Flexibility in the inducer binding region is crucial for allostery in the Escherichia coli lactose repressor

Biochemistry

Volumn 48, Issue 22, 2009, Pages 4988-4998

  Xu, Jia ^a   Matthews, Kathleen S ^a  

^a RICE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC MECHANISMS; ALLOSTERIC TRANSITION; ALLOSTERY; BINDING AFFINITIES; BOUND STATE; CELL EXTRACTS; CONFORMATIONAL CHANGE; DISULFIDE BONDS; DOUBLE MUTANTS; INTER-RESIDUE HYDROGEN BONDS; KINETIC CONSTANT; OXIDIZED STATE; PARALLEL CHANGES; REDUCED-STATE; SIDE CHAINS; SINGLE MUTANT; SPATIAL RELATIONSHIPS; TARGETED MOLECULAR DYNAMICS; WILD TYPES; WILD-TYPE PROTEINS;

AMINES; AMINO ACIDS; BINDING ENERGY; DYNAMICS; ESCHERICHIA COLI; HYDROGEN; HYDROGEN BONDS; MOLECULAR DYNAMICS; ORGANIC ACIDS; RATE CONSTANTS; SIGNAL TRANSDUCTION; SUGARS;

BINDING SITES;

AMINO ACID; ASPARTIC ACID; BACTERIAL PROTEIN; CELL EXTRACT; CYSTEINE; ISOPROPYL THIOGALACTOSIDE; LACTOSE; MUTANT PROTEIN; PROTEIN LACI; REPRESSOR PROTEIN; SERINE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; DISULFIDE BOND; DNA BINDING; ESCHERICHIA COLI; HYDROGEN BOND; MOLECULAR DYNAMICS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; ASPARTIC ACID; BACTERIAL PROTEINS; BINDING SITES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; ISOPROPYL THIOGALACTOSIDE; MUTAGENESIS, SITE-DIRECTED; OPERATOR REGIONS, GENETIC; OXIDATION-REDUCTION; PROTEIN BINDING; REPRESSOR PROTEINS; SERINE;

ESCHERICHIA COLI;

EID: 66649102153     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9002343     Document Type: Article

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