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Volumn 31, Issue 3, 1999, Pages 169-177

N-tert-butyl-alpha-phenylnitrone protects against 3,4- methylenedioxymethamphetamine-induced depletion of serotonin in rats

Author keywords

3,4 methylenedioxyamphetamine; 3,4 ethylenedioxymethamphetamine; Ethanol; Hydroxyl radicals; MDMA; N tert butyl phenylnitrone; Neurotoxicity; PBN; Superoxide radicals

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; 5 HYDROXYINDOLEACETIC ACID; ALCOHOL; BRAIN MONOAMINE; FREE RADICAL; N TERT BUTYL ALPHA PHENYLNITRONE; SCAVENGER; SEROTONIN; SEROTONIN TRANSPORTER;

EID: 0033103959     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(19990301)31:3<169::AID-SYN1>3.0.CO;2-N     Document Type: Article
Times cited : (32)

References (40)
  • 2
    • 0024159060 scopus 로고
    • MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons
    • Battaglia G, Yeh SY, De Souza EB. 1988. MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons. Pharmacol Biochem Behav 29:269-274.
    • (1988) Pharmacol Biochem Behav , vol.29 , pp. 269-274
    • Battaglia, G.1    Yeh, S.Y.2    De Souza, E.B.3
  • 4
    • 0028856659 scopus 로고
    • Age-dependent sensitivity of rats to long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethylamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response
    • Broening HW, Bowyer JF, Slikker W Jr. 1994. Age-dependent sensitivity of rats to long-term effects of the serotonergic neurotoxicant (+/-)-3,4-methylenedioxymethylamphetamine (MDMA) correlates with the magnitude of the MDMA-induced thermal response. J Pharmacol Exp Ther 275:325-333.
    • (1994) J Pharmacol Exp Ther , vol.275 , pp. 325-333
    • Broening, H.W.1    Bowyer, J.F.2    Slikker W., Jr.3
  • 5
    • 0027978346 scopus 로고
    • CuZn-superoxide dismutase (CuZnSOD) transgenic mice show resistance to the lethal effects of methylenedioxyamphetamine (MDA) and of methylenedioxymethamphetamine (MDMA)
    • Cadet JL, Ladenheim B, Baum I, Calson E, Epstein C. 1994. CuZn-superoxide dismutase (CuZnSOD) transgenic mice show resistance to the lethal effects of methylenedioxyamphetamine (MDA) and of methylenedioxymethamphetamine (MDMA). Brain Res 655:259-262.
    • (1994) Brain Res , vol.655 , pp. 259-262
    • Cadet, J.L.1    Ladenheim, B.2    Baum, I.3    Calson, E.4    Epstein, C.5
  • 6
    • 0029126705 scopus 로고
    • Superoxide radical mediate the biochemical effects of methylenedioxymethamphetamine (MDMA): Evidence from using CuZn-superoxide dismutase transgenic mice
    • Cadet JL, Ladenheim B, Hirata H, Rothman R, Ali S, Calson E, Epstein C, Moran TH. 1995. Superoxide radical mediate the biochemical effects of methylenedioxymethamphetamine (MDMA): Evidence from using CuZn-superoxide dismutase transgenic mice. Synapse 21:169-176.
    • (1995) Synapse , vol.21 , pp. 169-176
    • Cadet, J.L.1    Ladenheim, B.2    Hirata, H.3    Rothman, R.4    Ali, S.5    Calson, E.6    Epstein, C.7    Moran, T.H.8
  • 7
    • 0028895035 scopus 로고
    • Body temperature effect on methylenedioxymethamphetamine-induced acute decrease in tryptophan hydroxylase activity
    • Che S, Johnson M, Hanson GR, Gibb JW. 1995. Body temperature effect on methylenedioxymethamphetamine-induced acute decrease in tryptophan hydroxylase activity. Eur J Pharmacol 293:447-453.
    • (1995) Eur J Pharmacol , vol.293 , pp. 447-453
    • Che, S.1    Johnson, M.2    Hanson, G.R.3    Gibb, J.W.4
  • 8
    • 0027400449 scopus 로고
    • Distribution of spin trapping compounds in rat blood and brain: In vivo microdialysis determination
    • Cheny HY, Liu T, Fererstein G, Barone FC. 1993. Distribution of spin trapping compounds in rat blood and brain: In vivo microdialysis determination. Free Radic Biol Med 14:243-250.
    • (1993) Free Radic Biol Med , vol.14 , pp. 243-250
    • Cheny, H.Y.1    Liu, T.2    Fererstein, G.3    Barone, F.C.4
  • 9
    • 0028650399 scopus 로고
    • Enzymatic/nonenzymatic sources of oxyradicals and regulation of antioxidant defenses
    • Cohen G. 1994. Enzymatic/nonenzymatic sources of oxyradicals and regulation of antioxidant defenses. Ann NY Acad Sci 738:8-14.
    • (1994) Ann NY Acad Sci , vol.738 , pp. 8-14
    • Cohen, G.1
  • 10
    • 0023204457 scopus 로고
    • Free radical mediated cell toxicity by redox cycling chemicals
    • Cohen GM, d'Arcy Doherty M. 1987. Free radical mediated cell toxicity by redox cycling chemicals. Br J Cancer Suppl 8:46-52.
    • (1987) Br J Cancer Suppl , vol.8 , pp. 46-52
    • Cohen, G.M.1    D'Arcy Doherty, M.2
  • 11
    • 0029006196 scopus 로고
    • The spin trap reagent α-phenyl-N-tert-butyl nitrone prevents "ecstasy"-induced neurodegeneration of 5-hydroxytrvptamine neurones
    • Colado MI, Green AR. 1995. The spin trap reagent α-phenyl-N-tert-butyl nitrone prevents "Ecstasy"-induced neurodegeneration of 5-hydroxytrvptamine neurones. Eur J Pharmacol 280:343-346.
    • (1995) Eur J Pharmacol , vol.280 , pp. 343-346
    • Colado, M.I.1    Green, A.R.2
  • 12
    • 0027462464 scopus 로고
    • 5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine
    • Colado MI, Murray TK, Green AR. 1993. 5-HT loss in rat brain following 3,4-methylenedioxymethamphetamine (MDMA), p-chloroamphetamine and fenfluramine administration and effects of chlormethiazole and dizocilpine. Br J Pharmacol 108:583-589.
    • (1993) Br J Pharmacol , vol.108 , pp. 583-589
    • Colado, M.I.1    Murray, T.K.2    Green, A.R.3
  • 13
    • 0029112473 scopus 로고
    • The hyperthermic and neurotoxic effects of 'ecstasy' (MDMA) and 3,4-methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype
    • Colado MI, Willaim JL, Green AR. 1995. The hyperthermic and neurotoxic effects of 'Ecstasy' (MDMA) and 3,4-methylenedioxyamphetamine (MDA) in the Dark Agouti (DA) rat, a model of the CYP2D6 poor metabolizer phenotype. Br J Pharmacol 115:1281-1290.
    • (1995) Br J Pharmacol , vol.115 , pp. 1281-1290
    • Colado, M.I.1    Willaim, J.L.2    Green, A.R.3
  • 14
    • 0030986255 scopus 로고    scopus 로고
    • In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ("ecstasy") and p-chloroamphetamine but not the degeneration follwing fenfluramine
    • Colado MI, O'Shea E, Granados R, Murray TK, Green AR. 1997. In vivo evidence for free radical involvement in the degeneration of rat brain 5-HT following administration of MDMA ("Ecstasy") and p-chloroamphetamine but not the degeneration follwing fenfluramine. Br J Pharmacol 121:889-900.
    • (1997) Br J Pharmacol , vol.121 , pp. 889-900
    • Colado, M.I.1    O'Shea, E.2    Granados, R.3    Murray, T.K.4    Green, A.R.5
  • 15
    • 0023255308 scopus 로고
    • Biochemical and histological evidence that methylenedioxymethamphetamine (MDMA) is toxic to neurons in the rat brain
    • Commins DL, Vosmer G, Virus RM, Woolverton WL, Schuster ER, Seiden LS. 1987. Biochemical and histological evidence that methylenedioxymethamphetamine (MDMA) is toxic to neurons in the rat brain. J Pharmacol Exp Ther 241:338-345.
    • (1987) J Pharmacol Exp Ther , vol.241 , pp. 338-345
    • Commins, D.L.1    Vosmer, G.2    Virus, R.M.3    Woolverton, W.L.4    Schuster, E.R.5    Seiden, L.S.6
  • 18
    • 0028833356 scopus 로고
    • Role of hypothermia in the mechanism of protection against serotonergic toxicity. I. Experiments using 3,4-methylenedioxymethamphetamine, dizocilpine, CGS 19755 and NBQX
    • Farfel GM, Seiden LS. 1995. Role of hypothermia in the mechanism of protection against serotonergic toxicity. I. Experiments using 3,4-methylenedioxymethamphetamine, dizocilpine, CGS 19755 and NBQX. J Pharmacol Exp Ther 272:860-867.
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 860-867
    • Farfel, G.M.1    Seiden, L.S.2
  • 20
    • 0026680529 scopus 로고
    • Toxicity and deaths from 3,4-methylenedioxy-methamphetamine ("ecstasy")
    • Henry JA, Jeffrey KJ, Dawling S. 1992. Toxicity and deaths from 3,4-methylenedioxy-methamphetamine ("Ecstasy"). Lancet 340:384-387.
    • (1992) Lancet , vol.340 , pp. 384-387
    • Henry, J.A.1    Jeffrey, K.J.2    Dawling, S.3
  • 21
    • 0028557961 scopus 로고
    • Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('ecstasy') to rats
    • Hewitt KE, Green AR. 1994. Chlormethiazole, dizocilpine and haloperidol prevent the degeneration of serotonergic nerve terminals induced by administration of MDMA ('Ecstasy') to rats. Neuropharmacology 33:1589-1595.
    • (1994) Neuropharmacology , vol.33 , pp. 1589-1595
    • Hewitt, K.E.1    Green, A.R.2
  • 22
    • 0015338517 scopus 로고
    • The temperature dependence of the components of the hepatic microsomal mixed-function oxidases
    • Holtzman JL, Carr ML. 1972. The temperature dependence of the components of the hepatic microsomal mixed-function oxidases. Arch Biochem Biophys 150:227-234.
    • (1972) Arch Biochem Biophys , vol.150 , pp. 227-234
    • Holtzman, J.L.1    Carr, M.L.2
  • 23
    • 0024383159 scopus 로고
    • 3,4-methylenenedioxymethamphetamine ("ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys
    • Insel TR, Battaglia G, Johannessen JN, Marra S, De Souza EB. 1989. 3,4-methylenenedioxymethamphetamine ("Ecstasy") selectively destroys brain serotonin terminals in rhesus monkeys. J Pharmacol Exp Ther 249:713-720.
    • (1989) J Pharmacol Exp Ther , vol.249 , pp. 713-720
    • Insel, T.R.1    Battaglia, G.2    Johannessen, J.N.3    Marra, S.4    De Souza, E.B.5
  • 24
    • 0027202219 scopus 로고
    • Electron spin resonance evidence for free radical generation in copper-treated vitamin E- and selenium-deficient rats: In vivo spin-trapping investigation
    • Kadiiska MB, Hanna PM, Jordan SJ, Mason RP. 1993. Electron spin resonance evidence for free radical generation in copper-treated vitamin E- and selenium-deficient rats: In vivo spin-trapping investigation. Mol Pharmacol 44:222-227.
    • (1993) Mol Pharmacol , vol.44 , pp. 222-227
    • Kadiiska, M.B.1    Hanna, P.M.2    Jordan, S.J.3    Mason, R.P.4
  • 27
    • 0024347994 scopus 로고
    • Evidence that both intragastic and subcutaneous administration of methylenendioxymethamphetamine (MDMA) produce serotonin neurotoxicity in rhesus monkeys
    • Kleven MS, Woolverton WL, Seiden LS. 1989. Evidence that both intragastic and subcutaneous administration of methylenendioxymethamphetamine (MDMA) produce serotonin neurotoxicity in rhesus monkeys. Brain Res 488:121-125.
    • (1989) Brain Res , vol.488 , pp. 121-125
    • Kleven, M.S.1    Woolverton, W.L.2    Seiden, L.S.3
  • 28
    • 0003110629 scopus 로고    scopus 로고
    • Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats
    • Kil YH, Zhang J, Piantadosi CA. 1996. Brain temperature alters hydroxyl radical production during cerebral ischemia/reperfusion in rats. J Cereb Blood Metab 16:100-106.
    • (1996) J Cereb Blood Metab , vol.16 , pp. 100-106
    • Kil, Y.H.1    Zhang, J.2    Piantadosi, C.A.3
  • 30
    • 0030438476 scopus 로고    scopus 로고
    • Coadministration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat
    • Malberg JE, Sabot KE, Seiden LS. 1996. Coadministration of MDMA with drugs that protect against MDMA neurotoxicity produces different effects on body temperature in the rat. J Pharmacol Exp Ther 278:258-267.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 258-267
    • Malberg, J.E.1    Sabot, K.E.2    Seiden, L.S.3
  • 31
    • 0027964301 scopus 로고
    • Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse
    • Miller DB, O'Callaghan JP. 1994. Environment-, drug- and stress-induced alterations in body temperature affect the neurotoxicity of substituted amphetamines in the C57BL/6J mouse. J Pharmacol Exp Ther 270:752-760.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 752-760
    • Miller, D.B.1    O'Callaghan, J.P.2
  • 32
    • 0023898060 scopus 로고
    • Elevation of serum prolactin and cortisone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine
    • Nash KF Jr, Meltzer HY, Gudelsky GA. 1988. Elevation of serum prolactin and cortisone concentrations in the rat after the administration of 3,4-methylenedioxymethamphetamine. J Pharmacol Exp Ther 245:873-879.
    • (1988) J Pharmacol Exp Ther , vol.245 , pp. 873-879
    • Nash K.F., Jr.1    Meltzer, H.Y.2    Gudelsky, G.A.3
  • 33
    • 0023735752 scopus 로고
    • Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminal in forebrain: Immunocytochemical evidence for neurotoxicity
    • O'Hearn E, Battaglia G, De Souza EB, Kuhar MJ, Molliver ME. 1988. Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminal in forebrain: Immunocytochemical evidence for neurotoxicity. J Neurosci 8:2788-2803.
    • (1988) J Neurosci , vol.8 , pp. 2788-2803
    • O'Hearn, E.1    Battaglia, G.2    De Souza, E.B.3    Kuhar, M.J.4    Molliver, M.E.5
  • 34
    • 0026612759 scopus 로고
    • Lasting effects of d,l-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: Neurochemical observations
    • Ricaurte GA, Martello AL, Katz JL, Martello MB. 1992. Lasting effects of d,l-3,4-methylenedioxymethamphetamine (MDMA) on central serotonergic neurons in nonhuman primates: Neurochemical observations. J Pharmacol Exp Ther 261:616-622.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 616-622
    • Ricaurte, G.A.1    Martello, A.L.2    Katz, J.L.3    Martello, M.B.4
  • 35
    • 0023163857 scopus 로고
    • Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine
    • Schmidt CJ. 1987. Neurotoxicity of the psychedelic amphetamine, methylenedioxymethamphetamine. J Pharmacol Exp Ther 240:1-7.
    • (1987) J Pharmacol Exp Ther , vol.240 , pp. 1-7
    • Schmidt, C.J.1
  • 37
    • 0022911033 scopus 로고
    • The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain
    • Stone DM, Stahl DC, Hanson GR, Gibb JW. 1986. The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain. Eur J Pharmacol 128:41-48.
    • (1986) Eur J Pharmacol , vol.128 , pp. 41-48
    • Stone, D.M.1    Stahl, D.C.2    Hanson, G.R.3    Gibb, J.W.4
  • 38
    • 0023484528 scopus 로고
    • Immediate and long time effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin pathways in brain of rats
    • Stone DM, Merchant KM, Hanson GR, Gibb JW. 1987. Immediate and long time effects of 3,4-methylenedioxymethamphetamine (MDMA) on serotonin pathways in brain of rats. Neuropharmacology 26:1677-1683.
    • (1987) Neuropharmacology , vol.26 , pp. 1677-1683
    • Stone, D.M.1    Merchant, K.M.2    Hanson, G.R.3    Gibb, J.W.4
  • 39
    • 0027482056 scopus 로고
    • Spin trapping of superoxide radicals following stimulation of neutrophils with fMLP is temperature dependent
    • Tanigawa T, Kotake Y, Reinke LA. 1993. Spin trapping of superoxide radicals following stimulation of neutrophils with fMLP is temperature dependent. Free Radic Biol Med 15:425-433.
    • (1993) Free Radic Biol Med , vol.15 , pp. 425-433
    • Tanigawa, T.1    Kotake, Y.2    Reinke, L.A.3
  • 40
    • 0030798269 scopus 로고    scopus 로고
    • The effect of salicylate on 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity in rats
    • Yeh SY. 1997. The effect of salicylate on 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity in rats. Pharmacol Biochem Behav 58:701-708.
    • (1997) Pharmacol Biochem Behav , vol.58 , pp. 701-708
    • Yeh, S.Y.1


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