Loss of ligand-binding specificity of fibroblast growth factor receptor 2 by RNA splicing in human chondrosarcoma cells

Cancer Letters

Volumn 191, Issue 2, 2003, Pages 215-222

  Jang, Jun Hyeog ^a   Chung, Chong Pyoung ^a  

^a Seoul National University   (South Korea)

Author keywords

Chondrosarcoma; FGFR2; Fibroblast growth factor; Isoform; RNA splicing

Indexed keywords

FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; IMMUNOGLOBULIN G3; KERATINOCYTE GROWTH FACTOR; MESSENGER RNA;

ARTICLE; BINDING AFFINITY; BINDING SITE; CANCER CELL; CELL SPECIFICITY; CHONDROSARCOMA; CONTROLLED STUDY; DELETION MUTANT; EXON; GENE DELETION; HUMAN; HUMAN CELL; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN VARIANT; RECEPTOR BINDING; RNA SPLICING;

EID: 0037430451     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S030-43835(02)00694-8     Document Type: Article

References (33)

1. Muenke M., Schell U. Fibroblast-growth-factor receptor mutations in human skeletal disorders. Trends Genet. 11:1995;308-313.
2. Webster M.K., Donoghue D.J. FGFR activation in skeletal disorders: too much of a good thing. Trends Genet. 13:1997;178-182.
3. Lajeunie E., Ma H.W., Bonaventure J., Munnich A., Le Merrer M., Renier D. FGFR2 mutations in Pfeiffer syndrome. Nat. Genet. 9:1995;108.
4. Tavormina P.L., Shiang R., Thompson L.M., Zhu Y.Z., Wilkin D.J., Lachman R.S., Wilcox W.R., Rimoin D.L., Cohn D.H., Wasmuth J.J. Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3. Nat. Genet. 9:1995;321-328.
5. Reardon W., Winter R.M., Rutland P., Pulleyn L.J., Jones B.M., Malcolm S. Mutations in the fibroblast growth factor receptor 2 gene cause Crouzon syndrome. Nat. Genet. 8:1994;98-103.
6. McKeehan W.L., Wang F., Kan M. The heparan sulfate-fibroblast growth factor family: diversity of structure and function. Prog. Nucleic Acid Res. Mol. Biol. 59:1998;135-176.
7. Peters K., Ornitz D., Werner S., Williams L. Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis. Dev. Biol. 155:1993;423-430.
8. Dionne C.A., Crumley G., Bellot F., Kaplow J.M., Searfoss G., Ruta M., Burgess W.H., Jaye M., Schlessinger J. Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. EMBO J. 9:1990;2685-2692.
9. Jaye M., Schlessinger J., Dionne C.A. Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction. Biochim. Biophys. Acta. 1135:1992;185-199.
10. Goldfarb M. Functions of fibroblast growth factors in vertebrate development. Cytokine Growth Factor Rev. 7:1996;311-325.
11. Miki T., Bottaro D.P., Fleming T.P., Smith C.L., Burgess W.H., Chan A.M., Aaronson S.A. Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc. Natl. Acad Sci. USA. 89:1992;246-250.
12. Plotnikov A.N., Hubbard S.R., Schlessinger J., Mohammadi M. Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity. Cell. 101:2000;413-424.
13. Stauber D.J., DiGabriele A.D., Hendrickson W.A. Structural interactions of fibroblast growth factor receptor with its ligands. Proc. Natl. Acad Sci. USA. 97:2000;49-54.
14. Shi D.L., Launay C., Fromentoux V., Feige J.J., Boucaut J.C. Expression of fibroblast growth factor receptor-2 splice variants is developmentally and tissue-specifically regulated in the amphibian embryo. Dev. Biol. 164:1994;173-182.
15. Lu W., Luo Y., Kan M., McKeehan W.L. Fibroblast growth factor-10. A second candidate stromal to epithelial cell andromedin in prostate. J. Biol. Chem. 274:1999;12827-12834.
16. Igarashi M., Finch P.W., Aaronson S.A. Characterization of recombinant human fibroblast growth factor (FGF)-10 reveals functional similarities with keratinocyte growth factor (FGF-7). J. Biol. Chem. 273:1998;13230-13235.
17. Orr-Urtreger A., Givol D., Yayon A., Yarden Y., Lonai P. Developmental expression of two murine fibroblast growth factor receptors, flg and bek. Development. 113:1991;1419-1434.
18. Ornitz D.M. FGFs, heparan sulfate and FGFRs: complex interactions essential for development. Bioessays. 22:2000;108-112.
19. Berman B., Ostrovsky O., Shlissel M., Lang T., Regan D., Vlodavsky I., Ishai-Michaeli R., Ron D. Similarities and differences between the effects of heparin and glypican-1 on the bioactivity of acidic fibroblast growth factor and the keratinocyte growth factor. J. Biol. Chem. 274:1999;36132-36138.
20. DiGabriele A.D., Lax I., Chen D.I., Svahn C.M., Jaye M., Schlessinger J., Hendrickson W.A. Structure of a heparin-linked biologically active dimer of fibroblast growth factor. Nature. 393:1998;812-817.
21. Jang J.H., Wang F., Kan M. Heparan sulfate is required for interaction and activation of the epithelial cell fibroblast growth factor receptor-2IIIb with stromal-derived fibroblast growth factor-7. In Vitro Cell Dev. Biol. Anim. 33:1997;819-824.
22. Munson P.J., Rodbard D. Ligand: a versatile computerized approach for characterization of ligand-binding systems. Anal. Biochem. 107:1980;220-239.
23. Robertson S.C., Meyer A.N., Hart K.C., Galvin B.D., Webster M.K., Donoghue D.J. Activating mutations in the extracellular domain of the fibroblast growth factor receptor 2 function by disruption of the disulfide bond in the third immunoglobulin-like domain. Proc. Natl. Acad. Sci. USA. 95:1998;4567-4572.
24. Mohammadi M., Dionne C.A., Li W., Li N., Spivak T., Honegger A.M., Jaye M., Schlessinger J. Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature. 358:1992;681-684.
25. Naski M.C., Wang Q., Xu J., Ornitz D.M. Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Nat. Genet. 13:1996;233-237.
26. Kan M., Wang F., Xu J., Crabb J.W., Hou J., McKeehan W.L. An essential heparin-binding domain in the fibroblast growth factor receptor kinase. Science. 259:1993;1918-1921.
27. Ye S., Luo Y., Lu W., Jones R.B., Linhardt R.J., Capila I., Toida T., Kan M., Pelletier H., McKeehan W.L. Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs. Biochemistry. 40:2001;14429-14439.
28. Ostrovsky O., Berman B., Gallagher J., Mulloy B., Fernig D.G., Delehedde M., Ron D. Differential effects of heparin saccharides on the formation of specific fibroblast growth factor (FGF) and FGF receptor complexes. J. Biol. Chem. 277:2002;2444-2453.
29. Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A., Coulier F., Gao G., Goldfarb M. Receptor specificity of the fibroblast growth factor family. J. Biol. Chem. 271:1996;15292-15297.
30. Jang J.H., Shin K.H., Park Y.J., Lee R.J., McKeehan W.L., Park J.G. Novel transcripts of fibroblast growth factor receptor 3 reveal aberrant splicing and activation of cryptic splice sequences in colorectal cancer. Cancer Res. 60:2000;4049-4052.
31. Pellegrini L., Burke D.F., von Delft F., Mulloy B., Blundell T.L. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Nature. 407:2000;1029-1034.
32. Avivi A., Yayon A., Givol D. A novel form of FGF receptor-3 using an alternative exon in the immunoglobulin domain III. FEBS Lett. 330:1993;249-252.
33. Jang J.H. Identification and characterization of soluble isoform of fibroblast growth factor receptor 3 in human SaOS-2 osteosarcoma cells. Biochem. Biophys. Res. Commun. 292:2002;378-382.