Cations modulate polysaccharide structure to determine FGF-FGFR signaling: A comparison of signaling and inhibitory polysaccharide interactions with FGF-1 in solution

Biochemistry

Volumn 48, Issue 22, 2009, Pages 4772-4779

  Guimond, Scott E ^a   Rudd, Timothy R ^a   Skidmore, Mark A ^a   Ori, Alessandro ^a   Gaudesi, Davide ^b   Cosentino, Cesare ^b   Guerrini, Marco ^b   Edge, Ruth ^c   Collison, David ^c   McInnes, Eric ^c   Torri, Giangiacomo ^b   Turnbull, Jeremy E ^a   Fernig, David G ^a   Yates, Edwin A ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b Istituto di Ricerche Chimiche e Biochimiche G Ronzoni   (Italy)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATION CONTENT; CELL-BASED; COPPER IONS; DISORDERED STRUCTURES; ELECTRON PARAMAGNETIC RESONANCE; FIBROBLAST GROWTH FACTOR RECEPTORS; HEPARAN SULFATES; INHIBITORY COMPLEX; MOLECULAR COMPONENTS; POLYSACCHARIDE STRUCTURE; SECONDARY STRUCTURES; SIGNALING ACTIVITY; SIGNALING SYSTEMS; STRUCTURAL DIFFERENCES; SYNCHROTRON RADIATION CIRCULAR DICHROISM SPECTROSCOPY; TYROSINE KINASE;

AMINO ACIDS; BIOPOLYMERS; CELL CULTURE; CIRCULAR DICHROISM SPECTROSCOPY; CONFORMATIONS; COPPER; DICHROISM; HYDRAULIC STRUCTURES; NUCLEAR MAGNETIC RESONANCE; PARAMAGNETIC RESONANCE; PARAMAGNETISM; POSITIVE IONS; RESONANCE; SIGNALING;

POLYSACCHARIDES;

CATION; COPPER; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR; HEPARIN DERIVATIVE; POLYSACCHARIDE; PROTEIN TYROSINE KINASE; SODIUM;

ANIMAL CELL; ARTICLE; CARBOHYDRATE ANALYSIS; CIRCULAR DICHROISM; ELECTRON SPIN RESONANCE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; SYNCHROTRON RADIATION;

ANIMALS; CELL LINE; COPPER; FIBROBLAST GROWTH FACTOR 1; HEPARITIN SULFATE; MICE; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; SIGNAL TRANSDUCTION; SODIUM; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66649105784     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi802318z     Document Type: Article

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