Pharmacokinetic changes of oltipraz after intravenous and oral administration to rats with liver cirrhosis induced by dimethylnitrosamine

International Journal of Pharmaceutics

Volumn 275, Issue 1-2, 2004, Pages 227-238

  Bae, Soo K ^a   Lee, Shin J ^a   Lee, Jang Y ^b   Lee, Youngsoo ^b   Lee, Inchul ^c   Kim, Sang G ^a   Lee, Myung G ^a  

^a Seoul National University   (South Korea)

^b CJ Corporation   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

Author keywords

Area under the plasma concentration time curve from time zero to time infinity; AUC; CL; CLNR; CLR; High performance liquid chromatography; HPLC; Time averaged renal clearance; Time averaged total body clearance

Indexed keywords

DIMETHYLNITROSAMINE; OLTIPRAZ;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD FLOW VELOCITY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; IN VITRO STUDY; LIVER BLOOD FLOW; LIVER CIRRHOSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BLOOD PROTEINS; DIMETHYLNITROSAMINE; INJECTIONS, INTRAVENOUS; LIVER CIRRHOSIS, EXPERIMENTAL; MALE; MICROSOMES, LIVER; PROTEIN BINDING; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; SCHISTOSOMICIDES; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 1842638361     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.02.004     Document Type: Article

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