The influence of domain structures on the signal transduction of chimeric receptors derived from the erythropoietin receptor

Journal of Biochemistry

Volumn 145, Issue 5, 2009, Pages 575-584

  Liu, Wenhai ^a   Kawahara, Masahiro ^a   Ueda, Hiroshi ^a   Nagamune, Teruyuki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Chimeric receptor; Conformational change; Erythropoietin receptor; Ligand; Signal transduction

Indexed keywords

CYTOKINE RECEPTOR; ERYTHROPOIETIN RECEPTOR; HEMAGGLUTININ; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE 1; STAT5 PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL GROWTH; CONTROLLED STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; B-LYMPHOCYTES; CELL LINE; CELL MEMBRANE; CELL PROLIFERATION; HUMANS; LIGANDS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, ERYTHROPOIETIN; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 66749134179     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvp013     Document Type: Article

References (28)

1. Ihle, J.N. (2002) Cytokine receptor signalling. Nature 377, 591-594
2. Constantinescu, S.N., Ghaffari, S., and Lodish, H.F. (1999) The erythropoietin receptor: structure, activation and intracellular signal transduction. Trends Endocrinol. Metab. 10, 18-23
3. D'Andrea, A.D., Fasman, G.D., and Lodish, H.F. (1989) Erythropoietin receptor and interleukin-2 receptor beta chain: a new receptor family. Cell 58, 1023-1024
4. Livnah, O., Stura, E.A., Middleton, S.A., Johnson, D.L., Jolliffe, L.K., and Wilson, I.A. (1999) Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. Science 283, 987-990
5. Watowich, S.S., Wu, H., Socolovsky, M., Klingmuller, U., Constantinescu, S.N., and Lodish, H.F. (1996) Cytokine receptor signal transduction and the control of hematopoie-tic cell development. Annu. Rev. Cell Dev. Biol. 12, 91-128
6. Syed, R.S., Reid, S.W., Li, C., Cheetham, J.C., Aoki, K.H., Liu, B., Zhan, H., Osslund, T.D., Chirino, A.J., Zhang, J., Finer-Moore, J., Elliott, S., Sitney, K., Katz, B.A., Matthews, D.J., Wendoloski, J.J., Egrie, J., and Stroud, R.M. (1998) Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature 395, 511-516
7. Yamaoka, K., Saharinen, P., Pesu, M., Holt Iii, V.E., Silvennoinen, O., and O'Shea, J.J. (2004) The Janus kinases (Jaks). Genome Biol. 5, 253
8. Livnah, O., Stura, E.A., Johnson, D.L., Middleton, S.A., Mulcahy, L.S., Wrighton, N.C., Dower, W.J., Jolliffe, L.K., and Wilson, I.A. (1996) Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 Å. Science 273, 464-471
9. Livnah, O., Johnson, D.L., Stura, E.A., Farrell, F.X., Barbone, F.P., You, Y., Liu, K.D., Goldsmith, M.A., He, W., Krause, C.D., Pestka, S., Jolliffe, L.K., and Wilson, I.A. (1998) An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation. Nat. Struct. Biol. 5, 993-1004
10. Constantinescu, S.N., Keren, T., Socolovsky, M., Nam, H., Henis, Y.I., and Lodish, H.F. (2001) Ligand-independent oligomerization of cell-surface erythropoietin receptor is mediated by the transmembrane domain. Proc. Natl Acad. Sci. USA 98, 4379-4384
11. Constantinescu, S.N., Liu, X., Beyer, W., Fallon, A., Shekar, S., Henis, Y.I., Smith, S.O., and Lodish, H.F. (1999) Activation of the erythropoietin receptor by the gp55-P viral envelope protein is determined by a single amino acid in its transmembrane domain. EMBO J. 18, 3334-3347
12. Kubatzky, K.F., Ruan, W., Gurezka, R., Cohen, J., Ketteler, R., Watowich, S.S., Neumann, D., Langosch, D., and Klingmuller, U. (2001) Self assembly of the transmem-brane domain promotes signal transduction through the erythropoietin receptor. Curr. Biol. 11, 110-115
13. Gurezka, R., Laage, R., Brosig, B., and Langosch, D. (1999) A heptad motif of leucine residues found in membrane proteins can drive self-assembly of artificial transmembrane segments. J. Biol. Chem. 274, 9265-9270
14. Constantinescu, S.N., Huang, L.J., Nam, H., and Lodish, H.F. (2001) The erythropoietin receptor cytosolic juxtamembrane domain contains an essential, precisely oriented, hydrophobic motif. Mol. Cell 7, 377-385
15. Greiser, J.S., Stross, C., Heinrich, P.C., Behrmann, I., and Hermanns, H.M. (2002) Orientational constraints of the gp130 intracellular juxtamembrane domain for signaling. J. Biol. Chem. 277, 26959-26965
16. Spaargaren, M., Defize, L.H., Boonstra, J., and de Laat, S.W. (1991) Antibody-induced dimerization activates the epidermal growth factor receptor tyrosine kinase. J. Biol. Chem. 266, 1733-1739
17. Liu, W., Kawahara, M., Ueda, H., and Nagamune, T. (2008) Construction of a fluorescein-responsive chimeric receptor with strict ligand dependency. Biotechnol. Bioeng. 101, 975-984
18. Kawahara, M., Ueda, H., Tsumoto, K., Kumagai, I., and Nagamune, T. (2004) AMEGA: antigen-mediated genetically modified cell amplification. J. Immunol. Methods 284, 187-194
19. D'Andrea, A.D. and Zon, L.I. (1990) Erythropoietin receptor. Subunit structure and activation. J. Clin. Invest. 86, 681-687
20. Yoshimura, A., D'Andrea, A.D., and Lodish, H.F. (1990) Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplas-mic reticulum and affects receptor metabolism. Proc. Natl Acad. Sci. USA 87, 4139-4143
21. Neumann, D., Wikstrom, L., Watowich, S.S., and Lodish, H.F. (1993) Intermediates in degradation of the erythropoietin receptor accumulate and are degraded in lysosomes. J. Biol. Chem. 268, 13639-13649
22. Neumann, D., Yuk, M.H., Lodish, H.F., and Lederkremer, G.Z. (1996) Blocking intracellular degradation of the erythropoietin and asialoglycoprotein receptors by calpain inhibitors does not result in the same increase in the levels of their membrane and secreted forms. Biochem. J. 313, 391-399
23. Supino-Rosin, L., Yoshimura, A., Altaratz, H., and Neumann, D. (1999) A cytosolic domain of the erythropoie-tin receptor contributes to endoplasmic reticulum-associated degradation. Eur. J. Biochem. 263, 410-419
24. Kawahara, M., Kimura, H., Ueda, H., and Nagamune, T. (2004) Selection of genetically modified cell population using hapten-specific antibody/receptor chimera. Biochem. Biophys. Res. Commun. 315, 132-138
25. Baumgartner, J.W., Wells, C.A., Chen, C.M., and Waters, M.J. (1994) The role of the WSXWS equivalent motif in growth hormone receptor function. J. Biol. Chem. 269, 29094-29101
26. Druhan, L.J., Ai, J., Massullo, P., Kindwall-Keller, T., Ranalli, M.A., and Avalos, B.R. (2005) Novel mechanism of G-CSF refractoriness in patients with severe congenital neutropenia. Blood 105, 584-591
27. Damen, J.E., Cutler, R.L., Jiao, H., Yi, T., and Krystal, G. (1995) Phosphorylation of tyrosine 503 in the erythro-poietin receptor (EpR) is essential for binding the P85 subunit of phosphatidylinositol (PI) 3-kinase and for EpR-associated PI 3-kinase activity. J. Biol. Chem. 270, 23402-23408
28. Klingmuller, U., Wu, H., Hsiao, J.G., Toker, A., Duckworth, B.C., Cantley, L.C., and Lodish, H.F. (1997) Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc. Natl Acad. Sci. USA 94, 3016-3021