Serum VEGF levels are related to the presence of pulmonary arterial hypertension in systemic sclerosis

BMC Pulmonary Medicine

Volumn 9, Issue , 2009, Pages

  Papaioannou, Andriana I ^a   Zakynthinos, Epaminondas ^a   Kostikas, Konstantinos ^a   Kiropoulos, Theodoros ^a   Koutsokera, Angela ^a   Ziogas, Athanasios ^a   Koutroumpas, Athanasios ^a   Sakkas, Lazaros ^a   Gourgoulianis, Konstantinos I ^a   Daniil, Zoe D ^a  

^a UNIVERSITY OF THESSALY   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; VASCULOTROPIN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL EXAMINATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DYSPNEA; ECHOCARDIOGRAPHY; FEMALE; HUMAN; LUNG ARTERY PRESSURE; LUNG DIFFUSION; LUNG FUNCTION TEST; MALE; PATHOGENESIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PULMONARY HYPERTENSION; SYSTEMIC SCLEROSIS; AGED; BLOOD; LUNG; LUNG CIRCULATION; METABOLISM; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDICTION AND FORECASTING; STATISTICAL MODEL;

ADULT; AGED; DYSPNEA; FEMALE; HUMANS; HYPERTENSION, PULMONARY; LINEAR MODELS; LUNG; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PREDICTIVE VALUE OF TESTS; PULMONARY CIRCULATION; RESPIRATORY FUNCTION TESTS; SCLERODERMA, SYSTEMIC; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 66649101854     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/1471-2466-9-18     Document Type: Article

References (37)

1. Sakkas LI Chikanza IC Platsoucas CD Mechanisms of Disease: The role of immune cells in the pathogenesis of systemic sclerosis Nat Clin Pract Rheumatol 2006, 2(12):679-685 10.1038/ncprheum0346 17133253
2. Chung L Lin J Furst DE Fiorentino D Systemic and localized scleroderma Clin Dermatol 2006, 24(5):374-392 10.1016/j.clindermatol.2006.07.004 16966019
3. Preston IR Hill NS Evaluation and management of pulmonary hypertension in systemic sclerosis Curr Opin Rheumatol 2003, 15(6):761-765 10.1097/ 00002281-200311000-00013 14569207
4. Battle RW Davitt MA Cooper SM Buckley LM Leib ES Beglin PA Tischler MD Prevalence of pulmonary hypertension in limited and diffuse scleroderma Chest 1996, 110(6):1515-1519 10.1378/chest.110.6.1515 8989070
5. McGoon M Gutterman D Steen V Barst R McCrory DC Fortin TA Loyd JE Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines Chest 2004, 126(1 Suppl):14S-34S 10.1378/chest.126.1_suppl.14S 15249493
6. Ferrara N Gerber HP LeCouter J The biology of VEGF and its receptors Nat Med 2003, 9(6):669-676 10.1038/nm0603-669 12778165
7. Neufeld G Cohen T Gengrinovitch S Poltorak Z Vascular endothelial growth factor (VEGF) and its receptors Faseb J 1999, 13(1):9-22 9872925
8. Kikuchi K Kubo M Kadono T Yazawa N Ihn H Tamaki K Serum concentrations of vascular endothelial growth factor in collagen diseases Br J Dermatol 1998, 139(6):1049-1051 10.1046/j.1365-2133.1998.02563.x 9990370
9. Asai K Kanazawa H Kamoi H Shiraishi S Hirata K Yoshikawa J Increased levels of vascular endothelial growth factor in induced sputum in asthmatic patients Clin Exp Allergy 2003, 33(5):595-599 10.1046/ j.1365-2222.2003.01576.x 12752587
10. Papaioannou AI Kostikas K Kollia P Gourgoulianis KI Clinical implications for vascular endothelial growth factor in the lung: Friend or foe? Respir Res 2006, 7:128 1629021 17044926 10.1186/1465-9921-7-128
11. Kranenburg AR de Boer WI Alagappan VK Sterk PJ Sharma HS Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease Thorax 2005, 60(2):106-113 1747292 15681497 10.1136/thx.2004.023986
12. Meyer KC Cardoni A Xiang ZZ Vascular endothelial growth factor in bronchoalveolar lavage from normal subjects and patients with diffuse parenchymal lung disease J Lab Clin Med 2000, 135(4):332-338 10.1067/ mlc.2000.105618 10779049
13. Eddahibi S Humbert M Sediame S Chouaid C Partovian C Maitre B Teiger E Rideau D Simonneau G Sitbon O et al Imbalance between platelet vascular endothelial growth factor and platelet-derived growth factor in pulmonary hypertension. Effect of prostacyclin therapy Am J Respir Crit Care Med 2000, 162(4 Pt 1):1493-1499 11029367
14. Mata-Greenwood E Meyrick B Soifer SJ Fineman JR Black SM Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension Am J Physiol Lung Cell Mol Physiol 2003, 285(1):L222-231 12665467
15. Tuder RM Voelkel NF Pulmonary hypertension and inflammation J Lab Clin Med 1998, 132(1):16-24 10.1016/S0022-2143(98)90020-8 9665367
16. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee Arthritis Rheum 1980, 23(5):581-590 10.1002/art.1780230510 7378088
17. Mahler DA Wells CK Evaluation of clinical methods for rating dyspnea Chest 1988, 93(3):580-586 10.1378/chest.93.3.580 3342669
18. Standardization of Spirometry, 1994 Update. American Thoracic Society Am J Respir Crit Care Med 1995, 152(3):1107-1136 7663792
19. Yock PG Popp RL Noninvasive estimation of right ventricular systolic pressure by Doppler ultrasound in patients with tricuspid regurgitation Circulation 1984, 70(4):657-662 6478568
20. Himelman RB Stulbarg M Kircher B Lee E Kee L Dean NC Golden J Wolfe CL Schiller NB Noninvasive evaluation of pulmonary artery pressure during exercise by saline-enhanced Doppler echocardiography in chronic pulmonary disease Circulation 1989, 79(4):863-871 2924417
21. Barst RJ McGoon M Torbicki A Sitbon O Krowka MJ Olschewski H Gaine S Diagnosis and differential assessment of pulmonary arterial hypertension J Am Coll Cardiol 2004, 43(12 Suppl S):40S-47S 10.1016/ j.jacc.2004.02.032 15194177
22. Joppa P Petrasova D Stancak B Tkacova R Systemic inflammation in patients with COPD and pulmonary hypertension Chest 2006, 130(2):326-333 10.1378/chest.130.2.326 16899829
23. Varga J Abraham D Systemic sclerosis: A prototypic multisystem fibrotic disorder J Clin Invest 2007, 117(3):557-567 1804347 17332883 10.1172/ JCI31139
24. Voelkel NF Cool C Taraceviene-Stewart L Geraci MW Yeager M Bull T Kasper M Tuder RM Janus face of vascular endothelial growth factor: The obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension Crit Care Med 2002, 30(5 Suppl):S251-256 10.1097/00003246-200205001-00013 12004244
25. Tuder RM Chacon M Alger L Wang J Taraseviciene-Stewart L Kasahara Y Cool CD Bishop AE Geraci M Semenza GL et al Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: Evidence for a process of disordered angiogenesis J Pathol 2001, 195(3):367-374 10.1002/path.953 11673836
26. Partovian C Adnot S Eddahibi S Teiger E Levame M Dreyfus P Raffestin B Frelin C Heart and lung VEGF mRNA expression in rats with monocrotaline- or hypoxia-induced pulmonary hypertension Am J Physiol 1998, 275(6 Pt 2):H1948-1956 9843792
27. Christou H Yoshida A Arthur V Morita T Kourembanas S Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension Am J Respir Cell Mol Biol 1998, 18(6):768-776 9618381
28. Hirose S Hosoda Y Furuya S Otsuki T Ikeda E Expression of vascular endothelial growth factor and its receptors correlates closely with formation of the plexiform lesion in human pulmonary hypertension Pathol Int 2000, 50(6):472-479 10.1046/j.1440-1827.2000.01068.x 10886723
29. Distler O Del Rosso A Giacomelli R Cipriani P Conforti ML Guiducci S Gay RE Michel BA Bruhlmann P Muller-Ladner U et al Angiogenic and angiostatic factors in systemic sclerosis: Increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers Arthritis Res 2002, 4(6):R11 153841 12453314 10.1186/ar596
30. Dor Y Porat R Keshet E Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis Am J Physiol Cell Physiol 2001, 280(6):C1367-1374 11350731
31. Fujita M Mason RJ Cool C Shannon JM Hara N Fagan KA Pulmonary hypertension in TNF-alpha-overexpressing mice is associated with decreased VEGF gene expression J Appl Physiol 2002, 93(6):2162-2170 12391106
32. Taraseviciene-Stewart L Kasahara Y Alger L Hirth P Mc Mahon G Waltenberger J Voelkel NF Tuder RM Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension Faseb J 2001, 15(2):427-438 10.1096/fj.00-0343com 11156958
33. Campbell AI Zhao Y Sandhu R Stewart DJ Cell-based gene transfer of vascular endothelial growth factor attenuates monocrotaline-induced pulmonary hypertension Circulation 2001, 104(18):2242-2248 10.1161/ hc4201.097838 11684638
34. Proudman SM Stevens WM Sahhar J Celermajer D Pulmonary arterial hypertension in systemic sclerosis: The need for early detection and treatment Intern Med J 2007, 37(7):485-494 10.1111/ j.1445-5994.2007.01370.x 17547726
35. Currie PJ Seward JB Chan KL Fyfe DA Hagler DJ Mair DD Reeder GS Nishimura RA Tajik AJ Continuous wave Doppler determination of right ventricular pressure: A simultaneous Doppler-catheterization study in 127 patients J Am Coll Cardiol 1985, 6(4):750-756 4031289
36. Simonson JS Schiller NB Petri M Hellmann DB Pulmonary hypertension in systemic lupus erythematosus J Rheumatol 1989, 16(7):918-925 2769664
37. Aguglia G Sgreccia A Bernardo ML Carmenini E Giusti De Marle M Reali A Morelli S Left ventricular diastolic function in systemic sclerosis J Rheumatol 2001, 28(7):1563-1567 11469462