    • 0035490913 scopus 로고    scopus 로고
    • Molecular mechanisms of corticosteroids in allergic diseases
    • Barnes PJ. Molecular mechanisms of corticosteroids in allergic diseases. Allergy 2001; 56 (10): 928-36
    • (2001) Allergy , vol.56 , Issue.10 , pp. 928-936
    • Barnes, P.J.1
  • 10
    • 0036352690 scopus 로고    scopus 로고
    • Review of the molecular and cellular mechanisms of action of glucocorticoids for use in asthma
    • Umland SP, Schleimer RP, Johnston SL. Review of the molecular and cellular mechanisms of action of glucocorticoids for use in asthma. Pulm Pharmacol Ther 2002; 15: 35-50
    • (2002) Pulm Pharmacol Ther , vol.15 , pp. 35-50
    • Umland, S.P.1    Schleimer, R.P.2    Johnston, S.L.3
  • 11
    • 85031079191 scopus 로고    scopus 로고
    • Potential adverse effects of the inhaled corticosteroids
    • Kelly HW, Nelson HS. Potential adverse effects of the inhaled corticosteroids. J Allergy Clin Immunol 2003; 112 (3): 469-78
    • (2003) J Allergy Clin Immunol , vol.112 , Issue.3 , pp. 469-478
    • Kelly, H.W.1    Nelson, H.S.2
  • 12
    • 3242734980 scopus 로고    scopus 로고
    • The local side effects of inhaled corticosteroids: Current understanding and review of the literature
    • Roland NJ, Bhalla RK, Earis J. The local side effects of inhaled corticosteroids: current understanding and review of the literature. Chest 2004; 126 (1): 213-9
    • (2004) Chest , vol.126 , Issue.1 , pp. 213-219
    • Roland, N.J.1    Bhalla, R.K.2    Earis, J.3
  • 13
    • 33745375299 scopus 로고    scopus 로고
    • Systemic side effects of inhaled corticosteroids in patients with asthma
    • Dahl R. Systemic side effects of inhaled corticosteroids in patients with asthma. Respir Med 2006; 100 (8): 1307-17
    • (2006) Respir Med , vol.100 , Issue.8 , pp. 1307-1317
    • Dahl, R.1
  • 14
    • 0031794756 scopus 로고    scopus 로고
    • Establishing a therapeutic index for the inhaled corticosteroids: Part I. Pharmacokinetic/pharmacodynamic comparison of the inhaled corticosteroids
    • Kelly HW. Establishing a therapeutic index for the inhaled corticosteroids: part I. Pharmacokinetic/pharmacodynamic comparison of the inhaled corticosteroids. J Allergy Clin Immunol 1998; 102 (4 Pt 2): S36-51
    • (1998) J Allergy Clin Immunol , vol.102 , Issue.4 PART 2
    • Kelly, H.W.1
  • 15
    • 0030724891 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic properties of inhaled corticosteroids in relation to efficacy and safety
    • Derendorf H. Pharmacokinetic and pharmacodynamic properties of inhaled corticosteroids in relation to efficacy and safety. Respir Med 1997; 91 Suppl. A: 22-8
    • (1997) Respir Med , vol.91 , Issue.SUPPL. A , pp. 22-28
    • Derendorf, H.1
  • 16
    • 0041735123 scopus 로고    scopus 로고
    • Inhaled corticosteroids: Past lessons and future issues
    • Allen DB, Bielory L, Derendorf H, et al. Inhaled corticosteroids: past lessons and future issues. J Allergy Clin Immunol 2003; 112 (3 Suppl.): S1-40
    • (2003) J Allergy Clin Immunol , vol.112 , Issue.3 SUPPL.
    • Allen, D.B.1    Bielory, L.2    Derendorf, H.3
  • 17
    • 33847420001 scopus 로고    scopus 로고
    • Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma
    • Derendorf H, Nave R, Drollmann A, et al. Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma. Eur Respir J 2006; 28 (5): 1042-50
    • (2006) Eur Respir J , vol.28 , Issue.5 , pp. 1042-1050
    • Derendorf, H.1    Nave, R.2    Drollmann, A.3
  • 18
    • 0033160997 scopus 로고    scopus 로고
    • Absolute oral versus inhaled bioavail-ability: Significance for inhaled drugs with special reference to inhaled gluco-corticoids
    • Rohatagi S, Rhodes GR, Chaikin P. Absolute oral versus inhaled bioavail-ability: significance for inhaled drugs with special reference to inhaled gluco-corticoids. J Clin Pharmacol 1999; 39 (7): 661-3
    • (1999) J Clin Pharmacol , vol.39 , Issue.7 , pp. 661-663
    • Rohatagi, S.1    Rhodes, G.R.2    Chaikin, P.3
  • 19
    • 0345733708 scopus 로고    scopus 로고
    • Risk-benefit value of inhaled glucocorticoids: A pharmacokinetic/pharmacodynamic perspective
    • Rohatagi S, Appajosyula S, Derendorf H, et al. Risk-benefit value of inhaled glucocorticoids: a pharmacokinetic/pharmacodynamic perspective. J Clin Pharmacol 2004; 44 (1): 37-47
    • (2004) J Clin Pharmacol , vol.44 , Issue.1 , pp. 37-47
    • Rohatagi, S.1    Appajosyula, S.2    Derendorf, H.3
  • 21
    • 33747156391 scopus 로고    scopus 로고
    • Comparable efficacy of ciclesonide once daily versus fluticasone propionate twice daily in asthma
    • Buhl R, Vinkler I, Magyar P, et al. Comparable efficacy of ciclesonide once daily versus fluticasone propionate twice daily in asthma. Pulm Pharmacol Ther 2005; 19 (6): 404-12
    • (2005) Pulm Pharmacol Ther , vol.19 , Issue.6 , pp. 404-412
    • Buhl, R.1    Vinkler, I.2    Magyar, P.3
  • 22
    • 0034910074 scopus 로고    scopus 로고
    • Treatment of asthma by the inhaled corticosteroid ciclesonide given either in the morning or evening
    • Postma DS, Sevette C, Martinat Y, et al. Treatment of asthma by the inhaled corticosteroid ciclesonide given either in the morning or evening. Eur Respir J 2001; 17: 1083-8
    • (2001) Eur Respir J , vol.17 , pp. 1083-1088
    • Postma, D.S.1    Sevette, C.2    Martinat, Y.3
  • 23
    • 24344444433 scopus 로고    scopus 로고
    • Once-daily ciclesonide 80 or 320 microg for 12 weeks is safe and effective in patients with persistent asthma
    • Langdon CG, Adler M, Mehra S, et al. Once-daily ciclesonide 80 or 320 microg for 12 weeks is safe and effective in patients with persistent asthma. Respir Med 2005; 99 (10): 1275-85
    • (2005) Respir Med , vol.99 , Issue.10 , pp. 1275-1285
    • Langdon, C.G.1    Adler, M.2    Mehra, S.3
  • 24
    • 29144449973 scopus 로고    scopus 로고
    • Comparison of the efficacy of ciclesonide 160 microg QD and budesonide 200 microg BID in adults with persistent asthma: A phase III, randomized, double-dummy, open-label study
    • Niphadkar P, Jagannath K, Joshi JM, et al. Comparison of the efficacy of ciclesonide 160 microg QD and budesonide 200 microg BID in adults with persistent asthma: a phase III, randomized, double-dummy, open-label study. Clin Ther 2005; 27 (11): 1752-63
    • (2005) Clin Ther , vol.27 , Issue.11 , pp. 1752-1763
    • Niphadkar, P.1    Jagannath, K.2    Joshi, J.M.3
  • 25
    • 14344250921 scopus 로고    scopus 로고
    • Maintenance of asthma control by once-daily inhaled ciclesonide in adults with persistent asthma
    • Chapman KR, Patel P, D'Urzo AD, et al. Maintenance of asthma control by once-daily inhaled ciclesonide in adults with persistent asthma. Allergy 2005; 60 (3): 330-7
    • (2005) Allergy , vol.60 , Issue.3 , pp. 330-337
    • Chapman, K.R.1    Patel, P.2    D'Urzo, A.D.3
  • 26
    • 33747711384 scopus 로고    scopus 로고
    • The systemic safety of inhaled corticosteroid therapy: A focus on ciclesonide
    • Metzer EO, Derendorf H. The systemic safety of inhaled corticosteroid therapy: a focus on ciclesonide. Ann Allergy Asthma Immunol 2006; 97: 149-57
    • (2006) Ann Allergy Asthma Immunol , vol.97 , pp. 149-157
    • Metzer, E.O.1    Derendorf, H.2
  • 27
    • 66949168724 scopus 로고    scopus 로고
    • Ciclesonide: A closer look at its systemic and oropharyngeal safety profile
    • Berger WE. Ciclesonide: a closer look at its systemic and oropharyngeal safety profile. Curr Drug Saf 2006; 1: 265-70
    • (2006) Curr Drug Saf , vol.1 , pp. 265-270
    • Berger, W.E.1
  • 28
    • 2642522877 scopus 로고    scopus 로고
    • 14C]ciclesonide after oral and intravenous administration to healthy subjects
    • 14C]ciclesonide after oral and intravenous administration to healthy subjects. Clin Pharmaco-kinet 2004; 43 (7): 479-86
    • (2004) Clin Pharmaco-kinet , vol.43 , Issue.7 , pp. 479-486
    • Nave, R.1    Bethke, T.D.2    van Marle, S.P.3
  • 29
    • 0012614672 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmaco-dynamics of ciclesonide and its active principle after inhalative and intravenous administration in healthy subjects [abstract]
    • Nave R, Bethke TD, Seiberling M, et al. Pharmacokinetics and pharmaco-dynamics of ciclesonide and its active principle after inhalative and intravenous administration in healthy subjects [abstract]. Eur Respir J 2002; 20 Suppl. 38: P749
    • (2002) Eur Respir J , vol.20 , Issue.SUPPL. 38
    • Nave, R.1    Bethke, T.D.2    Seiberling, M.3
  • 30
    • 32644435870 scopus 로고    scopus 로고
    • 99m)Tc-labeled ciclesonide administered via HFA-MDI to patients with asthma
    • 99m)Tc-labeled ciclesonide administered via HFA-MDI to patients with asthma. Respir Med 2006; 100 (3): 375-84
    • (2006) Respir Med , vol.100 , Issue.3 , pp. 375-384
    • Newman, S.1    Salmon, A.2    Nave, R.3
  • 31
    • 20044369411 scopus 로고    scopus 로고
    • Lower oropharyngeal deposition of inhaled ciclesonide via hydrofluoroalkane metered-dose inhaler compared with budesonide via chlorofluorocarbon metered-dose inhaler in healthy subjects
    • Nave R, Zech K, Bethke TD. Lower oropharyngeal deposition of inhaled ciclesonide via hydrofluoroalkane metered-dose inhaler compared with budesonide via chlorofluorocarbon metered-dose inhaler in healthy subjects. Eur J Clin Pharmacol 2005; 61 (3): 203-208. 49-258
    • (2005) Eur J Clin Pharmacol , vol.61 , Issue.3
    • Nave, R.1    Zech, K.2    Bethke, T.D.3
  • 32
    • 16244397682 scopus 로고    scopus 로고
    • Comparison of the oropharyngeal deposition of inhaled ciclesonide and fluticasone propionate in patients with asthma
    • Richter K, Kanniess F, Biberger C, et al. Comparison of the oropharyngeal deposition of inhaled ciclesonide and fluticasone propionate in patients with asthma. J Clin Pharmacol 2005; 45 (2): 146-52
    • (2005) J Clin Pharmacol , vol.45 , Issue.2 , pp. 146-152
    • Richter, K.1    Kanniess, F.2    Biberger, C.3
  • 33
    • 0037378092 scopus 로고    scopus 로고
    • Population pharmacokinetics and pharmcodynamics of ciclesonide
    • Rohatagi S, Arya V, Zech K, et al. Population pharmacokinetics and pharmcodynamics of ciclesonide. J Clin Pharmacol 2003; 43 (4): 365-78
    • (2003) J Clin Pharmacol , vol.43 , Issue.4 , pp. 365-378
    • Rohatagi, S.1    Arya, V.2    Zech, K.3
  • 34
    • 30644462963 scopus 로고    scopus 로고
    • Pharmacokinetic disposition of inhaled ciclesonide and its metabolite desisobutyryl-ciclesonide in healthy subjects and patients with asthma are similar. IntJ
    • Nave R, Gunawardena KA, Zech K, et al. Pharmacokinetic disposition of inhaled ciclesonide and its metabolite desisobutyryl-ciclesonide in healthy subjects and patients with asthma are similar. IntJ Clin Pharmacol Ther 2006; 44 (1): 1-7
    • (2006) Clin Pharmacol Ther , vol.44 , Issue.1 , pp. 1-7
    • Nave, R.1    Gunawardena, K.A.2    Zech, K.3
  • 35
    • 20444466142 scopus 로고    scopus 로고
    • Protein binding and its potential for eliciting minimal systemic side effects with a novel inhaled corticosteroid, ciclesonide
    • Rohatagi S, Luo Y, Shen L, et al. Protein binding and its potential for eliciting minimal systemic side effects with a novel inhaled corticosteroid, ciclesonide. Am J Ther 2005; 12 (3): 201-9
    • (2005) Am J Ther , vol.12 , Issue.3 , pp. 201-209
    • Rohatagi, S.1    Luo, Y.2    Shen, L.3
  • 36
    • 0029845201 scopus 로고    scopus 로고
    • Glucocorticoid receptor localization in normal and asthmatic lung
    • Adcock IM, Gilbey T, Gelder CM, et al. Glucocorticoid receptor localization in normal and asthmatic lung. Am J Respir Crit Care Med 1996; 154 (3 Pt 1): 771-82
    • (1996) Am J Respir Crit Care Med , vol.154 , Issue.3 PART 1 , pp. 771-782
    • Adcock, I.M.1    Gilbey, T.2    Gelder, C.M.3
  • 37
    • 1642340164 scopus 로고    scopus 로고
    • In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide
    • Stoeck M, Riedel R, Hochhaus G, et al. In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide. J Pharmacol Exp Ther 2004; 309 (1): 249-58
    • (2004) J Pharmacol Exp Ther , vol.309 , Issue.1 , pp. 249-258
    • Stoeck, M.1    Riedel, R.2    Hochhaus, G.3
  • 38
    • 34047160413 scopus 로고    scopus 로고
    • The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue
    • Mutch E, Nave R, McCracken N, et al. The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue. Biochem Pharmacol 2007; 73 (10): 1657-64
    • (2007) Biochem Pharmacol , vol.73 , Issue.10 , pp. 1657-1664
    • Mutch, E.1    Nave, R.2    McCracken, N.3
  • 39
    • 35748979427 scopus 로고    scopus 로고
    • Ciclesonide uptake and metabolism in human alveolar type IIepithelial cells (A549)
    • Nonaka T, Nave R, McCrackenN, et al. Ciclesonide uptake and metabolism in human alveolar type IIepithelial cells (A549). BMC Pharmacology 2007; 7: 12
    • (2007) BMC Pharmacology , vol.7 , pp. 12
    • Nonaka, T.1    Nave, R.2    McCrackenN3
  • 40
    • 33744467048 scopus 로고    scopus 로고
    • In vitro metabolism of ciclesonide in human lung and liver precision-cut tissue slices
    • Nave R, Fisher R, Zech K. In vitro metabolism of ciclesonide in human lung and liver precision-cut tissue slices. Biopharm Drug Dispos 2006; 27 (4): 197-207
    • (2006) Biopharm Drug Dispos , vol.27 , Issue.4 , pp. 197-207
    • Nave, R.1    Fisher, R.2    Zech, K.3
  • 41
    • 38449086781 scopus 로고    scopus 로고
    • In vitro metabolism of beclomethasone dipropionate, budesonide, ciclesonide, and fluticasone propionate in human lung precision-cut tissue slices
    • Nave R, Fisher R, McCracken N. In vitro metabolism of beclomethasone dipropionate, budesonide, ciclesonide, and fluticasone propionate in human lung precision-cut tissue slices. Respir Res 2007; 8: 65
    • (2007) Respir Res , vol.8 , pp. 65
    • Nave, R.1    Fisher, R.2    McCracken, N.3
  • 42
    • 34249053215 scopus 로고    scopus 로고
    • In vivo metabolism of ciclesonide in the human lung [abstract]
    • Drollmann A, Watz H, Nave R, et al. In vivo metabolism of ciclesonide in the human lung [abstract]. Proc Am Thorac Soc 2006; 3: A75
    • (2006) Proc Am Thorac Soc , vol.3
    • Drollmann, A.1    Watz, H.2    Nave, R.3
  • 43
    • 66949159685 scopus 로고    scopus 로고
    • Metabolism of ciclesonide in the upper and lower airways: Review of available data
    • Nave R, McCracken N. Metabolism of ciclesonide in the upper and lower airways: review of available data. J Asthma Allergy 2008; 1: 11-8
    • (2008) J Asthma Allergy , vol.1 , pp. 11-18
    • Nave, R.1    McCracken, N.2
  • 44
    • 34249027887 scopus 로고    scopus 로고
    • 14C-ciclesonide in hepatocytes from the mouse, rat, rabbit, dog, and human
    • 14C-ciclesonide in hepatocytes from the mouse, rat, rabbit, dog, and human. Am J Ther 2007; 14 (3): 280-90
    • (2007) Am J Ther , vol.14 , Issue.3 , pp. 280-290
    • Gu, Z.1    Zhao, X.2    Nave, R.3
  • 45
    • 30744464352 scopus 로고    scopus 로고
    • Identification of enzymes involved in phase I metabolism of ciclesonide by human liver microsomes
    • Peet CF, Enos T, Nave R, et al. Identification of enzymes involved in phase I metabolism of ciclesonide by human liver microsomes. Eur J Drug Metab Pharmacokinet 2005; 30 (4): 275-86
    • (2005) Eur J Drug Metab Pharmacokinet , vol.30 , Issue.4 , pp. 275-286
    • Peet, C.F.1    Enos, T.2    Nave, R.3
  • 46
    • 33751369847 scopus 로고    scopus 로고
    • Ciclesonide disposition and metabolism: Pharmacokinetics, metabolism, and excretion in the mouse, rat, rabbit, and dog
    • Guo Z, Gu Z, Howell SR, et al. Ciclesonide disposition and metabolism: pharmacokinetics, metabolism, and excretion in the mouse, rat, rabbit, and dog. Am J Ther 2006; 13: 490-501
    • (2006) Am J Ther , vol.13 , pp. 490-501
    • Guo, Z.1    Gu, Z.2    Howell, S.R.3
  • 47
    • 0031944825 scopus 로고    scopus 로고
    • Cytokine mRNA expression in asthma is not restricted to the large airways
    • Minshall EM, Hogg JC, Hamid QA. Cytokine mRNA expression in asthma is not restricted to the large airways. J Allergy Clin Immunol 1998; 101 (3): 386-90
    • (1998) J Allergy Clin Immunol , vol.101 , Issue.3 , pp. 386-390
    • Minshall, E.M.1    Hogg, J.C.2    Hamid, Q.A.3
  • 48
    • 22044435423 scopus 로고    scopus 로고
    • Hydrofluoroalkane-134A beclomethasone or chlorofluorocarbon fluticasone: Effect on small airways in poorly controlled asthma
    • Thongngarm T, Silkoff PE, Kossack WS, et al. Hydrofluoroalkane-134A beclomethasone or chlorofluorocarbon fluticasone: effect on small airways in poorly controlled asthma. J Asthma 2005; 42 (4): 257-63
    • (2005) J Asthma , vol.42 , Issue.4 , pp. 257-263
    • Thongngarm, T.1    Silkoff, P.E.2    Kossack, W.S.3
  • 49
  • 50
    • 0034278559 scopus 로고    scopus 로고
    • In vitro characterisation of metered dose inhaler versus dry powder inhaler glucocorticoid products: Influence of inspiratory flow rates
    • Feddah MR, Brown KF, Gipps EM, et al. In vitro characterisation of metered dose inhaler versus dry powder inhaler glucocorticoid products: influence of inspiratory flow rates. J Pharm Pharm Sci 2000; 3 (3): 318-24
    • (2000) J Pharm Pharm Sci , vol.3 , Issue.3 , pp. 318-324
    • Feddah, M.R.1    Brown, K.F.2    Gipps, E.M.3
  • 51
    • 33745601984 scopus 로고    scopus 로고
    • 2-D and 3-D imaging show ciclesonide has high lung deposition and peripheral distribution: A nonrandomized study in healthy volunteers
    • Leach C, Bethke T, Boudreau R, et al. 2-D and 3-D imaging show ciclesonide has high lung deposition and peripheral distribution: a nonrandomized study in healthy volunteers. J Aerosol Med 2006; 19 (2): 117-26
    • (2006) J Aerosol Med , vol.19 , Issue.2 , pp. 117-126
    • Leach, C.1    Bethke, T.2    Boudreau, R.3
  • 52
    • 33745284283 scopus 로고    scopus 로고
    • Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma
    • Buhl R. Local oropharyngeal side effects of inhaled corticosteroids in patients with asthma. Allergy 2006; 61 (5): 518-26
    • (2006) Allergy , vol.61 , Issue.5 , pp. 518-526
    • Buhl, R.1
  • 53
    • 11144349963 scopus 로고    scopus 로고
    • Low incidence of oropharyngeal adverse events in asthma patients treated with ciclesonide: Results from a pooled analysis [abstract]
    • Engelstaetter R, Steinijans V, Wurst W. Low incidence of oropharyngeal adverse events in asthma patients treated with ciclesonide: results from a pooled analysis [abstract]. Am J Respir Crit Care Med 2004; 169 (7): A92
    • (2004) Am J Respir Crit Care Med , vol.169 , Issue.7
    • Engelstaetter, R.1    Steinijans, V.2    Wurst, W.3
  • 54
    • 20944444681 scopus 로고    scopus 로고
    • Effect of ciclesonide and fluticasone on hypothalamic-pituitary-adrenal axis function in adults with mild-to-moderate persistent asthma
    • Lipworth BJ, Kaliner MA, LaForce CF, et al. Effect of ciclesonide and fluticasone on hypothalamic-pituitary-adrenal axis function in adults with mild-to-moderate persistent asthma. Ann Allergy Asthma Immunol 2005; 94 (4): 465-72
    • (2005) Ann Allergy Asthma Immunol , vol.94 , Issue.4 , pp. 465-472
    • Lipworth, B.J.1    Kaliner, M.A.2    LaForce, C.F.3
  • 55
    • 33745599325 scopus 로고    scopus 로고
    • Equivalent pharmacokinetics of the active metabolite of ciclesonide with and without use of the AeroChamber Plus spacer for inhalation
    • Drollmann A, Nave R, Steinijans VW, et al. Equivalent pharmacokinetics of the active metabolite of ciclesonide with and without use of the AeroChamber Plus spacer for inhalation. Clin Pharmacokinet 2006; 45: 729-36
    • (2006) Clin Pharmacokinet , vol.45 , pp. 729-736
    • Drollmann, A.1    Nave, R.2    Steinijans, V.W.3
  • 56
    • 0000707136 scopus 로고    scopus 로고
    • Bioequivalence of two ciclesonide dosing regimen (4 puffs of 200 μg versus 16 puffs of 50 μg using a MDI) [abstract]
    • Bethke TD, Drollmann A, Hauns B, et al. Bioequivalence of two ciclesonide dosing regimen (4 puffs of 200 μg versus 16 puffs of 50 μg using a MDI) [abstract]. Eur Respir J 2002; 20 Suppl. 38: P1914
    • (2002) Eur Respir J , vol.20 , Issue.SUPPL. 38
    • Bethke, T.D.1    Drollmann, A.2    Hauns, B.3
  • 57
    • 0000707136 scopus 로고    scopus 로고
    • Bioequivalence of two ciclesonide dosing regimen (4 puffs of 200 μg versus 8 puffs of 100 μg using a MDI) [abstract]
    • Drollmann A, Bethke TD, Nave R, et al. Bioequivalence of two ciclesonide dosing regimen (4 puffs of 200 μg versus 8 puffs of 100 μg using a MDI) [abstract]. Eur Respir J 2002; 20 Suppl. 38: P1914
    • (2002) Eur Respir J , vol.20 , Issue.SUPPL. 38
    • Drollmann, A.1    Bethke, T.D.2    Nave, R.3
  • 58
    • 21044432400 scopus 로고    scopus 로고
    • Lack of pharmacokinetic drug-drug interaction between ciclesonide and erythromycin
    • Nave R, Drollmann A, Steinijans VW, et al. Lack of pharmacokinetic drug-drug interaction between ciclesonide and erythromycin. Int J Clin Pharmacol Ther 2005; 43 (6): 264-70
    • (2005) Int J Clin Pharmacol Ther , vol.43 , Issue.6 , pp. 264-270
    • Nave, R.1    Drollmann, A.2    Steinijans, V.W.3
  • 59
    • 41949128962 scopus 로고    scopus 로고
    • Effect of coadministered ketoconazole, a strong cytochrome P450 3A4 enzyme inhibitor, on the pharmaco-kinetics of ciclesonide and its active metabolite desisobutyryl- ciclesonide
    • Bohmer G, Drollmann A, Gleiter C, et al. Effect of coadministered ketoconazole, a strong cytochrome P450 3A4 enzyme inhibitor, on the pharmaco-kinetics of ciclesonide and its active metabolite desisobutyryl- ciclesonide. Clin Pharmacokinet 2008; 47 (5): 343-9
    • (2008) Clin Pharmacokinet , vol.47 , Issue.5 , pp. 343-349
    • Bohmer, G.1    Drollmann, A.2    Gleiter, C.3
  • 60
    • 0031957146 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of inhaled corticosteroids
    • Derendorf H, Hochhaus G, Meibohm B, et al. Pharmacokinetics and pharmacodynamics of inhaled corticosteroids. J Allergy Clin Immunol 1998; 101 (4 Pt 2): S440-6
    • (1998) J Allergy Clin Immunol , vol.101 , Issue.4 PART 2
    • Derendorf, H.1    Hochhaus, G.2    Meibohm, B.3
  • 61
    • 0032846437 scopus 로고    scopus 로고
    • Measures of hypothalamic-pituitary-adrenal function in patients with asthma treated with inhaled glucocorticoids: Clinical and research implications
    • Wolthers OD, Honour JW. Measures of hypothalamic-pituitary-adrenal function in patients with asthma treated with inhaled glucocorticoids: clinical and research implications. J Asthma 1999; 36 (6): 477-86
    • (1999) J Asthma , vol.36 , Issue.6 , pp. 477-486
    • Wolthers, O.D.1    Honour, J.W.2
  • 62
    • 33645045860 scopus 로고    scopus 로고
    • Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticosteroids
    • Taylor S, Harker A. Modification of the ultrafiltration technique to overcome solubility and non-specific binding challenges associated with the measurement of plasma protein binding of corticosteroids. J Pharm Biomed Anal 2006; 41 (1): 299-303
    • (2006) J Pharm Biomed Anal , vol.41 , Issue.1 , pp. 299-303
    • Taylor, S.1    Harker, A.2
  • 63
    • 34249053215 scopus 로고    scopus 로고
    • Negligible concentration of unbound des-CIC in muscle and subcutaneous adipose tissue after inhalation of ciclesonide in a supra-therapeutic dose [abstract]
    • Abstract Suppl
    • Drollmann A, Nave R, Steiner I, et al. Negligible concentration of unbound des-CIC in muscle and subcutaneous adipose tissue after inhalation of ciclesonide in a supra-therapeutic dose [abstract]. Proc Am Thorac Soc 2006; 3 (Abstract Suppl.): A75
    • (2006) Proc Am Thorac Soc , vol.3
    • Drollmann, A.1    Nave, R.2    Steiner, I.3
  • 64
    • 20444415685 scopus 로고    scopus 로고
    • Effects of inhaled ciclesonide and fluticasone propionate on cortisol secretion and airway responsiveness to ade-nosine 5′monophosphate in asthmatic patients
    • Derom E, Van DV, Marissens S, et al. Effects of inhaled ciclesonide and fluticasone propionate on cortisol secretion and airway responsiveness to ade-nosine 5′monophosphate in asthmatic patients. Pulm Pharmacol Ther 2005; 18 (5): 328-36
    • (2005) Pulm Pharmacol Ther , vol.18 , Issue.5 , pp. 328-336
    • Derom, E.1    Van, D.V.2    Marissens, S.3
  • 65
    • 15844377108 scopus 로고    scopus 로고
    • Airway and systemic effects of hydrofluoroalkane formulations of high-dose ciclesonide and fluticasone in moderate persistent asthma
    • Lee DK, Fardon TC, Bates CE, et al. Airway and systemic effects of hydrofluoroalkane formulations of high-dose ciclesonide and fluticasone in moderate persistent asthma. Chest 2005; 127 (3): 851-60
    • (2005) Chest , vol.127 , Issue.3 , pp. 851-860
    • Lee, D.K.1    Fardon, T.C.2    Bates, C.E.3
  • 66
    • 18344393060 scopus 로고    scopus 로고
    • Circadian rhythm of serum cortisol after repeated inhalation of the new topical steroid ciclesonide
    • Weinbrenner A, Huneke D, Zschiesche M, et al. Circadian rhythm of serum cortisol after repeated inhalation of the new topical steroid ciclesonide. J Clin Endocrinol Metab 2002; 87 (5): 2160-3
    • (2002) J Clin Endocrinol Metab , vol.87 , Issue.5 , pp. 2160-2163
    • Weinbrenner, A.1    Huneke, D.2    Zschiesche, M.3
  • 67
    • 20444468843 scopus 로고    scopus 로고
    • Ciclesonide, a novel inhaled steroid, does not affect hypothalamic-pituitary-adrenal axis function in patients with moderate-to-severe persistent asthma
    • Szefler S, Rohatagi S, Williams J, et al. Ciclesonide, a novel inhaled steroid, does not affect hypothalamic-pituitary-adrenal axis function in patients with moderate-to-severe persistent asthma. Chest 2005; 128 (3): 1104-14
    • (2005) Chest , vol.128 , Issue.3 , pp. 1104-1114
    • Szefler, S.1    Rohatagi, S.2    Williams, J.3
  • 68
    • 18144383000 scopus 로고    scopus 로고
    • Short-term lower-leg growth rate and urine cortisol excretion in children treated with ciclesonide
    • Agertoft L, Pedersen S. Short-term lower-leg growth rate and urine cortisol excretion in children treated with ciclesonide. J Allergy Clin Immunol 2005; 115 (5): 940-5
    • (2005) J Allergy Clin Immunol , vol.115 , Issue.5 , pp. 940-945
    • Agertoft, L.1    Pedersen, S.2
  • 69
    • 26844558866 scopus 로고    scopus 로고
    • Model-based covariate pharmacokinetic analysis and lack of cortisol suppression by the new inhaled corticosteroid ciclesonide using a novel cortisol release model
    • Rohatagi S, Krishnaswami S, Pfister M, et al. Model-based covariate pharmacokinetic analysis and lack of cortisol suppression by the new inhaled corticosteroid ciclesonide using a novel cortisol release model. Am J Ther 2005; 12 (5): 385-97
    • (2005) Am J Ther , vol.12 , Issue.5 , pp. 385-397
    • Rohatagi, S.1    Krishnaswami, S.2    Pfister, M.3
  • 70
    • 33644986352 scopus 로고    scopus 로고
    • Safety, tolerability, and exposure of ciclesonide nasal spray in healthy and asymptomatic subjects with seasonal allergic rhinitis
    • Nave R, Wingertzahn MA, Brookman S, et al. Safety, tolerability, and exposure of ciclesonide nasal spray in healthy and asymptomatic subjects with seasonal allergic rhinitis. J Clin Pharmacol 2006; 46: 461-7
    • (2006) J Clin Pharmacol , vol.46 , pp. 461-467
    • Nave, R.1    Wingertzahn, M.A.2    Brookman, S.3
  • 71
    • 38649107735 scopus 로고    scopus 로고
    • Safety of once-daily ciclesonide nasal spray in children with perennial allergic rhinitis
    • Kim K, Weiswasser M, Nave R, et al. Safety of once-daily ciclesonide nasal spray in children with perennial allergic rhinitis. Pediatr Asthma Allergy Immunol 2007; 20 (4): 229-42
    • (2007) Pediatr Asthma Allergy Immunol , vol.20 , Issue.4 , pp. 229-242
    • Kim, K.1    Weiswasser, M.2    Nave, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.