A versatile photoactivatable probe designed to label the diphosphate binding site of farnesyl diphosphate utilizing enzymes

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4797-4805

  Henry, Olivier ^a   Lopez Gallego, Fernando ^b   Agger, Sean A ^b   Schmidt Dannert, Claudia ^b   Sen, Stephanie ^c   Shintani, David ^d   Cornish, Katrina ^e   Distefano, Mark D ^a  

^a University of Minnesota   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c The College of New Jersey   (United States)

^d UNIVERSITY OF NEVADA   (United States)

^e Yulex Corporation   (United States)

Author keywords

Benzophenone; Farnesyl diphosphate synthase; Farnesyltransferase; Photoaffinity labeling; Sesquiterpene cyclase

Indexed keywords

BENZOPHENONE DERIVATIVE; FARNESYL DIPHOSPHATE; GERANYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE; SESQUITERPENE SYNTHASE; SYNTHETASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; DROSOPHILA MELANOGASTER; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; NONHUMAN; NOSTOC; PHOTOACTIVATION; PHOTOLYSIS; SACCHAROMYCES CEREVISIAE; STRUCTURE ANALYSIS;

ANIMALS; BINDING SITES; CARBON-CARBON LYASES; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; FARNESYLTRANSTRANSFERASE; GERANYLTRANSTRANSFERASE; MODELS, MOLECULAR; NOSTOC; PHOTOAFFINITY LABELS; POLYISOPRENYL PHOSPHATES; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE; SESQUITERPENES;

CYANOBACTERIA; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; NOSTOC SP.; SACCHAROMYCES CEREVISIAE;

EID: 66449137814     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.034     Document Type: Article

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