Glycogen phosphorylase inhibitory effects of 2-oxo-1,2-dihydropyridin-3-yl amide derivatives

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4724-4733

  Karis, N David ^a   Loughlin, Wendy A ^a   Jenkins, Ian D ^a   Healy, Peter C ^a  

^a GRIFFITH UNIVERSITY   (Australia)

Author keywords

Glycogen phosphorylase; Inhibition; Pyridone amide; X ray structure

Indexed keywords

2 [3' (BENZYLAMINO) 2' OXOPYRIDIN 1'(2H) YL] N (3'',4'' DICHLOROBENZYL)ACETAMIDE; 2 OXO 1,2 DIHYDROPYRIDIN 3 YL AMIDE DERIVATIVE; CAFFEINE; DIHYDROPYRIDINE DERIVATIVE; GLUCOSE 1 PHOSPHATE; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; GLYCOGEN PHOSPHORYLASE INHIBITOR; UNCLASSIFIED DRUG;

AMINOLYSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DIABETES MELLITUS; DRUG POTENCY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROGEN BOND; IN VITRO STUDY; LIPOPHILICITY; MOLECULAR MODEL; NONHUMAN; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; X RAY ANALYSIS;

AMIDES; AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; GLYCOGEN PHOSPHORYLASE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUSCLES; PYRIDONES; RABBITS; RATS; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 66449105241     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.049     Document Type: Article

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