Retinoid receptor subtype-selective modulators through synthetic modifications of RARγ agonists

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4345-4359

  Álvarez, Susana ^a   Álvarez, Rosana ^a   Khanwalkar, Harshal ^b   Germain, Pierre ^b   Lemaire, Géraldine ^b   Rodríguez Barrios, Fátima ^a   Gronemeyer, Hinrich ^b   de Lera, Ángel R ^a  

^a UNIVERSITY OF VIGO   (Spain)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Antagonists; Arotinoids; Molecular modeling; Retinoid receptor subtypes; Synthesis

Indexed keywords

4 [3 (7,8 DIHYDRO 8,8 DIMETHYL 5 PHENYLNAPHTHALEN 2 YL) 3 OXOPROP 1 EN 1 YL]BENZOIC ACID; 4 [3 [7,8 DIHYDRO 8,8 DIMETHYL 5 (2 PHENYLETHYNYL)NAPHTHALEN 2 YL] 3 OXOPROP 1 EN 1 YL]BENZOIC ACID; 4 [3 [7,8 DIHYDRO 8,8 DIMETHYL 5 (4 TOLYL)NAPHTHALEN 2 YL) 3 OXOPROP 1 EN 1 YL]BENZOIC ACID; 4 [3 [7,8 DIHYDRO 8,8 DIMETHYL 5 (4 TOLYL)NAPHTHALEN 2 YL] 3 HYDROXYPROP 1 EN 1 YL]BENZOIC ACID; DNA BINDING PROTEIN; LIGAND; LUCIFERASE; PARTIAL AGONIST; RECEPTOR SUBTYPE; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR GAMMA; RETINOIC ACID RECEPTOR GAMMA AGONIST; RETINOID; TRANSCRIPTION FACTOR GAL4; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIGAND BINDING; PROTEIN DOMAIN; REPORTER GENE; TRANSACTIVATION;

CARRIER PROTEINS; GENES, REPORTER; HELA CELLS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECOMBINANT FUSION PROTEINS; RETINOID X RECEPTORS; RETINOIDS; TRANSCRIPTIONAL ACTIVATION;

EID: 66449116175     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.035     Document Type: Article

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