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Volumn 19, Issue 2, 2006, Pages 117-126

Two-dimensional and three-dimensional imaging show ciclesonide has high lung deposition and peripheral distribution: A nonrandomized study in healthy volunteers

Author keywords

Asthma; Ciclesonide; Lung deposition; Metered dose inhaler

Indexed keywords

CICLESONIDE; FLUORINATED HYDROCARBON; NORFLURANE; PROPELLANT; TECHNETIUM 99M;

EID: 33745601984     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.2006.19.117     Document Type: Article
Times cited : (84)

References (45)
  • 2
    • 0028969594 scopus 로고
    • A multicenter study of alternate-day prednisone therapy in patients with cystic fibrosis
    • Cystic Fibrosis Foundation Prednisone Trial Group
    • Eigen, H., B.J. Rosenstein, S. FitzSimmons, et al. 1995. A multicenter study of alternate-day prednisone therapy in patients with cystic fibrosis. Cystic Fibrosis Foundation Prednisone Trial Group. J. Pediatr. 126:515-523.
    • (1995) J. Pediatr. , vol.126 , pp. 515-523
    • Eigen, H.1    Rosenstein, B.J.2    Fitzsimmons, S.3
  • 3
    • 0029787984 scopus 로고    scopus 로고
    • Growth suppression by glucocorticoid therapy
    • Allen, D.B. 1996. Growth suppression by glucocorticoid therapy. Endocrinol. Metab. Clin. North Am. 25:699-717.
    • (1996) Endocrinol. Metab. Clin. North Am. , vol.25 , pp. 699-717
    • Allen, D.B.1
  • 4
    • 0031886377 scopus 로고    scopus 로고
    • Influence of inhaled corticosteroids on growth: A pediatric endocrinologist's perspective
    • Allen, D.B. 1998. Influence of inhaled corticosteroids on growth: a pediatric endocrinologist's perspective. Acta Paediatr. 87:123-129.
    • (1998) Acta Paediatr. , vol.87 , pp. 123-129
    • Allen, D.B.1
  • 5
    • 0029046176 scopus 로고
    • Growth of prepubertal children with mild asthma treated with inhaled beclomethasone dipropionate
    • Doull, I.J., N.J. Freezer, and S.T. Holgate. 1995. Growth of prepubertal children with mild asthma treated with inhaled beclomethasone dipropionate. Am. J. Respir. Crit. Care Med. 151:1715-1719.
    • (1995) Am. J. Respir. Crit. Care Med. , vol.151 , pp. 1715-1719
    • Doull, I.J.1    Freezer, N.J.2    Holgate, S.T.3
  • 6
    • 0028291973 scopus 로고
    • A meta-analysis of the effect of oral and inhaled corticosteroids on growth
    • Allen, D.B., M. Mullen, and B. Mullen. 1994. A meta-analysis of the effect of oral and inhaled corticosteroids on growth. J. Allergy Clin. Immunol. 93:967-976.
    • (1994) J. Allergy Clin. Immunol. , vol.93 , pp. 967-976
    • Allen, D.B.1    Mullen, M.2    Mullen, B.3
  • 7
    • 0030572466 scopus 로고    scopus 로고
    • Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate
    • Todd, G., K. Durdop, J. McNaboe, et al. 1996. Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate. Lancet 348:27-29.
    • (1996) Lancet , vol.348 , pp. 27-29
    • Todd, G.1    Durdop, K.2    McNaboe, J.3
  • 8
    • 0034704799 scopus 로고    scopus 로고
    • Risk of persistent growth impairment after alternate-day prednisone treatment in children with cystic fibrosis
    • Lai, H.C., S.C. FitzSimmons, D.B. Allen, et al. 2000. Risk of persistent growth impairment after alternate-day prednisone treatment in children with cystic fibrosis. N. Engl. J. Med. 342:851-859.
    • (2000) N. Engl. J. Med. , vol.342 , pp. 851-859
    • Lai, H.C.1    Fitzsimmons, S.C.2    Allen, D.B.3
  • 9
    • 0030008193 scopus 로고    scopus 로고
    • Comparative adrenal suppression with inhaled budesonide and fluticasone propionate in adult asthmatic patients
    • Clark, D.J., A. Grove, R.I. Cargill, et al. 1996. Comparative adrenal suppression with inhaled budesonide and fluticasone propionate in adult asthmatic patients. Thorax 51:262-266.
    • (1996) Thorax , vol.51 , pp. 262-266
    • Clark, D.J.1    Grove, A.2    Cargill, R.I.3
  • 10
    • 0030874197 scopus 로고    scopus 로고
    • A dose-response study comparing suppression of plasma cortisol induced by fluticasone propionate from Diskhaler and budesonide from Turbuhaler
    • Grahnen, A., B. Jansson, R.M. Brundin, et al. 1997. A dose-response study comparing suppression of plasma cortisol induced by fluticasone propionate from Diskhaler and budesonide from Turbuhaler. Eur. J. Clin. Pharmacol. 52:261-267.
    • (1997) Eur. J. Clin. Pharmacol. , vol.52 , pp. 261-267
    • Grahnen, A.1    Jansson, B.2    Brundin, R.M.3
  • 11
    • 0031044945 scopus 로고    scopus 로고
    • Pharmacokinetics and systemic effects of inhaled fluticasone propionate in healthy subjects
    • Thorsson, L., K. Dahlstrom, S. Edsbacker, et al. 1997. Pharmacokinetics and systemic effects of inhaled fluticasone propionate in healthy subjects. Br. J. Clin. Pharmacol. 43:155-161.
    • (1997) Br. J. Clin. Pharmacol. , vol.43 , pp. 155-161
    • Thorsson, L.1    Dahlstrom, K.2    Edsbacker, S.3
  • 12
    • 0030859363 scopus 로고    scopus 로고
    • Use of inhaled corticosteroids and the risk of cataracts
    • Cumming, R.G., P. Mitchell, and S.R. Leeder. 1997. Use of inhaled corticosteroids and the risk of cataracts. N. Engl. J. Med. 337:8-14.
    • (1997) N. Engl. J. Med. , vol.337 , pp. 8-14
    • Cumming, R.G.1    Mitchell, P.2    Leeder, S.R.3
  • 13
    • 0032891996 scopus 로고    scopus 로고
    • Comparative efficacy and safety of inhaled corticosteroids in asthma
    • Jackson, L.D., D. Polygenis, R.A. McIvor, et al. 1999. Comparative efficacy and safety of inhaled corticosteroids in asthma. Can. J. Clin. Pharmacol. 6:26-37.
    • (1999) Can. J. Clin. Pharmacol. , vol.6 , pp. 26-37
    • Jackson, L.D.1    Polygenis, D.2    McIvor, R.A.3
  • 14
    • 0035985611 scopus 로고    scopus 로고
    • Ciclesonide (Byk Gulden)
    • Dent, G. 2002. Ciclesonide (Byk Gulden). Curr. Opin. Invest. Drugs 3:78-83.
    • (2002) Curr. Opin. Invest. Drugs , vol.3 , pp. 78-83
    • Dent, G.1
  • 16
    • 0035744434 scopus 로고    scopus 로고
    • Airway pathology in asthma
    • Saetta, M., and G. Turato. 2001. Airway pathology in asthma. Eur. Respir. J. 18:18s-23s.
    • (2001) Eur. Respir. J. , vol.18
    • Saetta, M.1    Turato, G.2
  • 17
    • 0034502208 scopus 로고    scopus 로고
    • Increased number of glucocorticoid receptor-β-expressing cells in the airways in fatal asthma
    • Christodoulopoulos, P., D.Y.M. Leung, M. Elliott, et al. 2000. Increased number of glucocorticoid receptor-β-expressing cells in the airways in fatal asthma. J Allergy Clin. Immunol. 106:479-484.
    • (2000) J Allergy Clin. Immunol. , vol.106 , pp. 479-484
    • Christodoulopoulos, P.1    Leung, D.Y.M.2    Elliott, M.3
  • 18
    • 4644235617 scopus 로고    scopus 로고
    • Glucocorticoid receptors in human airways
    • Pujols, L., J. Mullol, G. Torrego, et al. 2004. Glucocorticoid receptors in human airways. Allergy 59:1042-1052.
    • (2004) Allergy , vol.59 , pp. 1042-1052
    • Pujols, L.1    Mullol, J.2    Torrego, G.3
  • 19
    • 0029845201 scopus 로고    scopus 로고
    • Glucocorticoid receptor localization in normal and asthmatic lung
    • Adcock, I.M., T. Gilbey, C.M. Gelder, et al. 1996. Glucocorticoid receptor localization in normal and asthmatic lung. Am. J. Respir. Crit. Care Med. 154:771-782.
    • (1996) Am. J. Respir. Crit. Care Med. , vol.154 , pp. 771-782
    • Adcock, I.M.1    Gilbey, T.2    Gelder, C.M.3
  • 20
    • 0036036475 scopus 로고    scopus 로고
    • Lung deposition of hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone: A cross-over study in healthy volunteers
    • Leach, C.L., P.J. Davidson, B.E. Hasselquist, et al. 2002. Lung deposition of hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone: a cross-over study in healthy volunteers. Chest 122:510-516.
    • (2002) Chest , vol.122 , pp. 510-516
    • Leach, C.L.1    Davidson, P.J.2    Hasselquist, B.E.3
  • 21
    • 0034567438 scopus 로고    scopus 로고
    • Efficacy and safety overview of a new inhaled corticosteroid, QVAR (hydrofluoroalkane-beclomethasone extrafine inhalation aerosol), in asthma
    • Vanden Burgt, J.A., W.W. Busse, R.J. Martin, et al. 2000. Efficacy and safety overview of a new inhaled corticosteroid, QVAR (hydrofluoroalkane- beclomethasone extrafine inhalation aerosol), in asthma. J. Allergy Clin. Immunol. 106:1209-1226.
    • (2000) J. Allergy Clin. Immunol. , vol.106 , pp. 1209-1226
    • Vanden Burgt, J.A.1    Busse, W.W.2    Martin, R.J.3
  • 22
    • 2642522877 scopus 로고    scopus 로고
    • 14C]ciclesonide after oral and intravenous administration to healthy subjects
    • 14C]ciclesonide after oral and intravenous administration to healthy subjects. Clin. Pharmacokinet. 43:479-486.
    • (2004) Clin. Pharmacokinet. , vol.43 , pp. 479-486
    • Nave, R.1    Bethke, T.D.2    Van Marle, S.P.3
  • 23
    • 0242450168 scopus 로고    scopus 로고
    • In vitro metabolism of ciclesonide in the human lung and liver as determined by use of precision-cut tissue slices
    • abst
    • Nave, R., R. Fisher, and K. Zech. 2003. In vitro metabolism of ciclesonide in the human lung and liver as determined by use of precision-cut tissue slices. Am. J. Respir. Crit. Care Med. 167:A771(abst).
    • (2003) Am. J. Respir. Crit. Care Med. , vol.167
    • Nave, R.1    Fisher, R.2    Zech, K.3
  • 24
    • 1642340164 scopus 로고    scopus 로고
    • In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide
    • Stoeck, M., R. Riedel, G. Hochhaus, et al. 2004. In vitro and in vivo anti-inflammatory activity of the new glucocorticoid ciclesonide. J. Pharmacol. Exp. Ther. 309:249-258.
    • (2004) J. Pharmacol. Exp. Ther. , vol.309 , pp. 249-258
    • Stoeck, M.1    Riedel, R.2    Hochhaus, G.3
  • 26
    • 0007752828 scopus 로고    scopus 로고
    • Efficacy and safety profile of the novel on-site activated corticosteroid ciclesonide
    • Bundschuh, D.S., R. Riedel, A. Hatzelmann, et al. 2001. Efficacy and safety profile of the novel on-site activated corticosteroid ciclesonide. Am. J. Respir. Crit. Care Med. 163:A588.
    • (2001) Am. J. Respir. Crit. Care Med. , vol.163
    • Bundschuh, D.S.1    Riedel, R.2    Hatzelmann, A.3
  • 28
    • 33745597139 scopus 로고    scopus 로고
    • Repeated inhalation of the new topical steroid ciclesonide does not lead to suppression of endogenous cortisol release in healthy subjects
    • Berlin, Germany
    • Drollmann, A., A. Weinbrenner, D. Hüneke, et al. 2001. Repeated inhalation of the new topical steroid ciclesonide does not lead to suppression of endogenous cortisol release in healthy subjects. Presented at the 11th Annual Congress of the European Respiratory Society (ERS), Berlin, Germany.
    • (2001) 11th Annual Congress of the European Respiratory Society (ERS)
    • Drollmann, A.1    Weinbrenner, A.2    Hüneke, D.3
  • 31
    • 0034967896 scopus 로고    scopus 로고
    • Effect of inhaled ciclesonide on airway responsiveness to inhaled AMP, the composition of induced sputum and exhaled nitric oxide in patients with mild asthma
    • Kanniess, F., K. Richter, S. Böhme, et al. 2001. Effect of inhaled ciclesonide on airway responsiveness to inhaled AMP, the composition of induced sputum and exhaled nitric oxide in patients with mild asthma. Pulm. Pharmacol. Ther. 14:141-147.
    • (2001) Pulm. Pharmacol. Ther. , vol.14 , pp. 141-147
    • Kanniess, F.1    Richter, K.2    Böhme, S.3
  • 32
    • 0034910074 scopus 로고    scopus 로고
    • Treatment of asthma by the inhaled corticosteroid ciclesonide given either in the morning or evening
    • Postma, D.S., C. Sevette, Y. Martinat, et al. 2001. Treatment of asthma by the inhaled corticosteroid ciclesonide given either in the morning or evening. Eur. Respir. J. 17:1083-1088.
    • (2001) Eur. Respir. J. , vol.17 , pp. 1083-1088
    • Postma, D.S.1    Sevette, C.2    Martinat, Y.3
  • 33
    • 0032794908 scopus 로고    scopus 로고
    • A dose-dependent effect of the novel inhaled corticosteroid ciclesonide on airway responsiveness to adenosine-5′-monophosphate in asthmatic patients
    • Taylor, D.A., M.W. Jensen, V. Kanabar, et al. 1999. A dose-dependent effect of the novel inhaled corticosteroid ciclesonide on airway responsiveness to adenosine-5′-monophosphate in asthmatic patients. Am. J. Respir. Crit. Care Med. 160:237-243.
    • (1999) Am. J. Respir. Crit. Care Med. , vol.160 , pp. 237-243
    • Taylor, D.A.1    Jensen, M.W.2    Kanabar, V.3
  • 34
    • 0007805278 scopus 로고    scopus 로고
    • Airway responsiveness to AMP: A sensitive method to evaluate the dose-response relationship of an inhaled steroid in asthma
    • abst
    • Taylor, D. A., M.W. Jensen, J.G. Harris, et al. 1997. Airway responsiveness to AMP: a sensitive method to evaluate the dose-response relationship of an inhaled steroid in asthma. Eur. Respir. J. 10:295s(abst).
    • (1997) Eur. Respir. J. , vol.10
    • Taylor, D.A.1    Jensen, M.W.2    Harris, J.G.3
  • 36
    • 0002277455 scopus 로고    scopus 로고
    • Ciclesonide-an inhaled corticosteroid prodrug-inhibits allergen induced early and late phase reactions
    • abst
    • Dahl, R., L.P. Nielsen, M.B. Christensen, et al. 1998. Ciclesonide-an inhaled corticosteroid prodrug-inhibits allergen induced early and late phase reactions. Eur. Respir. J. 12:62s(abst).
    • (1998) Eur. Respir. J. , vol.12
    • Dahl, R.1    Nielsen, L.P.2    Christensen, M.B.3
  • 37
    • 0033328304 scopus 로고    scopus 로고
    • The new topical steroid ciclesonide is effective in the treatment of allergic rhinitis
    • Schmidt, B.M.W., W. Timmer, A.C. Georgens, et al. 1999. The new topical steroid ciclesonide is effective in the treatment of allergic rhinitis. J. Clin. Pharmacol. 39:1062-1069.
    • (1999) J. Clin. Pharmacol. , vol.39 , pp. 1062-1069
    • Schmidt, B.M.W.1    Timmer, W.2    Georgens, A.C.3
  • 38
    • 0029092473 scopus 로고
    • Multimodality imaging: The use of single photon emission computed tomography and magnetic resonance imaging to assess regional intrapulmonary deposition of nebulised aerosols
    • Conway, J.H., P. Halson, and E. Moore. 1995. Multimodality imaging: the use of single photon emission computed tomography and magnetic resonance imaging to assess regional intrapulmonary deposition of nebulised aerosols. J. Aerosol Med. 8:293-295.
    • (1995) J. Aerosol Med. , vol.8 , pp. 293-295
    • Conway, J.H.1    Halson, P.2    Moore, E.3
  • 39
    • 3242722042 scopus 로고    scopus 로고
    • Oropharyngeal deposition of inhaled ciclesonide and budesonide in healthy subjects
    • abst
    • Nave, R., K. Zech, and T.D. Bethke. 2003. Oropharyngeal deposition of inhaled ciclesonide and budesonide in healthy subjects. J. Allergy Clin. Immunol. 111:S220(abst).
    • (2003) J. Allergy Clin. Immunol. , vol.111
    • Nave, R.1    Zech, K.2    Bethke, T.D.3
  • 40
    • 0036634183 scopus 로고    scopus 로고
    • The role of small airway inflammation in asthma
    • Tashkin, D.P. 2002. The role of small airway inflammation in asthma. Allergy Asthma Proc. 23:233-242.
    • (2002) Allergy Asthma Proc. , vol.23 , pp. 233-242
    • Tashkin, D.P.1
  • 41
    • 0036226440 scopus 로고    scopus 로고
    • Gamma scintigraphic evaluation of a novel budesonide dry powder inhaler using a validated radiolabeling technique
    • Warren, S., G. Taylor, J. Smith, et al. 2002. Gamma scintigraphic evaluation of a novel budesonide dry powder inhaler using a validated radiolabeling technique. J. Aerosol Med. 15:15-25.
    • (2002) J. Aerosol Med. , vol.15 , pp. 15-25
    • Warren, S.1    Taylor, G.2    Smith, J.3
  • 42
    • 0035513523 scopus 로고    scopus 로고
    • Pharmacokinetics and systemic activity of fluticasone via Diskus® and pMDI, and of budesonide via Turbuhaler®
    • Thorsson, L., S. Edsbäcker, A. Källen, et al. 2001. Pharmacokinetics and systemic activity of fluticasone via Diskus® and pMDI, and of budesonide via Turbuhaler®. Br. J. Clin. Pharmacol. 52:529-538.
    • (2001) Br. J. Clin. Pharmacol. , vol.52 , pp. 529-538
    • Thorsson, L.1    Edsbäcker, S.2    Källen, A.3
  • 43
    • 0001893108 scopus 로고    scopus 로고
    • Fluticasone propionate: Pharmacokinetic and pharmacodynamic implications of different aerosol delivery systems
    • Johnson, M. 1998. Fluticasone propionate: pharmacokinetic and pharmacodynamic implications of different aerosol delivery systems. Respir. Drug Deliv. 6:61-65.
    • (1998) Respir. Drug Deliv. , vol.6 , pp. 61-65
    • Johnson, M.1
  • 44
    • 0031659645 scopus 로고    scopus 로고
    • Comparative physicochemical and pharmacokinetic profiles of inhaled beclomethasone dipropionate and budesonide
    • Boobis, A.R. 1998. Comparative physicochemical and pharmacokinetic profiles of inhaled beclomethasone dipropionate and budesonide. Respir. Med. 92:2-6.
    • (1998) Respir. Med. , vol.92 , pp. 2-6
    • Boobis, A.R.1
  • 45
    • 0023948982 scopus 로고
    • Deposition of carbenicillin aerosols in cystic fibrosis: Effects of nebuliser system and breathing pattern
    • Newman, S.P., G. Woodman, and S.W. Clarke. 1988. Deposition of carbenicillin aerosols in cystic fibrosis: effects of nebuliser system and breathing pattern. Thorax 43:318-322.
    • (1988) Thorax , vol.43 , pp. 318-322
    • Newman, S.P.1    Woodman, G.2    Clarke, S.W.3


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