Listeriolysin O as cytotoxic component of an immunotoxin

Protein Science

Volumn 18, Issue 6, 2009, Pages 1210-1220

  Bergelt, Sabine ^a   Frost, Stefan ^a   Lilie, Hauke ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

B3; Cytotoxicity; Dimerization motif; Disulfide bond; Hemolysis; MCF7; Polyionic peptides

Indexed keywords

IMMUNOTOXIN; LISTERIOLYSIN O; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY B3; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN HT29; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIMERIZATION; DRUG CYTOTOXICITY; HEMOLYSIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN MOTIF;

ANTIBODIES, MONOCLONAL; BACTERIAL TOXINS; CELL LINE, TUMOR; CLONING, MOLECULAR; CYTOTOXICITY, IMMUNOLOGIC; HEAT-SHOCK PROTEINS; HEMOLYSIN PROTEINS; HEMOLYSIS; HUMANS; IMMUNOTOXINS; LEWIS BLOOD-GROUP SYSTEM; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

BACTERIA (MICROORGANISMS); TOXOPHORA;

EID: 66349099877     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.130     Document Type: Article

References (49)

1. Schrama D, Reisfeld RA, Becker JC (2006) Antibody targeted drugs as cancer therapeutics. Nat Rev Drug Discov 5:147-159.
2. Carter P (2001) Improving the efficacy of antibody-based cancer therapies. Nat Rev Cancer 1:118-129. (Pubitemid 33741887)
3. Kreitman RJ, Pastan I (1998) Immunotoxins for targeted cancer therapy. Adv Drug Deliv Rev 31:53-88. (Pubitemid 28191876)
4. FitzGerald DJ, Kreitman R, Wilson W, Squires D, Pastan I (2004) Recombinant immunotoxins for treating cancer. Int J Med Microbiol 293:577-582. (Pubitemid 38667582)
5. Gaillard JL, Berche P, Mounier J, Richard S, Sansonetti P (1987) In vitro model of penetration and intracellular growth of Listeria monocytogenes in the human enterocyte-like cell line Caco-2. Infect Immun 55:2822-2829.
6. Kuhn M, Kathariou S, Goebel W (1988) Hemolysin supports survival but not entry of the intracellular bacterium Listeria monocytogenes. Infect Immun 56:79-82. (Pubitemid 18032132)
7. Vázquez-Boland JA, Kuhn M, Berche P, Chakraborty T, Domínguez-Bernal G, Goebel W, González-Zorn B, Wehland J, Kreft J (2001) Listeria pathogenesis and molecular virulence determinants. Clin Microbiol Rev 14:584-640. (Pubitemid 32642752)
8. Schnupf P, Portnoy DA (2007) Listeriolysin O: a phagosome-specific lysin. Microbes Infect 9:1176-1187. (Pubitemid 47375145)
9. Geoffroy C, Gaillard JL, Alouf JE, Berche P (1987) Purification, characterization, and toxicity of the sulfhydryl-activated hemolysin listeriolysin O from Listeria monocytogenes. Infect Immun 55:1641-1646. (Pubitemid 17084156)
10. Bayley H (1997) Toxin structure: part of a hole? Curr Biol 7:763-767.
11. Palmer M (2001) The family of thiol-activated, cholesterol-binding cytolysins. Toxicon 39:1681-1689. (Pubitemid 32787000)
12. Tweten RK (2005) Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins. Infect Immun 73:6199-6209. (Pubitemid 41368781)
13. Kayal S, Charbit A (2006) Listeriolysin O: a key protein of Listeria monocytogenes with multiple functions. FEMS Microbiol Rev 30:514-529. (Pubitemid 43855765)
14. Bhakdi S, Tranum-Jensen J, Sziegoleit A (1985) Mechanism of membrane damage by streptolysin-O. Infect Immun 47:52-60. (Pubitemid 15194590)
15. Rossjohn J, Feil SC, McKinstry WJ, Tweten RK, Parker MW (1997) Structure of a cholesterol-binding, thiol-activated cytolysin and a model of its membrane form. Cell 89:685-692. (Pubitemid 27516171)
16. Michel E, Reich KA, Favier R, Berche P, Cossart P (1990) Attenuated mutants of the intracellular bacterium Listeria monocytogenes obtained by single amino acid substitutions in listeriolysin O. Mol Microbiol 4:2167-2178. (Pubitemid 120005277)
17. Sekino-Suzuki N, Nakamura M, Mitsui KI, Ohno-Iwashita Y (1996) Contribution of individual tryptophan residues to the structure and activity of theta-toxin (perfringolysin O), a cholesterol-binding cytolysin. Eur J Biochem 241:941-947. (Pubitemid 26379400)
18. Jacobs T, Cima-Cabal MD, Darji A, Méndez FJ, Vázquez F, Jacobs AA, Shimada Y, Ohno-Iwashita Y, Weiss S, de los Toyos JR (1999) The conserved undecapeptide shared by thiol-activated cytolysins is involved in membrane binding. FEBS Lett 459:463-466. (Pubitemid 29467388)
19. Giammarini C, Andreoni F, Amagliani G, Casiere A, Barocci S, Magnani M (2003) High-level expression of the Listeria monocytogenes listeriolysin O in Escherichia coli and preliminary characterization of the purified protein. Protein Expr Purif 28:78-85. (Pubitemid 36453181)
20. Glomski IJ, Gedde MM, Tsang AW, Swanson JA, Portnoy DA (2002) The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells. J Cell Biol 156:1029-1038. (Pubitemid 34839852)
21. Pastan I, Lovelace ET, Gallo MG, Rutherford AV, Magnani JL, Willingham MC (1991) Characterization of monoclonal antibodies B1 and B3 that react with mucinous adenocarcinomas. Cancer Res 51:3781-3787.
22. Brinkmann U, Reiter Y, Jung SH, Lee B, Pastan I (1993) A recombinant immunotoxin containing a disulfide-stabilized Fv fragment. Proc Natl Acad Sci USA 90:7538-7542. (Pubitemid 23249985)
23. Jung SH, Pastan I, Lee BK (1994) Design of interchain disulfide bonds in the framework region of the Fv fragment of the monoclonal antibody B3. Proteins 19:35-47. (Pubitemid 24151482)
24. Reiter Y, Pai LH, Brinkmann U, Wang QC, Pastan I (1994) Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment. Cancer Res 54:2714-2718. (Pubitemid 24173763)
25. Pastan IH, Archer GE, McLendon RE, Friedman HS, Fuchs HE, Wang QC, Pai LH, Herndon J, Bigner DD (1995) Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model. Proc Natl Acad Sci USA 28:2765-2769.
26. Richter SA, Stubenrauch K, Lilie H, Rudolph R (2001) Polyionic fusion peptides function as specific dimerization motifs. Protein Eng 14:775-783. (Pubitemid 34024659)
27. Kleinschmidt M, Rudolph R, Lilie H (2003) Design of a modular immunotoxin connected by polyionic adapter peptides. J Mol Biol 327:445-452. (Pubitemid 36298713)
28. Kurschus FC, Kleinschmidt M, Fellows E, Dornmair K, Rudolph R, Lilie H, Jenne DE (2004) Killing of target cells by redirected granzyme B in the absence of perforin. FEBS Lett 562:87-92. (Pubitemid 38388452)
29. Stubenrauch K, Gleiter S, Brinkmann U, Rudolph R, Lilie H (2001) Conjugation of an antibody Fv fragment to a virus coat protein: cell-specific targeting of recombinant polyoma-virus-like particles. Biochem J 356:867-873. (Pubitemid 32588460)
30. May T, Gleiter S, Lilie H (2002) Assessment of cell type specific gene transfer of polyoma virus like particles presenting a tumor specific antibody Fv fragment. J Virol Methods 105:147-157.
31. Adams GP, Weiner LM (2005) Monoclonal antibody therapy of cancer. Nat Biotechnol 23:1147-1157. (Pubitemid 41486396)
32. Shen WC, Ballou B, Ryser HJ, Hakala TR (1986) Targeting, internalization, and cytotoxicity of methotrexate-monoclonal anti-stage-specific embryonic antigen-1 antibody conjugates in cultured F-9 teratocarcinoma cells. Cancer Res 46:3912-3916. (Pubitemid 16075884)
33. Dillman RO, Johnson DE, Shawler DL, Koziol JA (1988) Superiority of an acid-labile daunorubicin-monoclonal antibody immunoconjugate compared to free drug. Cancer Res 48:6097-6102. (Pubitemid 18266807)
34. Press OW, Eary JF, Appelbaum FR, Martin PJ, Nelp WB, Glenn S, Fisher DR, Porter B, Matthews DC, Gooley T, Bernstein ID (1995) Phase II trial of 131I-B1 (anti-CD20) antibody therapy with autologous stem cell transplantation for relapsed B cell lymphomas. Lancet 346:336-340.
35. Kaminski MS, Zasadny KR, Francis IR, Fenner MC, Ross CW, Milik AW, Estes J, Tuck M, Regan D, Fisher S, Glenn SD, Wahl RL (1996) Iodine-131-anti-B1 radioimmunotherapy for B-cell lymphoma. J Clin Oncol 14:1974-1981. (Pubitemid 26230097)
36. Sievers EL, Appelbaum FR, Spielberger RT, Forman SJ, Flowers D, Smith FO, Shannon-Dorcy K, Berger MS, Bernstein ID (1999) Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate. Blood 93:3678-3684. (Pubitemid 29249814)
37. Brinkmann U, Keppler-Hafkemeyer A, Hafkemeyer P (2001) Recombinant immunotoxins for cancer therapy. Expert Opin Biol Ther 1:693-702. (Pubitemid 33769080)
38. Kreitman RJ (2006) Immunotoxins for targeted cancer therapy. AAPS J 8:532-551.
39. Hexham JM, Dudas D, Hugo R, Thompson J, King V, Dowling C, Neville, DM, Jr, Digan ME, Lake P (2001) Influence of relative binding affinity on efficacy in a panel of anti-CD3 scFv immunotoxins. Mol Immunol 38:397-408. (Pubitemid 33001249)
40. Frankel AE, Kreitman RJ, Sausville EA (2000) Targeted toxins. Clin Cancer Res 6:326-334. (Pubitemid 30111447)
41. Thorpe PE, Wallace PM, Knowles PP, Relf MG, Brown AN, Watson GJ, Blakey DC, Newell DR (1988) Improved antitumor effects of immunotoxins prepared with deglycosylated ricin A-chain and hindered disulfide linkages. Cancer Res 48:6396-6403. (Pubitemid 18269765)
42. Saito G, Amidon GL, Lee KD (2003) Enhanced cytosolic delivery of plasmid DNA by a sulfhydryl-activatable listeriolysin O/protamine conjugate utilizing cellular reducing potential. Gene Ther 10:72-83. (Pubitemid 36175828)
43. Giammarini C, Andreoni F, Amagliani G, Casiere A, Barocci S, Magnani M (2004) Purification and characterization of a recombinant listeriolysin O expressed in Escherichia coli and possible diagnostic applications. J Biotechnol 109:13-20. (Pubitemid 38452567)
44. Roberg K, Johansson U, Ollinger K (1999) Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress. Free Radic Biol Med 27:1228-1237. (Pubitemid 30001483)
45. Bursch W (2001) The autophagosomal-lysosomal compartment in programmed cell death. Cell Death Differ 8:569-581. (Pubitemid 32590778)
46. Guzmán CA, Domann E, Rohde M, Bruder D, Darji A, Weiss S, Wehland J, Chakraborty T, Timmis KN (1996) Apoptosis of mouse dendritic cells is triggered by listeriolysin, the major virulence determinant of Listeria monocytogenes. Mol Microbiol 20:119-126. (Pubitemid 26126050)
47. Carrero JA, Calderon B, Unanue ER (2004) Listeriolysin O from Listeria monocytogenes is a lymphocyte apoptogenic molecule. J Immunol 172:4866-4874. (Pubitemid 38456410)
48. Jacobs T, Darji A, Frahm N, Rohde M, Wehland J, Chakraborty T, Weiss S (1998) Listeriolysin O: cholesterol inhibits cytolysis but not binding to cellular membranes. Mol Microbiol 28:1081-1089. (Pubitemid 28293534)
49. Rudolph R, Boehm G, Lilie H, Jaenicke R, Folding proteins. In:Creighton TE, Ed.(1997) Protein function - a practical approach. Oxford: IRL Press, pp 57-99.