Increased vascular endothelial growth factor production in the lungs of rats with hypoxia-induced pulmonary hypertension

American Journal of Respiratory Cell and Molecular Biology

Volumn 18, Issue 6, 1998, Pages 768-776

  Christou, Helen ^a   Yoshida, Atsushi ^a   Arthur, Victoria ^a   Morita, Toshisuke ^a   Kourembanas, Stella ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL CELL GROWTH FACTOR; GROWTH FACTOR RECEPTOR; LYMPHOKINE; MESSENGER RNA; PROTEIN TYROSINE KINASE; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR;

ANIMAL; ANOXIA; ARTICLE; BLOOD; CAPILLARY PERMEABILITY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG; LUNG ALVEOLUS; MALE; METABOLISM; NORTHERN BLOTTING; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PULMONARY HYPERTENSION; RAT; SPRAGUE DAWLEY RAT; TIME; VASCULARIZATION;

ANIMALS; ANOXIA; BLOTTING, NORTHERN; CAPILLARY PERMEABILITY; ENDOTHELIAL GROWTH FACTORS; HYPERTENSION, PULMONARY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG; LYMPHOKINES; MALE; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; TIME FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0032090254     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.18.6.2980     Document Type: Article

References (41)

1. Minchenko, A., T. Bauer, S. Salceda, and J. Caro. 1994. Hypoxic stimulation of vascular endothelial growth factor expression in vitro and in vivo. Lab. Invest. 71:374-379.
2. Shweiki, D., A. Itin, D. Soffer, and E. Keshet. 1992. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature (London) 359:843-845.
3. Shweiki, D., M. Neeman, A. Itin, and E. Keshet. 1995. Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: Implications for tumor angiogenesis. Proc. Natl. Acad. Sci. USA 92:768-772.
4. Shibuya, M., S. Yamaguchi, A. Yamane, T. Ikeda, A. Tojo, H. Matsushime, and M. Sato. 1990. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene 5:519-524.
5. Hatva, E., A. Kaipainen, P. Mentula, J. Jaaskelainen, A. Paetau, M. Haltia, and K. Alitalo. 1995. Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors. Am. J. Pathol. 146:368-378.
6. Brown, L. F., B. Berse, R. W. Jackman, K. Tognazzi, A. J. Guidi, H. F. Dvorak, D. R. Senger, J. L. Connolly, and S. J. Schnitt. 1995. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer. Hum. Pathol. 26:86-61.
7. Plate, K. H., G. Breier, H. A. Weich, and W. Risau. 1992. Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo. Nature (London) 359:845-848.
8. Brogi, E., G. Schatteman, T. Wu, E. A. Kim, L. Varticovski, B. Keyt, and J. M. Isner. 1996. Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression. J. Clin. Invest. 97:469-476.
9. Aiello, L. P., R. L. Avery, P. G. Arrigg, B. A. Keyt, H. D. Jampel, S. T. Shah, L. R. Pasquale, H. Thieme, M. A. Iwamoto, H. E. Park, H. V. Nguyen, L. M. Aiello, N. Ferrara, and G. L. King. 1994. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331:1480-1487.
10. Peters, K. G., C. De Vries, and L. T. Williams. 1993. Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth. Proc. Natl. Acad. Sci. USA 90:8915-8919.
11. Brown, L. F., B. Berse, R. W. Jackman, K. Tognazzi, E. J. Manseau, D. R. Senger, and H. F. Dvorak. 1993. Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract. Cancer Res. 53:4727-4735.
12. Meyrick, B., and L. Reid. 1980. Endothelial and subintimal changes in rat hilar pulmonary artery during recovery from hypoxia. Lab. Invest. 42:603-615.
13. Tuder, R. M., B. E. Flook, and N. F. Voelkel 1995. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. J. Clin. Invest. 95:1798-1807.
14. Thompson, K., and M. Rabinovitch. 1996. Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular matrix-bound basic fibroblast growth factor. J. Cell. Physiol. 166:495-505.
15. Chomczynski, P., and N. Sacchi. 1987. Single step method of RNA isolation by guanidinium thiocyanate phenol chloroform extraction. Anal. Biochem. 162:156-159.
16. Berse, B., L. F. Brown, L. Van De Water, H. F. Dvorak, and D. R. Senger. 1992. Vascular permeability factor (vascular endothelial growth factor) gene is expressed differentially in normal tissues, macrophages, and tumors. Mol. Biol. Cell 3:211-220.
17. Patterson, C., M. A. Perrella, W. O. Endege, M. Yoshizumi, M.-E. Lee, and E. Haber. 1996. Downregulation of vascular endothelial growth factor receptors by tumor necrosis factor-α in cultured human vascular endothelial cells. J. Clin. Invest. 98:490-496.
18. Kourembanas, S., R. L. Hannan, and D. V. Faller. 1990. Oxygen tension regulates the expression of the platelet-derived growth factor-B chain gene in human endothelial cells. J. Clin. Invest. 86:670-674.
19. Patterson, C. E., R. A. Rhoades, and J. G. Garcia. 1992. Evans Blue dye as a marker of albumin clearance in cultured endothelial monolayer and isolated lung. J. Appl. Physiol. 72:865-873.
20. Sirois, M. G., S. Jancar, P. Braquet, G. E. Plante, and P. Sirois. 1988. PAF increases vascular permeability in selected tissues: Effects of BN-52021 and L-655.240. Prostaglandins 36:631-644.
21. Tavares de Lima, W., F. H. Kwasniewski, P. Sirois, and S. Janear. 1995. Studies on the mechanism of PAF-induced vasopermeability in rat lungs. Prostaglandins Leukocyte Essent. Fatty Acids 52:245-249.
22. Dallal, M. M., and S.-W. Chang. 1994. Evans blue dye in the assessment of permeability surface area product in perfused rat lungs. J. Appl. Physiol. 77:1030-1035.
23. Adnot, S., B. Raffestin, S. Eddahibi, P. Braquet, and P.-E. Chabrier. 1991. Loss of endothelium-dependent relaxant activity in the pulmonary circulation of rats exposed to chronic hypoxia. J. Clin. Invest. 87:155-162.
24. Meyrick, B. O., and E. A. Perkett. 1989. The sequence of cellular and hymodynamic changes of chronic pulmonary hypertension induced by hypoxia and other stimuli. Am. Rev. Respir. Dis. 140:1486-1489.
25. Davies, P., and L. Reid. 1991. Hypoxic remodeling of the rat pulmonary arterial microcirculation assessed by microdissection. J. Appl. Physiol. 71: 1886-1891.
26. Mecham, R. P., L. A. Whitehouse, D. S. Wrenn, W. C. Parks, G. L. Griffin, R. M. Senior, E. C. Crouch, K. R. Stenmark, and N. F. Voelkel. 1987. Smooth muscle-mediated connective tissue remodeling in pulmonary hypertension. Science 237:423-426.
27. Kourembanas, S., P. A. Marsden, L. P. McQuillan, and D. V. Faller. 1991. Hypoxia induces endothelin gene expression and secretion in cultured human endothelium. J. Clin. Invest. 88:1054-1057.
28. McQuillan, L. P., G. K. Leung, P. A. Marsden, S. K. Kostyk, and S. Kourembanas. 1994. Hypoxia inhibits expression of cNOS via transcriptional and posttranscriptional mechanisms. Am. J. Physiol. 267:H1921-H1927.
29. Johns, R. A., J. M. Linden, and M. J. Peach. 1989. Endothelium-dependent relaxation and cyclic GMP accumulation in rabbit pulmonary artery are selectively impaired by moderate hypoxia. Circ. Res. 65:1508-1515.
30. Morita, T., M. A. Perrella, M.-E. Lee, and S. Kourembanas. 1995. Smooth muscle cell-derived carbon monoxide is a regullator of vascular cGMP. Proc. Natl. Acad. Sci. USA 92:1475-1479.
31. Morita, T., and S. Kourembanas. 1995. Endothelial cell expression of vasoconstrictors and growth factors is regulated by smooth muscle cell-derived carbon monoxide. J. Clin. Invest. 96:2676-2682.
32. Kourembanas, S., L. P. McQuillan, G. K. Leung, and D. V. Faller. 1993. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia. J. Clin. Invest. 92:99-104.
33. Monacci, W. T., M. J. Merrill, and E. H. Oldfield. 1993. Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues. Am. J. Physiol. 264:C995-C1002.
34. Christou, H., I. Adatia, L. J. Van Marter, J. W. Kane, J. E. Thompson, A. R. Stark, D. L. Wessel, and S. Kourembanas. 1997. Effects of inhaled nitric oxide on endothelin-1 and cyclic guanosine 5′-monophosphate plasma concentrations in newborn infants with persistent pulmonary hypertension. J. Pediatr. 130:603-611.
35. Stewart, D. J., R. D. Levy, P. Cernacek, and D. Langleben. 1991. Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease? Ann. Intern. Med. 114:464-469.
36. Taipale, J., K. Koli, and J. Keski-Oja. 1992. Release of transforming growth factor-β1 from the pericellular matrix of cultured fibroblasts and fibrosarcoma cells by plasmin and thrombin. J. Biol. Chem. 267:25378-25384.
37. Kobayashi, J., D. Wigle, T. Childs, L. Zhu, F. W. Keeley, and M. Rabinovitch. 1994. Serum-induced vascular smooth muscle cell elastolytic activity through tyrosine kinase intracellular signalling. J. Cell. Physiol. 160:121-131.
38. Maruyama, K., C. Ye, M. Woo, H. Venkatacharya, L. D. Lines, M. M. Silver, and M. Rabinovitch. 1991. Chronic hypoxic pulmonary hypertension in rats and increased elastolytic activity. Am. J. Physiol. 261:H1716-H1726.
39. Sirois, M. G., W. T. De Lima, A. J. de Brum Fernandez, R. J. Johnson, G. E. Plante, and P. Sirois. 1994. Effects of PAF on rat lung vascular permeability: role of platelets and polymorphonuclear leucocytes. Br. J. Pharm. 111: 1111-1116.
40. Wu, H. M., O. Huang, Y. Yuan, and H. J. Granger. 1996. VEGF induces NO-dependent hyperpermeability in coronary venules. Am. J. Physiol. 271:H2735-H2739.
41. Morbidelli, L., C. H. Chang, J. G. Douglas, H. J. Granger, F. Ledda, and M. Ziche. 1996. Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium. Am. J. Physiol. 270:H411-H415.