Directed evolution of Escherichia coli farnesyl diphosphate synthase (IspA) reveals novel structural determinants of chain length specificity

Metabolic Engineering

Volumn 7, Issue 1 SPEC. ISS., 2005, Pages 18-26

  Lee, Pyung Cheon ^a   Petri, Ralf ^a   Mijts, Benjamin N ^a   Watts, Kevin T ^a   Schmidt Dannert, Claudia ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Carotenoid; FPP synthase; In vitro evolution; Prenyl diphosphate synthase

Indexed keywords

AMINO ACIDS; ENZYMES; PHOSPHATES; SUBSTRATES;

CAROTENOID; CHAIN ELONGATION REACTION; MUTANTS; MUTATION;

ESCHERICHIA COLI;

ASPARTIC ACID; CAROTENOID; GERANYLTRANSFERASE; PYROPHOSPHATE;

AMINO ACID SUBSTITUTION; ANALYTICAL ERROR; ARTICLE; DIRECTED MOLECULAR EVOLUTION; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; ESCHERICHIA COLI; GENE MUTATION; GENETIC SCREENING; MOLECULAR CLONING; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN STRUCTURE;

ESCHERICHIA COLI;

EID: 13844297445     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2004.05.003     Document Type: Article

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